Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Publication in 2015

Publication in 2015

A01A02A03

【A01】

【Group Ⅰ-Ⅱ】
Hiroshi Handa, A01 Group Leader
Professor, Dept.of Nanoparticle Translational Research,Handa Lab,Tokyo Medical University
  1. Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Qingfu, C., Egloff, S., Handa, H. and Murphy, S.* CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription. Transcription, , 6, 2015, 79-90. [10.1080/21541264.2015.1095269]
  2. Cao, Q. F., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y. * Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Non-overlapping Functions of Rtf1 and the Paf1 Complex. Mol. Cell. Biol., , 35, 2015, 3459-3470. [10.1128/MCB.00601-15]
  3. Ito, T. and Handa, H. Myeloid disease: Another action of a thalidomide derivative.Nature (News and Views), , 523, 2015, 167-168. [10.1038/nature14628]
  4. Kawano, M., Doi, K., Fukuda, H., Kita, Y., Imai, K., Inoue, T., Enomoto, T., Matsui, M., Hatakeyama, M., Yamaguchi, Y. and Handa, H. SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes. Biotechnology Reports, 5, 105-111, 2015.
【Group Ⅰ-Ⅱ】
Ryuichi Okamoto
Professor, Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University
  1. Ryuichi Okamoto, Mamoru Watanabe. Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases. Digestion 2015;92(2)73-77
  2. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy2015 ;11(7)1052-1062
  3. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci2015;106,1000-7
  4. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.(Epub ahead of print) Biochem. Biophys. Res. Commun 2015;456(1) 298-304
  5. Hayashi R , Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M. Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients. [Epub ahead of print] Inflammatory Bowel Diseases2015:10.1097/MIB.0000000000000707
【Group Ⅰ-Ⅱ】
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1. Suzuki A, Kato Y, Matsuura T, *Watanabe H ,Growth evaluation method by live imaging of Daphnia magna and its application to the estimation of an insect growth regulator. J Appl Toxicol 35: 68-74(2015)
  2. Peerakietkhajorn S, Tsukada K, Kato Y, Matsuura T, *Watanabe H ,Symbiotic bacteria contribute to increasing the population size of a freshwater crustacean, Daphnia magna. Environ Microbiol Rep 7: 364-372(2015)
  3. Peerakietkhajorn S, Kato Y, Kasalicky V, Matsuura T, *Watanabe H,Betaproteobacteria Limnohabitans strains increase fecundity in the crustacean Daphnia magna: symbiotic relationship between major bacterioplankton and zooplankton in freshwater ecosystem. Environ Microbiol
    (2015)
  4. Nakanishi T, Kato Y, Matsuura T, *Watanabe H ,TALEN-mediated homologous recombination in Daphnia magna. Sci Rep 5: 18312(2015)
  5. Naitou A, Kato Y, Nakanishi T, Matsuura T, *Watanabe H ,Heterodimeric TALENs induce targeted heritable mutations in the crustacean Daphnia magna. Biol Open 4: 364-369(2015)
  6. Uyeda A, Watanabe T, Kato Y, Watanabe H, Yomo T, Hohsaka T, Matsuura T,Liposome-based in vitro evolution of aminoacyl-tRNA synthetase for enhanced pyrrolysine derivative incorporation. Chembiochem 16: 1797-1802 (2015)
【Group Ⅰ-Ⅱ】
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku
  1. Sumii, Y.; *Kotoku, N.; Fukuda, A.; Kawachi, T.; Sumii, Y.; Arai, M.; *Kobayashi, M. , Structure-activity relationship and in vivo anti-tumor evaluation of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge. Marine Drugs 2015, 13, 7419-7432. DOI: 10.3390/md13127074
  2. *Arai, M.; Kamiya, K.; Pruksakorn, P.; Sumii, Y.; Kotoku, N.; Joubert, J.-P.; Moodley, P.; Han, C.; Shin, D.; *Kobayashi, M., Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg. Med. Chem. 2015, 23, 3534-3541. DOI: 10.1016/j.bmc.2015.04.033
  3. Sumii, Y.; Kotoku, N.; Fukuda, A.; Kawachi, T.; Sumii, Y.; Arai, M.; Kobayashi, M. Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge. Bioorg. Med. Chem., 23, 966-975 (2015).
【Group Ⅰ-Ⅱ】
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
【Group Ⅰ(A01) -Ⅱ(A03)】
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
【Group Ⅰ-Ⅱ】
Kohji Fukunaga
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. Moriguchi S, Sakagami H, Yabuki Y, Sasaki Y, Izumi H, Zhang C, Han F, *Fukunaga K. Stimulation of sigma-1 receptor ameliorates depressive-like behaviors in CaMKIV null mice. Mol Neurobiol. 2015; 52(3): 1210-1222. doi: 10.1007/s12035-014-8923-2.
  2. Yabuki Y, Shinoda Y, Izumi H, Ikuno T, Shioda N, *Fukunaga K. Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation. Brain Res. 2015; 1622: 102-113. doi: 10.1016/j.brainres.2015.05.006.
  3. Shioda N, Sawai M, Ishizuka Y, Shirao T, *Fukunaga K. Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons. J Biol Chem. 2015; 290(35):21663-21675. doi: 10.1074/jbc.M115.664920.
  4. Shioda N, *Fukunaga K. [Molecular mechanisms of synapse pathology in ATR-X syndrome]. Nihon Yakurigaku Zasshi. 2015;145(4):174-177. doi: 10.1254/fpj.145.174.
  5. Murata K, Yoshino Y, Tsuruma K, Moriguchi S, Oyagi A, Tanaka H, Ishisaka M, Shimazawa M, Fukunaga K, *Hara H. The extracellular fragment of GPNMB (Glycoprotein nonmelanosoma protein B, osteoactivin) improves memory and increases hippocampal GluA1 levels in mice. J Neurochem. 2015; 132: 583-594. doi: 10.1111/jnc.13010.
  6. K. Fukunaga, Cognitive function and calcium. Cognitive improvement through T type calcium channel stimulation, Clin Calcium, 25(2):247-254 (2015).
  7. S. Moriguchi, M. Nishi, Y. Sasaki, H. Takeshima, K. Fukunaga, Aberrant behavioral sensitization by methamphetamine in junctophilin-deficient mice, Mol Neurobiol. 51(2):533-542 (2015).
  8. K. Fukunaga, Y. Shinoda, H. Tagashira, The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis, J Pharmacol Sci, 127(1):36-41 (2015)
【Group Ⅰ-Ⅱ】
Maiko Okada
Assistant Professor, St.Marianna University School of Medicine.
  1. Okada M., Ohtake F., Nishikawa H., Wu W., Saeki Y., Tanaka K., Ohta T*., Liganded ER Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation., Mol Endocrinol.,, 29, 2015, 1646-1657, doi:10.1210/me.2015-1125.
  2. S. Tsukuda, K. Watashi, M. Iwamoto, R. Suzuki, H. Aizaki, M. Okada, M. Sugiyama, S. Kojima, Y. Tanaka, M. Mizokami, J. Li, S.Tong and T. Wakita*, Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of Sodium Taurocholate Cotransporting Polypeptide (NTCP) Expression. J. Biol. Chem , 290(9)5673-5684 (2015).【Co-study】
【Group Ⅰ-Ⅱ】
Nobuaki Matsumori
Professor, Graduate School of Science, Kyusyu Univeristy
  1. H. Shibata, H. Tsuchikawa, T. Hayashi, N. Matsumori, *M. Murata, T. Usui, Modification of bafilomycin structure to efficiently synthesize solid-state NMR probes that selectively bind to vacuolar-Type ATPase. Chem. Asian J. 10, 915-924 (2015). DOI:10.1002/asia.201403299 【Co-study】
  2. Y. Nakagawa, Y. Umegawa, K. Nonomura, N. Matsushita, T. Takano, H. Tsuchikawa, S, Hanashima, T. Oishi, N. Matsumori, *M. Murata, Axial hydrogen at C7 position and bumpy tetracyclic core markedly reduce sterol’s affinity to amphotericin B in membrane. Biochemistry 54, 303-312 (2015). DOI: 10.1021/bi5012942
  3. J. Cui, S. Lethu, T. Yasuda, S. Matsuoka, N. Matsumori, F. Sato, *M. Murata, Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state H-2 NMR probe for investigating membrane properties. Bioorg. Med. Chem. Lett. 25, 203-206 (2015). DOI: 10.1016/j.bmcl.2014.11.072
  4. T. Yasuda, N. Matsumori, H. Tsuchikawa, M. Lonnfors, T.K.M. Nyholm, J.P. Slotte, *M. Murata, Formation of Gel-like Nanodomains in Cholesterol-Containing Sphingomyelin or Phosphatidylcholine Binary Membrane As Examined by Fluorescence Lifetimes and 2H NMR Spectra. Langmuir, 31, 13783-13792 (2015). doi: 10.1021/acs.langmuir.5b03566.
  5. J. Cui, S. Kawatake, Y. Umegawa, S. Lethu, M. Yamagami, S. Matsuoka, F. Sato, N. Matsumori, *M. Murata, Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions. Org. Biomol. Chem., 13, 10578 (2015). doi: 10.1039/c5ob01252j.
  6. T. Yamamoto, Y. Umegawa, H. Tsuchikawa, N. Matsumori, S. Hanashima, *M. Murata, R. Haser, B. J. Rawlings, P. Caffrey, Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane. Bioorg. Med. Chem., 23, 5782-5788 (2015). doi: 10.1016/j.bmc.2015.07.009.
  7. *M. Murata, S. Sugiyama, S. Matsuoka, N. Matsumori, Bioactive Structure of Membrane Lipids and Natural Products Elucidated by a Chemistry-Based Approach. Chemical Record, 15, 675-690 (2015). doi: 10.1002/tcr.201402097.
  8. *N. Matsumori, T. Yamaguchi, Y. Maeta, *M. Murata, Orientation and order of the amide group of sphingomyelin in bilayers determined by solid-state NMR. Biophys. J., 108, 2816-2824 (2015). doi: 10.1016/j.bpj.2015.05.011.
  9. J. Cui, S. Matsuoka, M. Kinoshita, N. Matsumori, F. Sato, *M. Murata, J. Ando, H. Yamakoshi, K. Dodo, M. Sodeoka, Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior, Bioorg. Med. Chem., 23, 2989-2994 (2015). doi: 10.1016/j.bmc.2015.05.014.
  10. T. Yasuda, H. Tsuchikawa, *M. Murata, *N. Matsumori, Deuterium NMR of raft model membranes reveals domain-specific order profiles and compositional distribution. Biophys. J., 108, 2502-2506 (2015). doi: 10.1016/j.bpj.2015.04.008.
【Group Ⅰ-Ⅱ】
Akihiro Sugawara
Assistant Professor, Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
  1. N. Iwanaga, S. Nakamura, K. Oshima, T. Kajihara, T. Takazono, T. Miyazaki, K. Izumikawa, K. Yanagihara, A. Sugawara, T. Sunazuka, S. Omura, S. Kohno, Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonies in mice, J. Infect. Dis. 2015 accepted
【Group Ⅰ-Ⅱ】
Soichi Kojima
Unit Leader, Center for Life Science Technology,RIKEN
  1. Hara, M., Matsuura, T., and Kojima, S. TGF-β LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis. In Innovative Medicine : Basic Research and Development (Nakao, K., Minato, N., and Umeto, S. eds) Springer Tokyo, 317-325. (2015)
  2. Shrestha, R., Tatsukawa, H., Shrestha, R., Ishibashi, N., Matsuura, T., Kagechika, H., Kose, S., Hitomi, K., Imamoto, N., and *Kojima, S. Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells. Cell Death & Disease, 6,e2002. doi: 10.1038/cddis.2015.339. (2015) Press Released
  3. Hara, M., Inoue, I., Yamazaki, Y., Kirita, A., Matsuura T., Friedman, S., Rifkin, D.B., and *Kojima, S. L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice. Fibrogenesis Tissue Repair 8:17. doi: 10.1186/s13069-015-0034-9. (2015)
  4. Konuma, K., Itoh, M., Suganami, T., Kanai, S., Nakagawa, N., Sakai, T., Kawano, H., Hara, M., Kojima, S., Izumi, Y., and Ogawa, Y. Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin-4 receptor-deficient mice. PlosOne 10(3):e0121528 (2015)
  5. Tsukuda, S., Watashi, K., Iwamoto, M., Suzuki, R., Aizaki, H., Okada, M., Sugiyama, M., Kojima, S., Tanaka, Y., Mizokami, M., Li, J., Tong, S., and Wakita, T. Retinoic acid receptor modulates hepatocyte permissiveness to hepatitis B virus through transcriptional regulation of NTCP expression. J. Biol. Chem. 290(9):5673-5684. (2015)
  6. Erik Arner, Carsten O. Daub, Kristoffer Vitting-Seerup, Robin Andersson, Berit Lilje, Finn Drabløs, Andreas Lennartsson, Michelle Rönnerblad, Olga Hrydziuszko, Morana Vitezic, Tom C. Freeman, Ahmad M. N. Alhendi, Peter Arner, Richard Axton, J. Kenneth Baillie, Anthony Beckhouse, Beatrice Bodega, James Briggs, Frank Brombacher, Margaret Davis, Michael Detmar, Anna Ehrlund, Mitsuhiro Endoh, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Geoffrey J. Faulkner, Carmelo Ferrai, Malcolm E. Fisher, Lesley Forrester, Daniel Goldowitz, Reto Guler, Thomas Ha, Mitsuko Hara, Meenhard Herlyn, Tomokatsu Ikawa, Chieko Kai, Hiroshi Kawamoto, Levon M. Khachigian, S. Peter Klinken, Soichi Kojima, Haruhiko Koseki, Sarah Klein, Niklas Mejhert, Ken Miyaguchi, Yosuke Mizuno, Mitsuru Morimoto, Kelly J. Morris, Christine Mummery, Yutaka Nakachi, Soichi Ogishima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry Ovchinnikov, Robert Passier, Margaret Patrikakis, Ana Pombo, Xian-Yang Qin, Sugata Roy, Hiroki Sato, Suzana Savvi, Alka Saxena, Anita Schwegmann, Daisuke Sugiyama, Rolf Swoboda, Hiroshi Tanaka, Andru Tomoiu, Louise N. Winteringham, Ernst Wolvetang, Chiyo Yanagi-Mizuochi, Misako Yoneda, Susan Zabierowski, Peter Zhang, Imad Abugessaisa, Nicolas Bertin, Alexander D. Diehl, Shiro Fukuda, Masaaki Furuno, Jayson Harshbarger, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Yuri Ishizu, Masayoshi Itoh, Tsugumi Kawashima, Miki Kojima, Naoto Kondo, Marina Lizio, Terrence F. Meehan, Christopher J. Mungall, Mitsuyoshi Murata, Hiromi Nishiyori-Sueki, Serkan Sahin, Sayaka Nagao-Sato, Jessica Severin, Michiel J. L. de Hoon, Jun Kawai, Takeya Kasukawa, Timo Lassmann, Harukazu Suzuki, Hideya Kawaji, Kim M. Summers, Christine Wells, FANTOM Consortium, David A. Hume, Alistair R. R. Forrest, Albin Sandelin, Piero Carninci, and Yoshihide Hayashizaki. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347(6255):1010-1014. doi:10.1126/science.1259418. (2015)
  7. Xian-Yang Qin, Shinya Fujii, Akitaka Shimizu, Hiroyuki Kagechika and Soichi Kojima,
    Carboxylic derivatives of vitamin K2 inhibit hepatocellular carcinoma cell growth through caspase/transglutaminase-related signaling pathways. J. Nutr. Sci. Vitaminol. 61:285-290 doi: 10.3177/jnsv.61.285.(2015)
【Group Ⅰ-Ⅱ】
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. S. Sato, K. Li, T. Kameyama, T. Hayashi, Y. Ishida, S. Murakami, T. Watanabe, S. Iijima, Y. Sakurai, K. Watashi, S. Tsutsumi, Y. Sato, H. Akita, T. Wakita, CM. Rice, H. Harashima, M. Kohara, Y. Tanaka, A. Takaoka, The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus, Immunity, 42, 123-132 (2015).
  2. ◎ S. Tsukuda, K. Watashi*, M. Iwamoto, R. Suzuki, H. Aizaki, M. Okada, M. Sugiyama, S. Kojima, Y. Tanaka, M. Mizokami, J. Li, S. Tong, T. Wakita (*corresponding author), Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of Sodium Taurocholate Cotransporting Polypeptide (NTCP) Expression, J Biol Chem, 290, 5673-5684 (2015).【Co-study】
  3. ◎Yamashita A, Fujimoto Y, Tamaki M, Setiawan A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, de Voogd NJ, Maekawa S, Enomoto N, Tanaka J, Moriishi K. Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay. Mar Drugs: 13. 2015. 6759-6773
  4. Watashi K, Wakita T. Hepatitis B Virus and Hepatitis D Virus Entry, Species Specificity, and Tissue Tropism. Cold Spring Harb Perspect Med: 5. 2015. a021378
  5. Tasaka-Fujita M, Sugiyama N, Kang W, Masaski T, Murayama A, Yamada N, Sugiyama R, Tsukuda S, Watashi K, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T. Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression. Sci Rep: 2015. 13994 (2015)
  6. ◎Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K. Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. Sci Rep: 5. 2015. 17047
  7. Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Kimura H, Yamamoto N, Mizokami M, Wakita T, Ryo A. Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy. Oncotarget: 6. 2015. 21840-21852
  8. ◎Matsunaga H, Kamisuki S, Kaneko M, Yamaguchi Y, Takeuchi T, Watashi K, Sugawara F. Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp. Bioorg Med Chem Lett: 25. 2015. 4325-4328
  9. ◎Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T. A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide. J Virol: 89. 2015. 11945-11953
【Group Ⅱ】
Asako Sugimoto
Professor,Graduate School of Life Sciences, Tohoku University
【Group Ⅱ】
Hirokazu Arimoto
Professor,Graduate School of Life Sciences, Tohoku University
【Group Ⅱ】
Yoshihiro Miwa
Lecturer,Faculty of Medicine,University of Tsukuba
  1. Nakagawa H, Matsumoto Y, Matsumoto Y, Miwa Y, Nagasaki Y. Design of high-performance anti-adhesion agent using injectable gel with an anti-oxidative stress function. Biomaterials 2015 69, 165-173
  2. Suan D, Nguyen A, Moran I, Bourne K, Hermes JN, Arshi M, Hampton HR, Tomura M, Miwa Y, Kelleher AD, Kaplan W, Deenick EK, Tangye SG, Brink R, Chtanova T, Phan TG. T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses. Immunity. 2015; Apr 21;42(4):704-18. doi: 10.1016/j.immuni.2015.03.002. Epub 2015 Mar 31.PMID: 25840682.
  3. S. Tanaka, J. Tanaka, Y. Miwa, DD. Horikawa, T. Katayama, K. Arakawa, A. Toyoda, T. Kubo, T. Kunieda. Novel mitochondria-targeted heat-soluble proteins identified in the anhydrobiotic tardigrade improve osmotic tolerance of human cells. Plos One. Feb 12;10(2):e0118272. doi: 10.1371/journal.pone.0118272. eCollection (2015)
【Group Ⅱ】
Kumiko UI-TEI
Associate Professor, Graduate School of Science The University of Tokyo
  1. Nishi K, Takahashi T, Suzawa M, Miyakawa T, Nagasawa T, Ming Y, Tanokura M, * Ui-Tei K, (2015) Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein. Nucleic Acids Res. 43, 9856-9873. doi: 10.1093/nar/gkv1026.
  2. Ishikawa T, Takizawa T, Iwaki J, Mishima T, Ui-Tei K, Takeshita T, Matsubara S, *Takizawa T. (2015) Fc gamma receptor IIb participates in maternal IgG trafficking of human placental endothelial cells. Int. J. Mol. Med. 35, 1273-1789.
    doi: 10.3892/ijmm.2015.2141.
  3. Naito Y, Hino K, Bono H, *Ui-Tei K. (2015) CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites.
    Bioinformatics 31, 1120-1123. doi: 10.1093/bioinformatics/btu743.
【Group Ⅱ】
Hiroshi Hamamoto
Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  1. S. Jie, M. Iehara, J. Yasukawa, Y. Matsumoto, H. Hamamoto, K. Sekimizu*, A novel mutation in the vraS gene of Staphylococcus aureus contributes to daptomycin resistance, J Antibiot(Tokyo), 68 646-648,(2015) DOI: 10.1038/ja.2015.42,
  2. M. Murai, T. Kaji, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue*. Total synthesis and biological evaluation of the antibiotic lysocin e and its enantiomeric, epimeric, and N-demethylated analogues, Angew Chem Int Ed Engl, 54, 1556-1560 (2015), doi: 10.1002/anie.201410270,
  3. J. Mao, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue*, Rational design, synthesis, and biological evaluation of lactam-bridged gramicidin a analogues: discovery of a low-hemolytic antibacterial Peptide, ChemMedChem, 10, 540-545, (2015), doi: 10.1002/cmdc.201402473,
  4. H. Hamamoto, M. Urai, K. Ishii, J. Yasukawa, A. Paudel, M. Murai, T. Kaji, T. Kuranaga, K. Hamase, T. Katsu, J. Su, T. Adachi, R. Uchida, H. Tomoda, M. Yamada, M. Souma, H. Kurihara, M. Inoue, K. Sekimizu,* Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane, Nat Chem Biol, 11, 127-133 (2015), doi: 10.1038/nchembio.1710,
【Group Ⅱ】
Hiroaki Kato
Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
  1. ◎Moritsugu Kei, Koike Ryotaro, Yamada Kouki, Kato Hiroaki, *Kidera Akinori, Motion Tree Delineates Hierarchical Structure of Protein Dynamics Observed in Molecular Dynamics Simulation, PLoS One, 10, e0131583 (2015) doi: 10.1371/journal.pone.0131583
【Group Ⅱ】
Tatsuro Shimamura
Project Lecturer, Graduate School of Medicine, Kyoto University
  1. Nakane T, Song C, Suzuki M, Nango E, Kobayashi J, Masuda T, Inoue S, Mizohata E, Nakatsu T, Tanaka T, Tanaka R, Shimamura T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Iwata S, *Sugahara M. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography. Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2519-25. doi: 10.1107/S139900471501857X.
  2. Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, *Iwata S, *Drew D. Structure and mechanism of the mammalian fructose transporter GLUT5. Nature. 2015 Oct 15;526(7573):397-401. doi: 10.1038/nature14909.
  3. *Tono K, Nango E, Sugahara M, Song C, Park J, Tanaka T, Tanaka R, Joti Y, Kameshima T, Ono S, Hatsui T, Mizohata E, Suzuki M, Shimamura T, Tanaka Y, Iwata S, Yabashi M. Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser. J Synchrotron Radiat. 2015 May 1;22(Pt 3):532-7. doi: 10.1107/S1600577515004464.
  4. Sugahara M, Mizohata E, Nango E, Suzuki M, Tanaka T, Masuda T, Tanaka R, Shimamura T, Tanaka Y, Suno C, Ihara K, Pan D, Kakinouchi K, Sugiyama S, Murata M, Inoue T, Tono K, Song C, Park J, Kameshima T, Hatsui T, Joti Y, Yabashi M, Iwata S. Grease matrix as a versatile carrier of proteins for serial crystallography. Nat Methods. 2015 Jan;12(1):61-3. doi: 10.1038/nmeth.3172.
【Group Ⅱ】
Yoshio Hayashi
Professor, Tokyo University of Pharmacy and Life Sciences
  1. K. Hamada, A. Taguchi, M. Kotake, S. Aita, S. Murakami, K. Takayama, F. Yakushiji, Y. Hayashi, Structure−Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates, ACS Med.Chem Lett.,, 6, 2015, 689-694.

【A02】

【Group Ⅰ-Ⅱ】
Kazuhiro Irie, A02 Group Leader
Professor, Graduate School of Agriculture, Kyoto Universiy
  1. Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki, *K. Irie, Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activity, Biosci. Biotechnol. Biochem.,79.888-895(2015) (DOI: 10.1080/09168451.2014.1002452).【Co-study】
【Group Ⅰ-Ⅱ】
Masaya Imoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher: Etsu Tashiro
  1. Krajarng A, Imoto M, Tashiro E, Fujimaki T, Shinjo S, Watanapokasin R. Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid. BMC Complementary and Alternative Medicine. 15:26, (2015)
  2. Kiga M, Nakayama A, Shikata Y, Sasazawa Y, Murakami R, Nakanishi T, Tashiro E, Imoto M. SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in -catenin-mutated tumors. Scientific Report. 5: 8155 (2015)
  3. Tashiro E, *Imoto M. Chemistry and biology of the compounds that modulate cell migration (Review Article) . J Ind Microbiol Biotechnol. Jul 15. (2015).
  4. Tashiro E, *Imoto M. Chemical Biology of the compounds obtained from screening using disease models. Arch Pharm Res. 38:1651-1660 (2015)
  5. Mizotani Y, Itoh S, Hotta K, Tashiro E, Oka K, *Imoto M. Evaluation of drug toxicity profiles based on the phenotypes of ascidian Ciona intestinalis. Biochem Biophys Res Commun. 463: 656-660 ( 2015)
  6. Ishikawa F, Miyamoto K, Konno S, Kasai S, Kakeya H. Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains. ACS Chem Biol. 10:2816-2826. 2015. doi: 10.1021/acschembio.5b00595.
【Group Ⅰ-Ⅱ】
Shigeki Matsunaga
Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  1. Peddie, V.; *Takada, K.; Okuda, S.; Ise, Y.; Morii, Y.; Yamawaki, N.; Takatani, T.; Arakawa, O.; Okada, S.; *Matsunaga, S.: Cytotoxic Glycosylated Fatty Acid Amides from a Stelletta sp Marine Sponge. J. Nat. Prod. 2015, 78, 2808-2813: DOI:10.1021/acs.jnatprod.5b00795.
  2. Takanashi, E.; *Takada, K.; Hashimoto, M.; Itoh, Y.; Ise, Y.; Ohtsuka, S.; Okada, S.; *Matsunaga, S.: Cytotoxic linear acetylenes from a marine sponge Pleroma sp. Tetrahedron 2015, 71, 9564-9570: doi:10.1016/j.tet.2015.10.062.
  3. Moran, D. A. P.; *Takada, K.; Ise, Y.; Bontemps, N.; Davis, R. A.; Furihata, K.; Okada, S.; *Matsunaga, S.: Two cell differentiation inducing pyridoacridines from a marine sponge Biemna sp and their chemical conversions. Tetrahedron 2015, 71, 5013-5018: doi:10.1016/j.tet.2015.05.070.
  4. Fukuhara, K.; *Takada, K.; Okada, S.; *Matsunaga, S.: Nazumazoles A-C, Cyclic Pentapeptides Dimerized through a Disulfide Bond from the Marine Sponge Theonella swinhoei. Org. Lett. 2015, 17, 2646-2648: DOI: 10.1021/acs.orglett.5b01020.
  5. Arita, Y.; *Nishimura, S.; Ishitsuka, R.; Kishimoto, T.; Ikenouchi, J.; Ishii, K.; Umeda, M.; Matsunaga, S.; Kobayashi, T.; *Yoshida, M.: Targeting Cholesterol in a Liquid-Disordered Environment by Theonellamides Modulates Cell Membrane Order and Cell Shape. Chem. Biol. 2015, 22, 604-610: doi:10.1016/j.chembiol.2015.04.011.
【Group Ⅰ-Ⅱ】
Masami Ishibashi
Professor,Graduate School of Pharmaceutical Sciences, Chiba University
Co-Researcher:Midori Arai, Naoki Ishikawa
  1. M. A. Arai, K. Uemura, N. Hamahiga, N. Ishikawa, T. Koyano, T. Kowithayakorn, T. Kaddar, M. Carreau, M. Ishibashi, Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa, Med. Chem. Commun., 6, 455-460 (2015). DOI:10.1039/C4MD00495G
  2. K. Toume, T. Habu, M. A. Arai, T. Koyano, T. Kowithayakorn, M. Ishibashi, Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance, J. Nat. Prod., 78, 103-110 (2015). DOI:10.1021/np500734t
  3. M. A. Arai, K. Koryudzu, M. Ishibashi, Inubosin A, B, and C are new acridine alkaloids isolated from Streptomyces sp. IFM 11440 that show Ngn2 promoter activity, J. Nat. Prod., 78, 311-314 (2015). DOI:10.1021/np5006218
  4. R. G. Fuentes, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excels, Phytochem. Lett. 11, 280-285 (2015). DOI:10.1016/j.phytol.2015.01.015
  5. Yixizhuoma; Tsukahara, K.; Toume, K.; Ishikawa, N.; Abdelfattah, M. S.; *Ishibashi, M. “Novel cytotoxic isobenzofuran derivatives from Streptomyces sp. IFM 11490″ Tetrahedron Lett. 2015, 56, 6345-6347 DOI:10.1016/j.tetlet.2015.09.116
  6. Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits Wnt signaling pathway by decreasing β-catenin mRNA expression” Bioorg. Med. Chem. Lett. 2015, 25, 3937-3940 DOI:10.1016/j.bmcl.2015.07.036
  7. Yoneyama, T.; *Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Hedgehog inhibitors from Withania somnifera” Bioorg. Med. Chem. Lett. 2015, 25, 3541-3544 DOI:10.1016/j.bmcl.2015.06.081
  8. Karmakar, U. K.; Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumariumBioorg. Med. Chem. 2015, 23, 4746-4754 DOI:10.1016/j.bmc.2015.05.044
  9. *Arai, M. A.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Koyano, T.; Kowithayakorn, T.; *Ishibashi, M. “Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolensBioorg. Med. Chem. 2015, 23, 4150-4154 DOI:10.1016/j.bmc.2015.06.058
  10. *Arai, M. A.; Akamine, R.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Hedgehog/GLI- mediated transcriptional activity inhibitors from Crinum asiaticumJ. Nat. Med. 2015, 69, 538-542 DOI:10.1007/s11418-015-0922-8
  11. Shono, T.; Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Boehmenan, a lignan, isolated from Hibiscus ficulneus showed Wnt signal inhibitory activity” Bioorg. Med. Chem. Lett. 2015, 25, 2735-2738 DOI:10.1016/j.bmcl.2015.05.037
  12. Fuentes, R. G.; *Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Phenolic compounds from the bark of Oroxylum indicum identified as Ngn2 promoter activators” J. Nat. Med. 2015, 69, 589-594 DOI:10.1007/s11418-015-0919-3
  13. Ohishi, K.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Mizoguchi, T.; Itoh, M.; *Ishibashi, M. “9-Hydorxycanthin-6-one, a β-carboline alkaloid from Eurycoma longifolia, is the first Wnt signal inhibitor through activation of GSK3β without depending on CK1α” J. Nat. Prod. 2015, 78, 1139-1146 DOI:10.1021/acs.jnatprod.5b00153
  14. Fuentes, R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Scopadulciol, isolated from Scoparia dulcis, induces β-catenin degradation and overcomes tumor necrosis factor-related apoptosis ligand resistance in AGS human gastric adenocarcinoma cells” J. Nat. Prod. 2015, 78, 864-872 DOI:10.1021/np500933v
  15. Tahmina, H.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; *Ishibashi, M. “Isolation of alkamides with death receptor-enhancing activities from Piper chabaHeterocycles 2015, 90, 1317-1322 DOI:10.3987/COM-14-S(K)68
  16. Fuentes, R. G.; Arai, M. A.; *Ishibashi, M. “Natural compounds with Wnt signal modulating activity” Nat. Prod. Rep. 2015, 32, 1622-1628 DOI: 10.1039/C5NP00074B
【Group Ⅰ-Ⅱ】
Tetsuro Shinada
Professor, Graduate School of Science, Osaka City University
Co-Researcher: Yasufumi Ohfune
  1. A. Manabe, R. Matsumoto, *T. Shinada, Cyclopropanation of E-dehydroaspartic acid esters with furan derivatives: the synthesis of highly functionalized α-2,3-methanoamino acid esters, Synlett 2015, 26, 1710-1714. DOI: 10.1055/s-0034-1380812
  2. Facile Synthesis of Deuterium-Labelled Geranylgeraniols, Y. Totsuka, S. Ueda, T. Kuzuyama, T. Shinada, Bull. Chem. Soc. Jp . 2015, 44, 575-577. DOI: 10.1246/bcsj.20140384
  3. Total synthesis of a Monomeric Phloroglucinol Derivative isolated from Myrtus Communis, E. Nishimura, Y. Ohfune, T. Shinada, Chem. Lett. 44, 445-447. DOI: 10.1246/cl.141168
  4. Reaction of cyclopropenes with a trichloromethyl radical: unprecedented ring-opening reaction of cyclopropanes with migration, M. Ueda, N. Doi, H. Miyagawa, S. Sugita, N. Takeda, T. Shinada, O. Miyata, Chem. Commun. 2015, 4204-4207. DOI: 10.1039/C4CC09649E
  5. Total synthesis structure elucidation of (±)-triumphalone (±)-isotriumphalone, E. Nishimura, Y. Ohfune, T. Shinada, Tetrahedron Lett. 2015, 56, 539-541. DOI: 10.1016/j.tetlet.2014.12.005
【Group Ⅰ-Ⅱ】
Hidenori Watanabe
Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
  1. Naoki Mori, Takeshi Kitahara, Kenji Mori, *Hidenori Watanabe, Asymmetric Formal Synthesis of Azadirachtin. Angewandte Chemie, 127, 2015, 15133–15136.
  2. *Ken Ishigami, Shinya Yamada, Hidenori Watanabe, Synthesis of (±)-(Z)-2β-hydroxy-14-hydro-β-santalol employing tandem radical cyclization, Tetrahedron Letters, 56, 2015, 5816-5819.
  3. Ken Ishigami, Masaoki Yamamoto, *Hidenori Watanabe, Synthesis and revision of the relative configuration of glabramycin B, Tetrahedron Letters, 56, 2015, 6290-6293.
  4. *Ken Ishigami, Munetaka Kobayashi, Motoki Takagi, Kazuo Shin-ya, Hidenori Watanabe, Synthesis of marine oxylipin topsentolide A1 and its stereoisomers, and determination of the absolute configuration of the natural product. Tetrahedron, 71, 2015, 8436-8443.
【Group Ⅰ-Ⅱ】
Kosuke Namba
Professor, Graduate School of Pharmaceutical Science, The University of Tokushima
  1. R. Araki, K. Kousaka, K. Namba, Y. Murata, J. Murata, 2′-Deoxymugineic acid promotes growth of rice (Oryza sativa L.) by orchestrating iron and nitrate uptake processes under high pH conditions. Plant. J., 81, 233-246 (2015).
  2. K. Namba, A. Osawa, A. Nakayama, A. Mera, F. Tano, Y. Chuman, E. Sakuda, T. Taketsugu, K. Sakaguchi, N. Kitamura, K. Tanino. Synthesis of Yellow and Red Fluorescent 1,3a,6a-Triazapentalene and Theoretical Investigation of Optical Properties. Chem. Sci., 6, 1083-1093 (2015).
  3. M. Shibata, R. Fuchigami, R. Kotaka, K. Namba, K. Tanino. Acid-catalyzed [4+3] cycloaddition reaction of N-nosyl pyrroles. Tetrahedron,71, 2015, 4495-4499. (DOI: 10.1016/j.tet.2015.02.071)
  4. Namba, K.; Takeuchi, K.; Kaihara, Y.; Oda, M.; Nakayama, A.; Nakayama, A.; Yoshida, M.; *Tanino K. Total Synthesis of Palau’amine. Nature Communications6, 2015, 8731 (1-9). (DOI: 10.1038/ncomms9731)
  5. Murata, Y.*; Itoh, Y.; Iwashita, T.; Namba, K. Transgenic Petunia with the Iron(III)-Phytosiderophore Transporter Gene Acquires Tolerance to Iron Deficiency in Alkaline Environments. PloS one, 10(3) 2015, e0120227. (http://dx.doi.org/10.1371/journal.pone.0120227)
【Group Ⅰ-Ⅱ】
Satoshi Ichikawa
Professor,  Faculty of Pharmaceutical Science, Hokkaido University
  1. Nakaya, Takeshi; Matsuda, Akira; *Ichikawa, Satoshi. Design, synthesis and biological evaluation of 5′-C-piperidinyl-5′-O-aminoribosyluridines as a potential antibacterial agent. Org. Biomol. Chem. 2015, 14, 7720-7735, DOI: 10.1039/C5OB01037C.
  2. Chiba, Takuya; Matsuda, Akira; *Ichikawa, Satoshi. Synthesis and biological activity of syringolin A analogues. Bioorg. Med. Chem. Lett. 2015, 25, 4872-4877, DOI:10.1016/j.bmcl.2015.06.015.
  3. S. Ichikawa, M. Yamaguchi, L. S. Hsuan, Y. Kato, A. Matsuda. Carbacaprazamycins: Chemically Stable Analogues of the Caprazamycin Nucleoside Antibiotics. ACS Infect. Dis.  2015, 1, 151-156, DOI: 10.1021/id5000376.
【Group Ⅰ-Ⅱ】
Haruhiko Fuwa
Associate Professor, Graduate School of Life Sciences, Tohoku University
  1. J. A. Rubiolo, *C. Vale, V. Martin, H. Fuwa, M. Sasaki, *L. M. Botana, “Potassium Currents Inhibition by Gambierol Analogs Prevents Human T Lymphocyte Activation,” Archives of Toxicology, 89, 1119–1134 (2015). DOI: 10.1007/s00204-014-1299-2.
  2. *H. Fuwa, K. Sakamoto, T. Muto, M. Sasaki, “Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A,” Tetrahedron, 71, 6369–6383 (2015). DOI: 10.1016/j.tet.2015.04.001.
  3. H. Fuwa,* R. Fukazawa, and M. Sasaki, Concise synthesis of the A/BCD-ring fragment of gambieric acid A, Front. Chem., 2, 116 (2015). DOI: 10.3389/fchem.2014.00116
  4. M. Sasaki,* Y. Kawashima, and H. Fuwa, Studies toward the total synthesis of amphidinolide N: Stereocontrolled synthesis of the C13-C29 segment, Heterocycles, 90, 579-599 (2015). DOI: 10.3987/COM-14-S(K)66
  5. H. Fuwa,* Y. Okuaki, N. Yamagata, and M. Sasaki, Total synthesis, stereochemical reassignment, and biological evaluation of (-)-lyngbyaloside B, Angew. Chem. Int. Ed., 54, 868-873 (2015). DOI: 10.1002/anie.201409629
  6. H. Fuwa,* K. Sakamoto, T. Muto, and M. Sasaki, Concise synthesis of the C15-C38 fragment of okadaic acid: Application of Suzuki-Miyaura reaction to spiroacetal synthesis, Org. Lett., 17, 366-369 (2015). DOI: 10.1021/ol503491t
  7. K. Konoki,* Y. Suga, H. Fuwa, M. Yotsu-Yamashita, and M. Sasaki,* Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity, Bioorg. Med. Chem. Lett., 25, 514-518 (2015). DOI: 10.1016/j.bmcl.2014.12.022
【Group Ⅰ-Ⅱ】
Shinichi Nishimura
Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
  1. Sugiyama, R., Nishimura, S.*, Ozaki, T., Asamizu, S., Onaka, H., Kakeya, H.* 5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites, produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonis. Org. Lett..17, 1918-1921. DOI: 10.1021/acs.orglett.5b00607.【Co-study】
  2. Yoshimura, A., Nishimura, S., Otsuka, S., Hattori, A. & Kakeya, H. (2015) Structure elucidation of verucopeptin, a potent HIF-1 inhibitory polyketide-hexapeptide hybrid metabolite from an actinomycete. Org. Lett. 17, 5364-5367. DOI: 10.1021/acs.orglett.5b02718.
  3. Lu, S., Nishimura, S., Hirai, G., Ito, M., Kawahara, T., Izumikawa, M., Sodeoka, M., Shin-ya, K., Tsuchida, T. & Kakeya, H. (2015) Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. Chem. Commun. 51, 8074-8077. DOI: 10.1039/c5cc01953b.
【Group Ⅰ-Ⅱ(By August)-Advisory Members】
Katsunori Tanaka
Associate Chief Scientist,Biofunctional Synthetic Chemistry Laboratory, RIKEN
Co-Researcher: Takayuki Iwata, Co-Researcher: Masataka Kitadani.
  1. A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka, Exclusive Formation of Imino [4+4] cycloaddition Products with Biologically Relevant Amines: Plausible Candidates for Acrolein Biomarkers and Biofunctional Modulators, Med. Chem. Commun., 6, 431-436 (2015).
  2. K. Tanaka, K. Fukase, Chemical Approach to A Whole Body Imaging of Sialo-N-linked Glycans, In Topics in Current Chemistry volumes, SialoGlyco Chemistry and Biology, R. Gerardy-Schahn, P. Delannoy, and M. von Itzstein (eds), Springer, 査読有, 367, (2015), 201-230, DOI: 10.1007/128_2014_603
【Group Ⅰ-Ⅱ】
Kazunobu Toshima
Professor, Faculty of Science and Technology, Keio University
  1. T. Kimura, D. Takahashi, *K. Toshima, Glycosylation of glycals using N-iodosuccinimide (NIS) and phosphorus compounds for syntheses of 2-iodo- and 2-deoxyglycosides, Journal of Organic Chemistry, 80, 9552-9562 (2015).
    DOI: 10.1021/acs.joc.5b01542
  2. ◎A. Kasai, S. Arafuka, N. Koshiba, *D. Takahashi, *K. Toshima, Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells, Organic & Biomolecular Chemistry, 13, 10556-10568 (2015).
    DOI: 10.1039/C5OB01634G
  3. M. Aoyagi, T. Kimura, A. Ohba, Y. Katayama, D. Takahashi, *K. Toshima, One-pot transformation of N-succinyl chitosan to nitrogen-containing alkyl glycosides using an ionic liquid containing a protic acid, Chemistry Letters, 44, 1467-1469 (2015)
    DOI: 10.1246/cl.150623
  4. A. Nakagawa, M. Tanaka, S. Hanamura, *D. Takahashi, *K. Toshima, Regioselective and 1,2-cis-α-stereoselective glycosylation utilizing glycosyl-acceptor-derived boronic ester catalyst, Angewandte Chemie, International Edition, 54, 10935-10939 (2015).
    DOI: 10.1002/anie.201504182
  5. ◎*K. Toshima, D. Takahashi, Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules, Glycoconjugate Journal, 32, 475-482 (2015).
    DOI: 10.1007/s10719-015-9591-9
  6. *Y. Katayama, Y. Oshino, N. Ichihashi, N. Tachikawa, Y. Kazuki, K. Toshima, Electrochemical preparation of palladium nanoparticles in bis(trifluoromethylsulfonyl)amide ionic liquids consisting of pyrrolidinium cations with different alkyl chain lengths, Electrochimica Acta, 183, 37-41(2015).
    DOI: 10.1016/j.electacta.2015.02.211
  7. K. Yoshii, Y. Oshino, N. Tachikawa, K. Toshima, *Y. Katayama, Electrodeposition of palladium from palladium(II) acetylacetonate in an amide-type ionic liquid, Electrochemistry Communications, 52, 21-24 (2015).
    DOI: 10.1016/j.elecom.2015.01.003
  8. K. Sato, Y. Oaki, D. Takahashi, K. Toshima, *H. Imai, Hierarchical CaCO3 chromatography: A stationary shase based on biominerals, Chemistry-A European Journal, 21, 5034-5040 (2015).
    DOI: 10.1002/chem.201405724
【Group Ⅰ-Ⅱ】
Go Hirai
Senior Research Scientist, Synthetic Organic Chemistry Laboratory,RIKEN
  1. Eisuke Ota, Yu Mikame, *Go Hirai, Hiroyuki Koshino, Shigeru Nishiyama, *Mikiko Sodeoka, “Photo-induced formation of cyclopropanols from α-ketoamides via γ-C-H bond activation”, Tetrahedron Lett.、56, 2015, 5991-5994, DOI:10.1016/j.tetlet.2015.09.038
  2. *Go Hirai, Eri Nishizawa, Daiki Kakumoto, Masaki Morita, Mitsuaki Okada, Daisuke Hashizume, Sayoko Nagashima, *Mikiko Sodeoka, “Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine”, Chem. Lett.、44, 2015, 1389-1391, DOI:10.1246/cl.150523.
  3. Shan Lu, Shinichi Nishimura, Go Hirai, Masashi Ito, Teppei Kawahara, Miho Izumikawa, Mikiko Sodeoka, Kazuo Shin-ya, Toshio Tsuchida and Hideaki Kakeya*, “Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides from a rare actinomycete Saccharothrix sp.”, Chem. Commun.、51, 2015, 8074-8077, DOI: 10.1039/c5cc01953b.
  4. *Go Hirai, Eisuke Ota, Motonari Sakai, Shigeru Nishiyama, *Mikiko Sodeoka, “C-Sialosides: Synthesis and Biological Activities”, Trends in glycoscience and glycotechnology (Minireview)7, 2015, 47-60, DOI: 10.4052/tigg.1313.1.
  5. *Go Hirai and *Mikiko Sodeoka, “Focused Library with a Core Structure Extracted from Natural Products and Modified: Application to Phosphatase Inhibitors and Several Biochemical Findings”, Acc. Chem. Res.、48, 2015, 1464-1473, DOI: 0.1021/acs.accounts.5b00048.
  6. *Go Hirai, “Mimicking/Extracting Structure and Functions of Natural Products: Synthetic Approaches that Address Unexplored Needs in Chemical Biology”, Chem. Rec.、5, 2015, 445-456, DOI: 10.1002/tcr.201402074.
【Group Ⅱ】
Shigefumi Kuwahara
Professor, Graduate School of Agricultural Science, Tohoku University
  1. T. Teranishi, T. Murokawa, M. Enomoto, S. Kuwahara, Synthesis of (±)-terpendole E, Biosci. Biotechnol. Biochem., 79, 11-15 (2015).
  2. K. Fukuyama, H. Ohrui, S. Kuwahara, Synthesis of EFdA via a diastereoselective aldol reaction of a protected 3-keto furanose, Org. Lett., 17, 828-831 (2015).
  3. T. Suzuki, T. Nagasawa, M. Enomoto, S. Kuwahara, Stereoselective total synthesis of amicoumacin C, Tetrahedron, 71, 1992-1997 (2015).
【Group Ⅱ(By October)-Advisory Members】
Takayuki Doi
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. M. Yoshida, K. Sasahara, T. Doi, Total Synthesis of Spiruchostatin A on Silyl-linked Polymer-Support, Tetrahedron, 71, 7647-7653 (2015) DOI: 10.1016/j.tet.2015.07.064.
  2. T. Doi, H. Otaka, K. Umeda, M. Yoshida, Study for diastereoselective aldol reaction in flow: Synthesis of (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid, a key component of cyclodepsipeptide HDAC inhibitors, Tetrahedron, 71, 6463-6470 (2015): DOI: 10.1016/j.tet.2015.05.051.
【Group Ⅱ】
Takashi Kawakami
Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
  1. T. Kawakami, A. Shungo, K. Ogawa, T. Hatta, T. Kubo, N. Goshima, T. Natsume, Proteomic Mapping of Biological Complexes Using Directed Ligand Evolution and Ultra-High Sensitive Mass Spectrometry, Peptide Science, 2014, 339-340 (2015).
  2. Kawakami, T., Ogawa, K., Goshima, N., Natsume T. DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells. Chemistry & Biology, 、22, 2015, 1671-1679
【Group Ⅱ】
Daisuke Urabe
Lecturer, Graduate School of Pharmaceutical Sciences,
The University of Tokyo
  1. Asaba, T.; Katoh, Y.; Urabe, D.; *Inoue, M. “Total Synthesis of Crotophorbolone,” Angew. Chem. Int. Ed. 2015, 54, 14457-14461. DOI: 10.1002/anie.201509160
  2. Goto, T.; Urabe, D.; Isobe, Y.; Arita, M.; *Inoue, M. “Total synthesis of four stereoisomers of (5Z,8Z,10E,14Z)-12-hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic acid and their anti-Inflammatory activities,” Tetrahedron 2015, 71, 8320-8332. DOI: 10.1016/j.tet.2015.08.047
  3. Goto, T.; Urabe, D.; Masuda, K.; Isobe, Y.; Arita, M.; *Inoue, M. “Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities,” J. Org. Chem. 2015, 80, 7713-7726. DOI: 10.1021/acs.joc.5b01461
  4. Mukai, K.; Kasuya S.; Nakagawa, Y.; Urabe, D.; *Inoue, M. “A convergent total synthesis of ouabagenin,” Chem. Sci. 2015, 6, 3383-3387. DOI: 10.1039/C5SC00212E
  5. Hagiwara, K.; Iwatsu, M.; Urabe, D.; * Inoue, M.N-(2,3,4,5,6-Pentafluorophenyl)maleimide as a powerful dienophile in dearomatizing Diels-Alder reactions,” Heterocycles 2015, 90, 659-672. DOI: 10.3987/COM-14-S(K)23
  6. Urabe, D.; Todoroki, H.; *Inoue, M. “Asymmetric total synthesis of (-)-4-hydroxyzinowol, a highly oxygenated dihydro-beta-agarofuran” J. Synth. Org. Chem. Jpn. 2015, 73, 1081-1091. DOI: 10.5059/yukigoseikyokaishi.73.1081
  7. Urabe, D. “Radical-mediated three-component reaction: a study toward the total synthesis of resiniferatoxin” Chem. Pharm. Bull. 2015, 63, 565-572. DOI: 10.1248/cpb.c15-00373
  8. *Nishikawa, T.; Urabe, D.; Adachi, M.; Isobe, M. “Multifunctionality of the N-trichloroacetyl group developed in the synthesis of tetrodotoxin, a puffer fish toxin” Synlett 2015, 26, 1930-1939. DOI: 10.1055/s-0034-1380781
  9. Urabe, D.; Asaba, T.; *Inoue, M. “Convergent strategies in total syntheses of complex terpenoids,” Chem. Rev. 2015, 115, 9207-9231. DOI: 10.1021/cr500716f
【Group Ⅱ】
Hiroshi Tanaka
Associate Professor, Graduate Scool of Science and Engineering,  Tokyo Institute of Technology
【Group Ⅱ】
Yukari Fujimoto
Professor, Faculty of Science and Technology, Keio University
Co-Researcher:Shinsuke Inuki, Toshihiko Aiba
  1. Inuki, S., Sato, K., *Fujimoto, Y., Visible-light-mediated decarboxylative benzoyloxylation of -hydroxy amino acids and its application to synthesis of functional 1,2-amino alcohol derivatives. Tetrahedron Lett. 2015, 56, 5787-5790. DOI: 10.1016/j.tetlet.2015.09.012
  2. Aiba, T., Suehara, S., Bernin, H., Lotter, H., Inuki, S., Fukase, K., *Fujimoto, Y. Synthesis and Biological Activity of Inositol Phospholipid as NKT Cell Modulator. Glycoconjugate J. 2015, 32, 301. doi:10.1007/s10719-015-9596-4

【A03】

【Group Ⅰ-Ⅱ】
Minoru Ueda., A03 Group Leader
Professor,Graduate School of Science, Tohoku University
  1. K. Kurotani, K. Hayashi, S. Hatanaka, Y. Toda, D. Ogawa, H. Ichikawa, Y. Ishimaru, R. Tashita, M. Ueda, T. Hattori, *S. Takeda, Elevated levels of CYP94 family gene expression alleviate the jasmonate response and enhance salt tolerance in rice, Plant Cell Physiol., 56, 779-789 (2015).
  2. K. Bashir, Y. Ishimaru, R. Nakanishi Itai, T. Senoura, M. Takahashi, G. An, T. Oikawa, M. Ueda, A. Sato, N. Uozumi, H. Nakanishi, and *N. K Nishizawa, Iron deficiency regulated OsOPT7 is essential for iron homeostasis in rice, Plant Mol. Biol., 88, 165-176 (2015).
  3. Saito, H., Oikawa, T., Hamamoto, S., Ishimaru, Y., Sato, M.K, Sekimoto, Y. S., Utsumi, T., Chen, J., Kanno, Y., Masuda, S., Kamiya, Y., Seo, M., Uozumi, N., Ueda, M., Ohta, H.: The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis. Nat Commun (2015)6: 6095 doi: 10.1038/ncomms7095
  4. Ueda, M., Yang, G., Nukadzuka, Y., Ishimaru, Y., Tamura, S., Manabe, Y.: Functioncal importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity Org Biomol Chem 13: 55-58, 2015.
【Group Ⅰ-Ⅱ】
Naoki Kanoh
Associate Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
Co-Researcher: Takeo Usui
  1. T. Suzuki, T. Okamura, T. Tomohiro, Y. Iwabuchi, N. Kanoh, Third Generation Photo-Cross-Linked Small-Molecule Affinity Matrix: Photoactivatable and Photocleavable System Enables Quantitative Analysis of the Photo-Cross-Linked Small Molecules and Their Target Purification, Bioconjugate Chem., 3, 389-395 (2015).
  2. T. Chinen, P. Liu, S. Shioda, J. Pagel, B. Cerikan, T. Lin, O. Gruss, Y. Hayashi, H. Takeno, T. Shima, T. Okada, I. Hayakawa, Y. Hayashi, H. Kigoshi, T. Usui*, E. Schiebel*, The γ-tubulin specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle, Nat. Commun., 6, 8722 (2015), doi:10.1038/ncomms9722
  3. S.-i. Uesugi, T. Watanabe, T. Imaizumi, Y. Ota, K. Yoshida, H. Ebisu, T. Chinen, Y. Nagumo, M. Shibuya, N. Kanoh, T. Usui*, Y. Iwabuchi*, Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B, J. Org. Chem., 80, 12333-12350 (2015). DOI: 10.1021/acs.joc.5b02256
  4. S. Hirano, Q. Tu Hue, T. Watahabe, N. Kanoh, Y. Iwabuchi, T. Usui, T. Kataoka, Irciniastatin A, a Pederin Family of Translation Inhibitor, Promotes Ectodomain Shedding of Cell-surface Tumor Necrosis Factor (TNF) Receptor 1 and Blocks TNF-α-induced Nuclear Factor κB Signaling Pathway, J. Antibiot., 68, 417-420, (2015)
  5. S. Hirano, H. T. Quach, T. Watahabe, N. Kanoh, Y. Iwabuchi, T. Usui, T. Kataoka, Irciniastatin A Induces a Potent and Sustained Activation of Extracellular Signal-regulated Kinase and Thereby Promotes Ectodomain Shedding of TNF Receptor 1 in Human Lung Carcinoma A549 Cells, Biol. Pharm. Bull., 38, 941-946 (2015).
  6. H. Shibata, H. Tsuchikawa, T. Hayashi, N. Matsumori, M. Murata*, T. Usui, Modification of bafilomycin structure to efficiently synthesize solid-state NMR probes that selectively bind to vacuolar-type ATPase, Chem. Asian J., 10, 915-924 (2015). DOI: 10.1002/asia.201403299
【Group Ⅰ-Ⅱ】
Hideo Kigoshi
Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
Co-Researcher: Masaki Kita
  1. Yoneda, K.; Hu, Y.; *Kita, M.; *Kigoshi, H.,6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag:development of photoaffinity pyrene derivative, Sci. Rep. 2015, 5, 17853. 10.1038/srep17853
  2. *Kita, M.; Oka, H.; Usui, A.; Ishitsuka, T.; Mogi, Y.; Watanabe, H.; Tsunoda, M.; *Kigoshi, H.,Total Synthesis of Mycalolides A and B through Olefin Metathesis,
    Angew. Chem., Int. Ed. 2015, 54 (47), 14174–14178. 10.1002/ange.201507795
  3. M. Kita, H. Kigoshi, “Antitumor Effects of Sea Hare-derived Compounds in Cancer.” in Handbook of Anticancer Drugs from Marine Origin, Ed. S. -K. Kim (Springer International Publishing Switzerland), pp. 701-740 (2015). Amount pages 805.
  4. M. Kita, H. Kigoshi, “Antitumor Effects of Sea Hare-derived Compounds in Cancer.” in Handbook of Anticancer Drugs from Marine Origin, Ed. S. -K. Kim (Springer International Publishing Switzerland), pp. 701-740 (2015).
【Group Ⅰ-Ⅱ】
Toshio Nishikawa
Profrssor, Graduate School of Bioagricultural Sciences, Nagoya University
Co-Researcher :Masaatu Adachi,Keiichi Konoki
  1. Konoki, K., Suga, Y., Fuwa, H., Yotsu-Yamashita, M., *Sasaki, M. Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity. Bioorg. Med. Chem. Lett., 25, 514-518 (2015).(doi:10.1016/j.bmcl.2014.12.022)
  2. Tsuchiya, S., Cho, Y., Konoki, K, Nagasawa, K., Oshima, Y., *Yotsu-Yamashita, M. Synthesis of a Tricyclic Bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxin-producing microorganisms. Chem. Eur. J., 21, 7835-7840 (2015).(doi: 10.1002/chem.201500064)
  3. Ehara, H., Makino, M., Kodama, K., Konoki, K., Ito, T, Sekine, S., *Fukuzawa, S., *Yokoyama, S., *Tachibana, K. Crystal Structure of okadaic acid binding protein 2.1: A sponge protein implicated in cytotoxin accumulation. ChemBioChem, 16, 1435-1439 (2015).(doi: 10.1002/cbic.201500141)
  4. Kudo, Y., Chiba, C., Konoki, K., Cho Y., *Yotsu-Yamashita, M. Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS. Toxicon, 101, 101-105 (2015).(doi: 10.1016/j.toxicon.2015.05.008)
  5. Puilingi, C. G., Kudo, Y., Cho, Y., Konoki, K., *Yotsu-Yamashita, M. Tetrodotoxin and its analogues in the pufferfish Arothron hispidus and A. nigropunctatus from the Solomon Islands: A comparison of their toxin profiles with the same species from Okinawa, Japan. Toxins, 7, 3436-3454 (2015).(DOI:10.3390/toxins7093436)
  6. Cho, Y., Tsuchiya, S., Yoshioka, R., Omura, T., Konoki, K., Oshima, Y., *Yotsu-Yamashita, M. The presence of 12β-deoxydecarbamoylsaxitoxin in the Japanese toxic dinoflagellate Alexandrium determined by simultaneous analysis for paralytic shellfish toxins using HILIC-LC–MS/MS. Harmful Algae, 49, 58-67 (2015).(doi:10.1016/j.hal.2015.09.003)
  7. *Konoki, K., Okada, K., Kohama, M., Matsuura, H., Saito, K., Cho, Y., Nishitani, G., Miyamoto, T., Fukuzawa, S., Tachibana, K., Yotsu-Yamashita, M. Identification of okadaic acid binding protein 2 in reconstituted sponge cell clusters from Halichondria okadai and its contribution to the detoxification of okadaic acid, Toxicon, 108, 38-45 (2015).(doi:10.1016/j.toxicon.2015.09.026)
  8. Nakazaki, A., Nakane, Y., Ishikawa, Y., *Nishikawa, T. Synthesis of 1.5-dioxaspiro[3.4]octane through bromocation-induced cascade cyclization. Heterocycles, 91, 1157-1163 (2015).(doi:10.3987/COM-15-13208)
  9. Nakazaki, A., Miyagawa, K., Miyata, N., *Nishikawa, T. Synthesis of a C-N Axially Chiral N-Aryl Isatin through Asymmetric Intramolecular N-Arylation. Eur. J. Org. Chem., 4603-4606 (2015).(doi: 10.1002/ejoc.201500593)
  10. *Nishikawa, T., Urabe, D., Adachi, M., Isobe, M. Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin. Synlett, 26, 1930-1939 (2015).(doi: 10.1055/s-0034-1380781)
  11. R. Kimura, Y. Sawayama, A. Nakazaki, K. Miyamoto, M. Uchiyama, T. Nishikawa, Unexpected Metal-Free Transformation of gem-Dibromomethylenes to Ketones under Acetylation Conditions. Chem. Asian J, 10, 1035-1041 (2015). DOI: 10.1002/asia.201403277
  12. M. Adachi, M. Nakajima, M. Isobe, Asymmetric Synthesis of 3-Azide-4-fluoro-L-phenylalanine. Biosci. Biotechnol. Biochem. 79.707-709(2015). DOI:10.1080/09168451.2014.997185,
  13. M. Adachi, M. Torii, T. Nishikawa, Stereocontrolled Synthesis of ABC-tricycle of Solanoeclepin A. Synlett, 26 ,965-969 (2015). DOI: 10.1055/s-0034-1380399,
  14. A. Nakazaki, K. Miyagawa, T. Nishikawa, Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles Bearing C–N Axial Chirality via Nucleophilic Substitution. Synlett 26, 1116-1120 (2015)(doi: 10.1055/s-0034-1380266)(2015).
【Group Ⅰ-Ⅱ】
Makoto Sasaki
Professor, Graduate School of Life Sciences, Tohoku University
Co-Researcher :Kenichi Konoki
  1. Juan A. Rubiolo, Carmen Vale, Víctor Martín, Haruhiko Fuwa, Makoto Sasaki, and *Luis M. Botana, Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation, Archives of Toxicology, , 89, 2015, 1119–1134. DOI: 10.1007/s00204-014-1299-2
  2. H. Fuwa, Y. Okuaki, N. Yamagata, and M. Sasaki, Total synthesis, stereochemical reassignment, and biological evaluation of (–)-lyngbyaloside B, Angew. Chem. Int. Ed. 54, 868-873 (2015). DOI: 10.1002/anie.201409629
  3. K. Konoki, Y. Suga, M. Yotsu-Yamashita, H. Fuwa, and M. Sasaki, Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity, Bioorg. Med. Chem. Lett., 25, 514-518 (2015). DOI: 10.1007/s00204-014-1299-2
  4. H. Fuwa, R. Fukazawa, and M. Sasaki, Concise synthesis of the A/BCD-ring fragment of gambieric acids, Front. Chem., 2, 116 (2015). doi: 10.3389/fchem.2014.00116
  5. H. Fuwa, K. Sakamoto, T. Muto, and M. Sasaki, Concise synthesis of the C15–C38 fragment of okadaic acid: Application of Suzuki–Miyaura reaction to spiroacetal synthesis, Org. Lett., 17, 366-369 (2015). DOI: 10.1021/ol503491t
【Group Ⅰ-Ⅱ-Advisory Members】
Fumi Nagatsugi
Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  1. Akisawa, T., Ishizawa, Y., Nagatsugi, F, Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities, Molecules, 20, 4708-4719 (2015) 10.3390/molecules20034708
  2. Sato, N., Tsuji, G., Sasaki, Y., Usami, A., Moki, T., Onizuka, K., Yamada, K. and *Nagatsugi, F. A new strategy for site-specific alkylation of DNA using oligonucleotides containing an abasic site and alkylating probes. Chem.Commun., 51, 14885-14888 (2015). 10.1039/c5cc03915k
  3. ◎Kusano, S., Ishiyama, S., Lam, S.L., Mashima, T., Katahira, M., Miyamoto, K., Aida, M. and *Nagatsugi, F. Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts. Nucleic Acids Research, 43, 7717-7730 (2015) 10.1093/nar/gkv797
  4. Kikuta, K., Piao, H., Brazier, J., Taniguchi, Y., Onizuka, K., Nagatsugi, F. and *Sasaki, S. Stabilization of the i-motif structure by the intra-strand cross-link formation. Bioorganic & Medicinal Chemistry Letters, 25, 3307-3310 (2015) .10.1016/j.bmcl.2015.05.064
【Group Ⅱ】
Takamitsu Hosoya
Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
【Group Ⅰ-Ⅱ】Yousuke Takaoka
Lecturer, Graduate School of Science, Tohoku University (since July)
  1. Song Zhining, Yousuke Takaoka, Yoshiyuki Kioi, Kazuhiro Komatsu, Tomonori Tamura, Takayuki MIki, Itaru Hamachi*;Extended Affinity-guided DMAP Chemistry with Finely-tuned Acyl Donor for Intarcellular FKBP12 Labeling Chem. Lett. 44:333-335(2015)
  2. Yuki Yasueda, Tomonori Tamura, Keiko Kuwata, Yousuke Takaoka, Itaru Hamachi, Biomembrane-embedded Catalysis for Membrane-associated Protein Labeling on Red Blood Cells. Chem. Lett., 44, 1673-1675 (2015). DOI: 10.1246/cl160797.
  3. Takahiro Hayashi, Yuki Yasueda, Tomonori Tamura, Yousuke Takaoka, Itaru Hamachi*, Analysis of Cell-surface Dynamics Through Covalent Labeling by Catalyst-tethered Antibody. J. Am. Chem. Soc., 137, 5372-5380 (2015). DOI: 10.1021/jacs.5b02867.
  4. Yousuke Takaoka, Yuki Nishikawa, Yuki Hashimoto, Kenta Sasaki, Itaru Hamachi*, Ligand-directed Dibromophenyl Benzoate Chemistry for Rapid and Selective Acylation of Intracellular Natural Proteins. Chem. Sci., 6, 3217-3224 (2015). DOI: 10.1039/c5sc00190k.
【Group Ⅰ-Ⅱ】
Junko Ohkanda
Associate professor, Institute for Chemical Research, Kyoto University
  1. Prakash Parvatkar, Nobuo Kato, Motonari Uesugi, Shin-ichi Sato, *Junko Ohkanda
    “Intracellular generation of a diterpene-peptide conjugate that inhibits 14-3-3-mediated interactions”
    J. Am. Chem. Soc., 2015, 137, 15624-15627.
    DOI: 10.1021/jacs.5b09817
【Group Ⅰ-Ⅱ】
Misako Aida
Professor, Graduate School of Science, Hiroshima University
  1. Dai Akase, Hiroyuki Teramae, Misako Aida, A Comprehensive Search of Topologically Distinct Local Minimum Structures of Protonated Water Octamer and the Classification of O-H Topological Types, Chemical Physics Letters, 618, 51-56 (2015). DOI: 10.1016/j.cplett.2014.10.071
  2. Yusuke Hanaki, Ryo C. Yanagita, Takahiro Sugahara, Misako Aida, Harukuni Tokuda, Nobutaka Suzuki and Kazuhiro Irie, Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities, Bioscience, Biotechnology, and Biochemistry, Published online: 23 Jan 2015. DOI: 10.1080/09168451.2014.1002452【Co-study】
  3. Kusano, S. Ishiyama, SL, Lam, T. Mashima, M. Katahira, K. Miyamoto, M. Aida, F. Nagatsugi (2015) Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts. Nucleic Acids Research, 43, 7717-7730.
  4. Ami Kosaka, Misako Aida, Yukiteru Katsumoto (2015) Reconsidering the activation entropy for anomerization of glucose and mannose in water studied by NMR spectroscopy. Journal of Molecular Structures, 1093, 195-200.
  5. Tomonori Yamada and Misako Aida (2015) Fundamental frequency from classical molecular dynamics. Phys. Chem. Chem. Phys., 17, 3227-3240.
【Group Ⅰ-Ⅱ】
Hideo Takahashi
Professor, Graduate School of Medical Life Science, Yokohama City University
  1. Y. Mizukoshi, K. Takeuchi, M. Arutaki, T. Takizawa, H. Hanzawa, *H. Takahashi, and *I. Shimada, “Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines”, ChemMedChem, , 10 (2015) 736-741.
【Group Ⅰ-Ⅱ】
Toshiyuki Kan
Professor, School of Pharmaceutical Sciences, University of Shizuoka
  1. H. Katayama, K. Iwamoto, Y. Kariya, T. Asakawa, T. Kan, H. Fukuda, K. Ohashi-Ito* “A negative feedback loop controlling bHLH complexes is involved in vascular cell division and differentiation in the root apical meristem” Curr. Biol., 25, 3144–3150 (2015), DOI:10.1016/j.cub.2015.10.051.
  2. M. Inai, R. Ishikawa, N. Yoshida, N. Shirakawa, Y. Akao, Y. Kawabe, T. Asakawa, M. Egi, Y. Hamashima, T. Kan “Stereocontrolled Total Syntheses of Optically Active Furofuran Lignans” Synthesis, 47, 3513–3521 (2015), DOI: 10.1055/s-0034-1378812.
  3. T. Asai, J.-H. Choi, T. Ikka, K. Fushimi, N. Abe, H. Tanaka, Y. Yamakawa, H. Kobori, Y. Kiriiwa, R. Motohashi, V. K. Deo, T. Asakawa, T. Kan, A. Morita, H. Kawagishi* “Effect of 2-Azahypoxanthine (AHX) Produced by the Fairy-Ring-Forming Fungus on the Growth and the Grain Yield of Rice” Jpn. Agric. Res. Quart., 49, 45–49 (2015), DOI: 10.6090/jarq.49.45.
  4. V. Le, M. Inai, R. M. Williams,* T. Kan “Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics” Nat. Prod. Rep., 32, 328–347 (2015), DOI: 10.1039/C4NP00051J.
【Group Ⅰ-Ⅱ】
Hiroyuki Nakamura
Professor, Tokyo Institute of Technology
  1. S. Sato, K. Nakamura, *H. Nakamura, Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives. ACS Chem. Biol. 10, 2633–2640. (2015). doi: 10.1021/acschembio.5b00440.
  2. G. Li, S. Azuma, H. Minegishi, *H. Nakamura, Synthesis and Biological Evaluation of meta-Carborane-Containing phenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1 Transcriptional Activity. J. Organomet. Chem. 798, 189–195. (2015). doi:10.1016/j.jorganchem.2015.05.029.
  3. H. Minegishi, Y. Futamura, S. Fukashiro, M. Muroi, M. Kawatani, H. Osada, *H. Nakamura, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino) benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods, J. Med. Chem. 58, 4230-4241 (2015). doi: 10.1021/acs.jmedchem.5b00035.
  4. G. Li, S. Azuma, S. Sato, H. Minegishi, *H. Nakamura, ortho-Carboranylphenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1Transcriptional Activity and Heat Shock Protein (HSP) 60 Chaperon Activity. Bioorg. Med. Chem. Lett. 25, 2524-2628. (2015). doi: 10.1016/j.bmcl.2015.04.088.
  5. H. S. Ban, *H. Nakamura, Boron-Based Drug Design. Chem. Rec. 15, 616-635. (2015). doi: 10.1002/tcr.201402100.
  6. S. Sato, K. Morita, *H. Nakamura, Regulation of target protein knockdown and labeling using ligand-directed Ru(bpy)3 photocatalyst. Bioconjugate Chem. 26, 250-256. (2015). doi: 10.1021/bc500518t.
  7. *H. Nakamura, L. Tazaki, D. Kanoh, S. Sato, Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity, Pure Appl. Chem. 87,145-154. (2015). doi: 10.1515/pac-2014-0911.
【Group Ⅰ-Ⅱ】
Nobuyuki Kanzawa
Professor, Faculty of Science and Technology, Sophia University
  1. H. Ohsugi, J. Hatsukawa, M. Takahara, M. Aizawa, N. Kanzawa, Real-time evaluation of the effects of dexamethasone on osteoblasts using dual labeling with fluorescent probes, Key Enginner. Mater., 631, 379-383 (2015).
  2. K. Yasuda, M. Takahara, M. Aizawa, N. Kanzawa, P19.CL6 cells cultured in AFS differentiate into cardiomyocytes, Key Enginner. Mater., 631, 295-299 (2015).
  3. Y. Shimizu, Y. Kawanobe, T. Konishi, N. Kanzawa, M. Honda, M. Aizawa, Biocompatibility of silver-containing calcium-phosphate cements with anti-bacterial properties, Key Enginner. Mater., 631, 278-2859 (2015).
【Group Ⅱ】
Hiroki Oguri
Professor, Faculty of Engineering, Tokyo University of Agriculture and Technology
  1.  T. Ugai, A. Minami, R. Fujii, M. Tanaka, H. Oguri, K. Gomi, H. Oikawa, Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis, Chem. Commun. 51, 1878-1881 (2015).
【Group Ⅱ】
Hiroaki Saito
Assistant Professor, Graduate School of Natural Science & Technology, Kanazawa University
  1. Masashi Iwayama*, Kazutomo Kawaguchi, Hiroaki Saito, Hidemi Nagao, A hybrid type approach with MD and DFT calculations for evaluation of redox potential of molecules, Mol. Simu. 41, (2015) 936-941., DOI:10.1080/08927022.2015.1012641)
【Group Ⅰ(Advisory Members) -Ⅱ(A03)】
Motonari Uesugi
Professor, Institute for Integrated Cell-Material Sciences & Institute for Chemical Research,
Kyoto University
  1. Takaya, J., Mio, K., Shiraishi, T., Kurokawa, T., Otsuka, S., Mori, Y., Uesugi, M. A potent and site-selective agonist of TRPA1. J. Am. Chem. Soc. 137, 15859−15864 (2015). DOI: 10.1021/jacs.5b10162
  2. Sato, S.*, Watanabe, M., Katsuda, Y., Murata, A., Wang, D. O., Uesugi M. Live-cell Imaging of Endogenous mRNAs with a Small Molecule, Angew. Chem. Int. Ed., 54, 1855-1858 (2015).
    DOI: 10.1002/anie.201410339,
【Group Ⅱ】
Kazuhiro Mio
Senior Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
  1. Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, *Uesugi M. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 137, 15859-15864, 2015 doi: 10.1021/jacs.5b10162.
  2. Memtily N, Okada T, Ebihara T, Sato M, Kurabayashi A, Furihata M, Suga M, Nishiyama H, Mio K, *Sato C. Observation of tissues in open aqueous solution by atmospheric scanning electron microscopy: applicability to intraoperative cancer diagnosis. Int J Oncol. 46:1872-1882. 2015 doi: 10.3892/ijo.2015.2905

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