Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Publication in 2011

Publication in 2011

Publication in 2011

A01A02A03

【A01】

Hiroshi Handa, A01 Group Leader
Professor, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
  1. Y. Kitai, H. Fukuda, T. Enomoto, Y. Asakawa, T. Suzuki, S. Inouye, H. Handa
    Cell selective targeting of a simian virus 40 virus-like particle conjugated to epidermal growth factor J Biotechnol 155(2) 251-256 (2011)
  2. T. Enomoto, I. Kukimoto, M.-a. Kawano, Y. Yamaguchi, A. J. Berk,
    H. Handa
    In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer Virology 420(1) 1-9 (2011)
  3.  M. Hatakeyama, H. Kishi, Y. Kita, K. Imai, K. Nishio, S. Karasawa, Y. Masaike, S. Sakamoto, A. Sandhu, A. Tanimoto, T. Gomi, E. Kohda, M. Abe,
    H. Handa
    A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications J Mater Chem 21(16) 5959-5966 (2011)
  4.  M. Aizawa, Y. Abe, T. Ito, H. Handa, H. Nawa mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain Neurosci Res 69(4) 343-7 (2011)
  5.  A. Yasuma, T. Ochiai, M. Azuma, H. Nishiyama, K. Kikuchi, M. Kondo, H. Handa Exogenous coproporphyrin III production by Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions J Med Microbiol 60(Pt 7) 1038-42 (2011)
  6.  T. Ito, H. Ando, H. Handa Teratogenic effects of thalidomide: molecular mechanisms Cell Mol Life Sci 68(9) 1569-79 (2011)
  7. T. Taneda, W. Zhu, Q. Cao, H. Watanabe, Y. Yamaguchi, H. Handa, T. Wada Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation Genes Cells16(2) 231-42 (2011)
  8. N. Maekawa, M. Hiramoto, S. Sakamoto, M. Azuma, T. Ito, M. Ikeda, M. Naitou, H. P. Acharya, Y. Kobayashi, M. Suematsu, H. Handa, T. Imai High-performance affinity purification for identification of 15-deoxy-Delta 12,14 -PGJ interacting factors using magnetic nanobeads Biomed Chromatogr 25(4) 466-71 (2011)
  9. M. Kawano, Y. Hayashi, S. Noguchi, H. Handa, M. Horikoshi, Y. Yamaguchi, Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library, Genes Cells, 16, 590-607 (2011).
  10. M. Kawano, L. Xing, K. S. Lam, H. Handa, T. Miyamura, S. Barnett, I. K. Srivastava, R. H. Cheng Design Platforms of Nanocapsules for Human Therapeutics or Vaccines Development of Vaccines 125-139 (2011)
Ryuichi Okamoto
Associate Professor, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
  1. T. Shinohara, Y. Nemoto, T. Kanai, K. Kameyama, R. Okamoto, K. Tsuchiya, T. Nakamura, Totsuka T, K. Ikuta, M. Watanabe, Upregulated IL-7Rα expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol, 186, 2623-2632 (2011).
  2. X. Zheng, K. Tsuchiya, R. Okamoto, Iwasaki M, Y. Kano, N. Sakamoto, T. Nakamura, M.Watanabe, Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis, Inflamm Bowel Dis, 17, 2251-2260, (2011).
  3. Y. Nemoto, T. Kanai, T. Shinohara, T. Ito, T. Nakamura, R. Okamoto, K. Tsuchiya, M. Lipp, Y. Eishi, M. Watanabe, Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation, Gastroenterology, 141, 2130-2139 (2011).
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1.   H. Watanabe, Y. Kato, Evaluation of chemical impacts on organisms based on genomics. JARI Research Journal, 33, 3-8 (2011).
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku.
  1. S. Ishida, M. Arai, H. Nikawa, M. Kobayashi, Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium species., Biol. Pharm. Bull., 34, 917-920 (2011).
  2. P. Pruksakorn, M. Arai, L. Liu, P. Moodley, W.R. Jacobs Jr., M. Kobayashi, Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp., Biol. Pharm. Bull., 34, 1287-1290 (2011).
  3. N. Kotoku, S. Fujioka, C. Nakata, M. Yamada, Y. Sumii, T. Kawachi, M. Arai, M. Kobayashi, Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge. Tetrahedron, 67, 6673-6678 (2011).
  4. M. Arai, L. Liu, T. Fujimoto, A. Setiawan, M. Kobayashi, DedA protein relates to action-mechanism of halicyclamine A, a marine spongean macrocyclic alkaloid, as an anti-dormant mycobacterial substance. Marine Drugs, 9, 984-993 (2011).
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
Kohji Fukunaga
Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
  1. A. Oyagi, S. Moriguchi, A. Nitta, K. Murata, Y. Oida, K. Tsuruma, M. Shimazawa, K. Fukunaga, H. Hara, Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation, Brain Res, 1419, 97-104 (2011).
  2. YM. Lu, J. Huang, N. Shioda, K. Fukunaga, Y. Shirasaki, XM. Li, F. Han, CaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart, PLoS One, 6(9), e24724 (2011).
  3. H. Tagashira, S. Bhuiyan, N. Shioda, K. Fukunaga, Distinct cardioprotective effects of 17β-estradiol and dehydroepiandrosterone on pressure overload-induced hypertrophy in ovariectomized female rats, Menopause, 18(12), 1317-26 (2011).
Kazuhisa Sekimizu
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Maiko Okada
Assistant Professor, Department of Translational Oncology / St.Marianna University School of Medicine.
Nobuaki Matsumori
Associate Professor, Graduate School of Science, Osaka Univeristy
Toshiaki Okuno
Associate Professor, Juntendo University School of Medicine
Akihiro Sugawara
Assistant Professor,
Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. K. Otsu, H. Ishinaga, S. Suzuki, A. Sugawara, T. Sunazuka, S. Ōmura, H. Jono, K. Takeuchi, Effects of a Novel Nonantibiotic Macrolide, EM900, on Cytokine and Mucin Gene Expression in a Human Airway Epithelial Cell Line, Pharmacology, 88, 327–332, (2011).
Shuichi Sakamoto
Senior Researcher, Institute of Microbial Chemistry
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
Koichi Watashi
Senior Researcher,National Institute of Infectious Diseases
  1. M.T. Salim, H. Aoyama, K. Sugita, K. Watashi, T. Wakita, T. Hamasaki, M. Okamoto, Y. Urata, Y. Hashimoto, M. Baba, Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives, Biochem Biophys Res Commun, 415, 714-719 (2011).
  2. K. Morohashi, H. Sahara, K. Watashi, K. Iwabata, T. Sunoki, K. Kuramochi, K. Takakusagi, H. Miyashita, N. Sato, A. Tanabe, K. Shimotohno, S. Kobayashi, K. Sakaguchi, F. Sugawara, Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B, PLoS One, 6, e18285 (2011).

【A02】

Kazuhiro Irie, A02 Group Leader
Professor, Graduate School of Agriculture, Kyoto Universiy
Masaya Imoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher: Etsu Tashiro
  1. Kobayashi H, Ogura, Y, Sawada M, Nakayama T, Takano K, Minato Y, Takemoto Y, Tashiro.E, Watanabe H & Imoto M. Involvement of 14-3-3 proteins in the second EGF-nduced wave of Rac1 activation in the process of cell migration. J. Biol. Chem., 286, 39259-39268 (2011).
Shigeki Matsunaga
Professor,Graduate School of Agricultural and Life Sciences, The University of Tokyo
Masami Ishibashi
Professor, Graduate School of Pharmaceutical Sciences, Chiba University
Co-Researcher:Midori Arai, Kazufumi Toume
  1. M. S. Abdelfattah, K. Toume, M. Ishibashi, New pyranonaphthoquinones and phenazine alkaloid isolated from Streptomyces sp. IFM 11307 with TRAIL resistance-overcoming activity, J. Antibiot., 64, 729-734 (2011).
  2. K. Toume, T. Nakazawa, T. Ohtsuki, M. A. Arai, T. Koyano, T. Kowithayakorn, M. Ishibashi, Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity, J. Nat. Prod., 74, 249-255 (2011).
  3. M. S. Abdelfattah, K. Toume, M. Ishibashi, Isolation and structure elucidation of izuminosides A-C: a rare phenazine glycosides from Streptomyces sp. IFM 11260, J. Antibiot., 64, 271-275 (2011).
  4. M. A. Arai, C. Tateno, T. Koyano, T. Kowithayakorn, S. Kawabe, M. Ishibashi, New Hedgehog/GLI-signaling inhibitors from Adenium obesum, Org. Biomol. Chem., 9, 1133-1139 (2011).
  5. Y. Rifai, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha, Bioorg. Med. Chem. Lett., 21, 718-722 (2011).
Tetsuro Shinada
Professor, Graduate School of Science, Osaka City University
Co-Researcher: Yasufumi Ohfune
  1. T. Okada, K. Sakaguchi, T. Shinada, Y. Ohfune, Au-catalyzed Cyclization of Allenylsilanes. Regioselective Conversion to 2-Amino-4-silylmethylene-Butyrolactone. Tetrahedron Lett. 52, 5740-5743 (2011).
  2. T. Okada, K. Sakaguchi, T. Shinada, Y. Ohfune, Total Synthesis of (-)-Funebrine via Au-catalyzed Regio- and Stereoselective – Butyrolactonization of Allenylsilane. Tetrahedron Lett., 52, 5744-5746 (2011) .
Hidenori Watanabe
Professor,Graduate School of Agricultural and Life Sciences, The University of Tokyo
  1. D. Oguro, H. Watanabe, Asymmetric Synthesis and Sensory Evaluation of Sedanenolide, Biosci. Biotech. Biochem. 75, 1502-1505 (2011).
  2. Y. Kim, H. Watanabe, B.-K. Kim, Y.-B. Seu, Chemo-biological preparation of the chiral building block (R)-4-acetoxy-2-methyl-1-butanol using Pseudomonas putida, Tetrahedron: Assymmetry, 22, 1658-1661 (2011).
  3. H. Kobayashi, Y. Ogura, M. Sawada, R. Nakayama, K. Takano, Y. Minato, Y. Takemoto, E. Tashiro, H. Watanabe, M. Imoto, Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration, J. Biol. Chem. 286, 39259-39268 (2011).
Kosuke Namba
Associate Professor, Graduate School of Science Hokkaido University
Satoshi Ichikawa 
Associate Professor,  Faculty of Pharmaceutical Science, Hokkaido University
Haruhiko Fuwa
Associate Professor,Graduate School of Life Sciences, Tohoku University
  1. M. Ebine, H. Fuwa, M. Sasaki, Total synthesis of (–)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers, Chem. Eur. J., 17, 13754–13761 (2011).
  2. H. Fuwa, M. Ebine, M. Sasaki, Recent applications of the Suzuki–Miyaura cross-coupling to complex polycyclic ether synthesis, J. Syn. Org. Chem. Jpn., 69, 1251–1262 (2011).
Hideyuki Shigemori 
Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
Hirokazu Kawagishi 
Professor, Research Institute of Green Science and Technology, Shizuoka University
Makoto Ojika
Professor, Graduate School of Bioagricultural Sciences, Nagoya University
Shinichi Nishimura
Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
Katsunori Tanaka
Associate Chief, Scientist RIKEN
Co-Researcher: Co-Researcher: Takayuki Iwata, Masataka Kitadani.
  1. K. Tanaka, Effects on Glycan Heterogeneity on Microarray and Dendrimer, Trends in Glycoscience and Glycotechnology, 131, 155-157 (2011).
Kazunobu Toshima
Professor, Faculty of Science and Technology, Keio University
  1. D. Takahashi, S. Hirono, K. Toshima, Target-selective photodegradation of oligosaccharides by a fullerene-boronic acid hybrid upon visible light irradiation, Chemical Communications, 47, 11712-11714 (2011).
  2. T. Ohtani, S. Sakai, A. Takada, D. Takahashi, K. Toshima, Efficient and stereoselective synthesis of the disaccharide fragment of incednine, Organic Letters, 13, 6126-6129 (2011).
Yoko Saikawa
Lecture, Faculty of Science and Technology, Keio University
  1. Y. Matsuda, Y. Endo, Y. Saikawa, M. Nakata, Synthetic Studies on Polymaxenolides: Synthesis and Structure Elucidation of Nominal Epoxyafricanane and Other Africane-Type Sesquiterpenoids, J. Org. Chem. 76, 6258−6263 (2011).
  2. Seijiro Hosokawa
    Professor, Faculry of Science and Engineering, Waseda University
    Co-Researcher:Mayumi Okamoto, Isao Shimizu.
    Go Hirai
    Senior Research Scientist, RIKEN

    【A03】

    Minoru Ueda, A03 Group Leader
    Professor, Graduate School of Science, Tohoku University
    Naoki Kanoh
    Associate Professor, Graduate School of Pharmaceutical Sciences
    Tohoku University
    1. H. Takayama, S. Takahashi, T. Moriya, H. Osada, Y. Iwabuchi, and N. Kanoh, Detection of cytochrome P450 substrates by using a small-molecule droplet array on an NADH-immobilized solid surface, ChemBioChem, 12, 2748-2752 (2011).
    2. H. Takayama, T. Moriya, and N. Kanoh, Preparation of photo-cross-linked small molecule affinity matrices for affinity selection of protein targets for biologically active small molecules, in E. D. Zanders ed. “Chemical Genomics and Proteomics: Reviews and Protocols”, Humana Press pp. 75-83 (2011).
    Hideo Kigoshi
    Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
    Co-Researcher: Ichiro Hayakawa
    1. M. Kita, Y. Hirayama, M. Sugiyama, H. Kigoshi, Development of Highly Cytotoxic and Actin-Depolymerizing Biotin Derivatives of Aplyronine A, Angew. Chem. Int. Ed., 50, 9871-9874 (2011).
    Toshio Nishikawa
    Professor, Graduate School of Bioagricultural Sciences, Nagoya University
    Co-Researcher :Masaatsu Adachi,Keiichi Konoki.
    Makoto Sasaki
    Professor, Graduate School of Life Sciences, Tohoku University
    Co-Researcher: Haruhiko Fuwa, Kenichi Konoki
    1. M. Unno, M. Shinohara, K. Takayama, H. Tanaka, K. Teruya, K. Doh-ura, R. Sakai, M. Sasaki, M. Ikeda-Saito, Binding and Selectivity of the Marine Toxins Neodysiherbaine A, and Its Synthetic Analogues, to GluK1 and GluK2 Kainate Receptors, J. Mol. Biol., 413, 667-683 (2011).
    2. M. Ebine, H. Fuwa, M. Sasaki, Total Synthesis of (–)-Brevenal: A Streamlined Strategy for Practical Synthesis of Polycyclic Ethers, Chem. Eur. J., 17, 13754-13761 (2011).
    3. H. Fuwa, M. Ebine, M. Sasaki, Recent Applications of Suzuki–Miyaura Cross-Coupling to Complex Polycyclic Ether Synthesis, J. Synth. Org. Chem. Jpn. (Special Issue in English), 69, 1251-1262 (2011).
    Fumi Nagatsugi
    Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
    Takamitsu Hosoya
    Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
    Yousuke Takaoka
    Assistant Professor, Graduate School of Engineering, Kyoto University
    Junko Ohkanda
    Associate professor, Institute for Chemical Research, Kyoto University
    Misako Aida
    Professor, Graduate School of Science, Hiroshima University
    Akira Otaka
    Professor, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
    1. H. Ding, A. Shigenaga, K.Sato, K. Morishita, and A. Otaka. Dual kinetically-controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide. Org. Lett. 2011, 13, 5588-5591.
    2. A. Shigenaga, K. Morishita, K. Yamaguchi, H. Ding, K. Ebisuno, K. Sato, J. Yamamoto, K. Akaji, and A. Otaka. Development of UV-responsive catch-and-release system of a cysteine protease model peptide. Tetrahedron 2011, 67, 8879-8886.
    Hideo Takahashi
    Professor, Graduate School of Medical Life Science, Yokohama City University
    1. H. Inoue, A. Iihara, H. Takahashi, I. Shimada, I. Ishida, and Y. Maeda, Affinity transfer to a human protein by CDR3 grafting of camelid VHH, Protein Sci., 20, 1971–1981 (2011)
    2. Y. Fukunishi, Y. Mizukoshi, K. Takeuchi, I. Shimada, H. Takahashi, and H. Nakamura, Protein– ligand docking guided by ligand pharmacophore-mapping experiment by NMR, J. Mol. Graph. Mod., 31, 20-27 (2011)
    Toshiyuki Kan
    Professor, School of Pharmaceutical Sciences, University of Shizuoka
    1. S. PIYAVIRIYAKUL, K. Shimizu, T. Asakawa, T. Kan, P SIRIPONG, N Oku, Anti-angiogenic activity and intracellular distribution of epigallalocatechin-3-gallate analogs, Biol. Pharm. Bull. 34, 396-400 (2011).
    2. T. Asakawa, A. Hiza, M. Nakayama, M. Inai, D. Oyama, H. Koide, K. Shimizu, T. Wakimoto, N. Harada, H. Tsukada, N. Oku, T. Kan, PET Imaging Investigation of Nobiletin Based on a Practical Total Synthesis, Chem. Commun. 47, 2868-2870 (2011).
    3. T. Higashi, Y. Isobe, H. Ouchi, H. Suzuki, Y. Okazaki, T. Asakawa T. Furuta, T. Wakimoto T. Kan, Stereocontrolled Synthesis of (+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid Org. Lett. 13, 1089-1091 (2011)
    4. T. Wakimoto, K. Miyata, H. Ouchi, T. Asakawa, H. Nukaya, Y. Suwa, T. Kan, Enantioselective Total Synthesis of Aperidine, Org. Lett. 13, 2789-2791 (2011).
    5. T. Wakimoto, H. Kondo, H. Nii, K. Kimura, Y. Egami, Y. Oka, M. Yoshida, E. Kida, Y. Ye, S. Akahoshi, T. Asakawa, K. Matsumura, H. Ishida, H. Nukaya, K. Tsuji, T. Kan, I. Abe, Furan Fatty Acid as an Anti-inflammatory Component from Green-Lipped Mussel, Perna canaliculus, Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011).
    Hiroyuki Nakamura
    Professor, Gakusyuin University / Tokyo Institute of Technology
    1. Y. Ito, T. Mizuno, K. Yoshino, H.S. Ban, H. Nakamura, J. Hiratsuka, A. Ishikawa, H. Ohki, Biological evaluation of dopamine analogues containing phenylboronic acid group as new boron carriers, Appl. Radiat. Isotope., 69, 1771-1773 (2011).
    2. A. R. Genady, H. Nakamura, Amphiphilic Allylation of Arylidene-1,3-oxazol-5(4H)-one Using Bis-π-allylpalladium Complexes: An Approach to Synthesis of Cyclohexyl and Cyclohexenyl α-Amino Acid, Org. Biomol. Chem., 20, 7180-7189 (2011).
    3. H. Nakamura, A. Shoji, A. Takeuchi, H. B. Ban, J.-D. Lee, T. Yamori, S. O. Kang, Discovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors, Aust. J. Chem., 64, 1430-1437 (2011).
    4. Y. Kim and H. Nakamura, Copper(I)-Catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes, Chem. Eur. J., 17, 12561-12563 (2011).
    Nobuyuki Kanzawa
    Associate Professor, Faculty of Science and Technology, Sophia University
    Yu Nakagawa
    Senior Research Scientist, RIKEN
    Makoto Muroi
    Senior Research Scientist, RIKEN

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