Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Publication in 2016

Publication in 2016

A01A02A03

【A01】

【Group Ⅰ-Ⅱ】
Hiroshi Handa, A01 Group Leader
Professor, Dept.of Nanoparticle Translational Research,Handa Lab,Tokyo Medical University
  1. Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D., Qiao, H., Bergamini, G., Handa, H., Savitski, M, M., Bantscheff, M., Medard, G., Preissner, R. and Kuster, B. Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem.Biol., 2016. In press.(DOI:10.1021/acshembio.5b01063)
  2. Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi,Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. and Suematsu, M. Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat. Commun., 7, 11030, 2016. ( DOI: 10.1038/ncomms11030)
  3. Nguyen, T. V., Lee, J. E., Sweredoski, M. J., Yang, S.-J., Jeon, S.-J., Harrison, J. S., Yim, J.-H., Lee, S. G., Handa H., Kuhlman, B., Jeong, J.-S., Reitsma, J. M., Park, C.-S., Hess, S., and Deshaies, R. J.* Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon. Mol. Cell, , 61, 2016, 809-820. [10.1016/j.molcel.2016.02.032]
  4. Mukai, S., Moriya, S., Hiramoto, M., Kazama, H., Kokuba, H., Che, X. F., Yokoyama, T. Sakamoto, S., Sugawara, A., Sunazuka, T., Ōmura, S., Handa, H., Itoi, T., and Miyazawa, K.* Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. Int. J. Oncol. , 48, 2016, 45-54. [10.3892/ijo.2015.3237]
【Group Ⅰ-Ⅱ】
Ryuichi Okamoto
Professor, Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University
  1. Kengo Nozaki, Wakana Mochizuki, Yuka Matsumoto, Taichi Matsumoto, Masayoshi Fukuda, Tomohiro Mizutani, Mamoru Watanabe, Tetsuya Nakamura. Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. 2016;51(3) 206-213
  2. Ryuichi Okamoto, Mamoru Watanabe. Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J. Gastroenterol 2016;51(1)11-21
  3. Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe. Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells. Biochem. Biophys. Res. Commun 2016 ; 469:1062-1068
【Group Ⅰ-Ⅱ】
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
【Group Ⅰ-Ⅱ】
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku
  1. *Arai, M.; Kamiya, K.; Shin, D.; Matsumoto, H.; Hisa, T.; Setiawan, A.; Kotoku, N.; *Kobayashi, M. New 3-alkylpyridine alkaloid, N-methylniphatyne A as an inhibitor of cancer cells adapted to nutrient starvation from an Indonesia marine sponge of Xestospongia sp. Chem. Pharm. Bull. 2016, In press.
  2. *Arai, M.; Kawachi, T.; Kotoku, N.; Nakata, C.; Kamada, H.; Tsunoda, S.; Tsutsumi, Y.; Endo, H.; Inoue, M.; Sato, H.; *Kobayashi, M.  Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75.ChemBioChem 2016, 17, 181-189. DOI: 10.1002/cbic.201500519
  3. Kotoku, N.; Arai, M.; *Kobayashi, M. Search for Anti-angiogenic Substances from Natural Sources. Chem. Pharm. Bull. 2016, 64, 119-127. DOI: 10.1248/cpb.c15-00744
【Group Ⅰ-Ⅱ】
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
【Group Ⅰ(A01) -Ⅱ(A03)】
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
【Group Ⅰ-Ⅱ】
Kohji Fukunaga
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. L.L. Hong, Q. Jiang, S. Long, H. Wang, L.D. Zhang, Y. Tian, C.K. Wang, J.J. Cao, R.R. Tao, J.Y. Huang, M.H. Liao, Y.M. Lu, K. Fukunaga, N.M. Zhou, F. Han, Valproic acid influences MTNR1A intracellular trafficking and signaling in a β-arrestin 2-dependent manner, Mol Neurobiol,53(2): 1237-1246. (2016).doi: 10.1007/s12035-014-9085-y.
【Group Ⅰ-Ⅱ】
Maiko Okada
Assistant Professor, St.Marianna University School of Medicine.
【Group Ⅰ-Ⅱ】
Nobuaki Matsumori
Professor, Graduate School of Science, Kyusyu Univeristy
  1. R.A. Espiritu, K. Cornelio, M. Kinoshita, *N. Matsumori, M. Murata, S. Nishimura, H. Kakeya, M. Yoshida, S. Matsunaga, Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores. Biochim. Biophys. Acta, Biomembranes, 1858, 1373-1379 (2016). doi: 10.1016/j.bbamem.2016.03.019.
  2. Y. Umegawa, Y. Tanaka, N. Matsumori, *M. Murata, 13C-TmDOTA as versatile thermometer compound for solid-state NMR of hydrated lipid bilayer membranes. Magn. Reson. Chem., 54, 227-233 (2016). doi: 10.1002/mrc.4371.
【Group Ⅰ-Ⅱ】
Akihiro Sugawara
Assistant Professor, Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. N. Iwanaga, S. Nakamura, K. Oshima, T. Kajihara, T. Takazono, T. Miyazaki, K. Izumikawa, K. Yanagihara, A. Sugawara, T. Sunazuka, S. Omura, S. Kohno, Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonies in mice, J. Infect. Dis. 2015 accepted
  2. Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che X-F, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Ōmura S, Handa H, Itoi T, Miyazawa K “Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines” Int. J. Clin. Oncol. 2016, 48, 45-54. DOI: 10.3892/ijo.2015.3237
  3. Sugawara A, Shima H, Sueki A, Hirose T, Matsui H, Hanaki H, Akagawa KS, Ōmura S, Sunazuka T, “12-Membered non-antibiotic macrolides EM900 series; Design, synthesis, biological evaluation, and effect in cigarette-smoking model” J. Antibiot. 2015, in press. doi: 10.1038/ja.2015.91
【Group Ⅰ-Ⅱ】
Soichi Kojima
Unit Leader, Center for Life Science Technology,RIKEN
  1. Qin, X-Y., Tatsukawa, H., hitomi, K., Shirakami, Y., Ishibashi, N., Shimizu, M., Moriwaki, H., and *Kojima, S. Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model. Cancer Prevention Res. 9(3):205-14. doi: 10.1158/1940-6207.CAPR-15-0326. (2016) selected for cover Image
  2. Furutani, Y. and Kojima, S. Control of TG functions depending on their localization. In Transglutaminase – multiple functional modifiers and targets for new drug discovery (Hitomi, K., Kojima, S., and Fesus, L. eds) Springer Tokyo, 43-62. (2016)
【Group Ⅰ-Ⅱ】
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Shi G, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T. Single-domain Intrabodies against HCV Core Inhibit Viral Propagation and Core-induced NF-κB Activation. J Gen Virol: (2016 (in press))
  2. Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F. Anti-hepatitis C virus natural product from a fungus, Penicillium herquei. J Nat Prod: (in press)
  3. Sankhyan A, Sharma C, Dutta D, Sharma T, Chosdol K, Wakita T, Watashi K, Awasthi A, Acharya S, Khanna N, Tiwari A, Sinha S. Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals. Sci Rep: 5. 13994 (in press)
  4. Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley D, Kanto T, Mizokami M, Moriishi K, Matsuura Y. Hepatocyte factor JMJD5 regulates HBV replication through interaction with HBx. J Virol: (in press)
  5. Kong L, Fujimoto A, Nakamura M, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H. Prolactin regulatory element binding protein is involved in hepatitis C virus replication by interacting with NS4B. J Virol: (in press)
  6. Zhou X, Xu L, Wang W, Watashi K, Wang Y, Sprengers D, de Ruiter PE, van der Laan LJ, Metselaar HJ, Kamar N, Peppelenbosch MP, Pan Q. Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection. J Viral Hepat: (in press)
【Group Ⅱ】
Asako Sugimoto
Professor,Graduate School of Life Sciences, Tohoku University
【Group Ⅱ】
Hirokazu Arimoto
Professor,Graduate School of Life Sciences, Tohoku University
【Group Ⅱ】
Yoshihiro Miwa
Lecturer,Faculty of Medicine,University of Tsukuba
  1. Uchida D, Kawamata H, Omotehara F, Miwa Y, Horiuchi H, Furihata T, Tachibana M, Fujimori T. Overexpression of TSC-22 (transforming growth factor -β- stimulated clone-22) causes marked obesity, splenic abnormality and B cell lymphoma in transgenic mice. Oncotarget. 2016. Feb 10. doi: 10.18632/oncotarget.7308.
【Group Ⅱ】
Kumiko UI-TEI
Associate Professor, Graduate School of Science The University of Tokyo
  1. Kamola PJ, Nakano Y, Takahashi T, Wilson PA, *Ui-Tei K.
    The siRNA Non-Seed Region and its Target Sequences are Auxiliary Determinants of Off-Target Effects.
    PLoS Comput. Biol. (2015) in press.
【Group Ⅱ】
Hiroshi Hamamoto
Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  1. Hamamoto H*,Sekimizu K, Identification of lysocin E using a silkworm model of bacterial infection, Drug Discov Ther, 10, 24-29, 2016, 10.5582/ddt.2016.01012 review article
【Group Ⅱ】
Hiroaki Kato
Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
【Group Ⅱ】
Tatsuro Shimamura
Project Lecturer, Graduate School of Medicine, Kyoto University
  1. Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, *Suematsu M.
    Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat Commun. 2016 Mar 18;7:11030. doi: 10.1038/ncomms11030.
  2. Shimamura T. Springer, Advanced Methods in Structural Biology. Chapter 6 Overview of membrane protein purification and crystallization. 2016, in press.
【Group Ⅱ】
Yoshio Hayashi
Professor, Tokyo University of Pharmacy and Life Sciences

【A02】

【Group Ⅰ-Ⅱ】
Kazuhiro Irie, A02 Group Leader
Professor, Graduate School of Agriculture, Kyoto Universiy
  1. Kikumori, M., Yanagita, R. C., Tokuda, H., Suenaga, K., Nagai, H., *Irie, K., Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead, Biosci. Biotechnol. Biochem., 80, 221-231 (2016) (DOI: 10.1080/09168451.2015.1091718)
【Group Ⅰ-Ⅱ】
Masaya Imoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher: Etsu Tashiro
  1. Ioka S, Saitoh T, Iwano S, Suzuki K, Maki S.A., Miyawaki A, Imoto M, and *`Nishiyama S. Synthesis of firefly luciferin analogues and evaluation of the luminescent properties. Chem. Eur. J.. in press
  2. *Igarashi Y, Asano D, Sawamura M. In Y, Ishida T, Imoto M. :Ulbactins F and G, polycyclic Thiazoline derivatives with tumor cell migration inhibitory activity from Brevibacillus sp. Org. Lett in press
  3. Kritsanawong S, Innajak S, Imoto M, *Watanapokasin R. Antiproliferative and apoptosis induction of ?-mangostin in T47D breast cancer cells. International J. Oncology in press
  4. Kakeya H. Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification. Nat Prod Rep. Feb.17 (2016) doi: 10.1039/C5NP00120J
  5. Saito S, Fujimaki T, Panbangred W, Igarashi Y and *Imoto M. Antarlides, A new-type of Androgen Receptor (AR) Antagonist, that overcomes resistance to AR-targeted Therapy. Angewandte Chemie Int. Ed. 55(8):2728-32 (2016)
  6. Kaneta H, Koda M, Saito S, Imoto M, Kawada M, Yamazaki Y, Momose I & *Shindo K. Biological activities of unique isoflavones prepared from Apios americana Medik. Bioscience, Biotechnology, and Biochemistry Jan 25:1-5 (2016) doi: 10.1080/09168451.2015.1127132.
【Group Ⅰ-Ⅱ】
Shigeki Matsunaga
Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
【Group Ⅰ-Ⅱ】
Masami Ishibashi
Professor,Graduate School of Pharmaceutical Sciences, Chiba University
Co-Researcher:Midori Arai, Naoki Ishikawa
  1. Abdelfattah, M. S.; Arai, M. A.; *Ishibashi, M. “Bioactive secondary metabolites with unique aromatic and heterocyclic structures obtained from terrestrial actinomycetes species” Chem. Pharm. Bull. in press DOI:10.1248/cpb.c16-00038
  2. Ahmed F.; *Ishibashi, M. “Bio-active natural products with TRAIL-resistance overcoming activity” Chem. Pharm. Bull. 2016, 64, 119-127 DOI:10.1248/cpb.c15-00732
  3. *Arai, M. A.; Kofuji, Y.; Tanaka, Y.; Yanase, N.; Yamaku, K.; Fuentes, R. G.; Karmakar, U. K.; *Ishibashi, M. “Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities” Org. Biomol. Chem. 2016, 14, 3061-3068 DOI:10.1039/c5ob02537k
  4. Ahmed, F.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; *Ishibashi, M. “Constituents from Entada scandens with TRAIL-resistance overcoming activity” Nat. Prod. Commun. in press http://www.naturalproduct.us/
  5. Abdelfattah, M. S.; Ishikawa, N.; Karmakar, U. K.; Yamaku, K.; *Ishibashi, M. “New phenazine analogues from Streptomyces sp. IFM 11694 with Wnt signaling inhibitory and TRAIL resistance-overcoming activities” J. Antibiot. in press DOI:10.1038/ja.2015.129
  6. Karmakar, U. K.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Bioassay-guided isolation of compounds with TRAIL-resistance overcoming activity from Datura stramoniumNat. Prod. Commun. in press http://www.naturalproduct.us/
  7. *Arai, M. A.; Ishikawa, N.; Tanaka, M.; Uemura, K.; Sugimitsu, N.; Koyano, T.; Kowithayakorn, T.; *Ishibashi, M. “Hes1 dimer inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells” Chem. Sci. 2016, 7, 1514-1520 DOI:10.1039/c5sc03540f
  8. Abdelfattah, M. S.; Ishikawa, N.; Karmakar, U. K.; *Ishibashi, M. “Sulfotanone, a new alkyl sulfonic acid derivative from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activity” J. Nat. Med. in press DOI:10.1007/s11418-015-0951-3
【Group Ⅰ-Ⅱ】
Tetsuro Shinada
Professor, Graduate School of Science, Osaka City University
Co-Researcher: Yasufumi Ohfune
  1. ◎Y. Yasuno, M. Hamada, M. Kawasaki, K. Shimamoto, Y. Shigeri, T. Akizawa, M. Konishi, Y. Ohfune,* T. Shinada, (7S)-Kaitocephalin as a potent NMDA receptor selective ligand, Org. Biomol. Chem.2016, 14, 1206-1210. DOI: 10.1039/C5CC08458J.
  2. Y. Yasuno, Y. Yoshida, A. Nishimura, Y. Ohfune, *T. Shinada, A facile synthesis of (5-siloxymehtl)pyrrolidine-2- carboxylic acid ester, Heterocycles,2016, 91, 2377-2385. DOI: 10.3987/COM-15-13347
  3. Y. Yasuno, A. Nishimura, Y. Yasukawa, Y. Karita, Y. Ohfune, *T. Shinada, The stereoselective construction of E– and Z-Δ-Ile from E-dehydroamino acid ester: the synthesis of the phomopsin A tripeptide side chain, Chem. Commun. 2016, 52, 1478-1481. DOI: 10.1055/s-0034-1380812
【Group Ⅰ-Ⅱ】
Hidenori Watanabe
Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
【Group Ⅰ-Ⅱ】
Kosuke Namba
Professor, Graduate School of Pharmaceutical Science, The University of Tokushima
  1. Nakayama, A.; Nishio, S.; Otani, A.; Mera, A.; Osawa, A.; Tanino, K.; *Namba, K. Substituent Effect at the C4-Position of 1,3a,6a-Triazapentalene. Chem. Pharm. Bull.2016, in press.
【Group Ⅰ-Ⅱ】
Satoshi Ichikawa 
Professor,  Faculty of Pharmaceutical Science, Hokkaido University
【Group Ⅰ-Ⅱ】
Haruhiko Fuwa
Associate Professor, Graduate School of Life Sciences, Tohoku University
  1. *H. Fuwa, N. Yamagata, Y. Okuaki, Y. Ogata, A. Saito, M. Sasaki, “Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (?)-Lyngbyaloside B,” Chemistry ? A European Journal, 22, 6815-6829(2016). DOI: 10.1002/chem.201600341. (Selected as Hot Paper and Front Cover Article)
  2. *H. Fuwa, “Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product,” Marine Drugs, 14, 65 (2016). DOI: 10.3390/md14040065.
  3. R. Isaka, L. Yu, M. Sasaki, Y. Igarashi, *H. Fuwa, “Complete Stereochemical Assignment of Campechic Acids A and B,” The Journal of Organic Chemistry, 81, 3638-3647 (2016). DOI: 10.1021/acs.joc.6b00290.
  4. *H. Fuwa, S. Matsukida, T. Miyoshi, Y. Kawashima, T. Saito, *M. Sasaki, “Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12?C36 Fragment,” The Journal of Organic Chemistry, 81, 2213?2227 (2016). DOI: 10.1021/acs.joc.5b02650. (Selected as Front Cover Article)
  5. H. Fuwa, Elsevier, “Strategies and Tactics in Organic Synthesis,” 2016, in press.
  6. Y. Kawashima, A. Toyoshima, *H. Fuwa, *M. Sasaki, “Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8-C29 Fragment,” Organic Letters, 18, 2232-2235 (2016). DOI: 10.1021/acs.orglett.6b00871.
【Group Ⅰ-Ⅱ】
Shinichi Nishimura
Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
  1. Espiritu, R. A., Cornelio, K., Kinoshita, M., Matsumori, N., Murata, M., Nishimura, S., Kakeya, H., Yoshida, M. & Matsunaga, S. (2016) Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores. Biochim. Biophys. Acta 1858, 1373-1379. DOI: 10.1016/j.bbamem.2016.03.019.
【Group Ⅰ-Ⅱ(By August)-Advisory Members】
Katsunori Tanaka
Associate Chief Scientist,Biofunctional Synthetic Chemistry Laboratory, RIKEN
Co-Researcher: Takayuki Iwata, Co-Researcher: Masataka Kitadani.
【Group Ⅰ-Ⅱ】
Kazunobu Toshima
Professor, Faculty of Science and Technology, Keio University
  1. M. Okuyama, H. Ueno, Y. Kobayashi, H. Kawagishi, D. Takahashi, *K. Toshima, Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid, Chemical Communications, 52, 2169-2172 (2016).
    DOI: 10.1039/C5CC09542E
【Group Ⅰ-Ⅱ】
Go Hirai
Senior Research Scientist, Synthetic Organic Chemistry Laboratory,RIKEN
  1. Xiaoying Sun, Go Hirai, Masashi Ueki, Hiroshi Hirota, Qianqian Wang, Yayoi Hongo, Takemichi Nakamura, Yuki Hitora, Hidekazu Takahashi, Mikiko Sodeoka, Hiroyuki Osada5, Makiko Hamamoto, *Minoru Yoshida, *Yoko Yashiroda, “Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast”, Sci. Rep.、6, 2016, 20856, DOI:10.1038/srep20856.
【Group Ⅱ】
Shigefumi Kuwahara
Professor, Graduate School of Agricultural Science, Tohoku University
【Group Ⅱ(By October)-Advisory Members】
Takayuki Doi
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
【Group Ⅱ】
Takashi Kawakami
Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
  1. Kawakami, T., Ogawa, K., Hatta, T., Goshima, N., Natsume T. Directed Evolution of a Cyclized Peptoid-Peptide Chimera against a Cell-Free Expressed Protein and Proteomic Profiling of the Interacting Proteins to Create a Protein-Protein Interaction Inhibitor. ACS Chemical Biology, 11, 2016, in press
【Group Ⅱ】
Daisuke Urabe
Lecturer, Graduate School of Pharmaceutical Sciences,
The University of Tokyo
  1. Kamimura, D.; Nagatomo, M.; Urabe, D.; *Inoue, M. “Expanding the scope of Et3B/O2-mediated coupling reactions of O,Te-acetal,” Tetrahedron 2016, in press. DOI: 10.1016/j.tet.2016.04.023
  2. Hagiwara, K.; Tabuchi, T.; Urabe, D.; *Inoue, M. “Expeditious synthesis of the fused hexacycle of puberuline C via a radical-based cyclization/translocation/cyclization process,” Chem. Sci. 2016, in press. DOI: 10.1039/C6SC00671J
  3. Nagatomo, M.; Hagiwara, K.; Masuda, K.; Koshimizu, M.; Kawamata, T.; Matsui, Y.; Urabe, D.; *Inoue, M. “Symmetry-driven strategy for the assembly of the core tetracycle of (+)-ryanodine: synthetic utility of a cobalt-catalyzed olefin oxidation and α-alkoxy bridgehead radical reaction,” Chem. Eur. J. 2016, 22, 222-229. DOI: 10.1002/chem.201503640
【Group Ⅱ】
Hiroshi Tanaka
Associate Professor, Graduate Scool of Science and Engineering,  Tokyo Institute of Technology
  1. Ryota Suzuki, Shinichiro Fuse, and Hiroshi Tanaka*, Synthesis of Asymmetrically Terminal Bifunctionlized Alkanes by Sequential Suzuki-Miyaura Coupling using B-Thexyl Boracyclanes,
    Eur. J. Org. Chem., 2016, accepted for publication
  2. Hiroki Hamagami, Motofumi Kumazoe, Yoshiki Yamaguchi, Shinichiro Fuse, Hirofumi Tachibana, and Hiroshi Tanaka*,6-Azido-6-deoxy-L-idose as a hetero-bifunctional spacer for the synthesis of azido-containing chemical probes, Chem. Eur. J., 2016, accepted for publication
  3. Nana Shiraishi, Motofumi Kumazoe, Shinichiro Fuse, Hirofumi Tachibana, and Hiroshi Tanaka*, The synthesis of trans-flavan-3-ol gallates by regioselective oxidative etherification and their cytotoxicity mediated by 67LR, Chem. Eur. J., 2016, accepted for publication
【Group Ⅱ】
Yukari Fujimoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher:Shinsuke Inuki, Toshihiko Aiba
  1. Wang, N., Hirata, A., Nokihara, K., Fukase, K., *Fujimoto, Y., Peptidoglycan Microarray as A Novel Tool to Explore Protein-Ligand Recognition. Biopolymers. 2016, in press. doi: 10.1002/bip.22807. 
  2. Shiokawa, Z., Inuki, S., Fukase, K., *Fujimoto, Y., Efficient synthesis of (?)-hanishin, (?)-longamide B, and (?)-longamide B Methyl Ester via piperazinone formation with 1,2-cyclic sulfamidates. Synlett, 2016, 27(04), 616-620. DOI: 10.1055/s-0035-1560988 
  3. Aiba, T., Sato, M., Umegaki, D., Iwasaki, T., Kambe, N., Fukase, K., *Fujimoto, Y. Regioselective Phosphorylation of myo-Inositol with BINOL-Derived Phosphoramidites, and Its Application for Protozoan Lysophosphatidylinositol. Org. Biomol. Chem., 2016, in press. DOI: 10.1039/C6OB01062H.

【A03】

【Group Ⅰ-Ⅱ】
Minoru Ueda., A03 Group Leader
Professor,Graduate School of Science, Tohoku University
  1. S. Egoshi, Y. Takaoka, H. Saito, Y. Nukadzuka, K. Hayashi, Y. Ishimaru, H. Yamakoshi, K. Dodo, M. Sodeoka, *M. Ueda, Dual function of coronatine as a bacterial virulence factor against plant: possible COI1-JAZ-independent role, RSC Adv., 6, 19404-19412 (2016).
  2. Y. Takaoka, M. Shigenaga, Y. Nukadzuka, M. Imai, Y. Ishimaru, K. Saito, R. Yokoyama, K. Nishitani, *M. Ueda, Protein Ligand-tethered Synthetic Calcium Indicator for Localization Control and Spatiotemporal Calcium Imaging in Plant Cells, Bioorg. Med. Chem. Lett., 26, 9-14 (2016).
  3. T. Kobayashi, R. Nakanishi Itai, T. Senoura, T. Oikawa, Y. Ishimaru, M. Ueda, H. Nakanishi, *N. K. Nishizawa, Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots, Plant Mol. Biol. in press (2016).
【Group Ⅰ-Ⅱ】
Naoki Kanoh
Associate Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
Co-Researcher: Takeo Usui
  1. N. Kanoh*, S. Itoh, K. Fujita, K. Sakanishi, R. Sugiyama, Y. Terajima, Y. Iwabuchi, S. Nishimura, H. Kakeya, Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-range Stereochemical Communication on the Biological Activity, Chem. Eur. J., accepted (2016).
  2. N. Kanoh*, Photo-Cross-Linked Small-Molecule Affinity Matrix as a Tool for Target Identification of Bioactive Small Molecules, Nat. Prod. Rep., in press (2016), DOI: 10.1039/C5NP00117J
  3. T. Itagaki, A. Kawamata, M. Takeuchi, K. Hamada, Y. Iwabuchi, T. Eguchi, F. Kudo, T. Usui, N. Kanoh*, Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells, J. Antibiot., in press (2016), doi:10.1038/ja.2015.148
  4. Y. Nishiyama, T. Ohmichi, S. Kazami, S. Iwasaki, K. Mano, Y. Nagumo, F. Kudo, S. Ichikawa, Y. Iwabuchi, N. Kanoh, T. Eguchi, H. Osada, T. Usui*, Vicenistatin induces early endosome-derived vacuole formation in mammalian cells, Biosci. Biotech. Biochem., 80, 902-910 (2016),
【Group Ⅰ-Ⅱ】
Hideo Kigoshi
Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
Co-Researcher: Masaki Kita
【Group Ⅰ-Ⅱ】
Toshio Nishikawa
Profrssor, Graduate School of Bioagricultural Sciences, Nagoya University
Co-Researcher :Masaatu Adachi,Keiichi Konoki
  1. Tsuchiya, S., Cho, Y. Konoki, K., Nagasawa, K., Oshima, Y., *Yotsu-Yamashita, M. Biosynthetic route towards saxitoxin and shunt pathway, Sci. Rep., 6, 20340 (2016).(doi: 10.1038/srep20340)
【Group Ⅰ-Ⅱ】
Makoto Sasaki
Professor, Graduate School of Life Sciences, Tohoku University
Co-Researcher :Kenichi Konoki
【Group Ⅰ-Ⅱ-Advisory Members】
Fumi Nagatsugi
Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
【Group Ⅱ】
Takamitsu Hosoya
Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
【Group Ⅰ-Ⅱ】Yousuke Takaoka
Lecturer, Graduate School of Science, Tohoku University (since July)
  1. ◎ Shusuke Egoshi, Yousuke Takaoka, Hiroaki Saito, Yuuki Nukadzuka, Kengo Hayashi, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Minoru Ueda*, Dual function of coronatine as a bacterial virulence factor against plants: possible COI1/JAZ independent role. RSC Adv., 6, 19404-19412 (2016). DOI 10.1039/c5ra20676f.
  2. ◎ Yousuke Takaoka, Miyuki Shigenaga, Yuuki Nukadzuka, Masaki Imai, Yasuhiro Ishimaru, Kei Saito, Ryusuke Yokoyama, Kazuhiko Nishitani, Minoru Ueda*, Protein Ligand-tethered Synthetic Calcium Indicator for Localization control and Spatiotemporal Calcium Imaging in Plant Cells. Bioorg. Med. Chem. Lett., 26, 9-14 (2016). DOI: 10.1016/j.bmcl.2015.11.055.
【Group Ⅰ-Ⅱ】
Junko Ohkanda
Associate professor, Institute for Chemical Research, Kyoto University
【Group Ⅰ-Ⅱ】
Misako Aida
Professor, Graduate School of Science, Hiroshima University
【Group Ⅰ-Ⅱ】
Hideo Takahashi
Professor, Graduate School of Medical Life Science, Yokohama City University
【Group Ⅰ-Ⅱ】
Toshiyuki Kan
Professor, School of Pharmaceutical Sciences, University of Shizuoka
【Group Ⅰ-Ⅱ】
Hiroyuki Nakamura
Professor, Tokyo Institute of Technology
  1. H. S. Ban, Y. Uto, M. Won, *H. Nakamura, Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015). Exp. Opin. Ther. Pat. 26, 309?322. (2016). doi: 10.1517/13543776.2016.
【Group Ⅰ-Ⅱ】
Nobuyuki Kanzawa
Professor, Faculty of Science and Technology, Sophia University
  1. R. Asahi, K. Tanaka, T.J. Fujimi, N. Kanzawa, S. Nakajima*, Proline decreases the suppressive effect of histidine on food intake and fat accumulation, J. Nutri. Sci Vitaminol. (2016) in press
  2. N. Kanzawa*, H. Takano, K. Yasuda, M. Takahara, M. Aizawa, Studies on connexin 43, a gap-junction protein, in P19 embryonal carcinoma cells after culture on an apatite fiber scaffold, Key Engineer. Mater., 696, 230-233 (2016).
【Group Ⅱ】
Hiroki Oguri
Professor, Faculty of Engineering, Tokyo University of Agriculture and Technology
  1.   Hiroki Oguri、Biomimetic assembly lines producing natural product analogs: Strategies from a versatile manifold to skeletally diverse scaffolds The Chemical Record 2016
    Article first published online: 1 FEB 2016 | DOI: 10.1002/tcr.201500213、
【Group Ⅱ】
Hiroaki Saito
Assistant Professor, Graduate School of Natural Science & Technology, Kanazawa University
  1. Syusuke Egoshi,Yousuke Takaoka, Hiroaki Saito, Yuuki Nukadzuka, Kengo Hayashi, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka and *Minoru Ueda “Dual function of coronatine as a bacterial virulence factor against plants: possible COI1?JAZ- independent role” Cite this: RSC Adv., 2016, 6, 19404-19412 (DOI: 10.1039/c5ra20676f)
  2. *K. Kawaguchi, H. Saito, and H. Nagao, “Decomposition analysis of free energy profile for Hsp90-ADP association”, Molecular Simulation, in press. (DOI: 10.1080/08927022.2015.1102249)
【Group Ⅰ(Advisory Members) -Ⅱ(A03)】
Motonari Uesugi
Professor, Institute for Integrated Cell-Material Sciences & Institute for Chemical Research,
Kyoto University
【Group Ⅱ】
Kazuhiro Mio
Senior Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
  1. Kazuhiro Mio, Masahiko Sato, Chikara Sato, Springer, Structural Biology and Electron Microscopy, 2016, p18

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