Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Publication in 2014

Publication in 2014

A01A02A03

【A01】

【Group Ⅰ-Ⅱ】
Hiroshi Handa, A01 Group Leader
Professor, Dept.of Nanoparticle Translational Research,Handa Lab,Tokyo Medical University

  1. Chamberlain, P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L., Ren, Y., Wang, M., Riley, M., Delker, S., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T. and Cathers, B. Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat. Struct. Mol. Biol., 21, 803-809, 2014.
  2. Pérez-Perarnau, A., Preciado, S., Palmeri, CM., Moncunill-Massaguer, C., Iglesias-Serret, D., González-Gironès, DM., Miguel, M., Karasawa, S., Sakamoto, S., Cosialls, AM., Rubio-Patiño, C., Saura-Esteller, J., Ramón, R., Caja, L., Fabregat, I., Pons, G., Handa, H., Albericio, F., Gil, J. and Lavilla, R. Novel trifluorinated thiazoline scaffold leading to proapoptotic agents targeting prohibitins. Angew. Chem. Int. Ed., 53, 10150-10154, 2014.
  3. Yamamoto, J., Hagiwara, Y., Chiba, K., Isobe, T., Narita, T., Handa, H. and Yamaguchi, Y. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat. Commun., 5, 4263, 2014.
  4. M. Takemoto, Y. Kawamura, M. Hirohama, Y. Yamaguchi, H. Handa, H. Saitoh, Y. Nakao, M. Kawada, K. Khalid, H. Koshino, K.-I. Kimura, A. Ito, M. Yoshida, Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrate, J. Antibiot.,37,335-338 (2014)
  5. S. Sakamoto, K. Omagari, Y. Kita, Y. Mochizuki, Y. Naito, S. Kawata, S. Matsuda, O. Itano, H. Jinno, H. Takeuchi, Y. Yamaguchi, Y. Kitagawa, H. Handa, Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle, Clin Chem., 60, 610-620 (2014).
  6. A. K. Gandhi, J. Kang, C. G. Havens, T. Conklin, Y. Ning, L. Wu, T. Ito, H. Ando, M. F. Waldman, A. Thakurta, A. Klippel, H. Handa, T.O. Daniel, P. H. Schafer, R. Chopra, Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN), Br. J. Haematol., 164, 811-821 (2014).
  7. M.-A. Kawano, K. Morikawa, T. Suda, N. Ohno, S. Matsushita, T. Akatsuka, H. Handa, M. Matsui, Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants, Virology, 448, 159-167 (2014).
  8. M.-A. Kawano, M. Matsui, H. Handa, SV40 virus-like particles as an effective delivery system and a vaccine platform, Future Medicine, 86-100 (2014).
【Group Ⅰ-Ⅱ】
Ryuichi Okamoto
Associate Professor, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
  1. Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.Biochem Biophys Res Commun, 456(1):298-304, DOI:10.1016/j.bbrc.2014.11.075, 査読有
  2. N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun, 454 , 493-499 (2014) , DOI:10.1016/j.bbrc.2014.10.091, 査読有
  3. H.Shimizu, R. Okamoto, G. Ito, S. Fujii, T. Nakata, K. Suzuki, T. Murano, T. Mizutani, K. Tsuchiya, T. Nakamura, K. Hozumi, M. Watanabe. Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine. PeerJ , 2 , e370-e370 ( 2014 ) , DOI:10.7717/peerj.370, 査読有
  4. M. Suzuki, T. Nagaishi, M. Yamazaki, M. Onizawa, T.Watabe, Y. Sakamaki, S.Ichinose, M. Totsuka, S. Oshima, R. Okamoto, M. Shimonaka, H. Yagita, T. Nakamura, M. Watanabe. Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS ONE, 9 , e88369 -e88369 (2014) , DOI:10.1371/journal.pone.0088369, 査読有
  5. T. Murano, R. Okamoto, G. Ito, T. Nakata, S. Hibiya, H. Shimizu, S. Fujii, Y. Kano, T. Mizutani, S. Yui, J. Akiyama-Morio, Y. Nemoto, K. Tsuchiya, T. Nakamura, M. Watanabe, Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells, Biochem Biophys Res Commun, 443, 840-846 (2014).
【Group Ⅰ-Ⅱ】
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1. Asada, M., Kato, Y., Matsuura, T. and Watanabe, H. Early Embryonic Expression of a Putative Ecdysteroid-Phosphate Phosphatase in the Water Flea, Daphnia magna (Cladocera: Daphniidae).Insect Sci,14(2014)
  2. Nakanishi, T., Kato, Y., Matsuura, T. and Watanabe, H. CRISPR/Cas-Mediated Targeted Mutagenesis in Daphnia magna.Plos One 9, e98363(2014)
  3. Soga, H., Fujii, S., Yomo, T., Kato, Y., Watanabe, H. and Matsuura, T.
    In vitro membrane protein synthesis inside cell-sized vesicles reveals the dependence of membrane protein integration on vesicle volume. ACS Synth. Biol. 3, 372-379(2014)
  4. Torner, K., Nakanishi, T., Matsuura, T., Kato, Y. and Watanabe, H.
    Optimization of mRNA design for protein expression in the crustace an Daphnia magna. Mol. Genet. Genomics 289, 707-715(2014)
  5. Toyota, K., Kato, Y., Miyakawa, H., Yatsu, R., Mizutani, T., Ogino, Y., Miyagawa, S., Watanabe, H., Nishide, H., Uchiyama, I., Tatarazako, N. and Iguchi, T. Molecular impact of juvenile hormone agonists on neonatal Daphnia magna. J. Appl. Toxicol. 34, 37-544(2014)
  6. Asada, M., Kato, Y., Matsuura, T., and Watanabe, H. Visualization of ecdysteroid activity using a reporter gene in the crustacean, Daphnia, Mar Environ Res.93;118-122(2014) (Epub2013)
  7. Akiko Suzuki, Yasuhiko Kato, Tomoaki Matsuura and Hajime Watanabe  (2014) Growth evaluation method by live imaging of Daphnia magna and its application to the estimation of an insect growth regulator J Appl Toxicol (in press) (wileyonlinelibrary.com) DOI 10.1002/jat.2988
【Group Ⅰ-Ⅱ】
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku
  1. Kotoku, N.; Higashimoto, K.; Kurioka, M.; Arai, M.; Fukuda, A.; Sumii, Y.; Sowa, Y.; Sakai, T.; Kobayashi, M. Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner. Bioorg. Med. Chem. Lett., 24, 3389-3391 (2014).
  2. Arai, M.; Kawachi, T.; Sato, H.; Setiawan, A.; Kobayashi, M. Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. Bioorg. Med. Chem. Lett., 24, 3155-3157 (2014).
  3. Kotoku, N.; Nakata, C.; Kawachi, T.; Sato, T.; Guo, X.; Ito, A.; Sumii, Y.; Arai, M.; Kobayashi, M. Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor. Bioorg. Med. Chem., 22, 2102-2112 (2014).
  4. Arai, M.; Han, C.; Yamano, Y.; Setiawan, A.; Kobayashi, M. Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances. J. Nat. Med., 68, 372-376 (2014).
  5. M. Arai, Y. Yamano, A. Setiawan, M. Kobayashi, Identification of target protein of agelasine D, a marine spongean diterpene alkaloid, as an anti-dormant mycobacterial substance. ChemBioChem, 15, 117-123 (2014).
【Group Ⅰ-Ⅱ】
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
  1. Kumazaki, K., Chiba, S., Takemoto, M., Furukawa, A., Nishiyama, K., Sugano, Y., Mori, T., Dohmae, N., Hirata, K., Nakada-Nakura, Y. Maturana, A.D., Tanaka, Y., Mori, H., Sugita, Y., Arisaka, F., Ito, K., Ishitani, R., Tsukazaki, T., Nureki, O., Structural basis of Sec-independent membrane protein insertion by YidC, Nature, 509, 516-520 (2014).
  2. Nishiyama, K., Shimamoto, K., Glycolipozyme membrane protein integrase (MPIase): recent data, BioMol Concepts, 5, 429–438 (2014).
【Group Ⅰ(A01) -Ⅱ(A03)】
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
  1. Hamamoto,S., and Uozumi,N. Organelle-localizated potassium transport system in plants,J.Plant Physiol,171(9)743-7(2014)
  2. Boccaccio, A., Scholz-Starke, J., Hamamoto, S., Larisch, N., Festa, M., Gutla, P. V. K., Costa, A., Dietrich, P., Uozumi, N., and Carpaneto, A. The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells. Cell. Mol. Life Sci.71; 4275-4283(2014)
【Group Ⅰ-Ⅱ】
Kohji Fukunaga
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. S. Moriguchi, H. Sakagami, Y. Yabuki, Y. Sasaki, H. Izumi, C. Zhang, F. Han, K. Fukunaga, Stimulation of sigma-1 receptor ameliorates depressive-like behaviors in CaMKIV null mice, Mol Neurobiol, in press (2014).
  2. H. Tagashira, Y. Shinoda, N. Shioda, K. Fukunaga, Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis, Biochim Biophys Acta, 1840(12):3320-3334 (2014).
  3. W.F. Ye, R.R. Tao, Q. Jiang, J.Y. Huang, N.N Lu, Y.M. Lu, K. Fukunaga, H. Wang, F. Han, Peroxiredoxin 1 participates in ischemia-triggered endothelial porlarization, CNS Neurosci Ther, 20(8):791-793 (2014).
  4. N. Shioda, Y. Yabuki, Y. Kobayashi, M. Onozato, Y. Owada, K. Fukunaga, FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity, J Biol Chem, 289(27):18957-18965 (2014).
  5. M.R. Islam, S. Moriguchi, H. Tagashira, K. Fukunaga, Rivastigmine restores 5-HT1A receptor levels in the hippocampus of olfactory bulbectomized mice, Adv Alzheimers Dis, 3(3):128-136 (2014).
  6. Y. Fujita, H. Tagashira, H. Hasegawa, K. Fukunaga, Ultrasonic visualization of propagation myocardial vibration driven by electrical excitation of myocardium of rat in ex vivo experiment, Jpn J Appl Physics, 53:07KF25 (2014).
  7. M.R. Islam, S. Moriguchi, H. Tagashira, K. Fukunaga, Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice, Neuroscience, 272:116-130 (2014).
  8. K. Fukunaga, Orphan receptor and chaperon functions of sigma-1 receptor, Nihon Yakurigaku Zasshi, 143(5):263-264 (2014).
  9. N.N. Lu, J. Liu, Y. Tian, M.H. Liao, H. Wang, Y.M. Lu, R.R. Tao, L.J. Hong, S.S. Liu, K. Fukunaga, Y.Z. Du, F. Han, Atg5 deficit exaggerates the lysosome formation and cathepsin B activation in mice brain after lipid nanoparticles injection, Nanomedicine, S1549-9634(14)00148-1 (2014).
  10. J.Y. Huang, L.T. Li, H. Wang, S.S. Liu, Y.M. Lu, M.H. Liao, R.R. Tao, L.J. Hong, K. Fukunaga, Z. Chen, C.S. Wilcox, E.Y. Lai, F. Han, In vivo two-photon fluorescence microscopy reveals disturbed cerebral capillary blood flow and increased susceptibility to ischemic insults in diabetic mice, CNS Neurosci Ther, (2014).
  11. RR. Tao, H. Wang, LJ. Hong, JY. Huang, YM. Lu, MH. Liao, WF. Ye, NN. Lu, DY. Zhu, Q. Huang, K. Fukunaga, YJ. Lou, I. Shoji, CS. Wilcox, EY. Lai, F. Han, Nitrosative Stress Induces Peroxiredoxin 1 Ubiquitination During Ischemic Insult via E6AP Activation in Endothelial Cells Both In Vitro and In Vivo, Antioxid Redox Signal, 21(1);1-16.(2014)
  12. Y. Yabuki, N. Shioda, T. Maeda, S. Hiraide, H. Togashi, K. Fukunaga, Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats, Brain Res, 1557, 90-100 (2014).
  13. H. Tagashira, MS. Bhuiyan, N. Shioda, K. Fukunaga, Fluvoxamine rescues mitochondrial Ca2+ transport and ATP production through σ(1)-receptor in hypertrophic cardiomyocytes, Life Sci, 95(2), 89-100 (2014).
  14. Y. Yabuki, Y. Ohizumi, A. Yokosuka, Y. Mimaki, K. Fukunaga, Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice, Neuroscience, 259, 126-141 (2014).
  15. Y. Tian, Y. Yabuki, S. Moriguchi, K. Fukunaga, PJ. Mao, LJ. Hong, YM. Lu, R. Wang, MM. Ahmed, MH. Liao, JY. Huang, RT. Zhang, TY. Zhou, S. Long, F. Han, Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism, J Pineal Res, 56(1), 1-11 (2014).
  16. S. Moriguchi, H. Tagashira, Y. Sasaki, JZ. Yeh, H. Sakagami, T. Narahashi, K. Fukunaga, CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment, J Neurochem, 128(6), 927-937 (2014).
【Group Ⅰ】
Kazuhisa Sekimizu
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  1. Ishii K, Hamamoto H, Sekimizu K,
Establishment of a bacterial infection model using the European honeybee, Apis mellifera L, PLoS One, 9, e89917 (2014)

【Group Ⅰ-Ⅱ】
Maiko Okada
Assistant Professor, St.Marianna University School of Medicine.
【Group Ⅰ-Ⅱ】
Nobuaki Matsumori
Professor, Graduate School of Science, Kyusyu Univeristy
  1. R. A. Espiritu, N. Matsumori, M. Tsuda, M. Murata, Direct and stereospecific interaction of amphidinol 3 with sterol in lipid bilayers. Biochemistry, 53, 3287-3293 (2014). DOI: 10.1021/bi5002932
  2. Y. Nakagawa, Y. Umegawa, T. Takano, H. Tsuchikawa, N. Matsumori, M. Murata, Effect of sterol side chain on ion channel formation by amphotericin B in lipid bilayers. Biochemistry 53, 3088-3094 (2014). DOI: 10.1021/bi500122c
  3. 【Co-study】 H. Shibata, H. Tsuchikawa, N. Matsumori, M. Murata, T. Usui, Design and synthesis of 24-fluorinated bafilomycin analogue as an NMR probe with potent inhibitory activity to vacuolar-type ATPase. Chem. Lett., 43, 474-476 (2014).]DOI: 10.1246/cl.131099
  4. Y. Nakagawa, Y. Umegawa, T. Takano, H. Tsuchikawa, N. Matsumori, M. Murata, Effect of sterol side chain on ion channel formation by amphotericin B in lipid bilayers. Biochemistry 53, 3088-3094 (2014). DOI: 10.1021/bi500122c
  5. T. Yasuda, M. Kinoshita, M. Murata, N. Matsumori*, Detailed comparison of deuterium quadrupole profiles between sphingomyelin and phosphatidylcholine bilayers. Biophys. J., 106, 631-638 (2014).
  6. M. Kinoshita, N. Matsumori, M. Murata, Coexistence of two liquid crystalline phases in dihydrosphingomyelin and dioleoylphosphatidylcholine binary mixtures. Biophsy. Biochem. Acta Biomembranes, 1838, 1372-1381 (2014).
  7. R. Sugiyama, S. Nishimura, N. Matsumori, Y. Tsunematsu, A. Hattori, H. Kakeya, Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes. J. Am. Chem. Soc., 136, 5209-5212 (2014).
【Group Ⅰ】
Toshiaki Okuno
Associate Professor, Juntendo University School of Medicine
【Group Ⅰ-Ⅱ】
Akihiro Sugawara
Assistant Professor, Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. R. Sugamata, A. Sugawara, T. Nagao, K. Suzuki, T. Hirose, K.I. Yamamoto, M. Oshima, K. Kobayashi, T. Sunazuka, K.S. Akagawa, S. Omura, T. Nakayama, K. Suzuki, Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression. J. Antibiot. 67, 213-222 (2014).
  2. Y.D. Kwon, J.M. Lalonde, Y. Yang, M.A. Elban, A. Sugawara, J.R. Courter, D.M. Jones, A.B. Smith III, A.K. Debnath, P.D. Kwong. Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. PLoS One. 9, e85940 (2014).
【Group Ⅰ】
Shuichi Sakamoto
Senior Researcher, Institute of Microbial Chemistry
【Group Ⅰ-Ⅱ】
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
  1. Sakata, K., Eda, S., Lee, E-S., Hara, M., Imoto, M., Kojima, S. Neovessel formation promotes liver fibrosis via providing latent transforming growth factor-β. Biochem. Biophys. Res. Commun. 1443(3):950-956. (2014)【Co-study】
  2. Hara, M., Kirita, A., Kondo, W., Matsuura, T., Nagatsuma, K., Dohmae, N., Ogawa, S., Imajoh-Ohmi, S., Friedman, S. L., Rifkin, D. B., Kojima, S. LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis. SpringerPlus3;221(2014)Doi:10.1186/2193-1801-3-221 
【Group Ⅰ-Ⅱ】
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. N. Ogura, K. Watashi, T. Noguchi, T. Wakita, Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line, Biochem Biophys Res Commun, 452, 315-321 (2014).
  2. M. Matsuda, R. Suzuki, C. Kataoka, K. Watashi, H. Aizaki, N. Kato, Y. Matsuura, T. Suzuki, T. Wakita, Alternative endocytosis pathway for productive entry of hepatitis C virus, J Gen Virol, 95, 2658-2667 (2014).
  3. T. Daito, K. Watashi*, A. Sluder, H. Ohashi, S. Nakajima, K. Borroto-Esoda, T. Fujita, T. Wakita (*corresponding author), Cyclophilin inhibitors reduce phosphorylation of RNA-dependent protein kinase to restore expression of IFN-stimulated genes in HCV-infected cells, Gastroenterology, 147, 463-472 (2014).
  4. K. Watashi*, A. Sluder, T. Daito, S. Matsunaga, A. Ryo, S. Nagamori, M. Iwamoto, S. Nakajima, S. Tsukuda, K. Borroto-Esoda, M. Sugiyama, Y. Tanaka, Y. Kanai, H. Kusuhara, M. Mizokami, T. Wakita (*corresponding author), Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP, Hepatology,59(5)1726-37(2014).
  5. K. Watashi*, S. Urban, W. Li, T. Wakita (*corresponding author), NTCP and beyond: Opening the door to unveil hepatitis B virus entry, Int J Mol Sci, 15, 2892-2905 (2014).
  6. S. Tsukuda, K. Watashi* (*corresponding author), NTCP transporter as novel target for anti-hepatitis B virus agents, Clin Res Infect Dis, 1, e1004 (2014).
  7. M. Iwamoto, K. Watashi*, S. Tsukuda, HH. Aly, M. Fukasawa, A. Fujimoto, R. Suzuki, H. Aizaki, T. Ito, O. Koiwai, H. Kusuhara, T. Wakita (*corresponding author), Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP, Biochem Biophys Res Commun, 443, 808-813 (2014).
  8. R. Suzuki, T. Ishikawa, E. Konishi, M. Matsuda, K. Watashi, H. Aizaki, T. Takasaki, T. Wakita, Production of single-round infectious chimeric flaviviruses with DNA-based Japanese encephalitis virus replicon, J Gen Virol, 95Pt1, 60-65 (2014).
【Group Ⅱ】
Asako Sugimoto
Professor,Graduate School of Life Sciences, Tohoku University
    【Group Ⅱ】
    Hirokazu Arimoto
    Professor,Graduate School of Life Sciences, Tohoku University
    【Group Ⅱ】
    Yoshihiro Miwa
    Lecturer,Faculty of Medicine,University of Tsukuba
    1. TNM. Tran, J. Tanaka, M. Hamada, Y. Sugiyama, S. Sakaguchi, M. Nakamura, S. Takahashi, and Y. Miwa, In vivo image analysis using iRFP transgenic mice. Exp. Anim. 63, 311-319 (2014)
    2. M. Tamura, H. Matsui, I. Hyodo, J. Tanaka, Y. Miwa. Fluorescence-based co-culture of normal and cancerous cells as an indicator of therapeutic effects in cancer. Eur. J. Pharm Sci. 63C, 1-7 doi: 10.1016 (2014)
    【Group Ⅱ】
    Kumiko UI-TEI
    Associate Professor, Graduate School of Science The University of Tokyo
    1. Y. Naito, K. Hino, H. Bono, K. UI-Tei, CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites, Bioinformatics, 2014, 1-4 (2014). doi: 10.1093/bioinformatics/btu743.
    2. H. Kum, K. Hino, H. Galipon, K. Ui-Tei, A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency, Nucleic Acids Res, 42, 10050-10060 (2014). doi: 10.1093/nar/gku662.
    3. T. Takahashi, S. Zenno, O. Ishibashi, T. Takizawa, K. Saigo, K. Ui-Tei, Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells, Nucleic Acids Res, 42, 5256-5269 (2014). doi: 10.1093/nar/gku153.
    4. T. Ishikawa, T. Takizawa, J. Iwaki, T. Mishima, K. Ui-Tei, T. Takeshita, S. Matsubara, T. Takizawa, Fc gamma receptor IIb participates in maternal IgG trafficking of human placental endothelial cells, Int. J. Mol. Med, 35,1273-1789 (2014) doi: 10.3892/ijmm.2015.2141.
    【Group Ⅱ】
    Hiroshi Hamamoto
    Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
    1. R. Uchida, H. Hanaki, H. Matsui, H. Hamamoto, K. Sekimizu, M. Iwatsuki, Y. P. Kim, H. Tomoda, In vitro and in vivo anti-MRSA activities of nosokomycins, Drug Discov Ther, 8, 249-254, (2014), 10.5582/ddt.2014.01050,
    【Group Ⅱ】
    Hiroaki Kato
    Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
      【Group Ⅱ】
      Tatsuro Shimamura
      Project Lecturer, Graduate School of Medicine, Kyoto University
      1. Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N. Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor. Monoclon Antib Immunodiagn Immunother. 2014 Dec;33(6):378-85. doi: 10.1089/mab.2014.0041.
      2. Koike-Takeshita A, Arakawa T, Taguchi H, Shimamura T. Crystal structure of a symmetric football-shaped GroEL:GroES2-ATP14 complex determined at 3.8Å reveals rearrangement between two GroEL rings. J Mol Biol. 2014 Oct 23;426(21):3634-41. doi: 10.1016/j.jmb.2014.08.017.
      【Group Ⅱ】
      Yoshio Hayashi
      Professor, Tokyo University of Pharmacy and Life Sciences
      1. A. Taguchi, K. Hamada, M. Kotake, M. Shiozuka, H. Nakaminami, T. Pillaiyar, K. Takayama, F. Yakushiji, N. Noguchi, T. Usui, R. Matsuda, Y. Hayashi, Discovery of Natural Products Possessing Selective Eukaryotic Readthrough Activity: 3-epi-Deoxynegamycin and Its Leucine Adduct, ChemMedChem, 9, 2233-2237 (2014).

      【A02】

      【Group Ⅰ-Ⅱ】
      Kazuhiro Irie, A02 Group Leader
      Professor, Graduate School of Agriculture, Kyoto Universiy
      1. M. Kikumori, R. C. Yanagita, K. Irie, Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug, Tetrahedron, 70, 9776-9782 (2014).
      2. K. Irie and R. C. Yanagita, Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin, Chem. Rec., 14, 251-267 (2014).
      【Group Ⅰ-Ⅱ】
      Masaya Imoto
      Professor, Faculty of Science and Technology, Keio University
      Co-Researcher: Etsu Tashiro
      1. Yoshimaru T, Komatsu M, Tashiro E, Imoto M, Osada H, Miyoshi M, Honda J, Sasa M, and Katagiri T. Xanthohumol suppresses oestrogen-signalling in breast cancer through the specific inhibition of BIG3-PHB2 interaction. Scientific Report. 4: 7335 (2014)
      2. Fujimaki T, Saiki S, Tashiro E, Yamada D, Kitagawa M, Hattori N and Imoto M. Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson’s disease. PLoS One. Jun 24;9(6):e100395 (2014)
      3. Magi S, Saeki Y, Kasamatsu M, Tashiro E, Imoto M. Chemical genomic-based pathway analyses for epidermal growth factor-mediated signaling in migrating cancer cells. PLoS One. 9 (5): e96776 (2014)
      4. Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K, Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S. Neovessel formation promotes liver fibrosis via providing latent transforming growth factor-β. Biochem. Biophys. Res. Commun. 1443:950-956(2014)
      5. Magi S, Takemoto Y, Kobayashi H, Kasamatsu M, Akita T, Tanaka A, Takano K, Tashiro E, Igarashi Y, Imoto M. 5-Lipoxygenase and CysLT1 regulate EGF‐induced cell migration through Tiam1 upregulation and Rac1 activation. Cancer Science 105:: 290-206, 2014
      【Group Ⅰ-Ⅱ】
      Shigeki Matsunaga
      Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
      1. Y. Sun, K. Takada, Y. Nogi, S. Okada, S. Matsunaga, Lower Homologues of Ahpatinin, Aspartic Protease Inhibitors, from a Marine Streptomyces sp., J. Nat. Prod. 77,01749-1752 (2014).
      2. K. Takada, S. Okada, S. Matsunaga, Structural reappraisal of corticatic acids, biologically active linear polyacetylenes, from a marine sponge of the genus Petrosia, Fich. Sci. 80, 1057-1064 (2014).
      【Group Ⅰ-Ⅱ】
      Masami Ishibashi
      Professor,Graduate School of Pharmaceutical Sciences, Chiba University
      Co-Researcher:Midori Arai, Kazufumi Toume (by October), Naoki Ishikawa(since November)
      1. M. Ishibashi, Bioactive heterocyclic natural products from actinomycetes having effects on cancer-related signaling pathways, Progress in the Chemistry of Organic Natural Products, Kinghorn, A. D.; Falk, H.; Kobayashi, J. (Eds.); Springer; Wien, 2014, 99, 147-198 DOI: 10.1007/978-3-319-04900-7_3
      2. K. Ohishi, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, T. Mizoguchi, M. Itoh, M. Ishibashi, Ricinine: a pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α, Bioorg. Med. Chem., 22, 4597-4601 (2014). DOI:10.1016/j.bmc.2014.07.027
      3. H.-Y. Park, K.Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, Calotropin: a cardenolide from Calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1α in colon cancer cells, ChemBioChem 15(6);872-8(2014).
      4. M. A. Arai, K. Uchida, S. K. Sadhu, F. Ahmed, M. Ishibashi, Physalin H from Solanum nigrum as Hh signaling inhibitor blocks GLI1-DNA complex formation, Beil. J. Org. Chem., 10, 134-140 (2014)
      【Group Ⅰ-Ⅱ】
      Tetsuro Shinada
      Professor, Graduate School of Science, Osaka City University
      Co-Researcher: Yasufumi Ohfune
      1. K. Maeda, Y. Kiniwa, Y. Ohfune, S. Ishiguro, K. Suzuki, K. Murata, H. Matsuda, T. Shinada, Solid Phase Synthesis of α-Amino Squaric Acid-containing Peptides, RSC Adv., 4, 50639–50643 (2014). DOI: 10.1039/C4RA10442K
      2. A. Manabe, Y. Ohfune and T. Shinada, Toward the Total Synthesis of Tetrodotoxin: Stereoselective Construction of the 7-Oxanorbornane Intermediate, Tetrahedron Lett., 55, 6077–6080 (2014). DOI: 10.1016/j.tetlet.2014.09.036
      3. K. Oe, Y. Ohfune and T. Shinada, “Short Total Synthesis of (-)-Kainic Acid”, Org. Lett., 16, 2550–2553 (2014). DOI: 10.1021/ol5009526
      4. T. Ozaki, P. Zhao, T. Shinada, ,M. Nishiyama, and T. Kuzuyama, Cyclolavandulyl Skeleton Biosynthesis via Both Condensation and Cyclization Catalyzed by an Unprecedented Member of the cis-Isoprenyl Diphosphate Synthase Superfamily, J. Am. Chem. Soc., 136(13)4837-4840 (2014).
      【Group Ⅰ-Ⅱ】
      Hidenori Watanabe
      Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
      1. K. Murata, S. Tamogami, M. Itou, Y. Ohkubo, Y. Wakabayashi, H. Watanabe, H. Okamura, Y. Takeuchi, Y. Mori, Identification of an Olfactory Signal Molecule that Activates the Central Regulator of Reproduction in Goats, Curr. Biol., 24, 681-686 (2014).
      【Group Ⅰ-Ⅱ】
      Kosuke Namba
      Professor, Graduate School of Pharmaceutical Science, The University of Tokushima
      1. K. Namba, Y. Shobo, K. Fujimoto, I. Shoji, K. Tanino,. N-Acyl-N-tosylhydrazine as a Synthon To Construct Tetrasubstituted Carbon Centers Possessing a Nitrogen Group. Eur. J. Org. Chem., 5196-5203 (2014).
      2. Y. Yoshida, T. Mizuguchi, K. Namba. One-pot synthesis of tri- and tetrasubstituted pyridines by sequential ring-opening-cyclization-oxidation reaction of N-arylmethyl 3-aziridinylpropiolate esters. Angew. Chem. Int. Ed., 22, 14550-14554 (2014).
      3. M. Yoshida, K. Kinoshita and K. Namba. Synthesis of functionalized 2-vinyl-2,3-dihydropyrroles and 3-methylene-1,2,3,4-tetrahydropyridines by palladium-catalyzed cyclization of ß-enaminocarbonyl compounds with allylic bisacetates. Org. Biomol. Chem. 12, 2394-2403 (2014).
      4. M. Yoshida, T. Kasai, T. Mizuguchi and K. Namba. Total synthesis of (-)-HM-3 and (-)-HM-4 utilizing a palladium-catalyzed addition of an arylboronic acid to an allenic alcohol-Eschenmoser-Claisen rearrangement. Synlett, e-first, (2014).
      【Group Ⅰ-Ⅱ】
      Satoshi Ichikawa 
      Associate Professor,  Faculty of Pharmaceutical Science, Hokkaido University
      1. M. Yamaguchi, A. Matsuda, S. Ichikawa. Synthesis of Isoxazolidine-containing Uridine Derivatives as Caprazamycin Analogues. Org. Biomol. Chem. 13, 1187-1197 (2014).
      2. K. Katayama, K. Nakagawa, Hiroshi. Takeda, A. Matsuda, S. Ichikawa*, Total Synthesis of Sandramycin and Its Analogues via a Multi-component Assemblage. Org. Lett. 16(2)428-431,(2014) (Publication Date (Web) 2013)
      3. Takeoka, Yusuke; Tanino, Tetsuya; Sekiguchi, Mitsuaki; Yonezawa, Shuji; Sakagami, Masahiro; Takahashi, Fumiyo; Togame, Hiroko; Tanaka, Yoshikazu; Takemoto, Hiroshi; Ichikawa, Satoshi*; Matsuda. Akira. Expansion of antibacterial spectrum of muraymycins toward Pseudomonas aeruginosa. ACS Med. Chem. Lett. 2014, 5(5)556-560.
      4. Chiba, Takuya; Hosono, Hidetaka; Nakagawa, Koji; Asaka, Masahiro; Takeda, Hiroshi; Matsuda, Akira; Ichikawa, Satoshi.* Total synthesis of syringolin A and its improvement of biological activity. Angew. Chem. Int. Ed. 2014, 53(19)4836-39,
      5. Katayama, Katsushi; Okamura, Takuya; Sunadome, Takuya; Nakagawa, Koji; Takeda, Hiroshi; Shiro, Motoo; Matsuda, Akira; Ichikawa, Satoshi.* Synthesis and biological evaluation of quinaldopeptin. J. Org. Chem. 2014, 79, 2580-2590.
      6. Tanino, Tetsuya; Yamaguchi, Mayumi; Matsuda, Akira; Ichikawa, Satoshi.* Function-oriented synthesis of liponucleoside natural products. Eur. J. Org. Chem. 2014, 1836-1840.
      【Group Ⅰ-Ⅱ】
      Haruhiko Fuwa
      Associate Professor, Graduate School of Life Sciences, Tohoku University
      1. H. Fuwa,* T. Noguchi, M. Kawakami, and M. Sasaki, Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain, Bioorg. Med. Chem. Lett., 24, 2415-2419 (2014). DOI: 10.1016/j.bmcl.2014.04.031
      2. M. Sasaki* and H. Fuwa, Total synthesis and complete structural assignment of gambieric acid A, a large polycyclic ether marine natural product, Chem. Rec., 14, 678-703 (2014). DOI: 10.1002/tcr.201402052
      3. H. Fuwa,* M. Sato, and M. Sasaki, Programmed cell death induced by (-)-8,9-dehydroneopeltolide in human promyelocytic HL-60 cells under energy stress conditions, Mar. Drugs, 12, 5576-5589 (2014). DOI: 10.3390/md12115576
      4. Y. Suga, *H. Fuwa, M. Sasaki, Stereoselective synthesis of medium-sized cyclic ethers: Application of C-glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts, J. Org. Chem., 79, 1656–1682 (2014).
      5. *H. Fuwa, T. Muto, K. Sekine, M. Sasaki, Total synthesis and structure revision of didemnaketal B, Chem. Eur. J., 20, 1848–1860 (2014).
        ※The frontispiece  of Chemistry–a European Journal
      【Group Ⅰ】
      Hideyuki Shigemori
      Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
      【Group Ⅰ(A02)-Ⅱ(Advisory Members)】
      Hirokazu Kawagishi
      Professor, Research Institute of Green Science and Technology, Shizuoka University
      1. J-H. Choi, T. Ohnishi, Y. Yamakawa, S. Takeda, S. Sekiguchi, W. Maruyama, K. Yamashita, T. Suzuki, A. Morita, T. Ikka, R. Motohashi, Y. Kiriiwa, H. Tobina, T. Asai, S. Tokuyama, H. Hirai, N. Yasuda, K. Noguchi, T. Asakawa, S. Sugiyama, T. Kan, H. Kawagishi, The source of “fairy rings”: 2-azahypoxanthine and its metabolite found in a novel purine metabolic pathway in plants, Angew. Chem., Int. Ed., 53, 1552-1555 (2014).
      2. T. Suzuki, H. Dohra, S. Omae, Y. Takeshima, J-H. Choi, H. Hirai, H. Kawagishi, Heterologous expression of a lectin from Pleurocybella porrigens (PPL) in Phanerochaete sordida YK-624, J. Microbiol. Meth., 100, 70–76 (2014)
      3. S. Nakaya, H. Kobori, A. Sekiya, H. Kawagishi, T. Ushimaru, Anti-aging and anti-microbial effects of melleolide on different types of yeast, Biosci. Biotechnol. Biochem.,78(3)455-7,2014.
      4. W. Qui, H. Kobori, T. Suzuki, J-H. Choi, V. K. Deo, H. Hirai, H. Kawagishi, A new compound from the mushroom Tricholoma flavovirens, Biosci. Biotechnol. Biochem.,78(5)755-757,2014.
      5. J. Wang, Y. Yamada, A. Notake, Y. Todoroki, T. Tokumoto, J. Dong, P. Thomas, H. Hirai, H. Kawagishi, Metabolism of bisphenol A by hyper lignin-degrading fungus Phanerochaete sordida YK-624 under non-ligninolytic condition, Chemosphere, 109;128-33(2014).
      6. H. Tobina, J-H. Choi, T. Asai, Y. Kiriiwa, T. Asakawa, T. Kan, A. Morita, H. Kawagishi, 2-Azahypoxanthine and Imidazole-4-carboxamide produced by the fairy-ring-forming fungus increase yields of wheat, Field Crop Res. 162.6-11,2014
      7. M. Komura, T. Genda, T. Fukuta, S. Hino, S. Aoe, H. Kawagishi, T. Morita, A Short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion, Biosci. Biotechnol. Biochem., 78(9)1592-1602(2014)
      【Group Ⅰ】
      Makoto Ojika
      Professor, Graduate School of Bioagricultural Sciences, Nagoya University
      【Group Ⅰ-Ⅱ】
      Shinichi Nishimura
      Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
      1. Nishimura, S.*, Tokukura, M., Ochi, J., Yoshida, M., Kakeya H.* Balance of exocytosis and endocytosis determines the efficiency of sterol-targeting antibiotics. Chem. Biol. 21, 1690-1699 (2014).【Co-study】
      2. Sugiyama, R., Nishimura, S., Matsumori, N., Tsunematsu, Y., Hattori, A., Kakeya, H. Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes. J. Am. Chem. Soc. DOI: 10.1021/ja500128u (2014).
      3. Sakanishi, K., Itoh, S., Sugiyama, R., Nishimura, S., Kakeya, H., Iwabuchi, Y., Kanoh, N. Total synthesis of the proposed structure of heronamide C. Eur. J. Org. Chem. 7, 1376–1380 (2014).
      【Group Ⅰ-Ⅱ】
      Katsunori Tanaka
      Associate Chief Scientist, RIKEN
      Co-Researcher: Co-Researcher: Takayuki Iwata, Masataka Kitadani.
      1. M. Takamatsu, K. Fukase, A. Kurbangalieva, K. Tanaka, Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker, Bioorg. Med. Chem., 22, 6380-6386 (2014).
      2. PET Imaging of Glycoconjugates, K. Tanaka, In Glycoscience: Biology and Medicine, T. Endo, P. H. Seeberger, G. W. Hart, C.-H. Wong, N. Taniguchi (eds), Springer,  pp1-6(2014).
      3. A. Ogura, A. Kurbangalieva, K. Tanaka, In Vivo Kinetics and Biodistribution Analysis of Neoglycoproteins: Effects of Chemically Introduced Glycans on Proteins, Glycoconj.J., (4)273-9(2014) DOI:10.1007/s10719-014-9520-3.
      4. K. Tsubokura, T. Iwata, M. Taichi, A. Kurbangalieva, K. Fukase, Y. Nakao, K. Tanaka, Direct Guanylation of Amino Groups by Cyanamide in Water: Catalytic Generation and Activation of Unsaturated Carbodiimide by Sc(OTf)3, Synlett, 1302-1306,2014
      5. K. Tanaka, R. Matsumoto, A. R. Pradipta, Y. Kitagawa, M. Okumura, Y. Manabe, K. Fukase, Facile Preparation of 1,5-Diazacyclooctanes from Unsaturated Imines: Effects of the Hydroxyl Groups on [4+4] Dimerization, Synlett, 1026-1030, (2014).
      6. Y. Uchinasi, K. Tanaka, Y. Manabe, Y. Fujimoto, K. Fukase, Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor, J. Carbohydr. Chem., 33, 55-67, (2014).
      7. K. Tanaka, M. Kitadani, A. Tsutsui, A. R. Pradipta, R. Imamaki, S. Kitazume, N. Taniguchi, K. Fukase, A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells, Org. Biomol. Chem., 12, 1412-1418, (2014).
      【Group Ⅰ-Ⅱ】
      Kazunobu Toshima
      Professor, Faculty of Science and Technology, Keio University
      1. H. Ikeda, E. Kaneko, S. Okuzawa, D. Takahashi, K. Toshima, Chemical and biological evaluation of unusual sugars, alpha-aculosides, as novel Michael acceptor, Organic & Biomolecular Chemistry, 12, 8832-8835 (2014).
      2. D. Kuwahara, T. Hasumi, H. Kaneko, M. Unno, D. Takahashi, K. Toshima, A solid-phase affinity labeling method for target-selective isolation and modification of proteins, Chemical Communications, 50, 15601-15604 (2014).
      3. S. Arafuka, N. Koshiba, D. Takahashi, K. Toshima Systematic synthesis of sulfated oligofucosides and their effect on breast cancer MCF-7 cells, Chemical Communications, 50, 9831-9834 (2014).
      4. R. Iwata, K. Uda, D. Takahashi, K. Toshima, Photo-induced glycosylation using reusable organophotoacids, Chemical Communications, 50, 10695-10698 (2014).
      5. A. Hirabayashi, Y. Shindo, K. Oka, D. Takahashi, K. Toshima, Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives, Chemical Communications, 50, 9543-9546 (2014).
      【Group Ⅰ】Yoko Saikawa
      Lecturer, Faculty of Science and Technology, Keio University
      【Group Ⅰ】Seijiro Hosokawa
      Professor, Faculry of Science and Engineering, Waseda University
      Co-Researcher:Mayumi Okamoto, Isao Shimizu
      1. T. Oshio, R. Kawashima, Y. I. Kawamura, T. Hagiwara, N. Mizukami, T. Okada, T. Otsubo, K. Inagaki-Ohara, A. Matsukawa, T. Haga, S. Kakuta, Y. Iwakura, S. Hosokawa, T, Dohi, Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in peritoneal macrophages, PLOS ONE, 9 (4), e94445.
      2. K. Tatsuta, S. Hosokawa, Total synthesis of hibarimicinone, a v-Src tyrosine kinase inhibitor possessing the pseudo-dimer structure of tetracycline, The Chemical Record, 14 (1), 28-40 (2014).
      【Group Ⅰ-Ⅱ】
      Go Hirai
      Senior Research Scientist, RIKEN
      1. Frederic Thuaud, Shuntaro Kojima, Go Hirai, Kana Oonuma, Ayako Tsuchiya, Takako Uchida, Teruhisa Tsuchitomo, Mikiko Sodeoka, RE12 Derivatives Displaying Vaccinia H1-related Phosphatase (VHR) Inhibition in the Presence of Detergent and Their Anti-Proliferative Activity against HeLa Cells, Bioorg. Med. Chem. 22, 2771-2782 (2014).
      【Group Ⅱ】
      Shigefumi Kuwahara
      Professor, Graduate School of Agricultural Science, Tohoku University
      1. T. Teranishi, S. Kuwahara, Stereoselective approach to the DEF ring system of terpendole E, Tetrahedron Lett., 55, 1486-1487 (2014).
      2. R. Towada, S. Kuwahara, Synthesis of topsentolides A2 and C2, and non-enzymatic conversion of the former to the latter, Tetrahedron, 70, 3774-3781 (2014).
      【Group Ⅱ】
      Takayuki Doi
      Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
      1. S. Fuse, H. Koinuma, A. Kimbara, M. Izumikawa, Y. Mifune, H. He, K. Shin-ya, T. Takahashi, T. Doi, Total Synthesis and Stereochemistry Revision of Mannopeptimycin Aglycone, J. Am. Chem. Soc., 136, 12011-12017 (2014) DOI:10.1021/ja505105t.
      2. T. Doi, Sythesis of the Biologically Active Natural Product Cyclodepsipeptides Apratoxin A and Its Analogues, Chem. Pharm. Bull., 62, 735-743 (2014) DOI: 10.1248/cpb.c14-00268.
      【Group Ⅱ】
      Takashi Kawakami
      Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
      【Group Ⅱ】
      Daisuke Urabe
      Lecturer, Graduate School of Pharmaceutical Sciences,The University of Tokyo
      1. H. Todoroki, M. Iwatsu, D. Urabe, M. Inoue, Total Synthesis of (-)-4-Hydroxyzinowol, J. Org. Chem. 79, 8835-8849 (2014).
      2. M. Nagatomo, M. Koshimizu, K. Masuda, T. Tabuchi, D. Urabe, M. Inoue, Total Synthesis of Ryanodol, J. Am. Chem. Soc. 136, 5916-5919 (2014).
      3. K. Hagiwara, D. Urabe, M. Inoue, Studies in symmetry-driven synthesis of ryanodol: application of nucleophilic alkynylation for regio- and stereoselective desymmetrization, Tetrahedron Lett. 55, 3817-3819 (2014).
      4. Y. Yokokura, Y. Isobe, S. Matsueda, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, M. Arita, Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite, J. Biochem. 156, 315-321 (2014).
      5. T. Kubota, M. Arita, Y. Isobe, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, “Eicosapentaenoic Acid Is Converted via omega-3 Epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid,” FASEB J. 28, 586-593 (2014).
      【Group Ⅱ】
      Hiroshi Tanaka
      Associate Professor, Graduate Scool of Science and Engineering,  Tokyo Institute of Technology
      【Group Ⅱ】
      Yukari Fujimoto
      Professor, Faculty of Science and Technology, Keio University
      Co-Researcher:Shinsuke Inuki, Toshihiko Aiba

      【A03】

      【Group Ⅰ-Ⅱ】
      Minoru Ueda., A03 Group Leader
      Professor,Graduate School of Science, Tohoku University
      【Group Ⅰ-Ⅱ】
      Naoki Kanoh
      Associate Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
      Co-Researcher: Takeo Usui
      1. A. Taguchi, K. Hamada, M. Kotake, M. Shiozuka, H. Nakaminami, T. Pillaiyar, K. Takayama, F. Yakushiji, N. Noguchi, T. Usui, R. Matsuda, and Y. Hayashi, Discovery of Natural Products Possessing Selective Eukaryotic Readthrough Activity: 3-epi-Deoxynegamycin and Its Leucine Adduct, ChemMedChem, 9, 2233-2237 (2014) 【Co-study】
      2. Y. Hayashi, H. Takeno, T. Chinen, K. Muguruma, K. Okuyama, A. Taguchi, K. Takayama, F. Yakushiji, M. Miura, T. Usui, and Y. Hayashi, ACS Med. Chem. Lett., 5, 1094-1098 (2014) 【Co-study】
      3. Y. Tarui, T. Chinen Y. Nagumo, T. Motoyama, T. Hayashi, H. Hirota, M. Muroi, Y. Ishii, H. Kondo, H. Osada, and T. Usui, Terpendole E and its derivative inhibit STLC- and GSK-1-resistant Eg5, ChemBioChem,15, 934-938 (2014)
      4. T. Chinen, Y. Nagumo, and T. Usui, Construction of a genetic analysis-available multidrug sensitive yeast strain by disruption of the drug efflux system and conditional repression of the membrane barrier system, J. Gen. Appl. Microbiol., 60, 160-162 (2014)
      5. S. Kazami, M. Takaine, H. Itoh, T. Kubota, J. Kobayashi, and T. Usui, Biol. Pharm. Bull., 37, 1944-1947 (2014)
      6. S. Takahashi, S. Nagano, T. Nogawa, N. Kanoh, M. Uramoto, M. Kawatani, Y. Shiro, H. Osada, Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T, J. Biol. Chem., 289:32446-32458(2014).
      7. N. Kanoh, A. Kawamata, T. Itagaki, Y. Miyazaki, K. Yahata, E. Kwon, Y. Iwabuchi, A Concise and Unified Strategy for Synthesis of the C1-C18 Macrolactone Fragments of FD-891, FD-892 and Their Analogues: Formal Total Synthesis of FD-891, Org. Lett., 16, 5216-5219 (2014).
      8. S. Uesugi, T. Watanabe, T. Imaizumi, M. Shibuya, N. Kanoh, Iwabuchi, Y. Eu(OTf)3-Catalyzed Highly Regioselective Nucleophilic Ring Opening of 2,3-Epoxy Alcohols: An Efficient Entry to 3-Substituted 1,2-Diol Derivatives Org. Lett., 16, 4408-4411 (2014).
      9. K. Sakanishi, S. Itoh, R. Sugiyama, S. Nishimura, H. Kakeya, Y. Iwabuchi, N. Kanoh, Total Synthesis of the Proposed Structure of Heronamide C, Eur. J. Org. Chem., 1376-1380 (2014).
      10. T. Shibuta, S. Sato, M. Shibuya, N. Kanoh, T. Taniguchi, K. Monde, Y. Iwabuchi, Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis, Heterocycles, 89 (3), 631-639 (2014).
      【Group Ⅰ-Ⅱ】
      Hideo Kigoshi
      Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
      Co-Researcher: Masaki Kita
      1. I. Hayakawa, S. Shioda, A. Ikedo, H. Kigoshi, Practical Synthesis of Glaziovianin A, a Cytotoxic Isoflavone, and Its O7-Propargyl Analogue, Bull. Chem. Soc. Jpn., 87 (4), 544-549 (2014). DOI: 10.1246/bcsj.20130342、【Co-study】
      2. Y. Kato, N. Fuchi, Y. Nishimura, A. Watanabe, M. Yagi, Y. Nakadera, E. Higashi, M. Yamada, T. Aoki, H. Kigoshi, Inhibition of Microtubule Assembly by A Complex of Actin and Antitumor Macrolide Aplyronine A, Bioorg. Med. Chem. Lett., 24, 565-570 (2014).
      【Group Ⅰ-Ⅱ】
      Toshio Nishikawa
      Profrssor, Graduate School of Bioagricultural Sciences, Nagoya University
      Co-Researcher :Masaatu Adachi,Keiichi Konoki
      1. Y. Satake, M. Adachi, S. Tokoro, M. Yotsu-Yamashita, M. Isobe, T. Nishikawa, Synthesis of 5- and 8-Deoxytetrodotoxin, Chem. Asian. J, 9, 1922-1932 (2014). DOI: 10.1002/asia.201402202
      2. M. Adachi, R. Sakakibara, Y. Satake, M. Isobe, T. Nishikawa, Synthesis of 5,6,11-Trideoxytetrodotoxin, Chem. Lett, 43, 1719-1721 (2014). DOI:10.1246/cl.140684
      3. M. Adachi, H. Hashimoto, R. Sakakibara, T. Imazu, T. Nishikawa, A New Deprotection Procedure of MTM Ether, Synlett, 25, 2498-2502 (2014). DOI: 10.1055/s-0034-1379027
      4. K. Konoki, Y. Suga, H. Fuwa, M. Yotsu-Yamashita, M. Sasaki, Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity, Bioorg. Med. Chem. Lett., 25, 514-518 (2014). DOI: 10.1016/j.bmcl.2014.12.022【Co-study】
      5. A. Nakazaki, Y. Ishikawa, Y. Sawayama, M. Yotsu-Yamashita, T. Nishikawa, Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channel, Org. Biomol. Chem. 12, 53-56(2014)
      6. M. Adachi, T. Imazu, R. Sakakibara, Y. Satake, M. Isobe, T. Nishikawa, Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog, Chem. Eur. J. 20, 1247-1251(2014)
      【Group Ⅰ-Ⅱ】
      Makoto Sasaki
      Professor, Graduate School of Life Sciences, Tohoku University
      Co-Researcher :Kenichi Konoki
      1. H. Fuwa, T. Noguchi, M. Kawakami, and M. Sasaki, Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain, Biorg. Med. Chem. Lett., 24, 2415-2419 (2014). DOI: org/10.1016/j/mbcl.2014.04.031 
      2. M. Sasaki and H. Fuwa, Total synthesis and complete structural assignment of gambieric acid A, a polycyclic ether marine natural product, Chem. Rec., 14, 678-703 (2014). DOI: 10.1002/tcr.201402052 
      3. J. A. Rubiolo, C. Vale, V. Martín, H. Fuwa, M. Sasaki, and L. M. Botana, Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation, Arch. Toxicol., 88, published online (2014). DOI: 10.1016/j.bmcl.2014.12.022 
      4. H. Fuwa, M. Sato, and M. Sasaki, Programmed cell death induced by (–)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions, Marine Drugs, 12, 5576-5589 (2014). DOI: 10.3390/md12115576 
      5. H. Fuwa, T. Muto, K. Sekine, M. Sasaki, Total Synthesis and Structure Revision of Didemnaketal B, Chem. Eur. J., 19, 1848-1860 (2014).
        ※Chemistry–a European Journal’s frontispiece
      6. Y. Suga, H. Fuwa, M. Sasaki, Stereoselective Synthesis of Medium-sized Cyclic Ethers: Application of C-Glycosylation Chemistry to Seven- to Nine-membered Lactone-derived Thioacetals and Their Sulfone Counterparts, J. Org. Chem., 79, 1656-1682 (2014).
      【Group Ⅰ-Ⅱ】
      Fumi Nagatsugi
      Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
      1. Onizuka, K., Nagatsugi, F., Ito, Y. and Abe, H. Automatic Pseudorotaxane Formation Targeting on Nucleic Acids Using a Pair of Reactive Oligodeoxynucleotides. J.Am. Chem. Soc., 136, 7201-7204 (2014). 10.1021/ja5018283
      2. S.Kusano, T. Haruyama, S. Ishiyama, S. Hagihara and F. Nagatsugi, Development of Crosslinking Reactions to RNA Triggered by Oxidation, Chem.Commun, 50, 3951-3954 (2014).
      【Group Ⅱ】
      Takamitsu Hosoya
      Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
      1. S. Yoshida, Y. Misawa, and *T. Hosoya, Formal C–H-Azidation Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes. Eur. J. Org. Chem., (19), 3991–3995 (2014).
      【Group Ⅰ-Ⅱ】Yousuke Takaoka
      Assistant Professor, Graduate School of Engineering, Kyoto University (by June)
      Lecturer, Graduate School of Science, Tohoku University (since July)
      【Group Ⅰ-Ⅱ】
      Junko Ohkanda
      Associate professor, Institute for Chemical Research, Kyoto University
      1. T. Suzuki, J. Ohkanda, T. Mori, M. Nakashima, M. Uesugi, Manifesting chemical biology in Manila, Biochem. J. 464, 1-3 (2014). doi:10.1042/BJ20140874
      2. K. Harada, S. Aoyama, A. Matsugami, P. K. R. Kumar, M. Katahira, N. Kato, J. Ohkanda, RNA-directed amino acid coupling as a model reaction for primitive coded translation, ChemBioChem. 15, 794-798 (2014). doi: 10.1002/cbic.201400029 
      3. J. Ohkanda, Chemicals modulate protein interactions, Research Activities 2014, Kyoto University, 29 (2014). 
      【Group Ⅰ-Ⅱ】
      Misako Aida
      Professor, Graduate School of Science, Hiroshima University
      1. Dai Akase, Misako Aida, Distribution of Topologically Distinct Isomers of Water Clusters and Dipole Moments of Constituent Water Molecules at Finite Atmospheric Temperatures, Journal of Physical Chemistry A, 118(36), 7911-7924 (2014). DOI: 10.1021/jp504854f  (査読有)
      2. Hideo Doi, Misako Aida, A new variant of multicanonical Monte Carlo algorithm with specifying the temperature range and its application to the hydration free energy change of fluorinated methane derivatives, Chemical Physics Letters, 595-596, 55-60 (2014).
      3. Hideo Doi, Yudai Watanabe, Misako Aida, Influence of Trimethylamine N-oxide (TMAO) on Three-Dimensional Distribution and Alignment of Solvent in Aqueous Solution, Chemistry Letters,.43(6)865-867(2014)
      【Group Ⅰ】
      Akira Otaka
      Professor, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences,
      The University of Tokushima
      1. Ebisuno, K.; Denda, M.; Ogura, K.; Inokuma, T.; Shigenaga, A.*; Otaka, A.* “Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein” Bioorg. Med. Chem.22(11)2984-91(2014) (doi: 10.1016/j.bmc.2014.04.002).
      2. Adachi, E.; Kosaka, A.; Tsuji, K.; Mizuguchi, C.; Kawashima, H.; Shigenaga, A.; Nagao, K.; Akaji, K.; Otaka, A.; Saito, H.* “The extreme N-terminal region of human apolipoproteinA-I has a strong propensity to form amyloid fibrils” FEBS Lett. 2014, 588, 389-394 (doi: 10.1016/j.febslet.2013.11.031).
      3. Nakamura, T.; Shigenaga, A.; Sato, K.; Tsuda, Y.; Sakamoto, K.; Otaka, A.* “Examination of native chemical ligation using peptidyl prolyl thioester” Chem. Commun. 2014, 50, 58-60.
        (doi: 10.1039/C3CC47228K)
      【Group Ⅰ-Ⅱ】
      Hideo Takahashi
      Professor, Graduate School of Medical Life Science, Yokohama City University
      1. K. Takeuchi, Y. Tokunaga, M. Imai, H. Takahashi, and I. Shimada, Dynamic multidrug recognition by multidrug transcriptional repressor LmrR, Scientific Reports, 4, doi:10.1038/srep06922, (2014),
      2. Y. Tokunaga, K. Takeuchi, H. Takahashi, and I. Shimada, Allosteric enhancement of MAP kinase p38 alpha’s activity and substrate selectivity by docking interactions, Nat. Struct. Mol. Biol., 21, 704-711 (2014),
      3. K. Ono, K. Takeuchi, H. Ueda, Y. Morita, R. Tanimura, I. Shimada, and H. Takahashi, Structure-based approach to improve a small molecule inhibitor utilizing a competitive peptide ligand, Angew. Chem. Int. Ed., 53, 2597-2601 (2014)
      【Group Ⅰ-Ⅱ】
      Toshiyuki Kan
      Professor, School of Pharmaceutical Sciences, University of Shizuoka
      1. Hiroko Ushikubo, Yui Tanimoto, Kazuho Abe, Tomohiro Asakawa, Toshiyuki Kan, Tatsuhiro Akaishi, 3,3′,4′,5′-Tetrahydroxyflavone Induces Formation of Large Aggregates of Amyloid β Protein, Biol. Pharm. Bull., 37, 748–754 (2014).
      2. Kanako Matsuura, Yumiko Usui, Toshiyuki Kan, Takeshi Ishii, Tsutomu Nakayama, Structual specificity of electric potentials in the coulometric-array analysis of catechins and theaflavins, J. Clin. Biochem. Nutr., 55, 103–109 (2014)
      3. Ryo Ishikawa, Naoto Yoshida, Yusuke Akao, Yusuke Kawabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan: Total Syntheses of (+)-Sesamin and (+)-Sesaminol, Chem. Lett., 43, 1572–1574 (2014).
      4. Kazutada Ikeuchi, Ryosuke Fujii, Shimpei Sugiyama, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Jae-Hoon Choi, Tomohiro Suzuki, Hirokazu Kawagishi, Toshiyuki Kan, Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes, Org. Biomol. Chem., 12, 3813–3815 (2014).
      5. Nodoka Yasuda, Takayuki Ishii, Dai Oyama, Tatsuya Fukuta, Yurika Agato, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada, Yasushi Ohizumi, Naoto Oku, Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats, Brain Res., 1559, 46–54 (2014).
      6. Hiroyuki Tobina, Jae-Hoon Choi, Tatsuo Asai, Yoshikazu Kiriiwa, Tomohiro Asakawa, Toshiyuki Kan, Akio Morita, Hirokazu Kawagishi, 2-Azahypoxanthine and imidazole-4-carboxamide produced by the fairy-ring-forming fungus increases wheat yield, Field Crops Res., 162C, 1–6 (2014).
      7. Hitoshi Ouchi, Aya Asahina, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan, Practical Total Syntheses of Acromelic Acids A and B, Org. Lett., 16, 1980–1983 (2014).
      8. Yusuke Kawabe, Ryo Ishikawa, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan, Stereocontrolled Total Synthesis of Hedyotol A, Org. Lett., 16, 1976–1979 (2014).
      9. A. Hiza, Y. Tsukaguchi, T. Ogawa, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules, HETEROCYCLES, 88, 1371–1396 (2014).
      10. S. Sasaki, H. Suzuki, H. Ouchi, T. Asakawa, M. Inai, R. Sakai, K. Shimamoto, Y. Hamashima, T. Kan, Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe, Org. Lett., 16, 564-567 (2014).
      11. J.-H. Choi, T. Ohnishi, Y. Yamakawa, S. Takeda, S. Sekiguchi, W. Maruyama, K. Yamashita, T. Suzuki, A. Morita, T. Ikka, R. Motohashi, Y. Kiriiwa, H. Tobina, T. Asai, S. Tokuyama, H. Hirai, N. Yasuda, K. Noguchi, T. Asakawa, S. Sugiyama, T. Kan, H. Kawagishi, The Source of “Fairy Rings”: 2-Azahypoxanthine and its Metabolite Found in a Novel Purine Metabolic Pathway in Plants, Angew. Chem. Int. Ed., 53, 1552–1555 (2014).
        ※本論文はNature とC&E Newsに紹介されました( A. Mitchinson, Nature, 2014, 505, 298; C&E News, 2014, 92, 25.)
      12. K. Shimizu, T. Asakawa, N. Harada, D. Fukumoto, H. Tsukada, T. Asai, S. Yamada, T. Kan, N. Oku, Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin, PLOS ONE, 9, e85520 (2014).
      13. Y. Hirooka, K. Ikeuchi, Y. Kawamoto, Y. Akao, T. Furuta, T. Asakawa, M. Inai, T. Wakimoto, T. Fukuyama, T. Kan, Total Synthesis of (–)-SB-203207, Org. Lett. 16, 1646–1649 (2014).
      【Group Ⅰ-Ⅱ】
      Hiroyuki Nakamura
      Professor, Tokyo Institute of Technology
      1. S. Tachikawa, M. E. El-Zaria, R. Inomata, S. Sato, H. Nakamura, Synthesis of protoporphyrin–lipids and biological evaluation of micelles and liposomes, Bioorg. Med. Chem. 22, 4745–4751 (2014).
      2. H. Nakamura, H. S. Ban, K. Shimizu, H. Minegishi, S. Sato, Design of Photoaffinity Probe Molecules for Identification and Modification of Target Proteins, J. Photopolym. Sci. Technol. 27, 453-458 (2014).
      3. M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, K. Kaneda, K. Awazu, A novel photodynamic therapy for drug resistant prostate cancer cells using porphyrus Envelope as a novel photosensitizer, Photodiag. Photodynam. Ther., 11, 48-54 (2014).
      4. H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, H. S. Ban, Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1 inhibitors, J. Chem. Soc., Dalton Trans (invited), 43, 4941-4944 (2014).
      5. C. Verdia-Baguena, A. Alcaraz, V. W. Aguilella, A. M. Cioran, S. Tachikawa, H. Nakamura, Amphiphillic COSAN and I2-COSAN crossing synthetic lipid membranes: planar bilayers and liposomes, Chem Commun, 50,6700-6703 (2014).
      【Group Ⅰ-Ⅱ】
      Nobuyuki Kanzawa
      Professor, Faculty of Science and Technology, Sophia University
      1. S. Motojima, N. Igeta, H. Muramatsu, H. Uchida, K. Itatani, N. Kanzawa, M. Honda, M. Aizawa, Fabrication of apatite-fiber scaffolds with enhanced mechanical property using chemical cross-linking of type I-collagen and their biocompatibility, J. Soc. Inorg Mater. Jpn 21, 278-285 (2014).
      【Group Ⅰ】
      Yu Nakagawa
      Senior Research Scientist, RIKEN
      【Group Ⅰ】
      Makoto Muroi
      Senior Research Scientist, RIKEN
      1. Tarui Y, Chinen T, Nagumo Y, Motoyama T, Hayashi T, Hirota H, Muroi M, Ishii Y, Kondo H, Osada H, Usui T. Terpendole E and its Derivative Inhibit STLC- and GSK-1-Resistant Eg5. ChemBioChem, 15(7)934-8.(2014)
      【Group Ⅱ】
      Hiroki Oguri
      Associate Professor, Graduate School of Science, Hokkaido University/Professor, Tokyo Institute of Technology
      1. G. Suzuki, A. Minami, M. Shimaya, T. Kodama, Y. Morimoto, H. Oguri, H. Oikawa, Analysis of enantiofacial selective epoxidation catalyzed by flavin-containing monooxygenase Lsd18 involved in ionophore polyether lasalocid biosynthesis, Chem. Lett. 43, 1779-1781 (2014).
      【Group Ⅱ】
      Hiroaki Saito
      Assistant Professor, Graduate School of Natural Science & Technology, Kanazawa University
      1. Takeshi Miyakawa, Ryota Morikawa, Masako Takasu, Kimikazu Sugimori, Kazutomo Kawaguchi, Hiroaki Saito, Hidemi Nagao, Analysis of water molecules around GTP in Hras-GTP complex and GDP in Hras-GDP complex by molecular dynamics simulations, Mol. Phys. 112, 526-532 (2014). DOI:10.1080/00268976.2013.852697)
      【Group Ⅰ(Advisory Members) -Ⅱ(A03)】
      Motonari Uesugi
      Professor, Institute for Integrated Cell-Material Sciences & Institute for Chemical Research,
      Kyoto University
      1. Hirata, N., Nakagawa, M., Fujibayashi, Y., Yamauchi, K., Murata, A., Minami, I., Tomioka, M., Kondo, T., Kuo, T.F., Endo, H., Inoue, H., Sato, S., Ando, S., Kawazoe, Y., Aiba, K., Nagata, K., Kawase, E., Chang, Y.T., Suemori, H., Eto, K., Nakauchi, H., Yamanaka, S., Nakatsuji, N., Ueda, K., Uesugi, M. A Chemical Probe That Labels Human Pluripotent Stem Cells, Cell Rep, 6, 1165-1174 (2014).
        DOI: http://dx.doi.org/10.1016/j.celrep.2014.02.006,
      2. Kuo, T.F., Mao, D., Hirata, N., Khambu, B., Kimura, Y., Kawase, E., Shimogawa, H., Ojika, M., Nakatsuji, N., Ueda, K., Uesugi, M., Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative, J. Am. Chem. Soc., 136 (28), 9798-9801 (2014).
        DOI: 10.1021/ja501795c,
      3. Frisco-Cabanos, H.L., Watanabe, M., Okumura, N., Kusamori, K., Takemoto, N., Takaya, J., Sato, S., Yamazoe, S., Takakura, Y., Kinoshita, S., Nishikawa, M., Koizumi, M., Uesugi, M, Synthetic Molecules That Protect Cells from Anoikis and Their Use in Cell Transplantation, Angew. Chem. Int. Ed., 126 (42), 11390-11395 (2014).

        DOI: 10.1002/ange.201405829,

      【Group Ⅱ】
      Kazuhiro Mio
      Senior Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
      1. Mio K, Tsukazaki T, Mori H, Kawata M, Moriya T, Sasaki Y, Ishitani R, Ito K, Nureki O, Sato C. Conformational variation of the translocon enhancing chaperone SecDF. J Struct Funct Genomics. 5, 107-115 (2014).
      2. Moriuchi T, Osumi T, Mio K, Muraoka T, Hirose F, Long-term Expression of the Lamin A Mutant Associated with Dilated Cardiomyopathy Induces Senescence. Genes to Cells, 19, 901-908 (2014).
      3. Owada T, Kaneko M, Matsumoto C, Sobata R, Igarashi M, Suzuki K, Matsubayashi K, Mio K, Uchida S, Satake M, Tadokoro K. Establishment of culture systems for Genotypes 3 and 4 hepatitis E virus (HEV) obtained from human blood and application of HEV inactivation using a pathogen reduction technology system. Transfusion. 54, 107-115 (2014).
      4. Sato C, Mio K, Kawata M, Ogura T. 3D structure determination of protein using TEM single particle analysis. Microscopy 63, i9-i10 (2014)

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