Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

International Confrence 2014

A01A02A03

【A01】

【Group Ⅰ-Ⅱ】
Hiroshi Handa, A01 Group Leader
Professor, Dept.of Nanoparticle Translational Research,Handa Lab,Tokyo Medical University
  1. Hiroshi Handa, Masaaki Kawano,” Medical application of functionalized SV40 virus-like particles”, ICSS MEETING, Hong Kong (Dec.2014)
  2. Hiroshi Handa,“Idenification of a primary target of thalidomide teratogenecity: towards the debelopment of new drugs”, RNA Biology, USA (Jun.2014)
  3. Takumi Ito, Hideki Ando, Yuki Yamaguchi, Hiroshi Handa,” Cereblon is a substrate receptor of the CUL4-DDB1 ubiquitin ligase whose activity is directly controlled by thalidomide and its analogs”, Protein Modification & Homeostasis ,China (Jun.2014)
  4. Hiroshi Handa, “Expansion from chemical target identification to drug discovery”, Thalidomide Embryopathy Conference, Geneva, Switzerland (Feb, 2014).
【Group Ⅰ-Ⅱ】
Ryuichi Okamoto
Associate Professor, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
  1. Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe . Notch signaling and TNF-α synergistically up-regulates expression of OLFM4 in human intestinal epithelial cells. 8th Japan-US Collabaration Conference in Gastroenterology, (Nov, 21, 2014) Tokyo , Oral
  2. Ryuichi Okamoto, Go Ito, Hiromichi Shimizu, Satoru Fujii , Toru Nakata, Kohei Suzuki, Mamoru Watanabe. Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells. UEGW2014, (Oct, 22, 2014) Vienna , Poster
  3. Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis. UEGW2014 (Oct, 21, 2014) Vienna, Poster
【Group Ⅰ-Ⅱ】
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1. Hajime Watanabe, Comparative Ecotoxicogenomics Using Medaka, Daphnia and Algae, International Environmental Omics Synthesis Conference. Cardiff, United Kingdom (Jun 2014)
  2. Akiko Naitou, Takashi Nakanishi, Yasuhiko Kato, Tomoaki Matsuura, Hajime Watanabe, “Establishment of gene knock out technology using TALEN in D.magna”, aphnia Genomics Consortium Meeting Birmingham, United Kingdom (Jan, 2014).
  3. Takashi Nakanishi, Yasuhiko Kato, Tomoaki Matsuura, Hajime Watanabe, “Establishment of gene knock out technology using CLISPR/Cas) system in D.magna”, aphnia Genomics Consortium Meeting Birmingham, United Kingdom (Jan, 2014).
【Group Ⅰ-Ⅱ】
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku
  1. Masayoshi Arai, “Phenotypic Screening and Chemical Biology for Exploring New Medicinal Seeds and Drug Targets” The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy, Fukuoka, Japan (Sep. 13, 2014)
  2. Masayoshi Arai, Naoyuki Kotoku, Motomasa Kobayashi “Creation of novel drug target for cancer chemotherapy by the study of furospinosulin-1, a hypoxia-selective growth inhibitor against cancer cells”, The 7th Japan-Korea Chemical Biology Symposium, Jeju Island, Korea (Feb, 2014).
【Group Ⅰ-Ⅱ】
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
  1. Nishiyama, K. “Interaction between MPIase, a glycolipid involved in membrane protein integration and preprotein translocation, and its target proteins” The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka (Oct 2014), poster presentation.
【Group Ⅰ(A01)-Ⅱ(A03)】
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
【Group Ⅰ-Ⅱ】
Kohji Fukunaga
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. Yasushi Yabuki, Norifumi Shioda, Misaki Onozato, Kohji Fukunaga, “FABP3 promotes α-synuclein oligomerization in dopaminergic neurons”, Taiwan-Tohoku University Neuroscience Workshop for Young Scientists, Miyagi (December 2014). Oral presentation.
  2. Yasuharu Shinoda, Hideaki Tagashira, Kohji Fukunaga, “Neuronal mitochondrial damage by SIGMAR1 mutation associated with amyotrophic lateral sclerosis”, Taiwan-Tohoku University Neuroscience Workshop for Young Scientists, Miyagi (December 2014). Poster presentation.
  3. Kohji Fukunaga, Norifumi Shioda, Motohiro Morioka, Yuji Owada, “FABP3 promotes α-synuclein oligomerization in dopaminergic neurons”, Neuroscience2014, Washington, D.C., USA (November 2014). Poster presentation.
  4. Kohji Fukunaga, Hideaki Tagashira, Yasuharu Shinoda, “Metyl pyruvate rescues mitochondrial degeneration by sigma-1 receptor mutation in amyotrophic lateral sclerosis”, Neuroscience2014, Washington, D.C., USA (November 2014). Poster presentation.
  5. Norifumi Shioda, Kohji Fukunaga, “BDNF expression through CaMKIIδ3 nuclear translocation in dopaminergic neurons”, Neuroscience2014, Washington, D.C., USA (November 2014). Poster presentation.
  6. Yasushi Yabuki, Minoru Wakamori, Kohji Fukunaga, Novel cognitive enhancer, SAK3 enhances T-type voltage-gated Ca2+ channel current in Neuro2A expressed Cav3.1 gene, Neuroscience2014, Washington, D.C., USA (November 2014). Poster presentation.
  7. Yasuharu Shinoda, Hideaki Tagashira, Kohji Fukunaga, Haloperidol promotes the progression of heart failure through inhibition of sigma-1 receptor, Neuroscience2014, Washington, D.C., USA (November 2014). Poster presentation.
  8. Yasushi Yabuki, Norifumi Shioda, Misaki Onozato, Yuji Owada, Kohji Fukunaga, “FABP3 promotes MPTP-induced α-synuclein accumulations in dopaminergic neurons”, The 8th Neurodegenerative Conditions Research & Development Conference, San Francisco, USA (September 2014). Poster presentation.
  9. Kohji Fukunaga, Yasushi Yabuki, Norifumi Shioda, Shigeki Moriguchi, “Translational research of T-type Ca2+ channel stimulator as Alzheimer disease therapeutics”, The 8th Neurodegenerative Conditions Research & Development Conference, San Francisco, USA (September 2014). Poster presentation.
  10. Yasushi Yabuki, Norifumi Shioda, Shigeki Moriguchi, Kohji Fukunaga, “Translational research of T-type Ca2+ channel stimulator as Alzheimer disease therapeutics”, The 12th meeting of the Asian-Pacific Society for Neurochemistry, Kaohsiung,Taiwan, (August 2014). Oral presentation.
  11. Yuzuru Sasaki, Shigeki Moriguchi, Hiroyuki Sakagami, Kohji Fukunaga, “Sigma-1 receptor stimulation by fluvoxamine rescues depressive-like behaviors in CaMKIV null mice”, The 12th meeting of the Asian-Pacific Society for Neurochemistry, Kaohsiung,Taiwan, (August 2014). Poster presentation.
【Group Ⅰ】Kazuhisa Sekimizu
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
【Group Ⅰ-Ⅱ】
Maiko Okada
Assistant Professor, St.Marianna University School of Medicine.
  1. Maiko Okada, Hiroyuki Nishikawa Wenwen Wu, Tomohiko Ohta, “A non-genomic role of Estrogen receptor alpha: Stimulation of E3 ubiquitin ligase activity of UBE3C in cell proliferation”, Nuclear Regulation by Ubiquitin (No. 60), Benzon symposium, Copenhargen (Aug, 2014), Poster
【Group Ⅰ-Ⅱ】
Nobuaki Matsumori
Professor, Graduate School of Science, Kyusyu Univeristy
【Group Ⅰ】
Toshiaki Okuno
Associate Professor, Juntendo University School of Medicine
【Group Ⅰ-Ⅱ】
Akihiro Sugawara
Assistant Professor, Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
【Group Ⅰ】
Shuichi Sakamoto
Senior Researcher, Institute of Microbial Chemistry
【Group Ⅰ-Ⅱ】
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
  1. Soichi Kojima, “Grnomic and Nongenomic actions of acyclic retinoid in selectively killing hepatocellular carcinoma cells”, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka, Japan, oral, invited (Oct 28th, 2014)
【Group Ⅰ-Ⅱ】
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. K. Watashi. Anti-HBV Approach by Interfering the Interaction between HBV large surface protein and NTCP. 2nd Japan-Taiwan Research Symposium on Hepatitis B virus, April, 2014, Taipei (Taiwan)(Invited)
  2. K. Watashi, M. Iwamoto, A. Sluder, S. Matsunaga, A. Ryo, R. Morishita, ATJ. Kwon, H. Suzuki, S. Tsukuda, R. Suzuki, H. Aizaki, K. Borroto-Esoda, M. Sugiyama, Y. Tanaka, M. Mizokami, T. Wakita. Characterization of a culture system reproducing the NTCP-mediated HBV entry and its application to drug development. 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses, Sep, 2014, Los Angeles (USA)(Oral)
  3. M. Iwamoto, K. Watashi, M. Sugiyama, R. Suzuki, H. Aizaki, Y. Tanaka, M. Mizokami, N. Ohtani, O. Koiwai, T. Wakita. Microtubule-dependent hepatitis B virus (HBV) replication revealed by chemical screening on an efficient HBV-replicating cell line. 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses, Sep, 2014, Los Angeles (USA) (Oral)
  4. S. Tsukuda, K. Watashi, M. Iwamoto, R. Suzuki, H. Aizaki, S. Kojima, M. Sugiyama, Y. Tanaka, M. Mizokami, T. Wakita. Retinoid inhibitors abolish the host permissiveness to HBV infection by modulating NTCP expression. 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses, Sep, 2014, Los Angeles (USA)(Poster)
  5. S. Matsunaga, K. Miyakawa, K. Watashi, T. Wakita, A. Ryo. Wheat germ cell-free system-based production of hepatitis B virus X (HBx) protein for generation and characterization of monoclonal antibody. 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses, Sep, 2014, Los Angeles (USA) (Poster)
  6. M. Fukasawa, Y. Shimizu, Y. Shirasago, M. Iwamoto, K. Watashi, Y. Tanaka, T. Wakita, Kondoh M, Yagi K, Hanada K. Efficient HBV infection system in cell cultured cells. 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses, Sep, 2014, Los Angeles (USA) (Poster)
  7. Y. Akahori, H. Kato, T. Fujita, K. Watashi, T. Wakita, M. Hijikata. Development of hepatitis B virus cell culture system using immortalized human hepatocytes pruducing exogenous Na+/taurocholate cotransporting polypeptide. 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses, Sep, 2014, Los Angeles (USA) (Poster)
  8. S. Nakajima S, K. Watashi, S. Kamisuki, K. Takemoto, J. Izaguirre-Carbonell, R. Suzuki, H. Aizaki, F. Sugawara, T. Wakita. Ruglation of hepatitis C virus replication by liver X receptor is disrupted by a fungi-derived neoechinulin B. 21th International Symposium on Hepatitis C Virus and Related Viruses, Sep, 2014, Banff (Canada) (Poster)
  9. H. Ohashi, K. Watashi, S. Nakajima, S. Kim, R. Suzuki, H. Aizaki, S. Kamisuki, F. Sugawara, T. Wakita. Flutamide inhibits hepatitis C virus assembly through disrupting lipid droplets. 21th International Symposium on Hepatitis C Virus and Related Viruses, Sep, 2014, Banff (Canada) (Poster)
  10. R. Saga, A. Fujimoto, N. Watanabe, M. Matsuda, M. Hasegawa, K. Watashi, H. Aizaki, N. Nakamura, E. Konishi, T. Kato, H. Takeyama, T. Wakita, R. Suzuki. Japanese Encephalitis Virus-subviral particles harboring HCV neutralization epitopes induce neutralizing antibodies against HCV. 21th International Symposium on Hepatitis C Virus and Related Viruses, Sep, 2014, Banff (Canada) (Oral)
  11. R. Suzuki, K. Saito, M. Matsuda, M. Sato, Y. Kanegae, K. Watashi, H. Aizaki, J. Chiba, I. Saito, T. Wakita, T. Suzuki. Single domain intrabodies against HCV core inhibit viral propagation and core-induced NF-kB activation. 21th International Symposium on Hepatitis C Virus and Related Viruses, Sep, 2014, Banff (Canada) (Poster)
  12. A. Fujimoto, H. Aizaki, M. Matsuda, N. Watanabe, K. Watashi, R. Suzuki, T. Suzuki, T. Wakita. Maintenance of HCV infectivity by down-regulating hepatic lipase expression. 21th International Symposium on Hepatitis C Virus and Related Viruses, Sep, 2014, Banff (Canada) (Poster)
  13. K. Goto, A. Fujimoto, K. Watashi, R. Suzuki, S. Yamagoe, K. Moriya, H. Yotsuyanagi, K. Koike, T. Suzuki, T. Miyamura, T. Wakita, H. Aizaki. NS5A-associated membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, regulates hepatitis C virus RNA synthesis and translation. 21th International Symposium on Hepatitis C Virus and Related Viruses, Sep, 2014, Banff (Canada) (Poster)
  14. S. Nakajima, K. Watashi. Identification of neoechinulin B that represses liver X receptor-mediated transcription and inhibits hepatitis C virus replication. The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Oct, 2014, Osaka (Japan) (Poster)
【Group Ⅱ】
Asako Sugimoto
Professor,Graduate School of Life Sciences, Tohoku University
  1. Akira Shibukawa, Eisuke Sumiyoshi, Haruhiko Fuwa, Makoto Sasaki, Asako Sugimoto, “Analyzing the effect of neopeltolide in cell division using C. elegans embryos”, C. elegans Development, Cell Biology and Gene Expression Meeting in association with the 6th Asia-Pacific C. elegans Meeting, Nara, Japan (July 2014). Poster.
【Group Ⅱ】
Hirokazu Arimoto
Professor,Graduate School of Life Sciences, Tohoku University
  1. Hirokazu Arimoto, “Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria” in Nitric Oxide-Nitrite/Nitrate Conference (Joint meeting of the 8th International Conference on the Biology, Chemistry, and Therapeutic Application of Nitric Oxide & the 6th International Meeting on the Role of Nitrite and Nitrate in Physiology, Pathophysiology, and Therapeutics) 2014, Cleveland, Ohio, USA (June 18, 2014), Invited lecture
  2. Hirokazu Arimoto, “Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria” in The 13th Awaji International Forum on Infection and Immunity in Nara Prefectural New Public Hall, Nara, Japan (Sep 23, 2014), Invited lecture
  3. Hirokazu Arimoto, “Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria” in The 4th Joint Campus Asia Symposium, Tohoku University, Sendai, Japan (Nov 27, 2014), Invited lecture
【Group Ⅱ】
Yoshihiro Miwa
Lecturer,Faculty of Medicine,University of Tsukuba
    【Group Ⅱ】
    Kumiko UI-TEI
    Associate Professor, Graduate School of Science The University of Tokyo
    1. Kumiko Ui-Tei, “Control of RNA silencing by thermodynamics in the nucleotide base-pairin”, The 41st International Symposium on Nucleic Acids Chemistry (ISNAC2014), Kitakyushu, Japan (Nov, 7, 2014). Invited
    【Group Ⅱ】
    Hiroshi Hamamoto
    Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
    1. Hiroshi Hamamoto, Jyunichiro Yasukawa, Kenich Ishii, Atmika Paudel, Kazuhisa Sekimizu, “Silkworm as an animal model for novel antibiotic development”, the Xth European Congress of Entomology, York, England (Aug, 2014), invited speaker
    2. Hiroshi Hamamoto, Su Jie, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Kazuhisa Sekimizu, Host factors enhance the antimicrobial activity of a novel antibiotics kaikosin E, The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, USA (Sep, 2014), poster
    3. Paudel Atmika, Hamamoto Hiroshi, Kaneko Keichi, Matsunaga Shigeki, Suzuki Yutaka, Kanai Motomu, Kazuhisa Sekimizu, Novel Therapeutically Effective Antimicrobial Agent Targets Bacterial RNA Polymerase Sigma Factor A, The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, USA (Sep, 2014), poster
    4. Hiroshi Hamamoto, Host factors enhance the antimicrobial activity of a novel antibiotics kaikosin E, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Life Science Center, Osaka (Oct, 2014), poster
    【Group Ⅱ】
    Hiroaki Kato
    Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
    1. Kato, H., Structural basis for allosteric inhibition of P-glycoprotein homologue CmABCB1, The 3rd international symposium on chemical biology of natural products: target ID and regulation of bioactivity, October 28th – 29th, 2014, Life Science Center (Osaka) (Invited).
    【Group Ⅱ】
    Tatsuro Shimamura
    Project Lecturer, Graduate School of Medicine, Kyoto University
      【Group Ⅱ】
      Yoshio Hayashi
      Professor, Tokyo University of Pharmacy and Life Sciences
      1. Keisuke Hamada, Akihiro Taguchi, Masaya Kotake, Suguru Aita, Shuntaro Ikezawa, Masataka Shiozuka, Yoshiaki Nonomura, Kentaro Takayama, Fumika Yakushiji, Takeo Usui, Ryoichi Matsuda, Yoshio Hayashi, “Structure activity relationship study of (+)- negamycin derivatives at the C-terminal part as a readthrough drug”, 18th Korean Peptide Protein Symposium, 7-8 July 2014, Busan, South Korea, Oral & Poster.
      2. Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Masataka Shiozuka, Kentaro Takayama, Fumika Yakushiji, Takeo Usui, Ryoichi Matsuda, Yoshio Hayashi, “Structure Activity Relationship Study of (+)-Negamycin for Readthrough Activity at Duchenne Muscular Dystrophy”, 33rd European Peptide Symposium, 31 August 2014 to 5 September 2014, Sofia, Bulgaria, Poster.
      3. Kentaro Takayama, Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Masataka Shiozuka, Fumika Yakushiji, Ryoichi Matsuda, Takeo Usui, Yoshio Hayashi, “Development of (+)-negamycin-derived ester-type prodrugs promoting premature termination codon-readthrough and its application for suppressing cancer cell growth”, The 2014 ASCB/IFCB Meeting, 6-10 December, 2014, Philadelphia, U.S.A., Poster.

      【A02】

      【Group Ⅰ-Ⅱ】
      Kazuhiro Irie, A02 Group Leader
      Professor, Graduate School of Agriculture, Kyoto Universiy
      【Group Ⅰ-Ⅱ】
      Masaya Imoto
      Professor, Faculty of Science and Technology, Keio University
      Co-Researcher: Etsu Tashiro
      1. Yuji Mizotani, Kohji Hotta, Kotaro Oka, Hidenori Watanabe, Kogiku Shiba, Kazuo Inaba, Mayu Suzuki, Etsu Tashiro, Masaya Imoto, Studies on the Mechanism of Ciona Notochord Tubulogesis Using UTKO1. The7th Japan-Korea Chemical Biology Symposium, Jeju-Do/Korea, (February, 10, 2014) 【Co-study】
      2. Imoto M. Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein. RIKEN-Max Planck-Joint Research Center for Systems Chemical Biology Symposium. Kreuth Germany May 21-26,2014(Invited Levcture)
      3. Tashiro E, Shinjo S, Mizotani Y. and Imoto M. Comparative Analysis of the Expression Patterns of UPR-Target Genes Caused by UPR-Inducing Compounds RIKEN-Max Planck-Joint Research Center for Systems Chemical Biology Symposium. Kreuth Germany May 21-26,2014 (Poster)
      4. M. Kiga, A. Nakayama, Y. Sasazawa, Y. Shikata, H. Ikeda, E. Tashiro, M. Imoto. MEK1/2 specific inhibitor, SMK-17 selectively induces apoptosis in ß-catenin mutated tumors. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. Barcelona, Spain Nov. 18-21,2014(Poster)
      【Group Ⅰ-Ⅱ】
      Shigeki Matsunaga
      Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
      1. Yi Sun, Kentaro Takada, Shigeru Okada, Yuichi Nogi, Shigeki Matsunaga, “Lower Homologues of Ahpatinin and Pepstatin, Aspartic Protease Inhibitors, from a Marine Streptomyces sp.” Gordon Conference on Marine Natural Products, Ventura, California (USA) (March 2014).Poster
      2. Kentaro Takada, Yasufumi Imae, Emi Takanashi, and Shigeki Matsunaga, “Structure elucidation of sponge metabolites with anti-tumor associated activities” 4th Juior International Conference on Cutting-Edge Organic Chemistry in Asia, Bangkok (Thailand) (November 2014)Invited
      【Group Ⅰ-Ⅱ】
      Masami Ishibashi
      Professor,Graduate School of Pharmaceutical Sciences, Chiba University
      Co-Researcher:Midori Arai, Kazufumi Toume(by October),Naoki Ishikawa(since November)
      1. M. A. Arai, “Search for Neural Stem Cells Activators based on Natural Products”, Asian Chemical Biology Initiative 2014 Manila Meeting, Manila (Jan, 2014)
      2. M. A. Arai, “Hes1 inhibitors from natural products”, Sino-Japan Workshop on Chemical Biology; Abstract p. 14, October 10-13, 2014, Beijin, China, Invited
      3. M. Ishibashi “Natural products screening studies on Wnt and Hedgehog signaling pathways”, The 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity (ISCNP-28 & ICOB-8), October 20-24, 2014, Shanghai, China, Invite」
      4. M. Ishibashi “Natural products screening studies targeting Wnt, Hedgehog, and TRAIL signaling pathways”, The 14th International Symposium on Traditional Medicine in Toyama 2014, Abstract p. 33-36, October 28, 2014, Toyama,Invited
      5. M. A. Arai, “Search for neural stem cells activators based on natural products”, Asian Chemical Biology Initiative (ACBI) 2014 Hangzhou Meeting, November 22-26, 2014, Hangzhou, China,Invited
      6. K. Toume, “Search for bioactive natural products that affect on WNT signaling pathway”, 2014 Joint Symposium of the Natural Products Research Institute at Seoul National University and the Institute of Natural Medicine at University of Toyama, December 10, 2014, Seoul, Korea,Invited
      【Group Ⅰ-Ⅱ】
      Tetsuro Shinada
      Professor, Graduate School of Science, Osaka City University
      Co-Researcher: Yasufumi Ohfune
      1. Tetsuro Shinada, Exploration of New Juvenile Hormone of Heteropteran Insects, Nakanishi Symposium, the 94th Annual Meeting of the Chemical Society of Japan, Nagoya University, (March 27, 2014)(Invited)
      【Group Ⅰ-Ⅱ】
      Hidenori Watanabe
      Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
      1. Yuji Mizotani, Kohji Hotta, Kotaro Oka, Hidenori Watanabe, Kogiku Shiba, Kazuo Inaba, Mayu Suzuki, Etsu Tashiro, Masaya Imoto, Studies on the Mechanism of Ciona Notochord Tubulogesis Using UTKO1. The7th Japan-Korea Chemical Biology Symposium, Jeju-Do/Korea, (February, 10, 2014)【Co-study】
      【Group Ⅰ-Ⅱ】
      Kosuke Namba
      Professor, Graduate School of Pharmaceutical Science, The University of Tokushima
      1. K. Namba,「Organic Chemistry Research on Iron Acquisition in Graminaceous Plants」, The 3rd International Symposium on Chemical Biology of Natural Products, 2014.10.28. Life Science Center (Osaka), Japan
      【Group Ⅰ-Ⅱ】
      Satoshi Ichikawa 
      Associate Professor,  Faculty of Pharmaceutical Science, Hokkaido University
      1. Takeshi Nakaya, Akira Matsuda, Satoshi Ichikawa, “Synthesis of piperidine analogues of caprazamycins by aza-Prins-Ritter reaction”, 248th ACS National Meeting, San Francisco, USA, poster presentation (Aug, 2014).
      2. Mayumi Yamaguchi, Akira Matsuda, Satoshi Ichikawa, “Design and synthesis of isoxazolidine-containing uridine derivatives as antibacterial agents”, 248th ACS National Meeting, San Francisco, USA, poster presentation (Aug, 2014).
      3. Takuya Chiba, Akira Matsuda, Satoshi Ichikawa, “Total synthesis of syringolin A and its structure-activity relationship study”, 248th ACS National Meeting, San Francisco, USA, poster presentation (Aug, 2014).
      【Group Ⅰ-Ⅱ】
      Haruhiko Fuwa
      Associate Professor, Graduate School of Life Sciences, Tohoku University
      1. H. Fuwa, “Synthetic and structural studies on lyngbyaloside B, a cytotoxic marine macrolide glycoside”, poster presentation, The 3rd International Symposiun on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka (Oct, 2014).
      【Group Ⅰ】
      Hideyuki Shigemori
      Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
      【Group Ⅰ(A02)-Ⅱ(Advisory Member)】
      Hirokazu Kawagishi
      Professor, Research Institute of Green Science and Technology, Shizuoka University
      【Group Ⅰ】
      Makoto Ojika
      Professor, Graduate School of Bioagricultural Sciences, Nagoya University
      【Group Ⅰ-Ⅱ】
      Shinichi Nishimura
      Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
      1. Nishimura, S., Sugiyama, R., Matsumori, N., Kakeya, H. “Marine natural products targeting cell membrane.” International Chemical Biology Society 2014, CA, USA, Nov. 2014 (poster).
      2. Nishimura, S. “Mode of action of heronamides, polyene macrolactams from marine-derived Streptomyces sp.” Gordon Research Conference-Marine Natural Products- CA, USA, (Mar. 2014).
      【Group Ⅰ-Ⅱ】
      Katsunori Tanaka
      Associate Chief Scientist, RIKEN
      Co-Researcher: Co-Researcher: Takayuki Iwata, Masataka Kitadani.
      1. Katsunori Tanaka, Therapeutic In Vivo Synthetic Chemistry: Synthesis of Bioactive Compounds in Live Animals, ICCEOCA-9/NICCEOCA, 2014.12.2(Eastin Hotel Petaling Jaya, Malaysia), Invited
      2. Ambara R. Pradipta, Katsunori Tanaka, Asymmetric Synthesis of Chiral Diamines by Imino Cyclization, The 3rd International Seminar on Chemistry 2014 – Innovation and Advances in Chemistry for the 21st Century Challenges, 2014.11.20-21(Bandung, Indonesia)
      3. Katsunori Tanaka, Therapeutic In Vivo Synthetic Chemistry by Glycocarriers, SFG-JSCR Joint Meeting 2014, Satelite 1: Chemical Aspects of Glycobiology, 2014.11.16 (Hilton Hawaiian Village Waikiki Beach Resort), Invited
      4. Katsunori Tanaka, Therapeutic In Vivo Synthetic Chemistry: Synthesis of Bioactive Compounds in Live Animals、Swiss-Japanese Chemical Biology Symposium 2014, 2014.10.2(University of Bern, Switzerland), Invited
      5. Ayumi Tsutsui, Tamotsu Zako, Tong Bu, Yoshiki Yamaguchi, Mizuo Maeda, Katsunori Tanaka, Polyamine-derived [4+4] cycloaddition products as biologically relevant compounds and their effects on Aβ fibrillation, Swiss-Japanese Chemical Biology Symposium 2014, 2014.10.2-4 (Bern, Switzerland) , Poster
      6. Takayuki Iwata, Koichi Fukase, Katsunori Tanaka, One-Pot Total Synthesis and Bioactivity Remodeling of Ageladine A, Swiss-Japanese Chemical Biology Symposium, 2014.10.2-4 (Bern, Switzerland) , Poster
      7. Takayuki Iwata, Koichi Fukase, Katsunori Tanaka, One-Pot Total Synthesis of Ageladine A: Remodeling of Bioactivity, EPFL-Osaka University workshop, 2014.9.29 (Lausanne, Switzerland)
      8. Katsunori Tanaka, Therapeutic In Vivo Synthetic Chemistry: Total Synthesis of Bioactive Compounds in Live Animals, CCS-CSJ Forum 2014, 2014.8.5(Peking University), Invited
      9. Katsunori Tanaka, Exploring Overlooked Chemistry and Biology of Unsaturated Imines towards In Vivo Glycan Dynamics and Polyamine Functions, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, 3rd Annual Symposium, 2014.5.23(Schloss Ringberg, Germany), Invited
      【Group Ⅰ-Ⅱ】
      Kazunobu Toshima
      Professor, Faculty of Science and Technology, Keio University
      1. K. Toshima, Total synthesis of vineomycin B2: Application of glycosylation method using 2,3-unsaturated sugars to natural products synthesis, Vietnam Malaysia International Chemical Congress (VMICC2014), Daewoo Hotel Hanoi, Vietnam, November 7-9, 2014.
      2. K. Toshima, Taeget-selective photodegradation of proteins and oligosaccharides, The 3rd International Symposium on Chemical Biology of Natural products : Target ID and Regulation of Bioactivity, Life Science Center, Life Hall 5F, Osaka, October 28-29, 2014.
      3. K. Toshima, Novel glycosylation method using 2,3-unsaturated sugars and its application to total synthesis of vineomycin B2, The 10th Keio LCC – Yonsei CBMH Joint Symposium, Yagami campus, Keio University, October 24-25, 2014. (October 24)
      4. D. Kuwahara, D. Takahashi, K. Toshima, A solid-phase chemical labeling method for isolation and modification of target proteins, 2nd National Tsing Hua University / Keio University Bilateral Symposium of Advanced Chemistry, Yagami campus, Keio University, July 10, 2014.
      5. T. Kimura, M. Sekine, D. Takahashi, K. Toshima, Chiral Bronsted acid-mediated glycosylation with recognition of alchol chirality and its application to natural product synthesis, The Second Mini-Symposium Between Keio University and National Tsing Hua University on Cutting-Egde Chemistry for Junior Chemists, Chemistry Building, National Tsing Hua University, Taiwan, July 10, 2014.
      6. K. Toshima, Recent topics on synthetic and chemical biological studies of biofunctional molecules, The 2nd Mini-Symposium on Cutting-Edge Chemistry between Keio University and National Tsing Hua University, MXIC Building, Hsinchu, Taiwan, March 13-14, 2014.
      【Group Ⅰ】
      Yoko Saikawa
      Lecturer, Faculty of Science and Technology, Keio University
      【Group Ⅰ】
      Seijiro Hosokawa
      Professor, Faculry of Science and Engineering, Waseda University
      Co-Researcher:Mayumi Okamoto, Isao Shimizu
      1. Seijiro Hosokawa, “Total Synthesis of Natural Products possessing the Substituted Quinone and Multiple Stereogenic Centers” in The 3rd Frontiers in Medicinal Chemistry, Seoul, Korea (Jan, 2014).
      【Group Ⅰ-Ⅱ】
      Go Hirai
      Senior Research Scientist, RIKEN
      1. Go Hirai, “Synthetic Studies towards Spectomycins, Candidates of Protein SUMOylation Inhibitors”, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka, Japan (October, 2014).
      【Group Ⅱ】
      Shigefumi Kuwahara
      Professor, Graduate School of Agricultural Science, Tohoku University
      【Group Ⅱ】
      Takayuki Doi
      Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
      1. Masahito Yoshida, Koya Saito, Yuta Fujino, Takayuki Doi, “Chemical Synthesis of Flavonoid Derivatives via Lewis Base-Catalyzed Tabdem Acyl Transfer-Cyclization”, XXVIIth International Conference on Polyphenols, September 2-6, Nagoya University.(Oral)
      【Group Ⅱ】
      Takashi Kawakami
      Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
      1. Takashi Kawakami, “Directed Evolution of Natural Product-Like Peptides”, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka (Oct, 2014), poster.
      【Group Ⅱ】
      Daisuke Urabe
      Lecturer, Graduate School of Pharmaceutical Sciences, The University of Tokyo
      1. Daisuke Urabe, Masayuki Inoue “Total Synthesis of 19-Hydroxysarmentogenin,” The International Startup Symposium of Cutting-Edge Organic Chemistry in Asia (III), Taiwan (Apr. 2014).
      2. Daisuke Urabe, “A Unified Approach to the Cardenolides and Bufadienolides: Total Synthesis of Ouabagenin,” The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka (Oct. 2014)
      【Group Ⅱ】
      Hiroshi Tanaka
      Associate Professor, Graduate Scool of Science and Engineering,  Tokyo Institute of Technology
      1. Hiroshi Tanaka,One-pot Sequential Suzuki-Miyura Coupling using Cyclic Borane Compounds,The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka (Oct, 2014), poster.
      【Group Ⅱ】
      Yukari Fujimoto
      Professor, Faculty of Science and Technology, Keio University
      Co-Researcher:Shinsuke Inuki, Toshihiko Aiba
      1. Yukari Fujimoto, “Microbial glycoconjugates and lipidconjugates as immunomodulators; Chemical synthesis and biological functions” in Asian Chemical Biology Conference (ACBC2014), U-Town NUS, Singapore (Dec, 2014). (Invited)
      2. Yukari Fujimoto, “Bacterial glycoconjugates; chemical synthesis and functional analysis” in The Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR) (SFG-JSCR 2014), Honolulu, Hawaii (Nov. 2014). (Invited)
      3. Toshihiko Aiba, Masaki Sato, Daichi Umegaki, Shou Nakagawa, Shinji Tanaka, Masato Kitamura, Shinsuke Inuki, Koichi Fukase, Yukari Fujimoto “Synthesis of Inositol Phospholipids as an NKT Cell Modulator” in Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR) (SFG-JSCR 2014), Honolulu, Hawaii (Nov. 2014). (Poster)

      【A03】

      【Group Ⅰ-Ⅱ】
      Minoru Ueda., A03 Group Leader
      Professor,Graduate School of Science, Tohoku University
      1. Minoru Ueda, Chemistry and Biology of Nyctinastic Plant Movement, Nakanishi Symposium, Nagoya, Japan (Mar 27, 2014) Poster
      2. Minoru Ueda, CHEMICAL BIOLOGY OF PLANT AND ANIMAL HORMONES: “GLYCOSYLATION SWITCHING” , 25th Mona Symposium, Kingston, Jamaica (Jan 6-9, 2014). Invited
      【Group Ⅰ-Ⅱ】Naoki Kanoh
      Associate Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
      Co-Researcher: Takeo Usui
      1. N. Kanoh, Chemical Strategy for Direct and Indirect Detection of Protein-Small Molecule Interactions: Drug target discovery and P450 substrate screening, 3rd Swiss-Japanese Chemical Biology Symposium 2014, University of Bern, Switzerland, Oct. 3, 2014
      2. Takumi Chinen and Takeo Usui, “Fungal metabolites terpendole E and the derivative inhibit mitotic kinesin KSP through novel mechanism” 2014 International Symposium on New Frontiers in Microbiology and Biotechnology, 2014, Wuxi, China (March, 2014), Oral presentation
      3. Takeo Usui, “Novel inhibitor of the protein interaction between F-actin and actin-binding proteins”, 3rd Annual Symposium of the RIKEN-Max Plank Joint Research Center for Systems Chemical Biology, 2014, Ringberg castle, Germany (May, 2014). Invited talk
      【Group Ⅰ-Ⅱ】
      Hideo Kigoshi
      Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
      Co-Researcher: Masaki Kita
      1. Yuichiro Hirayama, Kozo Yoneda, Kota Yamagishi, Kota Tsuchiya, Takumi Chinen, Takeo Usui, Eriko Sumiya, Motonari Uesugi, Tomohiro Suzuki, Hirokazu Kawagishi, Masaki Kita, Hideo Kigoshi, “Study on the Target Proteins of Antitumor Macrolide Aplyronine A”, 3rd Asian Chemical Biology Conference (ACBC3), Dec14-18,2014,Shingapore, Poster,P-10
      2. Kozo Yoneda, Yaping Hu, Masaki Kita, Hideo Kigoshi, “Study on the Novel Chemical Probes to Analyze Protein-ligand Interactions”, 3rd Asian Chemical Biology Conference (ACBC3), Dec14-18,2014,Shingapore, Poster,P-56【Co-study】
      3. Hideo Kigoshi, Aplyronine A, an antitumor marine macrolide from Aplysia kurodai, Sino-Japan Workshop on Chemical Biology, Beijing, China (Oct 11, 2014)
      【Group Ⅰ-Ⅱ】
      Toshio Nishikawa
      Profrssor, Graduate School of Bioagricultural Sciences, Nagoya University
      Co-Researcher :Masaatu Adachi,Keiichi Konoki
      1. Toshio Nishikawa, “Syntheses of Guanidine-Containing Natural products by Means of Cascade Boromocyclization”, The International Startup Symposium of Cutting-Edge Organic Chemistry in Aisa (III) , 2014.4.19-2014.4.21, Hsinchu (Taiwan) Invited
      2. Toshio Nishikawa: Synthesis of Guanidine-containing Natural Products by Means of Cascade Bromocylization. The international Symposium on Natural Products Chemistry and Chemical Biology 2014, 2014.11.22-2014-11.25, Hangzhou (China) Invited
      【Group Ⅰ-Ⅱ】
      Makoto Sasaki
      Professor, Graduate School of Life Sciences, Tohoku University
      1. M. Kanto and M. Sasaki, Synthetic studies on amphirionin-5, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, October 2014, Osaka.
      【Group Ⅰ-Ⅱ】
      Fumi Nagatsugi
      Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
      1. Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Kazumitsu Onizuka, Ken Yamada and Fumi Nagatsugi, Development of the Self Activated Cross-linking Agents for the Gene Regulation in Cells, 3rd Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS), Bern Swizerland, 2014/10/2-3 Invited
      2. F. Nagatsugi, Inhibition of the miRNA Function by Using of Crosslink Reactions, The 1st International Symposium of Chemistry and Biology of RNA Interference, Kitakyushu International Conference Center, Kitakyushu, Japan, 2014/11/4 Invited
      3. F. Nagatsugi, G. Tsuji, S.Norihiro, K. Onizuka, Development of the Strategy for the Selective Chemical Modification in Hydrophobic Pockets (Asian Chemical Biology Initiative 2014 Hangzhou Meeting, Hangzhou Shujinang Hotel 2014/11/23-27 Invited
      4. Shuhei Kusano,Takuya Haruyama, Shogo. Ishiyama, Kazumitsu. Onizuka and Fumi Nagatsugi, Highly Efficient Crosslink ReactionsTriggered by Oxidation, XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids, Lecture-Conference Center of Poznań University of Technology, POZNAŃ, POLAND, 2014/8/24-28 selected oral
      5. Ken Yamada, Alexander S. Wahba, Jean Bernatchez, Tatiana Ilina, Saúl Martinez Montero, Maryam Habibian, Matthias Götte, Michael A. Parniak, Masad J. Damha, Correlation of NRTI Sugar Pucker on Nucleotide Excision and Translocational State by/of HIV-1 Reverse Transcriptase, XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids,Lecture-Conference Center of Poznań University of Technology, Poznań, Poland, 2014/8/24-28 Poster
      6. Shogo Ishiyama, Shuhei Kusano, Fumi Nagatsugi, Reactivity of the cross-link forming pyrimidine derivative to guanine analogs and the structural analysis, Tohoku University Campus Asia Program Summer School 2014, 2014/8/25-26, Sendai, Japan Poster
      7. Kazumitsu Onizuka, Yoshihiro Ito, Hiroshi Abe, Fumi Nagatsugi, Development of pseudorotaxane formation method targeting on nucleic acids (3rd Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS) Bern Swizerland, 2014/10/2-3 Poster
      8. Kazumitsu Onizuka, Yoshihiro Ito, Hiroshi Abe, Fumi Nagatsugi, Automatic Pseudorotaxane Formation Targeting on Nucleic Acids, The 41th International Symposium on Nucleic Acids Chemistry, Kitakyushu International Conference Center, Kitakyushu, Japan, 2014/11/5-7 Poster
      9. Norihiro Sato, Gen-ichiro Tsuji, Takuma Moki, Kazumitsu Onizuka, Fumi Nagatsugi, Development of the Method for Selective Modification of Duplex DNA with a Hydrophobic Pocket, The 41th International Symposium on Nucleic Acids Chemistry, Kitakyushu International Conference Center, Kitakyushu, Japan, 2014/11/5-7 Poster
      10. Fumi Nagatsugi, Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Kazumitsu Onizuka, Development of the Crosslinking Reaction Activated by Oxidation, 9thInternational Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA), Eastin Hotel Petaling Jaya, Malaysia, 2014/12/1-5.Poster
      11. Norihiro Sato, Gen-ichiro Tsuji, Kazumitsu Onizuka, Fumi Nagatsugi, Development of the Strategy for the Selective Chemical Modification in an Abasic Site of Duplex DNA, 3rd Asian Chemical Biology Conference, University Town, NUS, Singapore, 2014/12/15-17 Poster
      【Group Ⅰ-Ⅱ】
      Takamitsu Hosoya
      Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
      1. Takamitsu Hosoya, “Novelsynthetic approaches to diazido probes for target identification by photoaffinity labeling”, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka, Japan, Poster (Oct 28, 2014)
      Yousuke Takaoka
      Assistant Professor, Graduate School of Engineering, Kyoto University (by June)
      Lecturer, Graduate School of Science, Tohoku University (since July)
      1. Y. Takaoka, Development of Specific and Efficient Protein Labeling Method in Live Cell The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity Osaka 2014 Oct 28(Poster)
      2. Y. Takaoka, Self-assembling turn-on nanoprobe for endogenous protein sensing CCS-CSJ Forum(中国化学会) 2014 Aug5 Beijing Univ(China)
      【Group Ⅰ-Ⅱ】
      Junko Ohkanda
      Associate professor, Institute for Chemical Research, Kyoto University
      1. J. Ohkanda, “Module-assembled, mid-sized agents for controlling protein-protein interactions”, Department Seminar, National University of Singapore, Singapore (December 12, 2014). Invited
      2. J. Ohkanda, “Fusicoccins: Naturally-occurring stabilizers of protein-protein interactions”, The 4th Asian Chemical Biology Initiative, Hangzhou, China (November 24, 2014). Invited
      3. J. Ohkanda, “Fusicoccins: naturally-occurring stabilizers of protein-protein interactions”, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka (October 28, 2014). Poster
      4. J. Ohkanda, “Module assembly for mid-sized molecules that disrupt intracellular protein-protein interactions”, Sino-Japan Workshop on Chemical Biology, Beijing, China (October 12, 2014). Invited
      5. J. Ohkanda, M. Tsubamoto, N. Kato, J. Sun, P. Parvatkar, M. Uesugi, “K-Ras specific inactivation by inhibitors of protein-protein interactions”, Swiss-Japanese Chemical Biology Symposium 2014, Bern, Switzerland (October 2, 2014). Poster
      6. J. Ohkanda, “Design of mid-sized molecules that disrupt intracellular protein-protein interactions”, Recent Advances in Nanobiotechnology and Chemical Biology 2014, Seoul National University, Korea (August 21, 2014). Invited
      7. J. Ohkanda, “Rational design of fusicoccin-based fluorescent probes for detecting 14-3-3 complexes”, 2014 Queenstown Molecular Biology Meetings in Shanghai –Drug Discovery and International Collaboration, Shanghai (Mar, 2014).
      8. J. Ohkanda , “Module assembly for designing mid-sized inhibitors of protein-protein interactions:Bivalent dual inhibitors of protein prenyltransferases for selective inactivation of K-Ras”, The 3nd Asian Chemical Biology Initiative, Manila, Philippines (Jan, 2014).
      9. A. Kusumoto, N. Kato, J. Ohkanda, “Design and synthesis of fusicoccin-J-based chemical probes for elucidation of structural effects on binding to 14-3-3/phospholigand complexes”, 17th SANKEN International Symposium, Osaka (Jan, 2014).
      【Group Ⅰ-Ⅱ】
      Misako Aida
      Professor, Graduate School of Science, Hiroshima University
      1. Misako Aida, “A theoretical study on the geometrical characteristics of stereoisomers of hexopyranoses,,” The 3rd International Symposium Chemical Biology (October 28 – 29, 2014) Toyonaka, Japan.(Poster)
      2. Dai Akase, Misako Aida, Sotiris S. Xantheas, “Intra- and intermolecular interactions of α-, β-, γ-cyclodextrins: from the gas phase to aqueous solution,” Symposium on Molecular Science and Synthesis of Functional Molecules for Next Generation, Higashi-Hiroshima, Japan (March, 2014).
      3. Sakiko Idei, Misako Aida, “A Theoretical study of hydration effects on hexopyranoses,” Symposium on Molecular Science and Synthesis of Functional Molecules for Next Generation, Higashi-Hiroshima, Japan (March, 2014).
      【Group Ⅰ】
      Akira Otaka
      Professor, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
      【Group Ⅰ-Ⅱ】
      Hideo Takahashi
      Professor, Graduate School of Medical Life Science, Yokohama City University
      1. Hideo Takahashi, “An NMR-based approach to improve a small-molecule inhibitor”, IPR seminar: International NMR Symposium on Pharmaceutical NMR, Osaka, (Dec. 2014), Invited
      【Group Ⅰ-Ⅱ】
      Toshiyuki Kan
      Professor, School of Pharmaceutical Sciences, University of Shizuoka
      1. Yusuke Kawabe, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan, “Synthetic Studies of Tea Polyphenols and its Probes” The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference, Nagoya (Sept. 4th, 2014, Poster presentation).
      2. Makoto Inai, Ryunosuke Yoshida, Aya Asahina, Atsushi Yoshida, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan “Stereocontrolled Total Synthesis of Teadenols A and B” The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference, Nagoya (Sept. 4th, 2014, Poster presentation).
      3. Ryo Ishikawa, Yusuke Kawabe, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan “Synthetic Study on Furofuran Lignans” The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference, Nagoya (Sept. 5th, 2014, Poster presentation).
      4. Tomohiro Asakawa, Aiki Hiza, Yuta Tsukaguchi, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan “Practical Synthesis of Nobiletin and its PET Imaging Study” The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference, Nagoya (Sept. 5th, 2014, Poster presentation).
      5. Toshiyuki Kan, Tomohiro Asakawa, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Naoto Oku “Efficient Synthesis of Catechin Probe and its Molecular Dynamics” The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference, Nagoya (Sept. 5th, 2014, Poster presentation).
      6. Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Hirokazu Kawagishi, Toshiyuki Kan “Probe Molecule Synthesis based on Total Synthesis of Natural Product” The 3rd International Symposium on Chemical Biology of Natural Products, Osaka (Dec. 10th 2014, Poster presentation).
      7. Hitoshi Ouchi, Ryunosuke Yoshida, Aya Asahina, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan “Stereocontrolled Total Synthesis of Teadenols A and B” The 2nd International Conference on Pharma-Food, Shizuoka (Nov. 6th, 2014, Poster presentation).
      8. Ryo Ishikawa, Yusuke Kawabe, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan “Synthetic Study on Furofuran Lignans” The 2nd International Conference on Pharma-Food, Shizuoka (Nov. 6th, 2014, Poster presentation).
      9. Tomohiro Asakawa, Aiki Hiza, Yuta Tsukaguchi, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan “Practical Synthesis of Nobiletin and its PET Imaging Study” The 2nd International Conference on Pharma-Food, Shizuoka (Nov. 6th, 2014, Poster presentation).
      10. Toshiyuki Kan, Tomohiro Asakawa, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Naoto Oku “Efficient Synthesis of Catechin Probe and its Molecular Dynamics” The 2nd International Conference on Pharma-Food, Shizuoka (Nov. 6th, 2014, Poster presentation).
      【Group Ⅰ-Ⅱ】
      Hiroyuki Nakamura
      Professor, Tokyo Institute of Technology
      1. S. Sato, H. Nakamura, “Target-selective Protein Modification Based on Local Environmental Single Electron Transfer Catalysis” 
 18th Malaysian International Chemical Congress (18MICC), Nov 3-5,2014,
      2. H. Nakamura, “Photoaffinity Labeling Molecules as Tools for Identification and Modification of Target Proteins” 18th Malaysian International Chemical Congress (18MICC) Nov 3-5, 2014, Kuala Lumpur (Malaysia) Invited Lecture.
      3. H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, H. S. Ban, “Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity” XV Internationl Meeting of Boron Chemistry, Aug24-28,2014University of Prague (Zech Republic) Key Note Lecture.
      4. H. Nakamura, H. S. Ban, K. Shimizu, H. Minegishi, S. Sato, “Design of Photoaffinity Proble Molecules for Identification and Modification of Target Proteins” The 31st International Conference of Photopolymer Science and Technology Materials & Processes for Advanced Microlithography, Nanotechnology and Phototechnology (ICPST-31), Jul 8-11,2014,Chiba University (Chiba) Invited Lecture.
      5. S. Sato, H. Nakamura, “Target-selective Protein Modification Using Ligand-conjugated Ru(bpy)3 Catalyst” 
 XXVI International Congress of Organometallic Chemistry (ICOMC-XXVI) July 13-18,Sapporo(Japan)Poster Presentation.
      6. D. Kanoh, S. Tachikawa, S. Sato, H. Nakamura, “Development of Albumin-bound closo-Dodecaborate and its Promising Boron Delivery Efficacy to Tumor“
 16th International Congress on Neutron Capture Therapy, Jun14-19,2014,Helsink(Finland)Oral Presentation.
      【Group Ⅰ-Ⅱ】
      Nobuyuki Kanzawa
      Professor, Faculty of Science and Technology, Sophia University
      1. Y. Shimizu, Y. Kawanobe, T. Konishi, N. Kanzawa, M. Honda, M. Aizawa “Cytotoxicity of anti-bacterial calcium-phosphate cement with anti-washout property”, M. Bioceramics 26, 26th International Symposium on Ceramics in Medicine, Barcelona, Spain (Nov 2014)
      2. H. Kobayashi, A. Yamasawa, N. Kanzawa, T. Hashimoto, T. Hayashita, “Rapid and simple method of bacteria detection based on supramolecular complex”, International conference of Ion Exchange 2014, Okinawa, Japan, (Nov 2014)
      3. N. Kanzawa, H. Nakano, Y. Ishimaru, M. Ueda, “Studies on biological responses elicited by the binding of leaf opening factor and its receptorcandidate in Cassia obtusifoli”, The 3rd Int Symp Chem Biol Nat Prod, Ohsaka, Japan (Oct 2014)
      【Group Ⅰ】
      Yu Nakagawa
      Senior Research Scientist, RIKEN
      【Group Ⅰ】
      Makoto Muroi
      Senior Research Scientist, RIKEN
      【Group Ⅱ】
      Hiroki Oguri
      Associate Professor, Graduate School of Science, Hokkaido University/Professor, Tokyo Institute of Technology
      1. Hiroki Oguri, “Chemo-enzymatic and Biogenetically-inspired Synthesis of Natural Products”, Ecole polytechnique fédérale de Lausanne (EPFL) Host: Prof. Jieping Zhu, Lausanne, Switzerland. (May 30, 2014). (Invited)
      2. Hiroki Oguri, Haruki Mizoguchi, Hideaki Oikawa, “Development of a biogenetically inspired assembly line for skeletally diverse indole alkaloids”, The XXVI International Conference on Organometallic Chemistry, Sapporo, Japan (July 15, 2014). (Poster)
      3. Hiroki Oguri, “Development of a biogenetically inspired assembly line for skeletally diverse natural products and its analogs”, Gordon Research Conference 2014: Natural Products, The Central Role of Natural Products in Biology and Chemistry, New Hampsher, USA (July 20-25, 2014).(Poster)
      4. Hiroki Oguri, “Design and de novo synthesis of aza-artemisinins” The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Osaka, Japan (October 29, 2014)  (Invited)
      【Group Ⅱ】
      Hiroaki Saito
      Assistant Professor, Graduate School of Natural Science & Technology, Kanazawa University
      1. Hiroaki Saito, Hidemi Nagao, “Molecular Docking Study of Ligand-Protein System”, International Symposium On Computational Science 2014, Bandung, Indonesia (May, 2014)(Invited)
      2. Hiroaki Saito, “Thermal Stability of Gramicidin A in Lipid Bilayer: A Free Energy Analysis”, International Symposium on Extended Molecular Dynamics and Enhanced Sampling: Nosé Dynamics 30 Years (NOSE30), Conference Hall, North Building, Mita Campus, Keio University, Tokyo, Japan (Nov, 2014) (Poster)
      3. Hiroaki Saito, “Development of molecular docking method with flexible ligand/receptor model”, The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Life Science Center, Senri, Japan (Nov, 2014).(Poster)
      【Group Ⅰ(Advisory Member)-ⅡA03)】
      Motonari Uesugi
      Professor, Institute for Integrated Cell-Material Sciences & Institute for Chemical Research,
      Kyoto University
      1. Motonari Uesugi, “Small Molecules that Block Fat Synthesis”, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology 3rd Annual Symposium, Kreuth, Germany (May 21-24, 2014). Invited
      2. Motonari Uesugi, “Small Molecule Tools for Cell Biology and Cell Therapy”, The University of Tokyo School of Science 1527th Seminar, Tokyo, Japan (June 20, 2014). Invited
      3. Motonari Uesugi, “Introduction of Chemical Biology” and “Small-Molecule Tools for Cell Biology and Cell Therapy”, Asian Chemical Biology Initiative-Sponsored Lectures, Hanoi, Vietnam (June 1, 2014). Invited
      4. Motonari Uesugi, “Small Molecule Tools for Cell Therapy”, Forth Norman Bethune International Forum on Medical Sciences, Jilin, China (September 20-22, 2014). Invited
      5. Motonari Uesugi, “Small Molecule Tools That Detect and Remove Human Pluripotent Stem Cells”, China-Japan Joint Seminar on Histochemistry and Cytochemistry, Nagano, Japan (September 28-29, 2014). Invited
      6. Motonari Uesugi, “Small molecules that detect and remove human pluripotent stem cells”, Sino-Japan Workshop on Chemical Biology, Beijing, China (October 10-13, 2014). Invited
      7. Motonari Uesugi, “New Functions of Endogenous Lipid Molecules and Their Modulation”, The 3rd International Symposium on Chemical Biology of Natural Products, Osaka, Japan (October 28-29, 2014). Poster
      8. Motonari Uesugi, “Small molecule tools for cell biology and cell therapy”, Chinese National Compound Library 2014 Seminar Series, Shanghai, China (November 21, 2014). Invited
      9. Motonari Uesugi, “Small Molecule Tools for Cell Biology and Cell Therapy”, Asian Chemical Biology Initiative 2014 Hangzhou Meeting, Hangzhou, China (November 22-25, 2014). Invited
      10. Motonari Uesugi, “Small Molecule Tools for Cell Biology and Cell Therapy”, Nanjing University School of Life Sciences Seminar, Nanjing, China (November 26, 2014). Invited
      11. Motonari Uesugi, “Small molecule tools for cell therapy”, The 3rd Asian Chemical Biology Conference, Singapore (December 15-17, 2014). Invited
      12. Motonari Uesugi, “Small Molecule Tools for Cell Biology and Cell Therapy”, Institute of Molecular and Cell Biology, Singapore (December 17, 2014). Invited
      13. Motonari Uesugi, “Introduction to Chemical Biology”, Asian Chemical Biology Initiative 2014 Kota Kinabalu Meeting: Open Tutorial Lectures, Kota Kinabalu, Malaysia (December 19, 2014). Invited
      【Group Ⅱ】
      Kazuhiro Mio
      Senior Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
      1. K.Mio, “Conformational variation of the peptide permeable channel chaperone revealed by electron microscopy” in the 4th Asia Pacific Protein Association Conference, Jeju, Korea, (May, 2014) Oral
      2. N. Mentily, K. Mio, M. Sato, T. Ebihara, C. Sato, “Observation of Tissues in Solution by Atmospheric Scanning Electron Microscope (ASEM)” in Microscopy & Microanalysis 2014, Hartford, CT (Aug, 2014) Oral

      Page Top