Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

International Confrence 2011

International Confrence 2011

A01A02A03

【A01】

Hiroshi Handa, A01 Group Leader
Professor, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Ryuichi Okamoto
Associate Professor, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku.
  1. Masayoshi Arai, Takashi Kawachi, Naoyuki Kotoku, Shinichi Fujioka, Chiaki Nakata, Masaki Yamada, Motomasa Kobayashi. “Analysis of Action-mechanism and Analogue Synthesis of Furospinosulin-1, a Hypoxia-selective Growth Inhibitor of Cancer Cells.”, The 8th AFMC International Medicinal Chemistry Symposium (AIMECS), Tokyo, Japan (Nov, 2011).
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
Kohji Fukunaga
Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
Kazuhisa Sekimizu
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Maiko Okada
Assistant Professor, Department of Translational Oncology / St.Marianna University School of Medicine.
Nobuaki Matsumori
Associate Professor, Graduate School of Science, Osaka Univeristy
Toshiaki Okuno
Associate Professor, Juntendo University School of Medicine
Akihiro Sugawara
Assistant Professor,
Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Kenichiro Nagai, Hiroaki Gouda, Shuichi Hirono, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka “Novel 12-membered Non-antibiotic Macrolides; EM900 Series As Novel Leads For Anti-inflammatory And/Or Immunomodulatory Agents.”8th Asian Federation for Medicinal Chemistry (AFMC) International Medicinal Chemistry Symposium (AIMECS11), 2011/11/29-12/2, Tokyo
Shuichi Sakamoto
Senior Researcher, Institute of Microbial Chemistry
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
Koichi Watashi
Senior Researcher,National Institute of Infectious Diseases

【A02】

Kazuhiro Irie, A02 Group Leader
Professor, Graduate School of Agriculture, Kyoto Universiy
  1. Irie, K., “Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with anti-proliferative activity like bryostatin 1”, in 27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity, Brisbane, Australia (Jul, 2011) (Invited Lecture).
  2. Irie, K., “Development of new molecular probes and therapeutic seeds having skeletons of naturally-occurring tumor promoters”, in 22nd French-Japanese Symposium of Medicinal and Fine Chemistry, Rouen, France (Sep, 2011) (Invited Lecture).
Masaya Imoto
Professor,Faculty of Science and Technology, Keio University
Co-Researcher: Etsu Tashiro
  1. Masaki Kiga, Fumie Tanzawa, Shiho Iwasaki, Fumi Inaba, Kosaku Fujiwara, Hayato Iwadare Tomoki Echigo, Yuji Nakamura, Tomoyuki Shibata, Kanae Suzuki, Isao Yasumatsu, Ayako Nakayama, Yukiko Sasazawa, Etsu Tashiro, Masaya Imoto, Shinichi Kurakata. ” Antitumor effects of novel high-hydrophilic and non-ATP-competitive MEK1/2 inhibitor SMK-17”. 23rd EORTC-AACR-NCI-International Conference, San Francisco (Nov. 2011)
  2. Shigeyuki Magi, Etsu Tashiro, Masaya Imoto. “Studies on the signaling pathway for cancer cell migration based on chemical genomic approach” 23th EORTC-AACR-NCI-International Conference, San Francisco (Nov. 2011)
Shigeki Matsunaga
Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Masami Ishibashi
Professor, Graduate School of Pharmaceutical Sciences, Chiba University
Co-Researcher:Midori Arai, Kazufumi Toume
  1. M. A. Arai, “Search for neural stem cells activators based on natural products”, 6th Korea-Japan Young Scientists Meeting on Bioorganic and Natural Products Chemistry; Seoul, Korea, (Jun, 2011)
  2. K. Toume, “Search for Bioactive Natural Products Targeting TRAIL Signaling for Tumor-selective Apoptosis Inducement”, BIOTEC and Chiba University Joint Meeting; Thailand (Mar, 2011)
Tetsuro Shinada
Professor, Graduate School of Science, Osaka City University
Co-Researcher: Yasufumi Ohfune
  1. Y. Yasuno, M. Hamada, T. Yamada, A. Manabe, T. Shinada, Y. Ohfune, Stereoselective Synthesis of E-α,β-dehydroamino Acid Ester Using α-(Diphenylphosphono)glycine Derivatives, The 16th Osaka City University International Symposium on Dynamic Molecular Devices, 9 November 2011, Osaka, Japan.
  2. A. Shimoda, T. Okada, T. Shinada, K. Sakaguchi, Y. Ohfune, Gold-Catalyzed Benzannulation of Homopropargyl Alcohol Derivatives, The 16th Osaka City University International Symposium on Dynamic Molecular Devices, 9 November 2011, Osaka, Japan.
  3. H. Kawakami, T Shinada, and Y. Ohfune, Structures and Biological Properties of The Novel Peptides of Xylocopa Appendiculate Circumvolans, The 16th Osaka City University International Symposium on Dynamic Molecular Devices, 9 November 2011, Osaka, Japan.
  4. Y. Wakabayashi1, K. Shimamoto, T. Shinada, Y. Ohfune, Synthetic Study of 2,6-Diaminopimeric Acid Derivatives as a Cystine Isostere, The 16th Osaka City University International Symposium on Dynamic Molecular Devices, 9 November 2011, Osaka, Japan.
  5. K. Maeda, T. Shinada, and Y. Ohfune, Iterative Linkage of α-Amino Squaric Acid, The 16th Osaka City University International Symposium on Dynamic Molecular Devices, 9 November 2011, Osaka, Japan.
  6. N. Ikeda, W. Akagi, M. Higashino, T. Shinada, K. Sakaguchi, and Y. Ohfune, Intramolecular Cationic Cyclization Reaction of α-Hydroxysilanes, The 16th Osaka City University International Symposium on Dynamic Molecular Devices, 9 November 2011, Osaka, Japan.
  7. T. Shinada, Y. Kiniwa, K. Maeda, and Y. Ohfune, Synthesis of Squaric Acid-containing Amino Acid and Its Incorporation into Peptide, 8th AFMC International Medicinal Chemistry Symposium. “Frontier of Medicinal Science”, 29 November-1 December 2011, Tokyo, Japan.
  8. K. Oe, T. Shinada, Y. Ohfune, Efficient Total Synthesis of (-)-Kainic Acid, 8th AFMC International Medicinal Chemistry Symposium. “Frontier of Medicinal Science”, 29 November-1 December 2011, Tokyo, Japan.
  9. Y. Yasuno, M. Hamada, T. Yamada, A. Manabe, T. Shinada, Y. Ohfune, Stereoselective Synthesis of E-α,β-dehydroamino Acid Ester Using α-(Diphenylphosphono)glycine Derivatives, 8th AFMC International Medicinal Chemistry Symposium. “Frontier of Medicinal Science”, 29 November-1 December 2011, Tokyo, Japan.
Hidenori Watanabe
Professor,Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kosuke Namba
Associate Professor, Graduate School of Science Hokkaido University
Satoshi Ichikawa 
Associate Professor,  Faculty of Pharmaceutical Science, Hokkaido University
Haruhiko Fuwa
Associate Professor,Graduate School of Life Sciences, Tohoku University
Hideyuki Shigemori 
Professor, Graduate School of Life and Environmental Sciences, University of Tsukuba
Hirokazu Kawagishi
Professor,Research Institute of Green Science and Technology, Shizuoka University
  1. Hirokazu Kawagishi, “Disclosure of the “fairy” of fairy-ring forming fungus Lepista sordida and possibility of its application to agriculture”, The 2011 International Symposium on Natural Products Chemistry and Chemical Biology, Hangzhou, China, (Nov, 2011)
Makoto Ojika
Professor, Graduate School of Bioagricultural Sciences, Nagoya University
  1. Makoto Ojika: Neurotrophic Steroid Glycosides from a Starfish: in vivo Activity and SAR-based Synthesis of Active Analogs, 7th US‐Japan Seminer, Okinawa (Dec, 2011).
Shinichi Nishimura
Assistant Professor,Graduate School of Pharmaceutical Sciences, Kyoto University
  1. Nishimura, S. “Marine Natural Products Targeting Cellular Membrane” 第7 回日米セミナー: 海洋天然物化学の領域横断的新展開,Okinawa (Dec,2011).
Katsunori Tanaka
Associate Chief Scientist, RIKEN
Co-Researcher: Co-Researcher: Takayuki Iwata, Masataka Kitadani.
  1. Masahiro Nagasaki, Yosuke Uchinashi, Jiazhou Zhou, Katsunori Tanaka and Koichi Fukase, “Reinvestigation of alpha-Sialylation under Microfluidic Conditions”, The 7th International Symposium on Integrated Synthesis (ISIS-7), 2011.10.9-10(Kobe)
  2. Jiazhou Zhou, Guang-ming Bao, Katsunori Tanaka and Koichi Fukase,“Synthesis of Mono- and Di-sialylated N-Glycan Motifs as Molecular Probes for Biological Evaluation”, The 7th International Symposium on Integrated Synthesis (ISIS-7), 2011.10.9-10(Kobe)
Kazunobu Toshima
Professor, Faculty of Science and Technology, Keio University
  1. Shuho Tanimoto, Yasunori Ishida, Daisuke Takahashi, Kazunobu Toshima, “Photo-degradation of proteins by fullerene derivatives”, 8th AFMC International Medicinal Chemistry Symposium -Frontier of Medicinal Science-, Keio Plaza Hotel, Tokyo, Japan, November 29-December 2, 2011.
  2. Takashi Ohtani, Shohei Sakai, Akira Takada, Daisuke Takahashi, Kazunobu Toshima, “Synthetic studies of a novel antibiotic, incednine”, 10th International Symposium on Organic Reactions, Keio University, Yokohama, Japan, November 21-24, 2011.
  3. Kazunobu Toshima, “Inhibition of amyloid β aggregation and cytotoxicity by photo-degradation using designed fullerene derivatives”, The 7th Yonsei CBMH-Keio LCC Joint Symposium, Jeju, Korea, October 28-29, 2011.
  4. Daisuke Takahashi, Shingo Hirono, Kazunobu Toshima, “Target-selective photodegradation of oligosaccharides by light-activated small molecules”, MDF International Workshop: Open-shell Organic Molecules –Synthesis and Electronic Structure Freedom– , Umeda Sky Building, Osaka, Japan, October 7-8, 2011.
Yoko Saikawa
Lecture, Faculty of Science and Technology, Keio University
Seijiro Hosokawa
Professor, Faculry of Science and Engineering, Waseda University
Co-Researcher:Mayumi Okamoto, Isao Shimizu.
  1. Seijiro Hosokawa, “Syntheses of Substituted Quinones in Natural Product Synthesis”, The 6th Global COE International Symposium on “Practical Chemical Wisdom”, Tokyo (Dec, 2011).
Go Hirai
Senior Research Scientist, RIKEN
  1. G. Hirai, A. Tsuchiya, K. Oonuma, Y. Koyama, H. Osada, and M. Sodeoka, “Non-Acidic and Non-Electrophilic Inhibitors of Dual Specificity Protein Phosphatases VHR and Cdc25A/B Based on Natural product RK-682”, AIMECS11(The 8th AFMC International Medicinal Chemistry Symposium “Frontier of Medicinal Science”), Shinjuku, Japan (Nov, 2011).

【A03】

Minoru Ueda , A03 Group Leader
Professor, Graduate School of Science, Tohoku University
Naoki Kanoh
Associate Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
Hideo Kigoshi
Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
Co-Researcher: Ichiro Hayakawa
Toshio Nishikawa
Professor,Graduate School of Bioagricultural Sciences, Nagoya University
Co-Researcher:Masaatsu Adachi,Keiichi Konoki.
  1. Toshio Nishikawa, Yusuke Sawayama, “A New Synthetic Route to the Saxitoxin Skelton”, The 6th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-6), The 2nd New Phase International Conference on Cutting-edge Organic Chemistry in Asia , Hong-Kong (Dec, 2011).
Makoto Sasaki
Professor Graduate School of Life Sciences, Tohoku University
Co-Researcher Haruhiko Fuwa, Keiichi Konoki
Fumi Nagatsugi
Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Takamitsu Hosoya
Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
Yousuke Takaoka
Assistant Professor, Graduate School of Engineering, Kyoto University
Junko Ohkanda
Associate Professor, Osaka University / Institute for Chemical Research, Kyoto University
  1. J. Ohkanda, M. Takahashi, A. Kawamura, N. Kato, T. Nishi, I. Hamachi, “Phosphopeptide-dependent fluorescence labeling of 14-3-3 zeta protein by fusicoccins”, France-Japan Workshop: Bio-inspired approaches: Micro-& Nano- Architectures, Materials & Imaging, Bordeaux University, France (Oct. 11-12, 2011).
Misako Aida
Professor, Graduate School of Science, Hiroshima University
Akira Otaka
Professor, Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
Hideo Takahashi
Professor, Graduate School of Medical Life Science, Yokohama City University
Toshiyuki Kan
Professor, School of Pharmaceutical Sciences, University of Shizuoka
  1. Toshiyuki Kan “Synthesis and bioactivity evaluation of catechin and flavonoid” International Society for Nutraceuticals and Functional Foods (ISNFF) (Sapprp) Nov 7th 2011 .
Hiroyuki Nakamura
Professor, Gakusyuin University
  1. H. Nakamura, H. S. Ban, K. Shimizu, H. Minegishi, Y. Yasui, M. Maruyama, Identification of Heat Shock Protein (Hsp) 60 as a Primary Target of Carboranylphenoxyacetanilides, HIF-1α Inhibitors, AIMECS11(Tokyo)Nov29th-Dec2nd 2011.
  2. H. Minegishi, H. S. Ban, H. Nakamura, Betulinic Acid as a Hypoxia-Inducible Factor-1α Inhibitor, AIMECS11 (Tokyo)Nov29th-Dec2nd 2011.
  3. S. Tachikawa, H. S. Ban, H. Nakamura, Development of Liposomal Boron Agents for Neutron Capture Therapy, AIMECS11(Tokyo)Nov29th-Dec2nd 2011.
  4. H. Nakamura, Development of Liposomal Boron Delivery System for Neutron Capture Therapy, 6th Young BNCT Meeting, Invited Lecture(Taiwan), Dec4th-8th 2011.
  5. S. Tachikawa, T. Miyoshi, H. Koganei, D. Kanoh, H. S. Ban, H. Nakamura, Development of Liposomal Boron Agents for Neutron Capture Therapy, 6th Young BNCT Meeting(Taiwan), Dec4th-8th 2011.
  6. H. Nakamura, Developement of Carboranylphenoxyanilides as HIF-1α Inhibitors: Photoaffinity Probe Design and Identification of the Primary target Protein, 3rd ICHC, Invited Lecture(aipur, India), Dec10th-13rd 2011.
Nobuyuki Kanzawa
Associate Professor, Faculty of Science and Technology, Sophia University
Yu Nakagawa
Senior Research Scientist, RIKEN
Makoto Muroi
Senior Research Scientist, RIKEN

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