Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Publication in 2013

Publication in 2013

A01A02A03

【A01】

Hiroshi Handa, A01 Group Leader
Professor, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
  1. J. Kang, Z. Shen, J.-M. Lim, H. Handa, L. Wells, D. Tantin, Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation., FASEB J., 27,2807-17 (2013).
  2. K. Hotta, A. Nashimoto, E. Yasumura, M. Suzuki, M. Azuma, Y. Iizumi, D. Shima, R. Nabeshima, M. Hiramoto, A. Okada, K. Sakata-Sogawa, M. Tokunaga, T. Ito, H. Ando, S. Sakamoto, Y. Kabe, S. Aizawa, T. Imai, Y. Yamaguchi, H. Watanabe, H. Handa, Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing, Mol. Pharmacol., 83, 930-938 (2013).
  3. S. Karasawa, M. Azuma, T. Kasama, S. Sakamoto, Y. Kabe, T. Imai, Y. Yamaguchi, K. Miyazawa, H. Handa, Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis, Mol. Pharmacol., 83, 613-620 (2013).
  4. M. Kawano, M. Matsui, H. Handa, SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier, Expert Rev. Vaccines, 12, 199-210 (2013).
  5. J. Kershaw, C. Leuze, I. Aoki, T. Obata, I. Kanno, H. Ito, Y. Yamaguchi, H. Handa, Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence, Neuroimage, 70, 10-20 (2013).
  6. Y. Yamaguchi, H. Shibata, H. Handa, Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond, Biochim. Biophs. Acta, 1829, 98-104 (2013).
  7. K. Ohno, J. Sawada, S. Takiya, M. Kimoto, A. Matsumoto, T. Tsubota, K. Uchino, C. C. Hui, H. Sezutsu, H. Handa, Y. Suzuki, Silk gland factor-2, involved in fibroin gene transcription, consists of LIM homeodomain, LIM-interacting, and single-stranded DNA-binding proteins, J. Biol. Chem., 288, 31581-31591 (2013).
  8. V. Gupta, S. Liu, H. Ando, R. Ishii, S. Tateno, Y. Kaneko, M. Yugami, S. Sakamoto, Y. Yamaguchi, O. Nureki, H. Handa, Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity, Mol. Pharmacol., 84, 824-833 (2013).
  9. H. Miyazaki, K. Higashimoto, Y. Yada, T. A. Endo, J. Sharif, T. Komori, M. Matsuda, Y. Koseki, M. Nakayama, H. Soejima, H. Handa, H. Koseki, S. Hirose, K. Nishioka. Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing, PLoS Genet., 9, e1003897 (2013).
  10. S. Iida, K. Imai, S. Matsuda, O. Itano, M. Hatakeyama, S. Sakamoto, D. Kokuryo, K. Okabayashi, T. Endo, Y. Ishii, H. Hasegawa, I. Aoki, H. Handa, Y. Kitagawa, In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles, J. Magn. Reson. Imaging, 38, 1346-1355 (2013).
  11. T. Enomoto, M.-A. Kawano, H. Fukuda, W. Sawada, T. Inoue, K. C. Haw, Y. Kita, S. Sakamoto, Y. Yamaguchi, T. Imai, M. Hatakeyama, S. Saito, A. Sandhu, M. Matsui, I. Aoki, H. Handa, Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1, J. Biotechnol., 167, 8-15 (2013).
Ryuichi Okamoto
Associate Professor, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
  1. Y. Kano, K. Tsuchiya, X. Zheng, N. Horita, K. Fukushima, S. Hibiya, Y. Yamauchi, T. Nishimura, K. Hinohara, N. Gotoh, S. Suzuki, R. Okamoto, T. Nakamura, M. Watanabe, The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein, Biochem Biophys Res Commun, 432, 175-181 (2013).
  2. Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M, Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice, Hepatology, 57,2502-13. (2013).
  3. G. Ito, R. Okamoto, T. Murano, H. Shimizu, S. Fujii, T. Nakata, T. Mizutani, S. Yui, J. Akiyama-Morio, Y. Nemoto, E. Okada, A. Araki, K. Ohtsuka, K. Tsuchiya, T. Nakamura, M. Watanabe, Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells, PLoS One, 8:e79693 (2013).
  4. M. Takahara, Y. Nemoto, S. Oshima, Y. Matsuzawa, T. Kanai, R. Okamoto, K. Tsuchiya, T. Nakamura, K. Yamamoto, M. Watanabe, IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice, Immunol Lett, 156, 82-93, (2013).
  5. Y. Nemoto, T. Kanai, M. Takahara, S. Oshima, R. Okamoto,K. Tsuchiya, S. Matsumoto, M. Watanabe: Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota, J Immunol, 190, 6616-6625, (2013).
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1. K. Hotta, A. Nashimoto, E. Yasumura, M. Suzuki, M. Azuma, Y. Iizumi, D. Shima, R. Nabeshima, M. Hiramoto, A. Okada, K. Sakata-Sogawa, M. Tokunaga, T. Ito, H. Ando, S. Sakamoto, Y. Kabe, S. Aizawa, T. Imai, Y. Yamaguchi, H. Watanabe, and H. Handa, Vesnarinone Suppresses TNFα mRNA Expression by Inhibiting Valosin-containing Protein. Molecular Pharmacology, 83, 930 (2013).
  2. K. Toyota, Y. Kato, M. Sato, N. Sugiura, S. Miyagawa, H. Miyakawa, H. Watanabe, S. Oda, Y. Ogino, C. Hiruta, T. Mizutani, N. Tatarazako, S. Paland, C. Jackson, John K Colbourne and T. Iguchi, Molecular cloning of doublesex genes of four cladocera (water flea) species. BMC Genomics, 14, 239 (2013).
  3. Toyota, K., Kato, Y., Sato, M., Sugiura, N., Miyagawa, S., Miyakawa, H., Watanabe, H., Oda, S., Ogino, Y., Hiruta, C., Mizutani, T., Tatarazako, N., Paland, S., Jackson, C., Colbourne, J. K., and Iguchi, T. (2013) Molecular cloning of doublesex genes of four cladocera (water flea) species, BMC Genomics 14, 239.
  4. Toyota, K., Kato, Y., Miyakawa, H., Yatsu, R., Mizutani, T., Ogino, Y., Miyagawa, S., Watanabe, H., Nishide, H., Uchiyama, I., Tatarazako, N., and Iguchi, T. (2013) Molecular impact of juvenile hormone agonists on neonatal Daphnia magna, J Appl Toxicol. 34, 537-44
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku
  1. M. Arai, H. Niikawa, M. Kobayashi, Marine derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species. J. Nat. Med., 67, 271-275 (2013).
  2. M. Kobayashi, N. Kotoku, M. Arai, Search for New Medicinal Seeds from Marine Organisms. In; M. Shibasaki, M. Iino, H. Osada (Ed) Chembiomolecular Science: at the Frontier of Chemistry and Biology 93-101 (2013) Springer-Verlag GmbH, Deutschland
  3. N. Kotoku, K. Mizushima, S. Tamura, M. Kobayashi, Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2, Chem. Pharm. Bull., 61, 1024-1029 (2013).
  4. Z. Li, D. Shigeoka, T. R. Caulfield, T. Kawachi, Y. Qiu, T. Kamon, M. Arai, H. W. Tun, T. Yoshimitsu, An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses. MedChemComm, 4, 1093-1098 (2013).
  5. G. A. I. Moustafa, S. Nojima, Y. Yamano, A. Aono, M. Arai, S. Mitarai, T. Tanaka, T. Yoshimitsu, Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis. MedChemComm, 4, 720-723 (2013).
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
  1. Moser, M., Nagamori, S., Huber, M., Tokuda, H. and Nishiyama, K., Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation, Proc. Natl. Acad. Sci. USA, Jun 11;110(24):9734-9. (2013).
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
  1. M. Ihara, S. Hamamoto, Y. Miyanoiri, M. Takeda, M. Kainosho, I. Yabe, N. Uozumi, A. Yamashita, Molecular bases of multimodal regulation of a fungal transient receptor potential (TRP) channel, J Biol Chem., 24;288(21):15303-17. (2013). 2013 May
  2. Yamaguchi,T., Hamamoto,S.,and Uozumi,N. Sodium transport system in plant cells. Frontiers in plant Science,Plant Physiology,4, 410,1-7 (2013)
Kohji Fukunaga
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. S. Moriguchi, N. Shinoda, Y. Yamamoto, Y. Sasaki, K. Miyajima, H. Tagashira, K. Fukunaga, Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice, PLoS One, 8(4), e60863 (2013).
  2. K. Aoki, A. Yokosuka, Y. Mimaki, K. Fukunaga, T. Yamakuni, Nobiletin induces inhibitions of ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinasesignaling to suppress cell proliferation in c6 rat glioma cells, Biol Pharm Bull, 36(4), 540-7 (2013).
  3. H. Tagashira, C. Zhang, YM. Lu, H. Hasegawa, H. Kanai, F. Han, K. Fukunaga, Stimulation of σ1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy, Biochim Biophys Acta, 1830(4), 3082-94 (2013).
  4. AT. Nguyen, M. Nishijo, E. Hori, NM. Nguyen, TT. Pham, K. Fukunaga, H. Nakagawa, AH. Tran, H. Nishijo, Influence of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Socioemotional Behaviors in Offspring Rats, Environ Health Insights, 7, 1-14 (2013).
  5. MH. Liao, YC. Xiang, JY. Huang, RR. Tao, Y. Tian, WF Ye, GS. Zhang, YM. Lu, MM. Ahmed, ZR. Liu, K. Fukunaga, F. Han, The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus, CNS Neurosci Ther, 19(5):329-36 (2013).  2013 May
  6. Y. Yamamoto, N. Shinoda, F. Han, S. Moriguchi, K. Fukunaga, The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation, J Pharmacol Sci, 121(3), 212-26 (2013).
  7. S. Bhuiyan, H. Tagashira, K. Fukunaga, Crucial interactions between selective serotonin uptakeinhibitors and sigma-1 receptor in heart failure, J Pharmacol Sci, 121(3), 177-84 (2013).
  8. S. Moriguchi, T. Tanaka, H. Tagashira, T. Narahashi, K. Fukunaga, Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice, Behav Brain Res, 242, 150-7 (2013).
  9. GS. Zhang, Y. Tian, JY. Huang, RR. Tao, MH. Liao, YM. Lu, WF. Ye, R. Wang, K. Fukunaga, YJ. Lou, F. Han, The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia, CNS Neurosci Ther, 19(1), 53-60 (2013).
  10. RR. Tao, JY. Huang, XJ. Shao, WF. Ye, Y. Tian, MH. Liao, K. Fukunaga, YJ. Lou, F. Han, YM. Lu, Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin, J Pineal Res, 54(3), 271-81 (2013).
  11. H. Tagashira, T. Matsumoto, K. Taguchi, C. Zhang, F. Han, K. Ishida, S. Nemoto, T. Kobayashi, K. Fukunaga, Vascular Endothelial σ1-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding, Circ J, 77(11), 2831-2840 (2013).
  12. H. Tagashira, MS. Bhuiyan, K. Fukunaga, Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes, Am J Physiol Heart Circ Physiol, 305(8), H1201-1212 (2013).
  13. JY. Huang, YM. Lu, H. Wang, J. Liu, MH. Liao, LJ. Hong, RR. Tao, MM. Ahmed, P. Liu, SS. Liu, K. Fukunaga, YZ. Du, F. Han, The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain, Biomaterials, 34(32), 7960-7970 (2013).
  14. Y. Yabuki, K. Fukunaga, Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress, Neuroscience, 250, 394-407 (2013).
  15. Y. Katsushima, T. Sato, C. Yamada, M. Ito, Y. Suzuki, E. Ogawa, I. Sukegawa, J. Sukegawa, K. Fukunaga, T. Yanagisawa, Interaction of PICK1 with C-Terminus of Growth Hormone-Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR, J Pharmacol Sci, 122(3), 193-204 (2013).
  16. S. Moriguchi, T. Tanaka, T. Narahashi, K. Fukunaga, Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor, Hippocampus, (10)942-51 (2013).
  17. Y. Yabuki, N. Shioda, Y. Yamamoto, M. Shigano, K. Kumagai, M. Morita, K. Fukunaga, Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection, Brain Res, 1520, 157-167 (2013).
  18. Y. Yabuki, O. Nakagawasai, S. Moriguchi, N. Shioda, H. Onogi, K. Tan-No, T. Tadano, K. Fukunaga, Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats, Neuroscience, 234, 103-115 (2013).
Kazuhisa Sekimizu
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  1. Dzoyem JP, Hamamoto H, Ngameni B, Ngadjui BT, Sekimizu K, Antimicrobial action mechanism of flavonoids from Dorstenia species, Drug Discov Ther, 7, 66-72 (2013)
  2. Paudel A, Kaneko K, Watanabe A, Shigeki M, Motomu K, Hamamoto H, Sekimizu K, Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents, J Antibiot (Tokyo), 66, 663-667 (2013)
Maiko Okada
Assistant Professor, St.Marianna University School of Medicine.
Nobuaki Matsumori
Associate Professor, Graduate School of Science, Osaka Univeristy
  1. R. A. Espiritu, N. Matsumori, M. Murata, S. Nishimura, H. Kakeya, S. Matsunaga, M. Yoshida, Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state 2H nuclear magnetic resonance. Biochemistry, 52, 2410-2418 (2013).
  2. N. Matsumori,Y. Hiradate, H. Shibata, T. Oishi, S. Shimma, M. Toyoda, F. Hayashi, M. Yoshida, M. Murata, M. Morisawa, A novel sperm-activating and attracting factor from the ascidian Ascidia sydneiensis. Org. Lett., 15, 294-297 (2013).
  3. M. Kinoshita, S. Goretta, H. Tsuchikawa, N. Matsumori, M. Murata M, Characterization of the ordered phase formed by sphingomyelin analogues and cholesterol binary mixtures. Biophysics 9, 37-49 (2013).
  4. M. Ebine, M. Kanemoto, Y. Manabe, Y. Konno, K. Sakai, N. Matsumori, M. Murata, T. Oishi, Synthesis and structure revision of the C43-C67 part of amphidinol 3. Org. Lett., 15, 2846-2849 (2013).
Toshiaki Okuno
Associate Professor, Juntendo University School of Medicine
  1. Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB Journal., 27(8).3306-14(2013).
Akihiro Sugawara
Assistant Professor, Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. M. Wakasugi, H. Gouda, T. Hirose, A. Sugawara, T. Yamamoto, K. Shiomi, T. Sunazuka, S.Omura, S. Hirono, Human acidic mammalian chitinase as anovel target for anti-asthma drug design using in silico acreening, Bioorg. Med. Chem., 21, 3214-3220 (2013).
  2. A. Sugawara, T. Tanaka, T. Hirose, A. Ishiyama, Y. Takahashi, K. Otoguro, S. Omura, T.Sunazuka, Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites, Bioorg. Med. Chem. Lett., 23, 2302-2305 (2013).
  3. T. Hirose, N. Maita, H. Gouda, J. Koseki, T. Yamamoto, A. Sugawara, H. Nakano, S. Hirono, K. Shiomi, T. Watanabe, H. Taniguchi, K. B. Sharpless, S. Ōmura, and T. Sunazuka Observation of the controlled assembly of preclick components in the in situ click Chemistry generation of a chitinase inhibitor Proc. Natl. Acad. Sci. USA, 110, 15892-15897 (2013)
  4. T. Ideguchi, T. Yamada, T. Shirahata, T. Hirose, A. Sugawara, Y. Kobayashi, S. Omura, and T. Sunazuka Asymmetric Total Synthesis of Neoxaline J. Am. Chem. Soc., 135, 12568-12571 (2013)
Shuichi Sakamoto
Senior Researcher, Institute of Microbial Chemistry
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
  1. (Co-Study)Sakata, K., Hara, M., Terada, T., Watanabe, N., Takaya, D., Yaguchi, S., Matsumoto, T., Matsuura, T., Shirouzu, M., Yokoyama, S., Yamaguchi, T., Miyazawa, K., Aizaki, H., Suzuki, T., Wakita, T., Imoto, M., Kojima, S. HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor. Sci. Rep. 3:3243. (2013)
  2. Qin, X-Y., Wei, F., Tanokura, M., Ishibashi, N., Shimizu, M., Moriwaki, H., Kojima, S. The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells. PloS One 8(12):e82860. (2013)
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. S. Shimura, M. Ishima, S. Nakajima, T. Fujii, N. Himeno, K. Ikeda, J. Izaguirre-Carbonell, H. Murata, T. Takeuchi, S. Kamisuki, T. Suzuki, K. Kuramochi, K. Watashi, S. Kobayashi, F. Sugawara, Total Synthesis and Anti-Hepatitis C Virus Activity of MA026, J Am Chem Soc, 135, 18949-18956 (2013).
  2. S. Nakajima, K. Watashi*, S. Kamisuki, S. Tsukuda, K. Takemoto, M. Matsuda, R. Suzuki, H. Aizaki, F. Sugawara, T. Wakita (*corresponding author), Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives, Biochem Biophys Res Commun, 440, 515-20 (2013).
  3. K. Watashi*, G. Liang, M. Iwamoto, H. Marusawa, N. Uchida, T. Daito, K. Kitamura, M. Muramatsu, H. Ohashi, T. Kiyohara, R. Suzuki, J. Li, S. Tong, Y. Tanaka, K. Murata, H. Aizaki, T. Wakita (*corresponding author), Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID), J Biol Chem, 288, 31715-31727 (2013).
  4. R. Suzuki, M. Matsuda, K. Watashi, H. Aizaki, Y. Matsuura, T. Wakita, T. Suzuki, Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2, PLoS Pathog, 9, e1003589 (2013).
  5. Y. Matsumoto, T. Matsuura, H. Aoyagi, M. Matsuda, SS. Hmwe, T. Date, N. Watanabe, K. Watashi, R. Suzuki, S. Ichinose, K. Wake, T. Suzuki, T. Miyamura, T. Wakita, H. Aizaki, Antiviral activity of glycyrrhizin against hepatitis C virus in vitro, PLoS One, 8, e68992 (2013).

【A02】

Kazuhiro Irie, A02 Group Leader
Professor, Graduate School of Agriculture, Kyoto Universiy
  1. Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, K. Suzuki., *K. Irie, Structure-activity Studies at Position 27 of Aplog-1, a Simplified Analog of Debromoaplysiatoxin with Anti-proliferative activity, Tetrahedron, 69,7636-7645 (2013).
  2. H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa, *K. Irie, Structure-activity Studies on the Side Chain of a Simplified Analog of Aplysiatoxin (Aplog-1) with Anti-proliferative Activity, Bioorg. Med. Chem., 21, 2695-2702 (2013).
  3. R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai, *K. Irie, Effects of the Methoxy Group in the Side Chain of Debromoaplysiatoxin on Its Tumor-Promoting and Anti-Proliferative Activities, Bioorg. Med. Chem. Lett., 23, 4319-4323 (2013).
Masaya Imoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher: Etsu Tashiro
  1. Magi S, Shitara T, Takemoto Y, Sawada M, Kitagawa M, Tashiro.E. Takahashi Y, Imoto M. Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase. J. Antibiot., 66, 165-170 (2013).
  2. Ichige M, Fukuda E, Miida S, Hattan J, Misawa N, Saito S, Fujimaki T, Imoto M, Shindo K. Novel isoflavone glucosides in Groundnut (Apios americana Medik) and their antiandrogenic activities. J. Agric. Food Chem., 61, 2183-2187 (2013).
  3. Shinjo S, Mizotani Y, Tashiro.E, Imoto M. A Comparative Analysis of the Expression Patterns of UPR-Target Genes caused by UPR-inducing Compounds. Biosci. Biotechnol. Biochem. 77, 729-735 (2013).
  4. Shinjo S, Tashiro.E, Imoto M. Establishment of a new detection system for the dimerization of IRE1α by BiFC assay. Biosci. Biotechnol. Biochem. 77,1333-1336(2013).
  5. (Co-study)Sakata K, Eda S, Lee E, Hara M, Imoto M, Kojima S. HCV NS3 protease enhancesliver fibrosis via binding to and activating TGF-β type I receptor. Scientific Reports 3: 3243 (2013)
Shigeki Matsunaga
Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  1. Imae, Y.; Takada, K.; Okda, S.; Ise, Y.; Yoshimura, H.; Morii, Y.; Matsunaga, S.: Isolation of cilliatamide D from a marine sponge Stelletta sp. and a reinvestigation of the configuration of ciliatamide A J. Nat. Prod., 76, 755-758 (2013).
  2. Takada, K.; Ninomiya A.; Naruse, M.; Sun, Y.; Miyazaki, M.; Nogi, Y.; Okada, S. Matsunaga, S.:Surugamides A–E, Cyclic Octapeptides with Four D-Amino Acid Residues, from a Marine Streptomyces sp.: LC–MS-Aided Inspection of Partial Hydrolysates for the Distinction of D- and L-Amino Acid Residues in the Sequence. J. Org. Chem. 78, 6746-6750 (2013).
  3. Akiyama, T.; Takada, K.; Oikawa, T.; Matsuura, N.; Ise, Y.; Okada, S.; Matsunaga, S.: Stimulators of adiponenesis from the marine sponge Xestospongia testudinaria Tetrahedron, 69, 6560-6564 (2013).
  4. Hitora, Y.; Takada, K.; Matsunaga, S.:On the Assignment of the Absolute Configuration at the Isolated Methyl Branch in Miyakosyne A, Cytotoxic Linear Acetylene, from the Deep-Sea Marine Sponge Petrosia sp. Tetrahedron, 69, 11070-11073 (2013).
  5. Espiritu, R. A.; Matsumori, N.; Murata, M.; Nishimura, S.; Kakeya, H.; Matsunaga, S.; Yoshida, M.:Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilyaers as viewed by surface plasmon resonance and solid-state 2H nuclear magnetic resonance, Biochemistry, 52, 2410-2418 (2013).
  6. (Co-study) Nishimura, S.; Ishii, K.; Iwamoto, K.; Arita, Y.; Matsunaga, S.; Ohno-Iwashita, Y.; Sato, S. B.: Kakeya, H.; Kobayashi, T.; Yoshida, M.:Visualization of sterol-rich membrane domains with fluorecently-labeled theonellamides PloS ONE, e83716 (2013).
Masami Ishibashi
Professor,Graduate School of Pharmaceutical Sciences, Chiba University
Co-Researcher:Midori Arai, Kazufumi Toume
  1. M. A. Arai, T. Fujimatsu, K. Uchida, S. K. Sadhu, F. Ahmed, M. Ishibashi, Hh signaling inhibitors from Vitex negundo, naturally occurring inhibitor of GLI1-DNA complex, Mol. BioSys., 9, 1012-1018 (2013).
  2. T. Arai, Y. Yamamoto, A. Awata, K. Kamiya, M. Ishibashi, M. A. Arai, Catalytic asymmetric synthesis of mixed 3,3’-bisindoles and their evaluation as Wnt signaling inhibitors, Angew. Chem. Int. Ed., 52, 2486-2490 (2013).
  3. K. Toume, K. Kamiya, M. A. Arai, N. Mori, S. K. Sadhu, F. Ahmed, M. Ishibashi, Xylogranin B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatum, Org. Lett., 15, 6106-6109 (2013)
  4. T. Minakawa, K. Toume, M. A. Arai, T. Koyano, T. Kowithayakorn, M. Ishibashi, Prenylflavonoids isolated from Artocarpus champeden with TRAIL-resistance overcoming activity, Phytochemistry, 96, 299-304 (2013)
  5. M. A. Arai, K. Koryudzu, T. Koyano, T. Kowithayakorn, M. Ishibashi, Naturally occurring Ngn2 promoter activators from Butea superba, Mol. BioSys., 9, 2489-2497 (2013)
Tetsuro Shinada
Professor, Graduate School of Science, Osaka City University
Co-Researcher: Yasufumi Ohfune
  1. T. Sato, H. Yamaga, S. Kashima, Y. Murata, T. Shinada, C. Nakano, T. Hoshino, Identification of Novel Sesterterpene/Triterpene Synthase from Bacillus clausii, ChemBioChem, 14, 822-825 (2013).
  2. Y. Yasuno, M. Hamada, T. Yamada, T. Shinada, Y. Ohfune, Stereoselective Synthesis of (E)-α,β-Dehydroamino Acid Esters, Eur. J. Org. Chem., 1884-1888 (2013).
  3. Y. Kawanaka, A. Shimizu, T. Shinada, R. Tanaka, Y. Teki, Using Stable Radicals to Protect Pentacene Derivatives from Photogradation, Angew. Chem. Int. Ed. Engl., Jun 24;52(26):6643-7.
Hidenori Watanabe
Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
  1. K. Yoshikawa, H. Nakagawa, N. Mori, H. Watanabe, K. Touhara, An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor, Nature Chemical Biology, 9, 160-162 (2013).
Kosuke Namba
Professor, Graduate School of Pharmaceutical Science, The University of Tokushima
  1. A. Osawa, A. Mera, K. Namba, K. Tanino. Transformations of 1-(Oxiranylmethyl)-1,2,3-triazoles into 2-(Oxiranylmethyl)-1,2,3-triazoles and Alkanenitriles. Synlett, 24, 207-210 (2013).
  2. M. Yoshida, S. Ohno and K. Namba. Synthesis of substituted tetrahydrocyclobuta[b]benzofurans by palladium-catalyzed domino substitution-[2+2] cycloaddition of propargylic carbonates with 2-vinylphenols. Angew, Chem. Int. Ed. 52, 13597-13600 (2013).
Satoshi Ichikawa 
Associate Professor,  Faculty of Pharmaceutical Science, Hokkaido University
  1. S. Ichikawa,* T. Okamura, A. Matsuda, Total Synthesis of Quinaldopeptin and Its Analogues. J. Org. Chem. 78, (24)12662-12670 (2013)
  2. S. Ichikawa, * N. Tatebayashi, A. Matsuda, A Concise Synthesis of C-Glycosyl Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as a Scaffold for Check Point 1 Kinase Inhibitors. J. Org. Chem. 78, 12065-12075 (2013).
  3. S. Ichikawa,* H. Ueno, T. Sunadome, Ko. Sato, A. Matsuda, Tris(azidoethyl)amine Hydrochloride; a Versatile Reagent for Synthesis of Functionalized Dumbbell Oligodeoxynucleotides. Org. Lett. 15, 694-697 (2013).
Haruhiko Fuwa
Associate Professor, Graduate School of Life Sciences, Tohoku University
  1. H. Fuwa, N. Yamagata, A. Saito, M. Sasaki, Total synthesis of 13-demethyllyngbyaloside B, Org. Lett., 15, 1630–1633 (2013).
  2. H. Fuwa, K. Mizunuma, M. Sasaki, T. Suzuki, H. Kubo, Total synthesis and biological evaluation of (–)-exiguolide analogues: Importance of the macrocyclic backbone, Org. Biomol. Chem., 11, 3442–3450 (2013).
  3. K. Ishigai, H. Fuwa, K. Hashizume, R. Fukazawa, Y. Cho, M. Yotsu-Yamashita, *M. Sasaki, Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues, Chem. Eur. J., 19, 5276–5288 (2013).
  4. H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, M. Sasaki, Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements, Chem. Eur. J., Volume 19, Issue 25, pages 8100–8110, June 17, 2013
  5. H. Fuwa, K. Noto, M. Kawakami, M. Sasaki, Synthesis and biological evaluation of aspergillide A/neopeltolide chimeras, Chem. Lett., Vol. 42 (2013) No. 9 P 1020-1022.
  6. *H. Fuwa, K. Sekine, M. Sasaki, Total synthesis of the proposed structure of didemnaketal B, Org. Lett., 15, 3970–3973 (2013).
Hideyuki Shigemori
Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
  1. M. O. Villareal, J. Han, K. Matsuyama, Y. Sekii, A. Smaoui, H. Shigemori, and H. Isoda, Lupenone from Erica multiflora Leaf Extract Stimulates Melanogenesis in B16 Murine Melanoma Cells through the Inhibition of ERK1/2 Activation, Planta Med., 79, 236-243 (2013).
  2. J. Ueda, Y. Toda, K. Kato, Y. Kuroda, T. Arai, T. Hasegawa, H. Shigemori, K. Hasegawa, J. Kitagawa, K. Miyamoto, and E. Uheda, Identification of Dehydrocostus Lactone and 4-Hydroxy-β-thujone as Auxin Polar Transport Inhibitors, Acta Physiol. Plant,July 2013, Volume 35, Issue 7, pp 2251-2258.
  3. M. Kurisu, Y. Miyamae, K. Murakami, J. Han, H. Isoda, K. Irie, and H. Shigemori, “Acteoside, a phenylethanoid glycoside, inhibits amyloid β aggregation”, Biosci. Biotech. Biochem., 77, 1329-1332 (2013).
  4. R. Nakasone, M. Kurisu, M. Onodera, Y. Miyamae, D. Matsuura, H. Kanatani, S. Yano, and H. Shigemori, “Promoting effects on hepatocyte growth factor production of daphnane diterpenoids from Daphne odora”, Heterocycles, 87, 1087-1092 (2013).
  5. Y. Tanabe, T. Matsumoto, T. Hosoya, H. Sato, and H. Shigemori, “Palmaerins A-D, new chlorinated and brominated dihydroisocoumarins with antimicrobial and plant growth regulating activities from discomycete Lachnum palmae”, Heterocycles, 87, 1481-1491 (2013).
  6. T. Arai, Y. Toda, K. Kato, K. Miyamoto, T. Hasegawa, K. Yamada, J. Ueda, K. Hasegawa, T. Inoue, and H. Shigemori, “Artabolide, a novel polar auxin transport inhibitor isolated from Artemisia absinthium”, Tetrahedron, 69, 7001-7005 (2013).
  7. M. Kurisu, R. Nakasone, Y. Miyamae, D. Matsuura, H. Kanatani, S.Yano, and H. Shigemori, “Induction of hepatocyte growth factor production in human dermal fibroblasts by caffeic acid derivatives”, Biol. Pharm. Bull., 36, 2018-2021 (2013).
Hirokazu Kawagishi
Professor, Research Institute of Green Science and Technology, Shizuoka University
  1. J. Wang, H. Hirai, and H. Kawagishi, Dimerization of bisphenol A by hyper lignin-degrading fungus Phanerochaete sordida YK-624 under ligninolytic condition. Curr. Microbiol., 66, 544-547 (2013)
  2. J. Wu, H. Kobori, M. Kawaide, S. Suzuki, J-H.Choi, N. Yasuda, K. Noguchi, T. Matsumoto, H. Hirai, and H. Kawagishi, Isolation of bioactive steroids from the Stropharia rugosoannulata mushroom and absolute configuration of strophasterol B, Biosci. Biotechnol. Biochem., 77,1779-81(2013).
  3. H. Hirai, K. Misumi, T. Suzuki, T., H. Kawagishi, Improvement of manganese peroxidase production by the hyper lignin-degrading fungus Phanerochaete sordida YK-624 by recombinant expression of the 5-aminolevulinic acid synthase gene, Curr. Microbiol., 67, 708-711(2013).
  4. T. Suzuki, K. Igarashi, H. Dohra, T. Someya, T. Takano, K. Harada, S. Omae, S., H. Hirai, K. Yano, H. Kawagishi, A new omics data resource of Pleurocybella porrigens for gene discovery, PloS ONE, 8, e69681(2013).
  5. J. Wu, T. Suzuki, J-H. Choi, N. Yasuda, K. Noguchi, H. Hirai, H. Kawagishi, An unusual sterol from the mushroom Stropharia rugosoannulata, Tetrahedron Lett., 54, 4900-4902 (2013).
  6. J. Wang, R. Yamamoto, Y. Yamamoto, T. Tokumoto, J. Dong, J., P. Thomas,H. Hirai, H Kawagishi, Hydroxylation of bisphenol A by hyper lignin-degrading fungus Phanerochaete sordida YK-624 undernon-ligninolytic condition, Chemosphere, 93, 1419-1423(2013).
  7. J-H. Choi, M. Yoshida, T. Suzuki, E. Harada, M. Kawade, K. Yazawa, S. Nishimoto, H. Hirai, H. Kawagishi, A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal, Tetrahedron, 69, 8609-8611 (2013).
  8. H. Kobori, A. Sekiya, N. Yasuda, K. Noguchi, T. Suzuki, J-H. Choi, H. Hirai, H. Kawagishi, Armillariols A to C from the culture broth of Armillaria sp., Tetrahedron Lett., 54, 5481-5483 (2013).
Makoto Ojika
Professor, Graduate School of Bioagricultural Sciences, Nagoya University
  1. K. Horikawa, T. Yagyu, Y. Yoshioka, T. Fujiwara, K. Kanamoto, T. Okamoto, M. Ojika, Petrosiols A−E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata, Tetrahedron, 69, 101-106 (2013).
  2. B.-K. Choi, B.-Y. Cha, T. Yagyu, J.-T. Woo, M. Ojika, Sponge-derived acetylenic alcohols, petrosiols, inhibit proliferation and migration of platelet-derived growth factor (PDGF)-induced vascular smooth muscle cells, Bioorg. Med. Chem. 21, 1804-1810 (2013).
  3. M. Matsukawa; Y. Shibata; M. Ohtsu; A. Mizutani; H. Mori; P. Wang; M. Ojika; K. Kawakita; D. Takemoto, Nicotiana benthamiana calreticulin 3a is required for the ethylene-mediated production of phytoalexins and disease resistance against oomycete pathogen Phytophthora infestans, Mol. Plant Microbe Int. 26, 880-892 (2013).
  4. B.-K. Choi; B.-Y. Cha; T. Fujiwara; K. Kanamoto; J.-T. Woo; M. Ojika; G. Imokawa, Arenarol isolated from a marine sponge abrogates endothelin-1-stimulated melanogenesis by interrupting MEK phosphorylation in normal human melanocytes, Cytotechnology, 65, 915-926 (2013).
  5. Y. Oba Yuichi; N. Yoshida; S. Kanie; M. Ojika; S. Inouye, Biosynthesis of Firefly Luciferin in Adult Lantern: Decarboxylation of L-Cysteine is a Key Step for Benzothiazole Ring Formation in Firefly Luciferin Synthesis, PloS one, 8, e84023 (2013).
Shinichi Nishimura
Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
  1. Espiritu, R. A., Matsumori, N., Murata, M., Nishimura, S., Kakeya, H., Matsunaga, S. & Yoshida, M. Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid state 2H NMR. Biochemistry 52, 2410-2418 (2013).
  2. Otsuki, S., Nishimura, S., Takabatake, H., Nakajima, K., Takasu, Y., Yagura, T., Sakai, Y., Hattori, A. & Kakeya, H. Chemical tagging of a drug target using 5-sulfonyl tetrazole. Bioorg. Med. Chem. Lett. 23, 1608-1611 (2013).
  3. Sugiyama, R., Nishimura, S. & Kakeya, H. Stereochemical reassignment of heronamide A, a polyketide macrolactam from Streptomyces sp. Tetrahedron Lett. 54, 1531-1533 (2013).
  4. (Co-study)Nishimura, S., Ishii, K., Iwamoto, K., Arita, Y., Matsunaga, S., Ohno-Iwashita, Y., Sato, S.B., Kakeya, H., Kobayashi, T., Yoshida, M. Visualization of sterol-rich membrane domains with fluorescently-labeled theonellamides. PLOS ONE 8, e83716 (2013).
  5. Fustin, J.M., Doi, M., Yamaguchi, Y., Hida, H., Nishimura, S., Yoshida, M., Isagawa, T., Morioka, M.S., Kakeya, H., Manabe, I., Okamura, H. RNA methylation shows its mettle: m6A-dependent RNA processing modulates the speed of the circadian clock. Cell 155, 793-806 (2013).
  6. (Co-study)Fustin, J.M., Doi, M., Yamaguchi, Y., Hida, H., Nishimura, S., Yoshida, M., Isagawa, T., Morioka, M.S., Kakeya, H., Manabe, I., Okamura, H. RNA methylation shows its mettle: m6A-dependent RNA processing modulates the speed of the circadian clock. Cell 155, 793-806 (2013).
Katsunori Tanaka
Associate Chief Scientist, RIKEN
Co-Researcher: Co-Researcher: Takayuki Iwata, Masataka Kitadani.
  1. K. Tanaka, T. Tahara, S. Nozaki, H. Onoe, Y. Watanabe, K. Fukase, Conformationally Fixed Analog of Peptide Mimic of Grb2-SH2 Domain: Synthesis and Evaluation Against A431 Cancer Cell, Mol. BioSyst., 9, 1019-1025 (2013).
  2. K. Tanaka, K. Moriwaki, S. Yokoi, K. Koyama, E. Miyoshi, K. Fukase, Whole-Body Imaging of Tumor Cells by Azaelectrocyclization: Visualization of Metastasis Dependence on Glycan Structure, Bioorg. Med. Chem., 21, 1074-1077 (2013).
  3. (Co-study) K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, K. Fukase, Development of Bis-unsaturated Ester Aldehydes as Amino-glue Probes: Sequential Double Azaelectrocyclization as Promising Strategy for Bioconjugation, Org. Biomol. Chem., 11, 7326-7333, (2013).
  4. A. Tsutsui, K. Tanaka, 2,6,9-Triazabicyclo[3.3.1]nonanes as Overlooked Amino-modification Products by Acrolein, Org. Biomol. Chem., 11, 7208-7211, (2013).
  5. K. Fukase, K. Tanaka, Y. Fujimoto, Y. Manabe, Microfluidic Synthesis: A New Strategy for Practical Synthesis of Oligosaccharides, In Glycochemical Synthesis: Strategies and Applications, H. Shang-Cheng (ed), Wiley, in press (2013).
  6. K. Mazumder, K. Tanaka, K. Fukase, Cytotoxic Activity of Ursolic Acid Derivatives Obtained by Isolation and Oxidative Derivatization, Molecules, 18, 8929-8944, (2013)
  7. A. R. Pradipta, K. Tanaka, Synthesis of 3,7,9- and 2,6,9- Triazabicyclo[3.3.1]nonane Derivatives, Heterocycles, 87, 2001-2014, (2013).
  8. K. Tanaka, K. Fukase,, Chemical Approach to A Whole Body Imaging of Sialo-N-linked Glycans, In Topics in Current Chemistry volumes, SialoGlyco Chemistry and Biology, R. Gerardy-Schahn, P. Delannoy, and M. von Itzstein (eds), Springer, in press (2013).
  9. Kazunobu Toshima
    Professor, Faculty of Science and Technology, Keio University
    1. Takada, K. Uda, T. Ohtani, S. Tsukamoto, D. Takahashi, K. Toshima, Improved total synthesis of incednam, The Journal of Antibiotics, 66, 155-159 (2013).
    2. Y. Aoki, S. Tanimoto, D. Takahashi, K. Toshima, Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids, Chemical Communications, 49, 1169-1171 (2013).
    3. S. Kusumi, S. Tomono, S. Okuzawa, E. Kaneko, T. Ueda, K. Sasaki, D. Takahashi, K. Toshima, Total synthesis of vineomycin B2, Journal of the American Chemical Society, 135, 15909-15912 (2013).
    4. T. Kimura, M. Sekine, D. Takahashi, K. Toshima, Chiral Brønsted acid-mediated glycosylation with recognition of alcohol chirality, Angewandte Chemie International Edition, 52, 12131-12134 (2013).
    5. H. Ueno, T. Iwata, N. Koshiba, D. Takahashi, K. Toshima, Design, synthesis and evaluation of a boronic acid based artificial receptor for L-DOPA in aqueous media, Chemical Communications, 49, 10403-10405 (2013).
    6. M. Sekine, T. Kimura, Y. Katayama, D. Takahashi, K. Toshima, The direct and one-pot transformation of xylan into the biodegradable surfactants, alkyl xylosides, is aided by an ionic liquid, RSC Advances, 3, 19756-19759 (2013).
    7. M. Nakanishi, D. Takahashi, K. Toshima, Light-induced O-glycosylation of unprotected deoxythioglycosyl donors, Organic & Biomolecular Chemistry, 11, 5079-5082 (2013).
    8. A. Okochi, S. Tanimoto, D. Takahashi, K. Toshima, Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids, Chemical Communications, 49, 6027-6029 (2013).
    9. D. Takahashi, K. Toshima, Stereoselective formation of 2-deoxyglycosidic bonds in biologically active natural products, Stereoselective Synthesis of Drugs and Natural Products, 2, 1137-1171(2013).
    10. K. Toshima, Chemical biology based on target-selective degradation of proteins and carbohydarates using light-activable organic molecules, Molecular BioSystems, 9, 834-854, (2013).
    Yoko Saikawa
    Lecture, Faculty of Science and Technology, Keio University
    1. S. Adachi, K. Watanabe, Y. Iwata, S. Kameda, Y. Miyaoka, M. Onozuka, R. Mitsui, Y. Saikawa, Masaya Nakata, Total Syntheses of Lactonamycin and Lactonamycin Z with Late-Stage A-Ring Formation and Glycosylation, Angew. Chem. Int. Ed. 52, 2087 -2091 (2013).
    Seijiro Hosokawa
    Professor, Faculry of Science and Engineering, Waseda University
    Co-Researcher:Mayumi Okamoto, Isao Shimizu
    1. Hiroyuki Tsukada, Yuki Mukaeda, and Seijiro Hosokawa, Syn-selective Kobayashi aldol reaction using acetals. Organic Letters, 15, 678-681 (2013).
    2. T. Nakamura, M. Harachi, T. Kano, Y. Mukaeda, S. Hosokawa, Concise Synthesis of Reduced Propionates by Stereoselective Reduction Combined with the Kobayashi Reactions, Organic Letters, 15 (12), 3170-3173 (2013).
    3. S. Hosokawa, Asymmetric aldol reactions in the total syntheses of natural products, in V. Andrushko and N. Andrushko eds. “Stereoselective Synthesis of Drugs and Natural Products, Volume 1” John Weily & Sons Inc. pp.215-247, (2013).
    Go Hirai
    Senior Research Scientist, RIKEN
    1. G. Hirai, A. Tsuchiya, M. Sodeoka, New Insights from a Focused Library Approach Aiming at Development of Inhibitors of Dual-Specificity Protein Phosphatases, in M. Shibasaki, M. Iino, and H. Osada eds. “Chembiomolecular Science: at the Frontier of Chemistry and Biology”, Springer, pp.69-81, (2013).
    2. A. Tsuchiya, M. Asanuma, G. Hirai, K. Oonuma, M. Muddassar, E. Nishizawa, Y. Koyama, Y. Otani, K. Y. J. Zhang, and M. Sodeoka, CDC25A-inhibitory RE Derivatives Bind to Pocket Adjacent to the Catalytic Site, Mol. BioSyst., 3, 1026-1034 (2013).
    3. M. Ozawa, M. Morita, G. Hirai, S. Tamura, M. Kawai, A. Tsuchiya, K. Oonuma, K. Maruoka, M. Sodeoka, Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-kB Action, ACS Med. Chem. Lett., 4, 730-735 (2013).
    4. K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, K. Fukase, Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation, Org. Biomol. Chem., 11, 7326-7333 (2013).
    5. T. Suzuki, Y. Miyajima, K. Suzuki, K. Iwakiri, M. Koshimizu, G. Hirai, M. Sodeoka, S. Kobayashi, Unexpected Diels–Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of Chloropupukeananin, Org. Lett., 15, 1748-1751 (2013).

    【A03】

    Minoru Ueda., A03 Group Leader
    Professor,Graduate School of Science, Tohoku University
    1. S. Tamura, S. Inomata, M. Ebine, T. Genji, I. Iwakura, M. Mukai, M. Shoji, T. Sugai, M. Ueda, Triazoyl-Phenyl Linker System Enhancing Aqueous Solubility of Molecular Probe and Efficiency in Affinity Labeling of Target Protein for Jasmonate Glucoside, Bioorg. Med. Chem. Lett. 23, 188-193 (2013).
    2. E. Suzuki, M. Ueda, S. Ohba, T. Sugai, M. Shoji, Stereoselective Construction of cis-Decalin Framework via Radical Domino Cyclization, Tetrahedron Lett., 54, 1589-1592 (2013).
    3. Y. Ikuta, Y. Koseki, T. Murakami, M. Ueda, H. Oikawa, H. Kasai, Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity, Chem. Lett., Vol. 42 (2013) No. 8 P900-901
    Naoki Kanoh
    Associate Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
    1. N. Kanoh, T. Suzuki, M. Kawatani, Y. Katou, H. Osada, and Y. Iwabuchi, Dual Structure-Activity Relationship of Osteoclastogenesis Inhibitor Methyl Gerfelin Based on TEG Scanning, Bioconjugate Chem. 24, 44-52 (2013).
    2. N. Kanoh, Y. Ohno, H. Fukuda, Y. Iwabuchi, On the Origin of cine-Substitution in the Stille Coupling of Trisubstituted Iodoalkene and trans-Vinylstannane, Synlett 2660-2665 (2013).
    3. T. Moriya, A. Kawamata, Y. Takahashi, Y. Iwabuchi, N. Kanoh, Development of Fluorogenic NAD(P)+ Detection Assay for High-Throughput Cytochrome P450 Substrate Screening by Use of 2-Acetylbenzofuran, Chem. Commun. 49, 11500-11502 (2013).
    4. T.Chinen, S. Kazami, Y. Nagumo, I. Hayakawa, A. Ikedo, M.Takagi, A. Yokosuka, N. Imamoto, Y. Mimaki, H. Kigoshi, H. Osada, T. Usui, Glaziovianin A Prevents Endosome Maturation via Inhibiting Microtubule Dynamics, ACS Chem. Biol. 8, 884-889 (2013)
    5. T. Shiobara, T. Usui, J. Han, H. Isoda, Y. Nagumo, The Reversible Increase in Tight Junction Permeability Induced by Capsaicin is Mediated via Cofilin-Actin Cytoskeletal Dynamics and Decreased Level of Occludin, PLoS One, DOI:10.1371/journal.pone.0079954
    6. M. Kita, Y. Hirayama, K. Yoneda, K. Yamagishi, T. Chinen, T. Usui, E. Sumiya, M. Uesugi, H. Kigoshi, Antitumor Macrolide Aplyronine A Inhibits Microtubule by Interaction with Actin, J. Am. Soc. Chem. 135, 18089-18095 (2013)
    Hideo Kigoshi
    Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
    Co-Researcher: Ichiro Hayakawa
    1. O. Ohno, M. Morita, K. Kitamura, T. Teruya, K. Yoneda, M. Kita, H. Kigoshi,and K. Suenaga, Apoptosis-inducing Activity of the Actin-depolymerizing Agent Aplyronine A and Its Side-chain Derivative.,Bioorg. Med. Chem. Lett., 23 (5), 1467-1471 (2013).
    2. T. Chinen, S. Kazami, Y. Nagumo, I. Hayakawa, A. Ikedo, M. Takagi, A. Yokosuka, N. Imamoto, Y. Mimaki, H. Kigoshi, H. Osada, and T. Usui, Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics., ACS Chem. Biol. , 8, 884-889 (2013).
    3. M. Kita, B. Gise, A. Kawamura, and H. Kigoshi, Stylissatin A, a cyclic peptide that inhibits nitric oxide production from the marine sponge Stylissa massa. ,Tetrahedron Lett., 54, 6826-6828 (2013).
    4. M. Kita, Y. Hirayama, K. Yoneda, K. Yamagishi, T. Chinen, T. Usui, E. Sumiya, M. Uesugi, and H. Kigoshi,Inhibition of Microtubule Assembly by A Complex of Actin and Antitumor Macrolide Aplyronine A. J. Am. Chem. Soc., 135, 18089-18095 (2013).
    Toshio Nishikawa
    Profrssor, Graduate School of Bioagricultural Sciences, Nagoya University
    Co-Researcher :Masaatu Adachi,Keiichi Konoki
    1. M. Yotsu-Yamashita, S. Kondo, S. Segawa, Y.C. Lin, H. Toyohara, H, H. Ito, K. Konoki, Y. Cho, T. Uchida, Isolation and Structural Determination of Two Novel Phlorotannins from the Brown Alga Ecklonia kurome Okamura, and Their Radical Scavenging Activities, Mar. Drugs , 11, 165-183 (2013).
    2. M. Adachi, T. Imazu, M. Isobe, T. Nishikawa, An Improved Synthesis of(-)-5,11-Dideoxytetrodotoxin, J. Org. Chem., 78, 1699-1705 (2013).
    3. A. Nakazaki, Y. Y. Hara, S. Kajii, T. Nishikawa, Synthesis of Tetracyclic Indoline and Indolenine Derivatives Having β-Lactam Using Amphiphilic Reactivity of 2-Methylindolenine, Heterocycles, 87, 611-625 (2013).
    4. K. Konoki, T. Onoda, R. Watanabe, Y. Cho, S. Kaga, T. Suzuki M. Yotsu-Yamashita. In Vitro Acylation of Okadaic Acid in the Presence of Various Bivalves’Extracts, Marine Drugs, 11, 300-315 (2013).
    5. H. Yamada, M. Adachi, M. Isobe, T. Nishikawa, Stereocontrolled Total Synthesis of Polygalolide A, Chem. Asian. J. 8, 1428-1435(2013).
    6. K. Kai, Y. Oba, R. Akaike, A. Murata, T. Nishikawa, N. Watanabe, Insight into the chemistry of cycloaddition between α-ketol oxylipin and epinephrine: isolation and structure elucidation of a new reaction product, Tetrahedron Lett. 54, 2247-2250.(2013).
    7. M. Yotsu-Yamashita, Y. Abe, Y. Kudo, R. Ritson-Williams, V. J. Paul, K. Konoki, Y. Cho, M. Adachi, T. Imazu, T. Nishikawa, M. Isobe, First Identification of 5,11-Dideoxytetrodotoxin in Marine Animals, and Characterization of Major Fragment Ions of Tetrodotoxin and Its Analogs by High Resolution ESI-MS/MS, Mar. Drugs 11, 2799-2813(2013).
    8. T. Nishikawa, M. Isobe, Synthesis of Tetrodotoxin, a Classic but Still Fascinating Natural Product, Chem. Rec.13, 286-302(2013).
    9. H. Yamada, M. Adachi, M. Isobe, T. Nishikawa, Stereocontrolled Synthesis of the Oxathiabicylo[3.3.1]nonane Core Structure of Tagetitoxin, Chem. Commun.49, 11221-11223(2013).
    10. A. Nakazaki, W.-Y. Huang, K. Koga, B. Yingyongnarongkul, J. Boonsombat, Y. Sawayama, T. Tsujimoto, T. Nishikawa, Structural Study on a Naturally Occurring Terphenyl Quinone, Biosci. Biotechnol. Biochem. 77, 1529-1532(2013).
    11. K. Konoki, T. Onoda, S. Furumochi, Y. Cho, M. Yotsu-Yamashita, T. Yasumoto, The binding of okadaic acid analogues to recombinant OABP2.1 originally isolated from the marine sponge Halichondria okadai, Bioorg. Med. Chem. Lett.23, 5833-5835(2013).
    12. H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, and M. Sasaki, Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements,Chem. Eur.J.,19,8100-8110 (2013).
    Makoto Sasaki
    Professor, Graduate School of Life Sciences, Tohoku University
    Co-Researcher Haruhiko Fuwa, Kenichi Konoki
    1. H. Fuwa, N. Yamagata, A. Saito, M. Sasaki, Total Synthesis of 13-demethyllyngbyaloside B, Org. Lett., 15, 1630–1633 (2013).
    2. K. Ishigai, H. Fuwa, K. Hashizume, R. Fukazawa, Y. Cho, M. Yotsu-Yamashita, M. Sasaki, Total Synthesis and Biological Evaluation of (+)-Gambieric Acid A and Its Analogues, Chem. Eur. J., 19, 5276-5288 (2013). This paper was selected as VIP (Very Important Paper) and featured on the Front Cover.
    3. H. Fuwa, K. Mizunuma, M. Sasaki, T. Suzuki, H. Kubo, Total Synthesis and Biological Evaluation of (−)-Exiguolide Analogues: Importance of the Macrocyclic Backbone, Org. Biomol. Chem., 11, 3442-3450 (2013). This paper was featured on the Inside Front Cover.
    4. H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, M. Sasaki, Concise Synthesis and Biological Assessment of (+)-Neopeltolide and a 16-Member Stereoisomer Library of 8,9-Dehydroneopeltolide: Identification of Pharmacophoric Elements, Chem. Eur. J., Volume 19, Issue 25, pages8100–8110, June 17, 2013
    5. H. Fuwa, K. Sekine, M. Sasaki, Total Synthesis of the Proposed Structure of Didemnaketal B, Org. Lett., 15, 3970-3973 (2013).
    6. H. Fuwa, K. Noto, M. Kawakami, M. Sasaki, Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras, Chem. Lett., 42, 1020-1022 (2013).
    Fumi Nagatsugi
    Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
    1. Nagatsugi, F., Takahahi, Y., Kobayashi, M., Kuwahara, S., Kusano, S., Chikuni, T., Hagihara, S., Harada, N., Synthesis of the Peptide-Conjugated Light-driven Molecular Motors and Evaluation of their DNA-binding Properties, Mol. BioSyst., 9, 969-973 (2013).
    2. Nishimoto, A., Jitsuzaki, D., Onizuka, K., Taniguchi, Y., Nagatsugi, F. and Sasaki, S. 4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA. Nucleic Acids Research, 41, 6774-6781 (2013).
    3. Hagihara, S., Lin, W.C., Kusano, S., Chao, X.G., Hori, T., Imoto, S. and Nagatsugi, F. The Crosslink Formation of 2 ‘-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-Mediated Silencing. Chembiochem, 14, 1427-1429 (2013).
      This paper was featured on the Front Cover!
    4. (Co-study)K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, and *K. Fukase, Org. Biomol. Chem., 11, 7326–7333 (2013).
    Takamitsu Hosoya
    Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
    1. K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, and *K. Fukase, Org. Biomol. Chem., 11, 7326–7333 (2013).
    Yousuke Takaoka
    Assistant Professor, Graduate School of Engineering, Kyoto University
    1. Y. Takaoka, Y. Kioi, A. Morito, J. Otani, K. Arita, E. Ashihara, M. Ariyoshi, H. Tochio, M. Shirakawa, I. Hamachi, Quantitative comparison of protein dynamics in live cells and in vitro by in-cell 19F-NMR, Chem. Commun., 49, 2801-2803 (2013).
    2. Y. Takaoka, A. Ojida, I. Hamachi, Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems, Angew. Chem. Int. Ed., 52, 4088-4106 (2013).
    3. K. Matsuo, Y. Kioi, R. Yasui, Y. Takaoka, T. Miki, S. Fujishima, I. Hamachi, One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method, Chem. Sci., 2013,4, 2573-2580.
    4. H. Nakamura, Y. Yasui, M. Maruyama, H. Minegishi, H. S. Ban, S. Sato, Development of Hypoxia-Inducible Factor (HIF)-1α Inhibitors: Effect of ortho-Carborane Substituents on HIF Transcriptional -Activity under Hypoxia, Bioorg. Med. Chem. Lett., 23, 1455-1461 (2013).
    5. S. Sato and H. Nakamura, Ligand-directed Selective Protein Modification Based on Local Single Electron Transfer Catalysis, Angew. Chem. Int. Ed., 52, 8681-8684 (2013).
    6. H. Nakamura, Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy, Yakugaku Zasshi. (Review), 133, 1297-1306 (2013).
    7. K. Matsuo, Y. Kioi, R. Yasui, Y. Takaoka, T. Miki, S. Fujishima, I. Hamachi, One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method, Chem. Sci., 4, 2573-2580 (2013)
    8. K. Matsuo, R. Kamada, K. Mizusawa, H. Imai, Y. Takayama, M. Narazaki, T. Matsuda, Y. Takaoka, I. Hamachi, Specific Detection and Imaging of Enzyme Activity by Signal Amplifiable Self-Assembling 19F-MRI Probes, Chem. Eur. J. 19, 12875-12883 (2013).
    9. T. Hayashi, Y. Sun, T. Tamura, K. Kuwata, Z. Song, Y. Takaoka, I. Hamachi, Semisynthetic Lectin-DMAP Conjugates for Labeling and Profilling Glycoproteins on Live Cell Surfaces, J. Am. Chem. Soc., 135, 12252-12258 (2013).
    10. Y. Takaoka, Y. Fukuyama, K. Matsuo, I. Hamachi, Disassembly-driven Turn-on Sensing of Enzyme Activity by using Substrate-based Fluorescent Nanoprobe, Chem. Lett., 42, 1426-1428 (2013).
      ※Chemistry Letters 11月号、Editor’s choice受賞
    11. Y. Moriwaki, T. Terada, J. M. M. Caaveiro, Y. Takaoka, I. Hamachi, K. Tsumoto, K. Shimidu, Heme Binding Mechanism of Structurally Similar Iron-Regulated Surface Determinant Near Transporter Domains of Staphylococcus aureus Exhibiting Different Affinities for Heme, Biochemistry, 52, 8866-8877 (2013).
    Junko Ohkanda
    Associate professor, Institute for Chemical Research, Kyoto University
    1. D. Hayashi, N. Kato, T. Kuzuyama, Y. Sato, J. Ohkanda, AntimicrobialN-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase, Chem. Commun., 49, 5535-5537 (2013).Highlighted in the Inside Cover; Chem. Commun. 49, 5520 (2013).
    2. S. Machida, M. Tsubamoto, N. Kato, K. Harada, J. Ohkanda, Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors, Bioorg. Med. Chem., 2013 Jul 15;21(14):4004-10. (Epub 2012 Oct 11)
    3. C. Anders, Y. Higuchi, K. Koschinsky, M. Bartel, B. Schumacher, P. Thiel, H. Nitta, R. Preisig-Müller, G. Schlichthörl, V. Renigunta, J. Ohkanda, J. Daut, N. Kato, C. Ottmann, A semi-synthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface, Chem. Biol., 20, 583-593 (2013).
    4. T. Maki, A. Kawamura, N. Kato, J. Ohkanda, Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein, Mol. BioSyst., 9, 940-943 (2013). Highlighted in the Cover; Mol. BioSyst. 9, 816-816 (2013). DOI: 10.1039/C3MB90010J.
    5. J. Ohkanda, Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions, Chem. Rec., 13, 561-575 (2013).
    6. M. Molzan, S. Kasper, L. Röglin, M. Skwarczynska, T. Sassa, T. Inoue, F. Breitenbuecher, J. Ohkanda, N. Kato, M. Schuler, C. Ottmann, Stabilization of Physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for Ras mutant cancers, ACS Chem. Biol., 8, 1869-1875 (2013).
    Misako Aida
    Professor, Graduate School of Science, Hiroshima University
    1. Hideo Doi, Misako Aida, Hydration of Adamantane Skeleton: Water Assembling around Amantadine and Halo-substituted Adamantanes, Chemistry Letters, 42, 292-294 (2013).
    2. Shunsuke Mieda, Misako Aida, Macrodipole Moment of Polypeptides in β-Sheet and Its Prediction from Dipole Moments of Amino Acid Residues as Building Blocks: Alanine and Glycine in β-Strand, Chemistry Letters, 42, 473-475 (2013).
    3. Hidenori Miyamoto, Misako Aida, Ab Initio QM/MM-MC Study on Hydrogen Transfer of Glycine Tautomerization in Aqueous Solution: Helmholtz Energy Changes along Water-mediated and Direct Processes, Chemistry Letters, 42,(2013) No.6 P598-600
    4. Hidenori Miyamoto, Misako Aida, Helmholtz Energy Change between Neutral and Zwitterionic Forms of Glycine in Aqueous Solution Using Ab Initio Expanded QM/MM-MC with QM Solvent, Chemistry Letters, 42, 1010-1012, (2013).
    Akira Otaka
    Professor, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences,
    The University of Tokushima
    1. Tanegashima, K.#; Tsuji, K.#; Suzuki, K.; Shigenaga, A.; Otaka, A.; Hara, T.* “Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors” FEBS Lett. 2013, 587, 3770-3775 (doi: 10.1016/j.febslet.2013.10.017) (#Equal contribution)
    2. Sato, K.; Shigenaga, A.; Kitakaze, K.; Sakamoto, K.; Tsuji, D.; Itoh, K.; Otaka, A.* “Chemical synthesis of biologically active monoglycosylated GM2-activator protein analog using N-sulfanylethylanilide peptide” Angew. Chem. Int. Ed. 2013, 52, 7855-7859. (doi: 10.1002/anie.201303390).
    3. Tanegashima, K.#; Suzuki, K.#; Nakayama, Y.; Tsuji, K.; Shigenaga, A.; Otaka, A.; Hara, T.* “CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis” FEBS Lett. 2013, 587, 1731-1735. (doi: 10.1016/j.febslet.2013.04.046) (#Equal contribution)
    Hideo Takahashi
    Professor, Graduate School of Medical Life Science, Yokohama City University
    1. Y. Kodama, K. Takeuchi, N. Shimba, K. Ishikawa, E. Suzuki, I. Shimada, and H. Takahashi, Rapid identification of ligand-binding sites by using an assignment-free NMR approach, J. Med. Chem., 56, 9342-9350 (2013)
    2. M. Miyazawa-Onami, K. Takeuchi, T. Takano, T. Sugiki, I. Shimada, and H. Takahashi, Perdeuteration and methyl-selective 1H, 13C-labeling by using a Kluyveromyces lactis expression system, J. Biomol. NMR, 57, 297-304 (2013)
    Toshiyuki Kan
    Professor, School of Pharmaceutical Sciences, University of Shizuoka
    1. Y. Kawabe, Y. Aihara, Y. Hirose, A. Sakurada, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reaction, Synlett, 479–482 (2013).
    2. A. Kawanishi, C. Miyamoto, Y. Yabe, M. Inai, T. Asakawa, Y. Hamashima, H. Sajiki, T. Kan, Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group, Org. Lett.,15, 1306–1309 (2013).
    3. S. Onoue, T. Nakamura, A. Uchida, K. Ogawa, K. Yuminoki, N. Hashimoto, A. Hiza, Y. Tsukaguchi, T. Asakawa, T. Kan, S. Yamada, Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects, Euro. J. Pharm. Sci., 49, 453–460 (2013).
    4. K. Ikeuchi, M. Hayashi, T. Yamamoto, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, Stereocontrolled total synthesis of sphingofungin E, Eur. J. Org. Chem., 6789–6792 (2013).
    5. S. Misaka, K. Kawabe, S. Onoue, J. P. Werba, M. Giroli, S. Tamaki, T. Kan, J. Kimura, H. Watanabe, S. Yamada, Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes, Drug Metabolism and Pharmacokinetics., 28, 244–249 (2013).
    6. T. Asakawa, Y. Hamashima, T. Kan, Chemical synthesis of tea polyphenols and related compounds, Current Pharmaceutical Design., 19, 6207–6217 (2013).
    Hiroyuki Nakamura
    Professor, Tokyo Institute of Technology
    1. H. Nakamura and H. Minegishi, HSP60 as a drug target, Curr. Pharm. Des. (Review), 19, 441-451 (2013).
    2. H. Koganei, M. Ueno, S. Tachikawa, L. Tasaki, H. S. Ban, M. Suzuki, K. Shiraishi, K. Kawano, M. Yokoyama, Y. Maitani, K. Ono, H. Nakamura, Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers, Bioconjugate Chem., 24, 124-132 (2013).
    3. H. Nakamura, Y. Yasui, M. Maruyama, H. Minegishi, H. S. Ban, S. Sato, Development of Hypoxia-Inducible Factor (HIF)-1α Inhibitors: Effect of ortho-Carborane Substituents on HIF Transcriptional -Activity under Hypoxia, Bioorg. Med. Chem. Lett., 23, 1455-1461 (2013).
    4. H. Minegishi, T. Matsukawa, H. Nakamura, Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity, ChemMedChem, 8, 265-271 (2013).
    5. M. Bialek-Pietras, A. B. Olejniczak, S. Tachikawa, H. Nakamura, Z. J. Lesnikowski, Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their cholesterol conjugates, Bioorg. Med. Chem., 21, 1136-1142 (2013).
    6. H. Minegishi, S. Fukashiro, H. S. Ban, H. Nakamura, Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors, ACS Med. Chem. Lett., 4, 297-301 (2013).
    7. H. Nakamura, Boron lipid-based liposomal boron delivery system for neutron capture therapy: recent development and future perspective, Future Med. Chem., (invited) 5,715-730 (2013).
    8. H. Nakamura, Y. Yasui, H. S. Ban, Synthesis and Biological Evaluation of ortho-Carborane Containing Benzoxazole as an Inhibitor of Hypoxia Inducible Factor (HIF)-1Transcriptional Activity, J. Organomet. Chem., (special issue) 747(2013)189-194.
    Nobuyuki Kanzawa
    Associate Professor, Faculty of Science and Technology, Sophia University
    1. R. Okuhata, Y. Otsuka, T. Tsuchiya, N. Kanzawa, Mutagenesis of apyrase conserved region 1 alters the nucleotide substrate specificity, Plant Signaling & Behavior (2013). Volume 8, Issue 5 May DOI: 10.4161/psb.24131 e24131 (inpress) 2013 
    2. H. Ishii, Y. Mukai, M. Aizawa, N. Kanzawa, Analysis of gene expression and morphology of P19 cells cultured in an apatite-fiber scaffold, Key Enginner. Mater. 529-530: 370-373 (2013)
    3. H. Ohsugi, Y. Habuto, M. Honda, M. Aizawa, N. Kanzawa, Evaluation of the anti-bacterial activity of a novel chelate-setting apatite cement containing lactoferrin, Key Enginner. Mater. 529-530: 187-191 (2013)
    4. T. Inayama, H. Konishi, M. Aizawa, N. Kanzawa, Studies on the anti-tumor action of chelate-setting apatite cements, Key Enginner. Mater. 529-530: 178-182 (2013)
    5. M. Honda, N. Kanzawa, M. Aizawa, In vitro and in vivo antimicrobial properties of silver-containing hydroxyapatite prepared via ultrasonic spray pyrolysis route, Mater. Sci Eng. C. 33, 5008-2018 (2013).
    6. M. Honda, Y. Watanabe, T. Tsuchiya, N. Kanzawa, M. Aizawa, Selective differentiation of bone marrow-derived mesenchymal stromal cells into osteocytes via endochondral ossification in an apatite-fiber scaffold. J. Ceram. Soc. Jpn. 121: 759-769 (2013)
    Yu Nakagawa
    Senior Research Scientist, RIKEN
    1. Y. Nakagawa, T. Doi, T. Taketani, K. Takegoshi, Y. Igarashi, Y. Ito, Mannose binding geometry of pradimicin A. Chem. Eur. J., 19, 10516-10525 (2013).
    Makoto Muroi
    Senior Research Scientist, RIKEN
    1. Y. Futamura, M. Muroi and H. Osada, Target identification of small molecules based on chemical biology approaches, Mol. Biosyst., 9, 897-914 (2013).
    2. Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H, Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems., ChemBioChem, 14, 2456-63, 2378-2383 (2013).

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