Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

International Confrence 2013

International Confrence 2013

A01A02A03

【A01】

Hiroshi Handa, A01 Group Leader
Professor, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
  1. Hiroshi Handa, “Identification of a target of thalidomide teratogenicity”, 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”, Sapporo (Jul, 2013).
  2. Hiroshi Handa, “Encounter with Celgene”, Vice President Dinner Meeting, New Jersey, USA (Jul, 2013).
Ryuichi Okamoto
Associate Professor, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
  1. Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, “IL-22-mediated antimictobial response is regulated by hes1 via stat3-dependent transcription in human intestinal epithelial cells” UEGW2013, Berlin, Germany (Oct, 2013).
  2. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, “Lineage-specific expression of bestrophin-2 and bestrohin-4 is regulated by notch signaling in human intestinal epithelial cells” UEGW2013, Berlin, Germany (Oct, 2013).
  3. Hiromichi Shimizu, Ryuichi Okamoto, Toru Nakata, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, “Complete conversion of crypt progenitor cells into ATOH1-positive cells by targeted deletion of DLL1 and DLL4 in LFR5-positive intestinal stem cells” UEGW2013, Berlin, Germany (Oct, 2013).
  4. Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells. The 2nd Annual Meeting of Asian Organization for Crohn’s and Colitis (Jun, 21, 2013) Seoul, Poster
  5. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe. Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine. The 2nd Annual Meeting of Asian Organization for Crohn’s and Colitis (Jun, 21, 2013) Seoul, Poster
  6. Nobukatsu Horita, Kiichiro Tsuchiya, Shuuji Hibiya, Keita Fukushima, Yoshito Kano, Xiu Zheng, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, “Live imaging of single cell reveals single stem cell dynamics in an organoid derived from murine small intestine” DDW2013, Orlando, USA (Mar, 2013).
  7. Kiichiro Tsuchiya, Keita Fukushima, Yoshito Kano, Shuuji Hibiya, Nobukatsu Horita, Xiu Zheng, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, “Stabilization of Atoh1 protein by TNF-α in colitic cancer might acquire the cancer stemness” DDW2013, Orlando, USA (Mar, 2013).
  8. Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, “Complete conversion of crypt progenitor cells into ATOH1-positive cells by targeted deletion of Dll1 and Dll4 in LGR5-positive intestinal stem cells” DDW2013, Orlando, USA (Mar, 2013).
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1. Yasuhiko Kato, Yumi Sudou, Hajime Watanabe, Long noncoding RNA transcribed from sex determining gene doulesex1 promoter in the crustacean Daphnia magna. EMBL Symposia “Noncoding genome” Heidelberg, Germany (Oct. 2013)
  2. Hajime Watanabe, Takashi Nakanishi, Yasuhiko Kato, “Genetic enginieering of Daphnia magna” Bioscience seminor Birmingham (March, 2013)
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku.
  1. Masayoshi Arai, Motomasa Kobayashi “Search for anti-dormant mycobacterial substances from marine organisms and analysis of their target molecules”, JSPS Vietnam-Japan Joint Symposium, Osaka, Japan (Aug, 2013).
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
  1. Nishiyama, K., Kusumoto, S., Tokuda, H., and Shimamoto, K., “MPIase (Membrane Protein Integrase), a glycolipozyme involved in protein integration into and preprotein translocation across membranes”, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, Invited Talk, (28-29 Oct, 2013).
  2. Nishiyama, K. “Functional interaction between glycolipozyme MPIase and the YidC protein in protein integration into membranes”, The Gordon Research Conference on Bacterial Cell Surfaces , Mount Snow, VT, USA (Jun, 2013), poster presentation.
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
  1. Shin Hamamoto, Isamu Yabe, Nobuyuki Uozumi, Characterization of calcium channel in yeast vacuolar membrane, International Workshop on Plant Membrane Biology 2013, Kurashiki, Japan (Mar,2013)
  2. Yoshihiro Mizuguchi, Shin Hamamoto, Tatsuya Okuhara, Kota Nakayama, Naoki Matsumoto,Kei Nanatani, Nobuyuki Uozumi, Phosphorylation-dependent modulation of Shaker-type K channels in Arabidopsis thaliana, Kurashiki, Japan (Mar,2013)
  3. Hamamoto,S.,Yabe,I.,and Uozumi,N. Characterization of non-selective cation channel YVC1 in yeast vacuolar membrane, Nagoya Symposium-Frontiers in Structural Physioligy, Nagoya, Japan (Jan 2013)
Kohji Fukunaga
Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
  1. Kohji Fukunaga, “Development of potent T-VGCC activator SAK3 as Alzheimer therapeutics” (#175) in The 11th International Conference on Alzheimer’s & Parkinson’s Diseases (Mar, 2013).
  2. Kohji Fukunaga, “T-type voltage-gated calcium channel as a novel Alzheimer therapeutic target” (#181) in The 11th International Conference on Alzheimer’s & Parkinson’s Diseases (Mar, 2013).
  3. Fukunaga K, “Impact of sigma-1 receptor in cardiovascular and neurodegenerative diseases” in The 12th Meeting of the Asia Pacific Federation of Pharmacologists (MAPFP), Shanghai China (July, 2013).
  4. Fukunaga K, “A mutation of sigma-1 receptor associated with ALS causes neuronal mitochondrial dysfunction” in The 11th Korea-Japan Joint Symposium of Brian Sciences and Cardiac and Smooth Muscle Sciences, Hamamatsu Japan (September, 2013).
  5. Fukunaga K, “Novel CaM kinase II activator, ST101 improve the cognition in Schizophrenia model rats” in Neuroscience 2013, San Diego U.S.A. (Nov, 2013).
  6. Fukunaga K, “Sigma-1 receptor mutation in Amyotrophic Lateral Sclerosis causes neuronal inclusion of TDP-43” in Neuroscience 2013, San Diego U.S.A. (Nov, 2013).
  7. Fukunaga K, “FABP3 expression aggravates neuronal -synuclein accumulation in Pakinson’s model mice” in Neuroscience 2013, San Diego U.S.A. (Nov, 2013).
  8. Fukunaga K, “Synergic induction of cardiac hypertrophy by CaMKII and calcineurin activities” in The 2nd Taiwan-Japan Bilateral Conference on Protein phosphatases, Taiwan (Nov, 2013).
Kazuhisa Sekimizu
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  1. Hiroshi Hamamoto, Su Jie, Paudel Atomika, Makoto Urai, Kazuhisa Sekimizu, “Characterization and mechanistic analysis of novel antibiotics Kaikosin, produced by Lysobacter sp.”, International Symposium on Genome Science Expanding Frontiers of Genome Science, Tokyo, Japan (Jan. 2013)
  2. Hiroshi Hamamoto, Jie Su, Atmika Paudel, Makoto Urai, Keiko Kataoka, Kazuhisa Sekimizu, “Molecular Target analysis of Novel Antibiotics Kaikosins”, 53th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Denver, USA (Sep. 2013)
  3. Jyunichiro Yasukawa, Hiroshi Hamamoto, Kazuhisa Sekimizu, “Antibacterial activity of a novel lipopeptide antibiotic, kaikosin E, is enhanced by host factors”, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity in Yokohama, Japan (Oct. 2013)
  4. Kazuhisa Sekimizu, Hiroshi Hamamoto, “Molecular Target analysis of the Novel Antibiotics Kaikosins”, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity in Yokohama, Japan (Oct. 2013)
Maiko Okada
Assistant Professor, Department of Translational Oncology / St.Marianna University School of Medicine.
  1. Maiko Okada, “A mitotic estrogen receptor alpha complex acts as an E3 ubiquitin ligase”, The 35 th Naito conference on “ The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”July,2013
Nobuaki Matsumori
Associate Professor, Graduate School of Science, Osaka Univeristy
  1. Nobuaki Matsumori, “NMR investigations of organic molecules in lipid bilayers: application to amphotericin B and lipid rafts”, Atomic View of Biomolecular Function, Ann Arbor, USA (July, 2013). (Invited)
Toshiaki Okuno
Associate Professor, Juntendo University School of Medicine
Akihiro Sugawara
Assistant Professor,
Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. Akihiro Sugawara, Nobuo Maita, Tomoyasu Hirose, Hiroaki Gouda, Saori Kimura, Yoshifumi Saito, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Hirofumi Nakano, Shuichi Hirono, Toshiaki Taniguchi, Satoshi Ōmura, Toshiaki Sunazuka “Design, synthesis, biological activity, and x-ray crystallographic analysis of chitinase inhibitors with a 14-membered macrolide scaffold”, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, (Oct. 2013)
  2. Akihiro Sugawara, Aoi Kimishima, Hirokazu Takada, Tomoyasu Hirose, Takanori Matsumaru, Satoshi Ōmura, Toshiaki Sunazuka “Toward the Total Synthesis of Luminamicin, a Specific Anti-Anaerobic Bacteriacide”, Annual meeting of the american society of pharmacognosy 2013, St Louis, (Jul, 2013)
Shuichi Sakamoto
Senior Researcher, Institute of Microbial Chemistry
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
  1. Soichi Kojima, “Non-genomic and genomic actions of acyclic retinoid”, 1st International Retinoids Meeting 2013, Calabria, Italy, (September, 2013)
  2. (Co-study)Kotaro Sakata, Satoshi Eda, Eun-Seo Lee, Mitsuko Hara, Masaya Imoto, Soichi Kojima,“Neovessels contribute to liver fibrosis via providing latent Transforming Growth Factor (TGF)- to beactivated by hepatic stellate cells” AASLD (American Association for the Study of Liver Diseases) Basic Research Single Topic Conference on Portal Hypertension and Vascular Biology of the Liver, Atlanta, GA, USA, (June 7-8, 2013).
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. K. Watashi, G. Liang, M. Iwamoto, H. Marusawa, K. Kitamura, M. Muramatsu, R. Suzuki, J. Li, S. Tong, Y. Tanaka, K. Murata, H. Aizaki, T. Wakita, “Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase AID”, 2013 International Meeting on Molecular Biology of Hepatitis B viruses, Shanghai, China (Oct, 2013).
  2. K. Watashi, A. Sluder, S. Matsunaga, A. Ryo, S. Nakajima, M. Iwamoto, S. Tsukuda, K. Borroto-Esoda, M. Sugiyama, Y. Tanaka, M. Mizokami, T. Wakita, “Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting sodium taurocholate cotransporting polypeptide”, 2013 International Meeting on Molecular Biology of Hepatitis B viruses, Shanghai, China (Oct, 2013).
  3. N. Ogura, K. Watashi, T. Wakita, “Formation of covalently closed circular (ccc)DNA tetracycline inducible HBV expression cell line”, 2013 International Meeting on Molecular Biology of Hepatitis B viruses, Shanghai, China (Oct, 2013).
  4. HH. Aly, K. Watashi, K. Chayama, T. Wakita, “The discovery of a new virus/host interaction regulating HBV life cycle”, 2013 International Meeting on Molecular Biology of Hepatitis B viruses, Shanghai, China (Oct, 2013).
  5. S. Tsukuda, K. Watashi, M. Iwamoto, R. Suzuki, H. Aizaki, S. Kojima, T. Wakita, “A retinoid derivative inhibits hepatitis B virus entry mediated by NTCP”, 2013 International Meeting on Molecular Biology of Hepatitis B viruses, Shanghai, China (Oct, 2013).
  6. M. Iwamoto, K. Watashi, S. Tsukuda, HH. Aly, R. Suzuki, H. Aizaki, O. Koiwai, H.Kusuhara, T.Wakita, “Mechanistic analysis on hepatitis B virus entry in an NTCP-overexpressing cell line”, 2013 International Meeting on Molecular Biology of Hepatitis B viruses, Shanghai, China (Oct, 2013).
  7. K. Watashi, T. Daito, A. Sluder, K. Borroto-Esoda, T. Wakita, “Novel regulation mechanism of interferon signaling by cyclophilin through modulation of PKR in HCV-infected cells”, 20th International Symposium on Hepatitis C Virus and Related Viruses, Melbourne, Australia (Oct, 2013).
  8. A. Fujimoto, H. Aizaki, M. Matsuda, N. Watanabe, K. Watashi, R. Suzuki, T. Suzuki, T. Miyamura, T. Wakita, “Dynamics of the cellular metabolome during hepatitis C virus infection – Regulation of the lipoprotein metabolisms by hepatic lipase -”, 20th International Symposium on Hepatitis C Virus and Related Viruses, Melbourne, Australia (Oct, 2013).
  9. S. Nakajima, K. Watashi, S. Kamisuki, K. Takemoto, R. Suzuki, H. Aizaki, F. Sugawara, T. Wakita, “Isolation of a natural product inhibiting the transcriptional activity of liver X receptor and reducing the production of infectious HCV”, 20th International Symposium on Hepatitis C Virus and Related Viruses, Melbourne, Australia (Oct, 2013).
  10. K. Watashi, T. Daito, A. Sluder, K. Borroto-Esoda, T. Wakita, “Cyclophilin inhibitors potentiate interferon signaling through diminished PKR phosphorylation in HCV-infected cells”, European Association for the Study of the Liver 2013, Amsterdam, Netherlands (April, 2013).
  11. R. Suzuki, E. Konishi, T. Ishikawa, M. Matsuda, K. Watashi, H. Aizaki, T. Takasaki, T. Wakita, “Production of single-round infectious chimera flaviviruses with a DNA-based Japanese encephalitis virus replicon”, Keystone Symposia – Positive Strand RNA Viruses, Boston, USA (May, 2013).
  12. K. Watashi, “IL-1- and TNFalpha-triggered intracellular immune response against HBV”, 1st Japan-Taiwan Research Symposium on Hepatitis B, Tokyo, Japan (April, 2013).

【A02】

Kazuhiro Irie, A02 Group Leader
Professor, Graduate School of Agriculture, Kyoto Universiy
  1. K azuhiro Irie, Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin, International Symposium on Natural Products Chemistry and Chemical Biology 2013, Nagoya, Japan (Nov, 2013).(Invited)
Masaya Imoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher: Etsu Tashiro
  1. Takahiro Fujimaki, Shinji Saiki, Etsu Tashiro, Nobutaka Hattori, Masaya Imoto, Neuroscience 2013. San Diego/USA (November 9, 2013)
  2. Masaya Imoto, Metabolomic Identification of the Target of Microbial Probes Modulating Cellular Responses, The 2nd International Symposium on Chemical Biology of Natural Products. Yokohama Japan, (October 28, 2013)
  3. Yuki Shikata, Shuhei Kanagaki, Yukiko Sasazawa, Etsu Tashiro, Tetsuro Yoshimaru, Masato Komatsu, Toyomasa Katagiri, Masaya Imoto, Antitumor activity of xanthohumol, an inhibitor of valosin-containing protein. AACR-NCI-EORTTC International Conference, Boston, USA (October 22, 2013)
  4. Masaya imoto, “Chemistry and biology of Xanthohumol, an inhibitor of Valosin-Containing Protein.”  EMBO Workshop【AAA+ proteins: from mechanism and disease to targets】, Neuss/Germany, (September 19, 2013)
  5. (Co-study)Kotaro Sakata, Satoshi Eda, Eun-Seo Lee, Mitsuko Hara, Masaya Imoto, Soichi Kojima,“Neovessels contribute to liver fibrosis via providing latent Transforming Growth Factor (TGF)- to beactivated by hepatic stellate cells” AASLD (American Association for the Study of Liver Diseases) Basic Research Single Topic Conference on Portal Hypertension and Vascular Biology of the Liver, Atlanta, GA, USA, (June 7-8, 2013).
  6. Masaya Imoto, “Studies on the mechanism of cellular responses using small molecules”, KRIBB-RIKEN Young Scientist Joint Symposium on Chemical Biology, Korea (May 29, 2013).
  7. Yasubumi Sakakibara, Masaya Imoto. “Development of new androgen antagonists by in silico screening and natural product screening” 9th Joint Conference of AACR and the JCR. Maui (Feb. 2013)
Shigeki Matsunaga
Professor,Graduate School of Agricultural and Life Sciences, The University of Tokyo
  1. Shigeki Matsunaga, Kentaro Takada, Yuki Hitora, Akihiro Ninomiya, Yasufumi Imae, Yi Sun, Masato Naruse, Emi Takanashi, “Marine natural products with anti-cancer related activities”, XIV International Symposium on Marine Natural Products, La Toja, Spain (September, 2013).
  2. Shigeki Matsunaga,* Kentaro Takada, Yuki Hitora, Akihiro Ninomiya, Yasufumi Imae, Yi Sun, Masato Naruse, Emi Takanashi, Masashi Suzuki, “Marine Natural Products with Anti-cancer Related Activities”, 13th Intgernational Conference on the Chemistry of Antibiotics and Other Bioactive Compounds, Yamanaka-shi, Japan (September, 2013)
Masami Ishibashi
Professor,Graduate School of Pharmaceutical Sciences, Chiba University
Co-Researcher:Midori Arai Kazufumi Toume
  1. M. Ishibashi, “Bioactive Heterocyclic Natural Products from Actinomycetes Collected in Chiba Area Isolated in Screening Programs Targeting Signaling Pathways”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Kawaguchiko (Sep, 2013)
  2. M. A. Arai, “Search for cancer cells signaling inhibitors and neural stem cells activators based on natural products”, Asian Chemical Biology Initiative 2013 Bangkok Meeting, Bangkok (Jan, 2013)
Tetsuro Shinada
Professor, Graduate School of Science, Osaka City University
Co-Researcher: Yasufumi Ohfune
  1. T. Shinada, Total Synthesis of Natural Products Exhibiting Glutamate Receptor Binding Activities, 15th Asian Chemical Congress (15ACC), Session of Total Synthesis of Natural Products, Singapore, Aug. 19-23 (2013). (Invited)
  2. Y. Yasuno, T. Shinada, Y. Ohfune, Synthetic Study Toward Total Synthesis of Phomopsin A, The 17th Osaka City University International Symposium, February 4, 2013, Osaka City University, Media Center (poster)
  3. A. Manabe, T. Shinada, Y. Ohfune, Synthetic Study of Tetrodotoxin by Diels-Alder Reaction of Furan, February 4, 2013, Osaka City University, Media Center (poster)
  4. K. Maeda, T. Shinada, Y. Ohfune, Synthesis of Novel Peptide Analog by Linkage of Squaric Acid-Containing Amino Acid, February 4, 2013, Osaka City University, Media Center (poster)
  5. A. Shimoda, T. Okada, T. Shinada, K. Sakaguchi, Y. Ohfune, Au-Catalyzed Cyclization of 1-Arylbut-3-yn-1-ols. Synthesis of Substituted Naphthalene Derivatives, February 4, 2013, Osaka City University, Media Center (poster)
  6. Y. Wakabayashi, K. Shimamoto, T. Shinada, Y. Ohfune, Synthesis of Diaminopimelic Acid Derivatives and Their CTx inhibitory Effects, February 4, 2013, Osaka City University, Media Center (poster)
  7. Y. Ando, T. Shinada, Y. Ohfune, Synthesis of Juvenile Hormone (JHSB3) Analogs, February 4, 2013, Osaka City University, Media Center (poster)
Hidenori Watanabe
Professor,Graduate School of Agricultural and Life Sciences, The University of Tokyo
  1. H. Watanabe, S. Konishi, H. Kageji, “Synthesis of Exiguamide and Litseaone A” in The 8th International Conference on Cutting-Edge Organic Chemistry in Asia (The 4th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia), Osaka, Japan (Nov, 2013).
  2. S. Wakamori, H. Watanabe, “Synthetic Study on Ryanodane Diterpenes”, in 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, Japan (Sep, 2013).
  3. N. Kakimoto, H. Watanabe, “Synthetic Study of Clavigerin B Utilizing Ireland Claisen Rearrangement”, in 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, Japan (Sep, 2013).
Kosuke Namba
Professor, Graduate School of Pharmaceutical Science The University of Tokushima
  1. M. Yoshida, T. Muzuguchi and K. Namba, “Synthesis of Oxazolidinones by Efficient Fixation of Atmospheric CO2 with Propargylic Amines by using a Silver/1,8-Diazabicyclo[5.4.0] undec-7-ene (DBU) Dual-Catalyst System”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, Japan (Sep, 2013).
  2. K. Takeuchi, Y. Kaihara, K. Namba, K. Tanino, Synthetic Studies on Palau’amine, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, Japan (Sep, 2013).
  3. M. Yoshida, S. Ohno and Kosuke Namba, Palladium-catalyzed cascade nucleophilic substitution[2+2] cyclization of propargylic esters with 2-vinylphenols, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan, (Jul, 2013).
  4. M. Yoshida, M. Shibata and K. Namba, Palladium-catalyzed unusual cascade cyclization of 4-hydroxy-2-pyrones with allylic bisacetates, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (Jul, 2013).
  5. M. Yoshida, T. Muzuguchi and K. Namba, Synthesis of substituted pyridines by a ring openingcyclization reaction of propargylic aziridines, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (Jul, 2013).
  6. M. Yoshida, T. Kasai and Kosuke Namba : Enantioselective Total Synthesis of HM-3, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (Jul. 2013).
  7. M. Yoshida, S. Yodokawa, H. Takai, K. Shishido, K. Namba, Regio-and Diastereoselective Oxidative Radical Cyclization of Cyclic β-Keto Ester with Alkenes, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (Jul, 2013).
  8. Kosuke Namba, Organic Chemistry Research on Iron Acquisition in Graminaceous Plants, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (Jul, 2013).
Satoshi Ichikawa 
Associate Professor,  Faculty of Pharmaceutical Science, Hokkaido University
  1. Ichikawa, Satoshi. Liponucleoside Natural Products: Synthesis and Structure-Activity Relationship (invited lecture). 3rd International SFB 766 (The Bacterial Cell Envelope: Structure, Function, and Infection Interface) Symposium, 2013, May, Irsee, Germany.
Haruhiko Fuwa
Associate Professor, Graduate School of Life Sciences, Tohoku University
  1. H. Fuwa, Total synthesis and biological evaluation of marine macrolide natural products, International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sendai, Japan (29-Sep-2013).
Hideyuki Shigemori 
Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
Hirokazu Kawagishi 
Professor, Research Institute of Green Science and Technology, Shizuoka University
  1. Hirokazu Kawagishi, “Search for fruiting body inducing compounds in higher fungi – Strophasterols A to D with an unprecedented steroid skeleton: candidates for common fruiting body-inducers in mushrooms –, International Symposium on Natural Products Chemistry and Chemical Biology 2013, Nagoya (Nov, 2013).
  2. Hirokazu Kawagishi, “Disclosure of the “fairies” of fairy-ring forming fungus Lepista sordida and possibility of their application to agriculture”, The 50th Memorial Symposium on Phytochemistry, Tokyo (Nov, 2013).
  3. Hirokazu Kawagishi, “Disclosure of the “fairy” of fairy-ring forming fungus Lepista sordida – Discovery of a novel purine metabolic pathway in plants –, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama (Oct, 2013).
  4. (Co-study)Jae-Hoon Choi, Tomohiro Suzuki, Hirofumi Hirai, Tomohiro Asakawa, Toshiyuki Kan,Hirokazu Kawagishi, Discovery of a Novel Purine Metabolic Pathway with New Metabolites in Plants -The “Fairies” of Fairy Rings Exist in Plants- 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA), 2013.9.25
  5. Hirokazu Kawagishi, “Disclosure of the “Fairy” of Fairy-ring Forming Fungus Lepista sordida”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA), Yamanashi (Sep, 2013)
  6. Hirokazu Kawagishi, “Gargalols A, B and C, Osteoclast-Forming Suppressing Compounds from the Edible Mushroom Grifola gargal”, The 7th International Medicinal Mushroom Conference,August 27, 2013, Beijing, China (Aug, 2013)
Makoto Ojika
Professor, Graduate School of Bioagricultural Sciences, Nagoya University
Shinichi Nishimura
Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
  1. Nishimura, S., Tokukura, M., Ochi, J., Yoshida, M. & Kakeya, H. “Sterol-rich membrane domains and the balance of membrane traffic” 7th International fission Yeast Meeting, London, UK, (July 2013).
Katsunori Tanaka
Associate Chief Scientist, RIKEN
Co-Researcher: Takayuki Iwata, Masataka Kitadani.
  1. Katsunori Tanaka, Exploring the Chemistry and Biology of Unsaturated Imines, RIKEN-ICCAS-IOP-PKU-Tsinghua, Joint Symposium on Materials Science, 2013.11.11(RIKEN Wako)
  2. Katsunori Tanaka, Exploring the Chemistry and Biology of Unsaturated Imines, Tsukuba Global Science Week 2013 Integration of Chemistry and Life Science Session, 2013.10.02(Tsukuba)
  3. Katsunori Tanaka, Exploring the “Overlooked” Chemistry and Biological Functions of Unsaturated Imines, International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan, 2013.09.28(Sendai)
  4. Katsunori Tanaka, Introduction for ACMS 2013, The First Asian Conference for“MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), 2013.07.17(Okinawa)
  5. Katsunori Tanaka, Aza-Electrocyclic Reaction for Visualizing Biomolecules in Live Animals, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), 2013.07.17(Okinawa)
  6. Katsunori Tanaka, Molecular Imaging of N-Glycan Conjugates in Live Animals, The 3rd Austria/Japan Seminar on Comparative and Developmental Glycobiology, 2013.07.03(RIKEN Wako)
  7. Katsunori Tanaka, “Unexplored Reactivity of Unsaturated Imines: Application to Organic and Material Synthesis and Chemical Biology under Microfluidic Conditions”, National Center of Applied Microfluidic Chemistry Department of Chemical Engineering, POSTECH. Host: Prof. Dong-Pyo Kim 2013.1.23(Pohang,Korea)
Kazunobu Toshima
Professor, Faculty of Science and Technology, Keio University
  1. K. Toshima, Chemical glycosylation with recognition of alcohol chirality, International Symposium on Organic Reaction – 11, Howard Civil Service International House, Taipei, Taiwan, November 19-22, 2013.
  2. K. Toshima, Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids, The 2nd International Symposium on Chemical Biology of Natural Products : Target ID and Regulation of Bioactivity, Pacifico Yokohama, The Conference Center Renovation 5F, Yokohama, October 28-29, 2013.
  3. K. Toshima, Chemical glycosylation with recognition of alcohol chirality and its application to natural product synthesis, The 9th Yonsei CBMH – Keio LCC Joint Symposium, Yonsei University, Seoul, Korea, October 25-26, 2013.
  4. K. Toshima, Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids, The 15th Asian Chemical Congress, Resorts World Sentosa Singapore, Singapore, August 19-23, 2013.
Yoko Saikawa
Lecture, Faculty of Science and Technology, Keio University
  1. Yoko Saikawa, “Natural Sternutators Responsible for Non-allergic Sneeze Reflex” International Mini Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, in Keio University, Yokohama (Mar. 2013)
Seijiro Hosokawa
Professor, Faculry of Science and Engineering, Waseda University
Co-Researcher:Mayumi Okamoto, Isao Shimizu.
Go Hirai
Senior Research Scientist, RIKEN
  1. Yusaku Nomura, Frederic Thuaud, Go Hirai, Akihiro Ito, Minoru Yoshida, Mikiko Sodeoka, “Synthetic Study Aiming at SAR Investigations of Spectomycins”3rd ACP Junior Symposium, Chiba, Japan (Nov. 2013).
  2. Go Hirai, “Synthetic studies of spectomycins, protein SUMOylation inhibitors”The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, Japan (Oct. 2013).
  3. Motonari Sakai, Hiroshi Tsuchikawa, Go Hirai, Mikiko Sodeoka, “CF2-linked Disaccharide Synthesis by Characteristic SN2’ Coupling Reaction”10th International Symposium on Carbanion Chemistry, Kyoto, Japan (Sep., 2013).
  4. Go Hirai, “Fluorine Containing C-linked Gangliosides Analogues”The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (July, 2013).
  5. Eisuke Ota, Marie Kato, Kana Oonuma, Go Hirai, Shigeru Nishiyama, Mikiko Sodeoka, “Development of Molecular Probes Based on a Sialidase-resistant Ganglioside GM3 Analogue”
    The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, Japan (July, 2013).
  6. G. Hirai, “Creation of Novel Biologically Active Molecules Designed Based on Natural Products”, ACP Lectureship (at Chulabhorn Research Institute, Mehidol University, Kasetsart University, Chulalongkorn University), Bangkok, Thailand (Feb. 2013).
  7. G. Hirai, “Design and Development of Fluorine Containing Gangliosides: Establishing the Concept of Conformational Control”, Asian International Symposium at The 93rd Annual Meeting of Chemical Society of Japan, Shiga, Japan (Mar, 2013).

【A03】

Minoru Ueda, A03 Group Leader
Professor, Graduate School of Science, Tohoku University
  1. Minoru Ueda, “Glycosylation Switching”: In vivo glycosylation of bioactive natural products regulates their mode-of-action, ICCEOCA8/NICCEOCA4, Osaka, Japan (Nov 25-28, 2013).
  2. Minoru Ueda, “Chemical Biology of Glycoside Natural Products”, RACI NSW Natural Products Symposium 2013, Sydney, Australia (Oct 4, 2013).
  3. Minoru Ueda, “Glycosylation Switching”: In vivo glycosylation of bioactive natural products regulates their mode-of-action, 15th Asian Chemical Congress, Singapore (Aug 21, 2013).
Naoki Kanoh
Associate Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
Hideo Kigoshi
Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
Co-Researcher: Ichiro Hayakawa
  1. Hideo Kigoshi, “Aplyronine A, an Antitumor Marine Macrolide”, The 2nd International Symposium on Chemical Biology of Natural Products:Target ID and Regulation of Bioactivity, Yokohama (Oct, 2013).
Toshio Nishikawa
Professor, Graduate School of Bioagricultural Sciences, Nagoya University
Co-Researcher :Masaatsu Adachi, Keiichi Konoki.
  1. Hitomi Yamada, Masaatsu Adachi, Toshio Nishikawa,“Synthetic Studies on Tagetitoxin” The 8th International Conference on Cutting-Edge Organic Chemistry in Asia and The 4th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-8/NICCEOCA-4)(Nov,2013)
  2. Keiichi Konoki ,“Physiological Function Acquired by Diarrheic Shellfish Poisoning-Accumulating Species”The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity(Oct, 2013)
  3. Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Takuya Imazu, Yoshiki Satake, Shouta Tokoro, Atsuo Nakazaki, Yuuki Ishikawa, Yusuke Sawayama, Minoru Isobe, Keiichi Konoki, Yukie Chiba, Mari Yotsu-Yamashita, “ Synthesis of Marine Toxins Aiming at Developing Ion-Channel Inhibitors”The 2st International Symposium on Chemical Biology of Natural Products Target ID and Regulation of Bioactivity (Oct, 2013)
  4. Toshio Nishikawa, Masaatsu Adachi, a
    Ryo Sakakibara, Shouta Tokoro, Takuya Imazu, Yoshiki Satake, Minoru Isobe “Synthetic Studies on Nitrogen-Containing Natural Products”, Pure and Applied Chemistry International Conference 2013, Bangsaen Beach, Thailand (Jan, 2013).
Makoto Sasaki
Professor Graduate School of Life Sciences, Tohoku University
Co-Researcher Haruhiko Fuwa, Keiichi Konoki
Fumi Nagatsugi
Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  1. Fumi Nagatsugi, Development of the Chemical Strategy for Regulation of Gene Expression, 2st Asian Chemical Biology Initiative, Bangkok Thai, (Invited), 2013/1/25-1/28
  2. Fumi Nagatsugi, Regulation of the Gene Expression by the Use of Reactive Oligonucleotides, Technologies for Medical Diagnostic and Therapy Symposium, academia sinica Taiwan, 2013/10/22-23.
Takamitsu Hosoya
Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
Yousuke Takaoka
Assistant Professor, Graduate School of Engineering, Kyoto University
  1. Yousuke Takaoka, Itaru Hamachi, “Self-assembling turn-on nanoprobes for specific protein detection and imaging”, Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), 2013, Itoman, Okinawa, Japan (July, 2013)
Junko Ohkanda
Associate professor, Institute for Chemical Research, Kyoto University
  1. J. Ohkanda, “Fusicoccin-based chemical probes for 14-3-3 proteins: Toward understanding the mechanism of action of the antitumor agents”, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Pacifico Yokohama, Kanagawa (Oct, 2013).
  2. Y. Higuchi, T. Inoue, Y. Haranosono, H. Nitta, J. Ohkanda, N. Kato, “Can 14-3-3 proteins be drug targets?”, G3 Meeting International, Nano-Macro Materials, Devices and System Research Alliance, Taipei (Sep, 2013).
Misako Aida
Professor, Graduate School of Science, Hiroshima University
  1. Misako Aida, Hidenori Miyamoto, “Helmholtz Energy Change between Neutral and Zwitterionic Forms of Glycine in Aqueous Solution,” 5th JCS International Symposium on Theoretical Chemistry, Nara, Japan (December, 2013). (Invited)
  2. Dai Akase, Misako Aida, Hiroyuki Tramae, “Graph representation of protonated water cluster and a comprehensive search of local minimum structures of protonated water octamer,” The 10th Nano Bio Info Chemistry Symposium, Higashi-Hiroshima, Japan (December, 2013).
  3. Kentaro Okinaka, Misako Aida, “Theoretical study of hydration of serine,” The 11th Nano Bio Info Chemistry Symposium, Higashi-Hiroshima, Japan (December 13, 2013).(一般講演)
  4. Takahiro Sugahara, Misako Aida, “Theoretical study on the hydration of divalent ions,” The 11th Nano Bio Info Chemistry Symposium, Higashi-Hiroshima, Japan (December 13, 2013).(一般講演)
  5. Misako Aida, Sakiko Idei, “A theoretical study on hydration patterns of bioactive molecules,” The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, Japan (October, 2013).
Akira Otaka
Professor, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences,
The University of Tokushima
Hideo Takahashi
Professor, Graduate School of Medical Life Science, Yokohama City University
Toshiyuki Kan
Professor, School of Pharmaceutical Sciences, University of Shizuoka
  1. Y. Kawabe, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, “Synthetic studies of tea polyphenols and its probes”, The 5th International Conference on O-CHA (Tea) Culture and Science, Shizuoka, (November 8th 2013).
  2. A. Kawanishi, Y. Aihara, H. Sasaki, A. Asahina, T. Murata, S. Iwata, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, “Total synthesis of Palmerolide A”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, (September 25th, 2013).
  3. A. Hiza, Y. Tsukaguchi, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, “Practical Synthesis of Nobiletin and its PET Imaging Study”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, (September 25th, 2013).
  4. H. Ohuchi, A. Asahina, T. Asakawa, M. Inai, Y. Hamashima, T. Kan, “Total Synthesis of Acromelic Acid A and B”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, (September 25th, 2013).
  5. K. Ikeuchi, M. Hayashi, T. Yamamoto, M. Inai, T. Asakawa, Y. Hamashima, T. Kan, “Total synthesis of (–)-sphingofungin E”, 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds, Yamanashi, (September 25th, 2013).
  6. (Co-study)Jae-Hoon Choi, Tomohiro Suzuki, Hirofumi Hirai, Tomohiro Asakawa, Toshiyuki Kan,Hirokazu Kawagishi, Discovery of a Novel Purine Metabolic Pathway with New Metabolites in Plants -The “Fairies” of Fairy Rings Exist in Plants- 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA), 2013.9.25
  7. A. Hiza, Y. Tsukaguchi, M. Inai, T. Asakawa, Y. Hamashima,   T. Kan, “Practical Synthesis of Nobiletin and its PET Imaging Study”, The First Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry, Okinawa, (July 18th 2013).
Hiroyuki Nakamura
Professor, Gakushuin Iniversity / Tokyo Institute of Technology
  1. H. Nakamura, Design of Photoaffinity Labeling Molecules: Tools for Identification and Modification of Target Proteins, International Conference on Emerging Trends in Chemical Sciences (IETC 2013) Plenary Lecture, India, Dec 5‐7, 2013
  2. S. Sato and H. Nakamura, Target-selective Protein Labeling Based on Local Single Electron Transfer Catalysis, Shinichi Sato, Hiroyuki Nakamura, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, Oct 28-29, 2013.
  3. S. Sato and H. Nakamura, Ligand-directed Selective Protein Modification Based on Local Environmental Single Electron Transfer Catalysis, ICBS2013, Kyoto, Oct 7-9, 2013.
  4. H. Koganei, S. Tachikawa, M. Suzuki, K. Ono, and H. Nakamura, Development of high boron content molecules and their liposome encapsulation for neutron capture therapy. 7th Young Researchers In Boron Neutron Capture Therapy Meeting. Granada, Spain, Sep 23-26, 2013.
  5. M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu, Evaluation of protoporphyrin IX combined with lipid chains as a novel photosensitizer, 14th World Congress of the International Photodynamic Association in Seoul, May 28-31, 2013.
  6. H. Nakamura, Boron-based drug design: Discovery of HIF-1a degradation pathway induced by inhibiting hsp60 under hypoxia, XVth International Conference “Heterocycles in Bio-organic Chemistry”、Invited Lecture、Riga (Latvia)、May 27-30, 2013.
Nobuyuki Kanzawa
Associate Professor, Faculty of Science and Technology, Sophia University
  1. J. Matsumoto, Y. Habuto, M. Aizawa, N. Kanzawa, “Biological evaluation of lactoferrin-loaded chelate-setting apatite cement”, Archives of BioCeramics Research 2013, Kyoto, Japan (Dec 4-6, 2013).
  2. K. Kosaka, H. Ishii, M. Aizawa, N. Kanzawa, “Proliferation and differentiation of P19.CL6 cells cultured in apatite-fiber scaffolds”, Archives of BioCeramics Research 2013, Kyoto, Japan (Dec 4-6, 2013).
  3. H. Ohsugi, J. Hatsukawa, Y. Otsuka, N. Kanzawa, “Analysis of effects of glucocorticoid on osteoblast differentiation using a double-fluorescent marker system”, Archives of BioCeramics Research 2013, Kyoto, Japan (Dec 4-6, 2013).
  4. N. Kanzawa, Y. Otsuka, M. Takahara, S. Hamaguchi, H. Nakano, Y. Ishimaru, M. Ueda, “MetE binds directly to leaf-opening factor and regulates nyctinastic movement of Cassia plant”, The 2nd Int. Symp Chem Biol Nat Prod, Yokohama, Japan (Oct 28- 29, 2013)
Yu Nakagawa
Senior Research Scientist, RIKEN
  1. Yu Nakagawa, Takashi Doi, Takara Taketani, Kiyonori Takegoshi, Yasuhiro Igarashi, Yukishige Ito, “Geometry of the Primary Mannose Binding of Pradimicin A”, The 8th International Conference on Cutting-Edge Organic Chemistry, Osaka (November, 2013).
  2. Yu Nakagawa, “Dimeric Calcium Complex of Pradimicin: Physiologically Active Form of Sugar Binding Natural Product”, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama (October, 2013).
  3. Yu Nakagawa, Takashi Doi, Takara Taketani, Kiyonori Takegoshi, Yasuhiro Igarashi, Yukishige Ito, “Solid-state NMR analysis of mannose binding of pradimicin A”, The 1st Asian Conference for “MONODUKURI” Strategy by Synthetic Organic Chemistry (ACMS), Okinawa, (July, 2013).
Makoto Muroi
Senior Research Scientist, RIKEN
  1. Identification of molecular target of pyrrolizilactone by ChemProteoBase, Muroi M, Futamura Y, Kawatani M, Nogawa T, Osada H, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, Japan, 2013 Oct
  2. 2D gel electrophoresis-based proteomic profiling approach to predict targets of bioactive small molecules(ProteoBase), Muroi M, Kawatani M, Osada H. The Second Symposium of RIKEN–Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan, Apr. 2013

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