Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

International Confrence in 2015

International Confrence in 2015

A01A02A03

【A01】

【Group Ⅰ-Ⅱ】
Hiroshi Handa, A01 Group Leader
Professor, Dept.of Nanoparticle Translational Research,Handa Lab,Tokyo Medical University
  1. Satoshi Sakamoto, Yuki Yamaguchi Takumi Ito, Hideki Ando and Hiroshi Handa, Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs), PACIFICHEM2015:2015.12.15-20, Hilton Hawaiian Village (Hawaii, USA)
  2. Satoshi Sakamoto, Yuki Yamaguchi, Takumi Ito, and Hiroshi Handa, Elucidation of the
    molecular mechanisms of action of bioactive natural products using high performance affinity beads, PACIFICHEM2015:2015.12.15-20, Hilton Hawaiian Village (Hawaii, USA)
  3. Hiroshi Handa, Cereblon (CRBN), the common target of multiple pharmacological actions of thalidomide and its derivatives, New developments of zebrafish research, 2015.11.24-25 (Shizuoka, Japan)
  4. Hiroshi Handa, Basic aspects concerning the mechanisms of actions of immunomodulatory drugs (IMiDs) in multiple myeloma, The 20th Congress of EHA-JSH Joint Symposium (Multiple Myeloma), 2015.6.11-14 (Wien, Austria)
【Group Ⅰ-Ⅱ】
Ryuichi Okamoto
Professor, Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University
  1. M. A. Arai, R. Akamine, R. Okamoto, T. Koyano, T. Kowithayakorn, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Search for Notch signaling inhibitors from natural products”, Pacifichem 2015; December 17, 2015, Honolulu, (U.S.A.)
  2. T. Yoneyama, M. A. Arai, R. Okamoto, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Isolation of Notch inhibitors from Calotropis gigantea”, Pacifichem 2015; December 17, 2015, Honolulu, (U.S.A.)
  3. Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract. Pacifichem2015, 20151217 : Hawaii (USA)
  4. Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential. UEGW2015, 20151028 : Barcelona ( Spain)
  5. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima , Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture. UEGW2015, 20151027 : Barcelona ( Spain )
  6. Tetsuya Nakamura. Epithelial Regeneration by Transplantation of Intestinal Epithelial Stem Cells. The 2nd International Meeting for Epithelial Tubulology, 20150822:Sapporo(Japan)
  7. Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer. AOCC2015, 20150619 : Beijing ( China)
  8. Horita N, Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Fukuda M, Mizutani T, Okamoto R, Nakamura T and Watanabe M. A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt. AOCC2015, 20150619 : Beijing( China)
  9. Kohei Suzuki, Satoru Fujii, Toru Nakata, Ami Kawamoto, Fumiaki Ishibashi, Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Kazuo Otsuka, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe. Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium. AOCC2015, 20150619 : Beijing ( China )
  10. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells. DDW 2015, 20150519 : Washington DC ( U.S.A)
  11. Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe. Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium. DDW 2015 , 20150519 : Washington, D.C. (U.S.A)
  12. Keita Fukushima, Kiichiro Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 Protein Expression by TNF-a and the Acquisition of Malignant Potential in Colitis- Associated Colorectal Cancer. DDW 2015, 20150517 : Washington, D.C. ( U.S.A )
  13. Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe. Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine. DDW 2015 , 20150516 : Washington, D.C. ( U.S.A)
  14. Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T. Live imaging analysis of intraepithelial lymphocytes (IELs) co-cultured with intestinal epithelial organoids. Cold Spring Harbor Meeting “Fundamental Immunology and Its Therapeutic Applications”, 20150416:New York (U.S.A)
  15. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Continuous stimulation with cytokines leads to irreversible accumulation of NF-κB signaling in colonic epithelial cells. The 5th International Symposium on Carcinogenic Spiral, 20150226 : Kobe ( Japan )
  16. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term stimulation with cytokines acquires irreersible accumulation of NF-κB signaling in colonic epithelial cells. 10th Congress of ECCO – Inflammatory Bowel Diseases 2015, 20150220 : Barcelona ( Spain )
【Group Ⅰ-Ⅱ】
Hajime Watanabe
Professor, Graduate School of Engineering, Osaka University
  1. Yasuhiko KATO, Takashi NAKANISHI, Tomoaki MATSUURA, Hajime WATANABE,Development of transgenic Daphnia, Pacifichem 2015,Dec15-20 (Hawaii, USA)
  2. Takashi Nakanishi, Yasuhiko Kato, Tomoaki Matsuura, Hajime Watanabe, Efficient DNA integration into germ line genome via TALEN in Daphnia magna, Conference on Transposition and Genome Engineering 2015,Nov17-20,(Nara Japan)
  3. Yasuhiko Kato, Hajime Watanabe,
    A long noncoding RNA regulates a sex-determining gene doublesex1 in the crustacean Daphnia magna,
    EMBL Symposia “Noncoding Genome” Oct18-20 2015,(Germany)
  4. Takashi Nakanishi, Yasuhiko Kato, Tomoaki Matsuura, Hajime Watanabe, Efficient DNA integration into germ line genome via programmable nucleases in Daphnia magna, Cold Spring Harbor Laboratory Meetings & Courses Program “GENOME ENGINEERING: THE CRISPR/CAS REVOLUTION” Sept24-27 2015, Cold Spring Harbor(USA)
  5. Takashi NAKANISHI, Miki ASADA, Yasuhiko KATO, Hajime WATANABE, Development of transgenic Daphnia for monitoring hormonal activities of chemicals
    SETAC Europe 25th Annual Meeting May3-7 2015 Barcelona(Spain)
【Group Ⅰ-Ⅱ】
Motomasa Kobayashi
Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Co-Researcher:Masayoshi Arai, Naoyuki Kotoku
  1. ○Masayoshi Arai, Yoshi Yamano, Andi Setiawan and Motomasa Kobayashi 
    “Target identification of agelasine D, a marine spongean diterpene alkaloid, as an antidormant mycobacterial substance.” PACIFICHEM 2015, 2015/12/17, Hawaii (USA)
  2. ○Naoyuki Kotoku, Yuji Sumii, Takashi Kawachi, Akinori Fukuda, Masayoshi Arai and Motomasa Kobayashi “Synthetic study and target analysis of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge.”  PACIFICHEM 2015, 2015/12/17, Hawaii (USA)
  3. ○Kentaro Kamiya, Masayoshi Arai, Patamaporn Pruksakorn, Yuji Sumii, Naoyuki Kotoku, Chisu Han, Dayoung Shin and Motomasa Kobayashi  “Anti-dormant mycobacterial activity and action-mechanism of nybomycin produced by Streptomyces sp.” The 9th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists, 2015/11/17, Seoul (Korea)
  4. ○Ryosuke Ishida, Naoyuki Kotoku, Hirokazu Matsumoto, Masayoshi Arai, Kazunari Toda and Motomasa Kobayashi
    “Total synthesis of biakamides, selective growth inhibitors against cancer cells under nutrient-starved condition.”  The 9th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists, 2015/11/17, Seoul (Korea)
【Group Ⅰ-Ⅱ】
Kenichi Nishiyama
Professor, Cryobiofrontier Research Center, Faculty of Agriculture, Iwate University
  1. Yuta Endo, Toshiyuki Yamaguchi, Hideaki Matsubayashi, Yutetsu Kuruma, Takuya Ueda, Keiko Shimamoto, Ken-ichi Nishiyama, “Characterization of an MPIase homologue in plants that catalyses membrane protein integration”, The International Chemical Congress of Pacific Basin Societies, 17 Dec 2015, Honolulu (USA)
  2. Ryo Sato, Keiko Shimamoto, Toshiyuki Yamaguchi, Michael Moser, Ken-ichi Nishiyama, “Identification of biosynthetic enzymes for MPIase, a glycolipozyme essential for membrane protein integration, The International Chemical Congress of Pacific Basin Societies, 17 Dec 2015, Honolulu (USA)
  3. Katsuhiro Sawasato, Michael Moser, Ryo Sato, Ken-ichi Nishiyama, “Glycolipozyme MPIase functions as membrane protein integrase in vivo”, The International Chemical Congress of Pacific Basin Societies, 17 Dec 2015, Honolulu (USA)
  4. Masaru Sasaki, Hideaki Matsubayashi, Yutetsu Kuruma, Takuya Ueda, Ken-ichi Nishiyama, “Reconstitution of glycolipozyme MPIase-dependent protein integration into membrane”, The International Chemical Congress of Pacific Basin Societies, 17 Dec 2015, Honolulu (USA)
  5. Ken-ichi Nishiyama, Michael Moser, Shoichi Kusumoto, Keiko Shimamoto, “MPIase (membrane protein integrase), a glycolipozyme involved in protein integration into and protein translocation across the cytoplasmic membrane of E. coli, The International Chemical Congress of Pacific Basin Societies, 15 Dec 2015, Honolulu (USA)
【Group Ⅰ(A01) -Ⅱ(A03)】
Shin Hamamoto
Assistant Professor, Graduate School of Engineering, Tohoku University
  1. Hamamoto, S., Yabe, I., and Uozumi, N. Regulatory mechanism of TRP channel in yeast tonoplast 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015), Dec. 15-20 2015,Honolulu Hawai,USA
【Group Ⅰ-Ⅱ】
Kohji Fukunaga
Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
  1. Kohji Fukunaga: Post-traumatic stress disorder-like behaviors in FABP3 null mice. Neuroscience 2015. October 17-21, 2015, Chicago, USA
  2. Kohji Fukunaga: Sigma-1 receptor mediates depressive behaviors induced by cardiovascular diseases. Neuroscience 2015. October 17-21, 2015, Chicago, USA
  3. Kohji Fukunaga, Hiroyuki Sakagami, Shigeki Moriguchi, “Sigma-1 receptor agonist and fluvoxamine rescue depressive behaviors in CaMKIV null mice”, Experimental Biology 2015, Boston, Massachusetts (March 2015). Poster presentation.
  4. Hisanao Izumi, Shikei Moriguchi, Satomi Kita, Takahiro Iwamoto, Kohji Fukunaga, “Depression-like behaviors in NCX hetero-deficient mice”, 12th Korea-Japan joint symposium of brain sciences, and cardiac and smooth muscle sciences, Yongin、Korea (January 2015). Poster presentation.
  5. Yasushi Yabuki, Norifumi Shioda, Misaki Onozato, Kohji Fukunaga, “Arachidoic acid aggravates Parkinson disease pathology through α-synuclein oligomerization”, TOHOKU Brain Science Symposium, Miyagi (January 2015). Oral presentation.
【Group Ⅰ-Ⅱ】
Nobuaki Matsumori
Professor, Graduate School of Science, Kyusyu Univeristy
  1. N. Matsumori, NMR studies of lipid rafts, Pacifichem2015, Dec. 16, 2015, Honolulu (USA)
  2. N. Matsumori, Small molecule interactions with membrane sterol, Pacifichem 2015, Dec. 17. 2015 Honolulu (USA)
【Group Ⅰ-Ⅱ】
Akihiro Sugawara
Assistant Professor, Kitasato Institute for Life Sciences &Graduate School of Infection Control Sciences, Kitasato University
【Group Ⅰ-Ⅱ】
Soichi Kojima
Unit Leader, RIKEN Center for Life Science Technology
  1. Soichi Kojima, Mechanism of cancer-selective pro-apoptotic effect by acyclic retinoid and structurally related compounds derived from foods. International Chemical Congress of Pacific Basin Societies 2015, Dec15-20 (Hawaii, USA)
  2. Soichi Kojima, Novel molecular mechanisms of nuclear localization of TG2. 14th International Congress on Amino Acids, Peptides and Proteins, (Wien),August2015,(Invited)
  3. Soichi Kojima, “Identification of MYCN as a biomarker and therapeutic target of hepatocarcinoma under chemoprevention with acyclic retinoid”, MODHEP Symposium – System Biology of Liver Cancer, Yokohama, Japan, oral, invited (Jan 21th, 2015)
【Group Ⅰ-Ⅱ】
Koichi Watashi
Senior Researcher, National Institute of Infectious Diseases
  1. Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M. Development of a cell culture and infection system for hepatitis B virus using 3D cultured immortalized human hepatocytes. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  2. Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R. Japanese encephalitis virus (JEV)-subviral particles harboring HCV neutralization epitopes elicit neutralizing antibodies against JEV and HCV. 22nd International Symposium on Hepatitis C Virus and Related Viruses, Oct, 2015, Strasbourg(France)
  3. Iwami S, Tanaka Y, Wakita T, Watashi K. Quantifying activity optimizes drug combinations against hepatitis C virus infection. 22nd International Symposium on Hepatitis C Virus and Related Viruses, Oct, 2015, Strasbourg(France)
  4. Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Tanaka Y, Wakita T. Cilnidipine inhibits the early phase of HBV infection in a NTCP-independent mechanism. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  5. Shimura S, Watashi K, Sluder A, Peel M, Kawai F, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T. Identification of HBV entry inhibitors, based on the cyclosporin structure. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  6. Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice Cm, Harashima H, Kohara M, Tanaka Y, Takaoka A. Dual function of RIG-I as innate antiviral mediator against hepatitis B virus. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  7. Nicholson S, Moyo B, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P. Anti-HBV talens delivered by recombinant adeno-associated viral vectors (rAAV) efficiently inhibit HBV replication in vivo and in vitro. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  8. Matsunaga S, Miyakawa K, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A. Development of anti-HBs monoclonal antibody targeting HBs-NTCP interaction. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  9. Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M. Pyrimidotriazinone derivatives as novel inhibitors of hepatitis B virus core assembly. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  10. Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T. Identification of a new tricyclic polyketide, vanitaracin A, which inhibits the entry of HBV, HDV, and nucleoside analog-resistant HBV though targeting NTCP. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  11. Fukasawa M, Shimizu Y, Shirasago Y, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K. Inhibition of hepatitis B virus infection by docosahexaenoic acid in cultured cells. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  12. Watashi K, Tsukuda S, Shimura S, Kaneko M, Sluder A, Peel M, Kamisuki S, Matsunaga S, Morishita R, Futamura Y, Kondoh Y, Suzuki R, Aizaki H, Sugiyama M, Borroto-Esoda K, Ryo A, Sugawara F, Osada H, Tanaka Y, Mizokami M, Wakita T. Identification of NTCP-targeting small molecules that inhibit HBV entry by cell-based and in vitro technologies. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  13. Watashi K. Hepatitis C virus cell culture system identifies fungi-derived NeoB as a liver X receptor inhibitor. Pacifichem 2015, Dec, 2015, Honolulu(USA)
  14. Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A. Molecular dissection of HBV evasion from restriction factor tetherin. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  15. Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Kuno A, Sugiyama M, Mizokami M, Narimatsu H. Investigation of the mechanism of interaction between host glycosylation system and hepatitis B virus replication system. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  16. Aly HH, Watashi K, Chayama K, Kato T, Wakita T. SKIV2L-dependent HBV-RNA degradation by the RNA-exosome, a new anti-HBV host mechanism. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  17. Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M. Long chain saturated fatty acid contributes to efficient egression of hepatitis B virus particles. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
  18. Moyo B, Nicholson S, Roelofse I, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P. AAV-delivered engineered repressor transcription activator-like effectors (rTALEs) inactivate hepatitis B virus replication in hNTCP cells and in mice. 2015 International Meeting of Molecular Biology of Hepatitis B Viruses, Oct, 2015, Bad Nauheim(Germany)
【Group Ⅱ】
Asako Sugimoto
Professor,Graduate School of Life Sciences, Tohoku University
    【Group Ⅱ】
    Hirokazu Arimoto
    Professor,Graduate School of Life Sciences, Tohoku University
    1. Hirokazu Arimoto,Endogenous nitrated nucleotide is an autophagy inducer、
      The International Chemical Congress of Pacific Basin Societies 2015 (PACIFICHEM 2015)、Dec18 2015, (Hawaii, USA)
    2. Hirokazu Arimoto,Roles of 8-nitro-cGMP in autophagy regulation、The 7th International conference on cGMP (cGMP 2015)、June20 2015,Trier(Germany)
    【Group Ⅱ】
    Yoshihiro Miwa
    Lecturer,Faculty of Medicine,University of Tsukuba
    【Group Ⅱ】
    Kumiko UI-TEI
    Associate Professor, Graduate School of Science The University of Tokyo
    1. Kumiko Ui-Tei Suppression of siRNA off-target effect by chemical modifications which regulate thermodynamics in nucleotide base-pairing
      2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (2015.12.17) Hawaii Convention Center,HI,USA
    2. Qingbo Wang, Yuki Naito, Kumiko Ui-Tei
      COMPUTATIONAL IDENTIFICATION OF CRISPR/CAS9 TARGET SITES REVEALED POTENTIAL OFF-TARGET RISKS IN HUMAN AND MOUSE GENOMES
      Conference on Transposition and Genome Engineering 2015 (2015.11.18)Nara Kasugano International Forum IRAKA, Japan
    3. Qingbo Wang, Yuki Naito, Kumiko Ui-Tei
      GENOME-WIDE IDENTIFICATION OF CRISPR/CAS9 TARGET SITES WITH REDUCED OFF-TARGET EFFECTS IN ORGANISMS WITH DIFFERENT GENOME SIZES
      CSHL Meeting on GENOME ENGINEERING: THE CRISPR/CAS REVOLUTION(2015.9.24-27)Cold Spring Horbor Laboratory,NY,USA
    4. Yuki Naito, Kimihiro Hino, Kumiko Ui-Tei, Hidemasa Bono, “CRISPRdirect: web-based tool for designing CRISPR/Cas guide RNA with reduced off-target sites”, Oxford Symposia CRISPR 2015 OXFORD: Technology and Application, St. Hilda’s College, Oxford, UK (Mar, 23, 2015). Poster
    5. Hisashi Iizasa, Kenichiro Sakata, Josephine Galipon, Kojiro Maeda, Soh Ishiguro, Nozomi Sakurai, Hironori, Yoshiyama, Kazuyoshi Yanagihara, Takanori Kubo, Yoshimasa Kitagawa, Hideyuki Kawauchi, Kumiko Ui-Tei, Junichi Hamada
      A-to-I RNA editing enzyme ADAR2 regulates malignancy in human pleural mesothelioma.
      Gordon Research Conference on RNA editing(2015.3.8-13) Lucca (Barga), Italy
    6. Kumiko Ui-Tei, Fuminori Murakami, Tomoko Takahashi
      Global identification of the interacting RNAs with dual functional RNA binding protein TRBP by next-generation sequencing
      International Symposium on Genome Science 2015″Expanding Frontiers of Genome ScienceⅡ”(2015.1.20)Tokyo,Japan
    【Group Ⅱ】
    Hiroshi Hamamoto
    Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
    1. Hiroshi Hamamoto, Jie Su, Keniichi Ishii, Jyunichiro Yasukawa, Atmika Paudel, Kazuhisa Sekimizu, Host factors enhance antimicrobial activity of “Lysocin E”, The international chemical congress of pacific basin societies 2015 (Pacifichem 2015), Dec. 15-20 2015, Hawaii (USA)
    【Group Ⅱ】
    Hiroaki Kato
    Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
    1. Ka Lu, Yamaguchi Tomohiro, Nakatsu Toru, Kato Hiroaki, Altering stability of a transmembrane protein, MsbA by structural comparison with its thermophilic homolog, The International Chemical Congress of Pacific Basin Societies 2015, December 15 – 20, 2015, Honolulu (USA)
    【Group Ⅱ】
    Tatsuro Shimamura
    Project Lecturer, Graduate School of Medicine, Kyoto University
    【Group Ⅱ】
    Yoshio Hayashi
    Professor, Tokyo University of Pharmacy and Life Sciences
    1. Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Suguru Aita, Saori Murakami, Kentaro Takayama, Fumika Yakushiji, Yoshio Hayashi, “Structure-Activity Relationship Studies Focused on 3-Amino Moiety of Negamycin Derivatives for Potent Readthrough Activity”, 14-16, September, 2015, Antwerp, Belgium, Poster.

    【A02】

    【Group Ⅰ-Ⅱ】
    Kazuhiro Irie, A02 Group Leader
    Professor, Graduate School of Agriculture, Kyoto Universiy
    1. Irie, K., “Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare”, 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015), Hawaii, USA, Dec. 15, 2015 (Invited Lecture)
    2. Ashida, Y., Yanagita, R. C., Takahashi, C., Fujii, M., Kawanami, Y., Irie, K., “Structure–activity studies on the PKC-recognition domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare”, 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015), Hawaii, USA, Dec. 15, 2015 (Oral Presentation)
    3. Hanaki, Y., Yanagita, R. C., Takahashi, C., Sugahara, T., Aida, M., Tokuda, H., Suzuki, N., Irie, K., “Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities”, 2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015), Hawaii, USA, Dec. 15, 2015 (Poster Presentation)
    【Group Ⅰ-Ⅱ】
    Masaya Imoto
    Professor, Faculty of Science and Technology, Keio University
    Co-Researcher: Etsu Tashiro
    1. S.Saito, T.Fujimaki, E.Tashiro, Y.Igarashi, M.Imoto、Isolation and biological activities of novel androgen receptor antagonist produced by Streptomyces、(PACIFICHEM 2015)、Dec17 2015 (Hawaii, USA)
    2. M.Imoto, T.Fujimai, S.Saiki, E.Tashiro, D.Yamada, N.Hattor、Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson’s disease、(PACIFICHEM 2015)、Dec17 2015 (Hawaii, USA)
    3. S.Ioka, T.Saito, S.Iwano, S.Maki, H.Niwa, M.Imoto, S.Nishiyama、 Development of the new firefly luciferin analog aiming at detection of a free radical in the living body、(PACIFICHEM 2015)、Dec17 2015 (Hawaii, USA)
    4. Yuki Shikata, Etsu Tashiro, Masaya Imoto、Screening for the compound that induces cell death selectively in β-catenin mutant tumor cells、27th AACR-NCI-EORTC International Conference、Nov7 2015、Boston(USA)
    5. Yuji Mizotani, Shun Itoh, Kohji Hotta, Etsu Tashiro, Kotaro Oka, Masaya Imoto、Evalution of drug toxicity profile using Ciona intestinalis、8th International Tunicate Meeting、July16 2015、Aomori City Cultural Hall(Aomori City Aomori Pref. )
    6. M. Imoto、Chemistry and biology of natural products that modulate cellular responses、SIBM Natural Products 2015、Jan12 2015、San Diego(USA) (Oral.Invited)
    【Group Ⅰ-Ⅱ】
    Shigeki Matsunaga
    Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
    1. Matsunaga, S., “Search for marine natural products with anticancer associated activity”, 2015 International Chemical Congress of Pacific BAsin Societies (PACIFICHEM 2015), Hawaii, USA, Dec. 16, 2015 (Invited Lecture).
    2. Pederazzoli, M. D. A., Takada, K., Furihata, K., Okada, S., Matsunaga, S., Ise, Y., Bontemps, N., Davis, R. A.,”Cell differentiation inducing metabolites from marine sponges”2015 International Chemical Congress of Pacific BAsin Societies (PACIFICHEM 2015), Hawaii, USA, Dec. 17, 2015 (Poster Presentation).
    3. Matsunaga, S., “Search for marine natural products with anticancer associated activity”, 46th Annual Meeting of Korean Society of Pharmacognoxy, Seoul, Korea, Dec. 3, 2015 (Invited Lecture).
    4. Matsunaga, S., “Search for marine natural products with anticancer associated activity”, International Seminar and Workshop on Marine Natural Products, Burapha University, Thailand, Sep. 15, 2015 (Invited Lecture).
    【Group Ⅰ-Ⅱ】
    Masami Ishibashi
    Professor,Graduate School of Pharmaceutical Sciences, Chiba University
    Co-Researcher:Midori Arai, Kazufumi Toume (by October), Naoki Ishikawa(since November)
    1. M. Ishibashi, “Natural products screening studies on disease and development signaling pathways”, The 4th Annual Conference of the Society for Laboratory Automation and Screening (SLAS2015), February 10, 2015, Washington, DC, U.S.A. (Invited)
    2. M. Ishibashi,“Natural products-based screening study on disease and development pathways”, Pacifichem 2015; December 17, 2015, Honolulu, U.S.A.
    3. M. Ishibashi, “Natural products screening studies on disease and development signaling pathways”, The 4th Annual Conference of the Society for Laboratory Automation and Screening (SLAS2015), February 10, 2015, Washington, DC, U.S.A. (Invited)
    【Group Ⅰ-Ⅱ】
    Tetsuro Shinada
    Professor, Graduate School of Science, Osaka City University
    Co-Researcher: Yasufumi Ohfune
    【Group Ⅰ-Ⅱ】
    Hidenori Watanabe
    Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
    1. Nozomu Kakimoto, Ken Ishigami, Hidenori Watanabe, “Total Synthesis of (+)-Clavigerin B” in The 13th International Kyoto Conference on New Aspects of Organic Chemistry, 2015,Nov.10,Kyoto Japan.
    2. Masaoki Yamamoto, Ken Ishigami, Hidenori Watanabe, “Total Synthesis of Glabramycin B” in The 13th International Kyoto Conference on New Aspects of Organic Chemistry, 2015,Nov.12,Kyoto Japan.
    【Group Ⅰ-Ⅱ】
    Kosuke Namba
    Professor, Graduate School of Pharmaceutical Science, The University of Tokushima
    【Group Ⅰ-Ⅱ】
    Satoshi Ichikawa 
    Professor,  Faculty of Pharmaceutical Science, Hokkaido University
    1. Nakaya, T.; Matsuda, A.; Ichikawa, S. Design and synthesis of simplified caprazamycin analogs. PACIFICHEM, The International Chemical Congress of Pacific Basin Societies 2015 (Poster Presentation), 15th Dec. 2015, Honolulu (Hawaii, USA).
    2. Yamaguchi, M.; Ichikawa, S.; Matsuda, A. Design and synthesis of conformationally restricted caprazamycin analogs as antibacterial agents. PACIFICHEM, The International Chemical Congress of Pacific Basin Societies 2015 (Poster Presentation), 15th Dec. 2015, Honolulu (Hawaii, USA).
    3. Katsuyama, A.; Matsuda, A.; Ichikawa, S. Synthetic study of plusbacin A3 PACIFICHEM, The International Chemical Congress of Pacific Basin Societies 2015 (Poster Presentation), 15th Dec. 2015, Honolulu (Hawaii, USA).
    4. Chiba, T.; Matsuda, A.; Ichikawa, S. Improvement of biological activities of syringolin A PACIFICHEM, The International Chemical Congress of Pacific Basin Societies 2015 (Poster Presentation), 15th Dec. 2015, Honolulu (Hawaii, USA).
    5. Nakaya, T.; Matsuda, A.; Ichikawa, S. Design, synthesis and biological evaluation of 5′-C-piperidinyl-5′-aminoribosyluridines as potential antibacterial agents. The 42nd International Symposium on Nucleic Acids Chemistry 2015 (Oral Presentation), 23rd Sep. 2015, Hyogo(Japan)
    6. Ichikawa Satoshi, Medicinal chemistry based on natural products, Taipei Medical University, 2015, March, 17th, Taipei, Taiwan (invited lecture).
    【Group Ⅰ-Ⅱ】
    Haruhiko Fuwa
    Associate Professor, Graduate School of Life Sciences, Tohoku University
    1. H. Fuwa, Y. Okuaki, N. Yamagata, M. Sasaki, “Total Synthesis, Stereochemical Revision, and Biological Evaluation of Lyngbyaloside B, a Marine Macrolide Glycoside,” PACIFICHEM 2015, 15-Dec-2015, Honolulu (USA)
    2. K. Sakamoto, A. Hakamata, H. Fuwa, M. Sasaki, “Synthetic Studies on Iriomoteolide-2a,” PACIFICHEM 2015, 17-Dec-2015, Honolulu (USA)
    3. Y. Kawashima, H. Fuwa, M. Sasaki, “Studies toward the Total Synthesis of Amphidinolide N,” PACIFICHEM 2015, 17-Dec-2015, Honolulu (USA)
    【Group Ⅰ-Ⅱ】
    Shinichi Nishimura
    Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
    1. Sugiyama, R., Nishimura, S., Ozaki, T., Asamizu, S., Onaka, H., Kakeya, H. 5-Alkyl-1,2,3,4-tetrahydroquinolines (5aTHQs), new membrane-interacting lipophilic metabolites, produced by combined-culture of Streptomyces nigrescens and Tsukamurella pulmonis. The International Chemical Congress of Pacific Basin Societies 2015 (PACIFICHEM 2015). Dec. 15-20, 2015, Hawaii, USA.
    【Group Ⅰ-Ⅱ(By August)-Advisory Members】
    Katsunori Tanaka
    Associate Chief Scientist,Biofunctional Synthetic Chemistry Laboratory, RIKEN
    Co-Researcher: Co-Researcher: Takayuki Iwata, Masataka Kitadani.
    【Group Ⅰ-Ⅱ】
    Kazunobu Toshima
    Professor, Faculty of Science and Technology, Keio University
    1. T. Kimura, D. Takahashi, K. Toshima, Novel chemical glycosylation with recognition of alcohol chirality and its application to natural product synthesis, The 2015 International Chemical Congress of Pacific Basin Societies, December 20, 2015, Honolulu, ( USA).
    2. D. Takahashi, A. Nakagawa, M. Tanaka, K. Toshima, Regio- and 1,2-cis-α-stereoselective glycosylation utilizing glycosyl acceptor-derived boronic ester catalyst, The 2015 Chemical Congress of Pacific Basin Societies, December 19, 2015, Honolulu, ( USA).
    3. K. Toshima, Target-selective photodegradation of oilgosaccharides in health and disease, The 2015 International Chemical Congress of Pacific Basin Societies, December 16, 2015, Honolulu, ( USA).
    4. K. Toshima, Target-selective photodegradation of proteins in chemical biology, The 2015 International Chemical Congress of Pacific Basin Societies, December 15, 2015, Honolulu, ( USA).
    5. S. Kusumi, H. Nakayama, H. Kuriki, D. Takahashi, K. Toshima, Synthetic studies on vineomycin A1, The 13th International Kyoto Conference on New Aspects of Organic Chemistry(IKCOC-13), November 11, 2015, Rihga Royal Hotel (Kyoto).
    6. M. Tanaka, A. Nakagawa, D. Takahashi, K. Toshima, Regio- and stereoselective glycosylation using glycosyl acceptor-derived boronic ester catalyst, 3rd National Tsing Hua University / Keio University Bilateral Symposium of Advanced Chemistry, July 16, 2015,Yagami campus, Keio University(Kanagawa).
    【Group Ⅰ-Ⅱ】
    Go Hirai
    Senior Research Scientist, Synthetic Organic Chemistry Laboratory,RIKEN
    1. Shan Lu, Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides from a rare actinomycete saccharothrix sp, Natural Product-based Drug Discovery, PacifiChem 2015, Dec. 18th, 2015, Honolulu.
    2. Masaki Morita, Synthetic strategy toward unique complex right-side structures of physalins, Molecular Function of Natural Products: Advances towards Chemical Biology, PacifiChem 2015, Dec. 17th, 2015, Honolulu.
    3. Go Hirai, Fluorine containing C-linked gangliosides GM3 analogs: Synthesis, conformational analysis, and biological activities, Molecular Function of Natural Products: Advances towards Chemical Biology, PacifiChem 2015, Dec. 15th, 2015, Honolulu.
    4. Xiaoying Sun, Identification of an endogenous factor that regulates the adaptive uptake of amino acids in fission yeast, Pombe 2015 : 8th International Fission Yeast Meeting, June21-26 2015 Kobe,Japan
    【Group Ⅱ】
    Shigefumi Kuwahara
    Professor, Graduate School of Agricultural Science, Tohoku University
    1. Shuntaro Sato, Mayuko Murakami, Takafumi Hirokawa, Shigefumi Kuwahara 「Synthetic studies toward strophasterol A」, 2015 International Chemistry Congress of Pacific Basin Societies (Pacifichem 2015), December 17, 2015,  Honolulu (USA)
    【Group Ⅱ(By October)-Advisory Members】
    Takayuki Doi
    Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
    1. Takayuki Doi, Synthesis of cyclodepsipeptide histone deacetylase inhibitors, PACIFICHEM 2015, Dec 16, 2015, Honolulu (USA)
    2. Takayuki Doi, Total synthesis of cyclodepsipeptide natural products and their biological evaluation, PACIFICHEM 2015, Dec 16, 2015, Honolulu (USA)
    【Group Ⅱ】
    Takashi Kawakami
    Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
    【Group Ⅱ】
    Daisuke Urabe
    Lecturer, Graduate School of Pharmaceutical Sciences,
    The University of Tokyo
    1. Urabe, D.; Inoue, M. PACIFICEHM2015, Molecular Function of Natural Products: Advances towards Chemical Biology (#237) “Unified total synthesis of oxygenated cardenolides,” Honolulu, USA, Dec. 15, 2015.
    2. Urabe, D.; Inoue, M. the 15th Tateshina Conference on Organic Chemistry “Total Synthesis of Crotophorbolone,” Chino, Japan, Nov. 8, 2015.
    3. Urabe, D. Institute of Microbial Chemistry, The Shibasaki Group Seminar ” Radical-based couplings toward the total synthesis of tigliane/daphnane diterpene,” Tokyo, Japan, July 30, 2015.
    【Group Ⅱ】
    Hiroshi Tanaka
    Associate Professor, Graduate Scool of Science and Engineering,  Tokyo Institute of Technology
    1. Ryota Suzuki, Kou Sato, Shinichiro Fuse, Hiroshi Tanaka, One-pot Sequential Palladium-Catalyzed Cross-Coupling Reaction of Cyclic Boron Compounds, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec 15-20、Hilton Hawaiian Village (Honolulu, Hawaii, USA)
    2. Hiroki Hamagami, Yukinori Hatasa, Yoshiki Yamaguchi, Shinichiro Fuse, Takahiro Shibata, Hirofumi Tachibana, Koji Uchida, Hiroshi Tanaka , Synthesis of Sugar-Modified EGCGs by Direct C-Glycosylation and Its Application to a Chemical Biology, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), 2015, Dec 15-20、Hilton Hawaiian Village (Honolulu, Hawaii, USA)
    【Group Ⅱ】
    Yukari Fujimoto
    Professor, Faculty of Science and Technology, Keio University
    Co-Researcher:Shinsuke Inuki, Toshihiko Aiba
    1. Yukari Fujimoto The 2015 International Chemical Congress of Pacific Basin Societies “Synthesis of immunomodulatory glycoconjugates based on recently developed chemical glycosylation” (Honolulu (USA) 2015.12.19).(Invited)
    2. Shinsuke Inuki, Keisuke Sato, and *Yukari Fujimoto “Decarboxylative functionalization of b-hydoroxy amino acids via photoredox catalysis and its application to the synthesis of the functional 1,2-amino alcohol derivatives” The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015) (Honolulu, USA, 2015.12.15-20) Poster
    3. Sae Suehara, Toshihiko Aiba, Shou Nakagawa, Masaki Sato, Yuuki Maekawa, Toshiaki Murai, Koichi Fukase, Shinsuke Inuki, *Yukari Fujimoto
      “Synthesis of inositol phospholipids from Ascaris suum using regioselective phosphorylation” The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015) (Honolulu, USA, 2015.12.15-20) Poster
    4. Shunichi Ishibashi, Shinsuke Inuki, *Yukari Fujimoto “Synthetic study on cardiolipin containing cyclopropane fatty acids” The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015) (Honolulu, USA, 2015.12.15-20) Poster
    5. Sho Nakagawa, Atsushi Shimoyama, Toshihiko Aiba, *Yukari Fujimoto, *Koichi Fukase
      “Synthesis and biological activity of phosphatidylinositol for the elucidation of NKT cell pre-activation mechanism” The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015) (Honolulu, USA, 2015.12.15-20) Poster
    6. Toshihiko Aiba, Sae Suehara, Hannah Bernin, Hanna Lotter, Shinsuke Inuki, Koichi Fukase, *Yukari Fujimoto “Synthesis and Immunoregulatory Activity of Lipophosphoglycans as NKT Cell Modulator” The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)(Rihga Royal Hotel in Kyoto, Kyoto, JPN, 2015.11.9-13) Poster
    7. Shinsuke Inuki, Keisuke Sato, *Yukari Fujimoto “Decarboxylative functionalization of β-hydoroxy amino acids via photoredox catalysis and its application to the synthesis of the functional 1,2-amino alcohol derivatives” The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13) (Rihga Royal Hotel in Kyoto, Kyoto, JPN, 2015.11.9-13) Poster
    8. Toshihiko Aiba, Sae Suehara, Hannah Bernin, Hanna Lotter, Shinsuke Inuki, Koichi Fukase, *Yukari Fujimoto “Synthesis and Biological Activity of Inositol Phospholipid as NKT Cell Modulator” 23rd International Symposium on Glycoconjugates (Glyco23), (Split, Croatia, 2015.11.16-19) Poster
    9. Toshihiko Aiba, Sae Suehara, Bernin Hannah, Lotter Hanna, Shinsuke Inuki, Koichi Fukase *Yukari Fujimoto, Synthesis and biological activity of Inositol phospholipids as NKT cel modulator,The 3rd National Tsing Hua University-Keio University Bilateral Symposium of Advanced Chemistry(KeioUniv,Yokohama)2015.7.16
    10. Yukari Fujimoto, “Chemistry and Functional Analysis of Immunomodulatory Microbial Glycoconjugates” in International Mini Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Yokohama, Kanagawa (Mar. 2015). (Invited)
    11. Yukari Fujimoto, “Chemistry and Immunomodulation of Microbial Glycoconjugates” in The First Yoshida Prize Symposium, Kyoto (Jan, 2015). (Invited)

    【A03】

    【Group Ⅰ-Ⅱ】
    Minoru Ueda., A03 Group Leader
    Professor,Graduate School of Science, Tohoku University
    1. M. Ueda, Chemical biology of coronatine: Pathogenic infection in plants, Pacifichem 2015 symposium#66 Natural product-based drug discovery, 15-20 Dec 2015, Honolulu, (USA).
    2. M. Ueda, Plant Chemical Biology using Natural Products, NEA-ASIAHOC, 9-12 Nov 2015, OIST, Okinawa (Japan).
    【Group Ⅰ-Ⅱ】
    Naoki Kanoh
    Associate Professor,Graduate School of Pharmaceutical Sciences, Tohoku University
    Co-Researcher: Takeo Usui
    1. ○Ayano Kawamata, Tomohiro Itagaki, Yuta Miyazaki, Kenzo Yahata, Naoki Kanoh, and Yoshiharu Iwabuchi, Synthetic Study of FD-891 and FD-892(Poster presentation),Pacifichem 2015 (Hawaii, Dec15-20 2015)
    2. ○Naoki Kanoh, Third generation photo-cross-linked small-molecule affinity matrix enabling quantitative analysis of the photocross-linked small molecules and their target purification(oral presentation),Pacifichem 2015 (Hawaii, Dec15-20 2015)
    3. ○Naoki Kanoh, Photo-cross-linked Small Molecule Affinity Matrix as a Tool for Target Identification of Bioactive Small Molecules(oral presentation),
      Pharmaceutical Science Symposium 2015 in Sendai Nov16 2015 Tohoku Univ
    4. ○Naoki Kanoh, Shunya Itoh, Kohei Sakanishi, and Yoshiharu Iwabuchi, Total synthesis and structural revision of heronamide C(Poster presentation),
      14th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds (Texas Oct13-16 2015)
    【Group Ⅰ-Ⅱ】
    Hideo Kigoshi
    Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
    Co-Researcher: Masaki Kita
    1. Masaki Kita、Recent Advances in the Study of Actin-Targeting Natural Products.
      Tsukuba Global Science Week (TGSW2015), Sept28-30 2015, Tsukuba Univ.
    2. Masaki Kita、Comparative Analysis of Toxicity In the Cuban Solenodon and Its Potential Role in the Species. Vth International Wildlife Management Congress 2015 (IWMC2015), July26-30 2015,Sapporo.
    【Group Ⅰ-Ⅱ】
    Toshio Nishikawa
    Profrssor, Graduate School of Bioagricultural Sciences, Nagoya University
    Co-Researcher :Masaatu Adachi,Keiichi Konoki
    1. Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita: Synthesis of biologically active steroid-derived compounds from an edible mushroom. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) (Honolulu, Hawaii, USA) 2015.12.15-2015.12.20.
    2. Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita: Synthesis and biological activities of guanidine-containing natural products. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) (Honolulu, Hawaii, USA) 2015.12.15-2015.12.20.(Oral)
    3. Yuushi Hiratra, Toshio Nishikawa: Eight-step synthesis of chaxine B based on a proposed biosynthetic pathway. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) (Honolulu, Hawaii, USA) 2015.12.15-2015.12.20.(Poster)
    4. Yoshiki Nakane, Yuki Ishikawa, Atsuo Nakazaki, Toshio Nishikawa: Asymmetric synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channels, and its analogues. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) (Honolulu, Hawaii, USA) 2015.12.15-2015.12.20.(Poster)
    5. Toshio Nishikawa: Biomimetic Synthesis of Biologically Active Steroidal Natural Products. ICCEOCA-10/ARNCEOCA-1 (Taiwan) 2015.11.2-2015.11.5.
    6. Toshio Nishikawa: Syntheses of Guanidine-containing Natural Products Aiming at development of Ion-channel Blockers.10th AFMC International Medicinal Chemistry Symposium (AIMECS2015)(ICC JEJU, KOREA) 2015.10.18-2015.10.21.
    7. Toshio Nishikawa:Syntheses of Biologically Active natural products by Means of Cascade Reactions. The 6th Japanese-Sino Symposium on Organic Chemistry for Young Scientists (Sendai, Japan) 2015.9.6-2015.9.9.
    8. Toshio Nishikawa:Biomimetic Synthesis of Biologically Active Steroidal Natural Products. Kick-off Symposium on Advanced Research Network for Cutting-Edge Organic Chemistry in Asia (Tohoku University, Japan) 2015.8.25-2015.8.26.
    9. Masaatsu Adachi ,” Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog.”、 Asian International Symposium、Mar27 2015、Funabashi Japan (Invited)
    【Group Ⅰ-Ⅱ】
    Makoto Sasaki
    Professor, Graduate School of Life Sciences, Tohoku University
    Co-Researcher :Kenichi Konoki
    【Group Ⅰ-Ⅱ-Advisory Members】
    Fumi Nagatsugi
    Professor, The Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
    1. Kazumitsu Onizuka, Takuya Miyashita , Fumi Nagatsugi , Pseudorotaxane formation via slipping process targeting on nucleic acids, The 42th International Symposium on Nucleic Acids Chemistry, Egret Himeji, Himeji Japan, 2015/9/23-25
    2. Kenji Kikuta, Piao Haishun, John Brazir, Kazumitsu Onizuka, Fumi Nagatsugi, Yosuke Taniguchi, Shigeki Sasaki, The effect of intra-strand cross-link formation on the stability of DNA i-motif, The 42th International Symposium on Nucleic Acids Chemistry, Egret Himeji, Himeji Japan, 2015/9/23-25
    3. Fumi Nagatsugi, Shuhei Kusano, Shogo Ishiyama, Sik Lok Lam, Tsukasa Mashima, Masato KatahiraFumi Nagatsugi, Development of the selective crosslinking reactions to 8-oxoguanine The 42th International Symposium on Nucleic Acids Chemistry, Egret Himeji, Himeji Japan, 2015/9/23-25
    4. Yusuke Abe, Ken Yamada, Yuta Ida, and Fumi Nagatsugi, Synthesis and Evaluation of the Reactivity of 7-Deaza-6-vinylguanosine Derivatives, Tohoku University Campus Asia Program Summer School 2015, 2015/8/28-30, Sendai, Japan
    5. Tomohito Kobayashi, Kazumitsu Onizuka, Fumi Nagatsugi, Synthesis of vinyltriazine derivatives aiming at alkylation to U‒U mismatch structure in RNA, Tohoku University Campus Asia Program Summer School 2015, 2015/8/28-30, Sendai, Japan
    6. Yoshihiro Sasaki, Norihiro Sato, Genichiro Tsuji, Ken Yamada, Fumi Nagatsugi, Development of small molecular probes for selective alkylation of the higher-order structure of nucleic acids, Tohoku University Campus Asia Program Summer School 2015, 2015/8/28-30, Sendai, Japan
    7. Takuya Amemiya, Kazumitsu Onizuka, Fumi Nagatsugi, Development of the interlocked structure formation method targeted RNA, Tohoku University Campus Asia Program Summer School 2015, 2015/8/28-30, Sendai, Japan
    【Group Ⅱ】
    Takamitsu Hosoya
    Pofessor, Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University
    1. Hosoya T, Yoshida S, Misawa Y. Formal C–H azidation-based shortcut to diazido building blocks for the versatile preparation of photoaffinity labeling probes of natural products and pharmaceuticals. PACIFICHEM 2015, Honolulu, Hawaii, USA, Dec. 2015.
    2. Hosoya T, Yoshida S, Shiraishi A, Kanno K, Kii I, Johmoto K, Uekusa H, Hagiwara M. Azido-type selective reactions for molecular conjugation. PACIFICHEM 2015, Honolulu, Hawaii, USA, Dec. 2015.
    3. Yoshida S, Hatakeyama Y, Johmoto K, Uekusa H, Hosoya T. Transient Protection of strained alkynes from click reaction via complexation with copper. PACIFICHEM 2015, Honolulu, Hawaii, USA, Dec. 2015.
    4. Meguro T, Yoshida S, Hosoya T. Cycloaddition of Thiophene S,S-Dioxide Derivatives with Strained Cycloalkynes. The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13), Kyoto, Japan, Nov. 2015.
    5. Hosoya T, Hatakeyama Y, Karaki F, Johmoto K, Uekusa H, Yoshida S. Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper. The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13), Kyoto, Japan, Nov. 2015.
    【Group Ⅰ-Ⅱ】Yousuke Takaoka
    Lecturer, Graduate School of Science, Tohoku University (since July)
    1. Yuuki Nukadzuka, Yousuke Takaoka, Minoru Ueda, “Development of novel protein labeling method useful for plant chemical biology”,Pacifichem 2015, Dec17 2015 (Hawaii, USA)
    2. Yousuke Takaoka, Toshiki Iwashita, Takeshi Suzuki, Kengo Hayashi, Shusuke Egoshi, Yasuhiro Ishimaru, Minoru Ueda, “Development of novel fluorescent PPI detection system for subtype selective ligand of phytohormone co-receptor”Pacifichem 2015, Dec17 2015 (Hawaii, USA)
    【Group Ⅰ-Ⅱ】
    Junko Ohkanda
    Associate professor, Institute for Chemical Research, Kyoto University
    1. Junko Ohkanda “Structure-based Design of PPI Inhibitors that Disrupt Ras Prenylation”• Pacifichem2015, Hawaii, USA • December 15.
    2. Junko Ohkanda “Rational Design of Peptide-based Agents that Control Intracellular Protein-protein Interactions” • The Seventh Peptide Engineering Meeting PEM7 • Indian Institute of Science Education and Research •Pune, India • December 5 to 7.
    【Group Ⅰ-Ⅱ】
    Misako Aida
    Professor, Graduate School of Science, Hiroshima University
    1. Misako Aida, Theoretical study on the mutual influence of water and biomolecules. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem2015) (December 15, 2015, Honolulu, Hawaii, USA)
    2. Dai Akase, Misako Aida, Koichi Ohno, Suehiro Iwata, Analysis of hydrogen bond energies and hydrogen bonding networks in water clusters using the locally projected molecular orbital perturbation theory. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem2015) (December 17, 2015, Honolulu, Hawaii, USA)
    3. Yudai Watanabe, Dai Akase, Misako Aida, Theoretical study on the electronic structure of trimethylamine N-oxide (TMAO) in aqueous solution. The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem2015) (December 17, 2015, Honolulu, Hawaii, USA)
    【Group Ⅰ-Ⅱ】
    Hideo Takahashi
    Professor, Graduate School of Medical Life Science, Yokohama City University
    1. Hideo Takahashi, “NMR approach for biomedical application”, Pacifichem 2015: Biomolecular Structure and Dynamics: Recent Advances in NMR, 2015/12/18, Honolulu (USA)
    2. Hideo Takahashi, “An NMR approach to improve a small-molecule inhibitor”, The 4th International Symposium on Drug Discovery and Design by NMR, Yokohama, (Feb. 2015), (Invited)
    【Group Ⅰ-Ⅱ】
    Toshiyuki Kan
    Professor, School of Pharmaceutical Sciences, University of Shizuoka
    【Group Ⅰ-Ⅱ】
    Hiroyuki Nakamura
    Professor, Tokyo Institute of Technology
    1. 〇H. Nakamura, Discovery of carboranylphenoxyacetanilides as inhibitors of heat shock protein (HSP) 60 chaperone activity. The International Chemical Congress of Pacific Basin Societies 2015, (Pacifichem 2015), Invited Lecture, Dec15-20 2015 (Honolulu, USA)
    2. 〇S. Sato, K. Nakamura, H. Nakamura, Tyrosine-selective chemical modification using single-electron-transfer catalyst The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec15-20 2015 (Honolulu, USA)
    3. 〇H. Nakamura, S. Sato, K. Morita, Target Protein-Selective Labeling and Inactivation Using Ligand-Directed Ru(bpy)3 Photocatalysts, 1st Asian Conference on Chemosensors &; Imaging Probes, Invited Lecture, Nov16-18 2015 (Seoul, Korea)
    4. 〇S. Sato, K. Nakamura, H. Nakamura, Heme-Catalyzed Tyrosine Click Reaction with Luminol Derivatives, 1st Asian Conference on Chemosensors & Imaging Probes, Nov16-18 2015 (Seoul, Korea) Poster Presentation Award
    5. 〇H. Nakamura, Development of Chemical Tools for Target Protein-Selective Identification and Selective Modification Invited Lecture at Indian Institute of Science, Mar10 2015 (Bangalore, India)
    6. S. Sato, K. Morita, 〇H. Nakamura, Development of Ligand-directed Ru(bpy)3 Photocatalysts for Target Protein Knockdown and Labeling An International Symposium on Recent Advances in Chemistry (REACH-2015), Mar3-5 2015 (Shillong, India)
    7. 〇H. Nakamura, Development of Chemical Tools for Target Protein-Selective Identification and Modification Invited Lecture at Indian Institute of Technology, Mar2 2015 (Guwahati, India)
    【Group Ⅰ-Ⅱ】
    Nobuyuki Kanzawa
    Associate Professor, Faculty of Science and Technology, Sophia University
    1. N. Kanzawa, J. Nishiya, Y. Otsuka, Y. Ishimaru, Minoru Ueda. “Biological characterization of MetE as a receptor candidate in Cassia obtusifolia for the leaf opening factor”, Pacifichem 2015, Honolulu, Hawaii, USA (Dec 15-20, 2015)
    2. N. Kanzawa, H. Takano, K. Yasuda, M. Takahara, M. Aizawa. “Studies on connexin 43, a gap-junction protein, in P19 embryonal carcinoma cells after culture on an apatite fiber scaffold”, Bioceramics 27, 27 th International Symposium on Ceramics in Medicine. Bali, Indonesia (Oct 27-29, 2015)
    【Group Ⅱ】
    Hiroki Oguri
    Professor, Faculty of Engineering, Tokyo University of Agriculture and Technology
    1. Hiroki Oguri (invited)、Development of Artificial Assembly Line for Skeletally Diverse Natural Products and its Variants、Pacifichem2015 Molecular Function of Natural Products: Advances towards Chemical Biology 2015.12.16.、Hawaii (USA)
    2. Bonepally Karnakar Reddy, Takahisa Hiruma, Kyouhei Ochiai, Maruki Mizoguchi, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ōmura, Hiroki Oguri、Design and de novo synthesis of anti-malarial 6-aza-artemisinins、2015.11.11.、The 13th International Kyoto Conference on New Aspect of Organic Chemistry (IKCOC-13) Rihga Royal Hotel Kyoto (poster)
    3. Hiroki Oguri Development of Chemical Assembly Lines for Skeletally Diverse Natural Products and its Variants、The 15th Tateshina Conference of Organic Chemistry 2015.11.6 Tateshina Forum (Nagano) (invited: oral & poster)、
    4. Hiroki Oguri 、Chemical Assembly Lines for Skeletally Diverse Natural Product Analogs、IUPAC-2015 Busan 48th General Assembly, 45th World Chemistry Congress, Chemistry of Life: Advances in Molecular Diversity 2015.8. 11. BEXCO Busan (Korea)(invited)
    【Group Ⅱ】
    Hiroaki Saito
    Assistant Professor, Graduate School of Natural Science & Technology, Kanazawa University
    1. Hiroaki Saito, Kazutomo Kawaguchi, and Hidemi Nagao, “Exploring an appropriate ligand-binding pose by ensemble-based docking”, PACIFICHEM 2015, Hawai, USA (Dec, 2015).
    2. Hiroaki Saito, “Exploring an accurate ligand-binding pose: ensemble-based docking study”, 55th Sanibel symposium, St. Simons island, GA, USA (Feb, 2015). (Poster presentation)
    3. Masashi Iwayama, Kazutomo Kawaguchi, Hiroaki Saito, and Hidemi Nagao, “Computation of redox potential of molecules by energy representation method”, International Symposium On Computational Science 2015 Kanazawa, Ishikawa, Japan (Feb, 2015). (Oral Presentation)
    4. Sri R. Natasia, Hiroaki Saito, Taku Mizukami, Kazutomo Kawaguchi and Hidemi Nagao, “Prediction of Solvation Free Energy of Proteins: Molecular Dynamics Simulation and QSPR Model Approach”, International Symposium On Computational Science 2015 Kanazawa, Ishikawa, Japan (Feb, 2015). (Poster presentation・Oral Presentation)
    【Group Ⅰ(Advisory Members) -Ⅱ(A03)】
    Motonari Uesugi
    Professor, Institute for Integrated Cell-Material Sciences & Institute for Chemical Research,
    Kyoto University
    1. Uesugi, M., “Small Molecules That Modulate Protein Assemblies”, Pacifichem 2015 Synthetic Modulators of Protein-Protein Interactions (#461), Hawaii (USA), December 19, 2015. (Invited)
    2. Uesugi, M., “Small Molecule Tools for Cell Biology and Cell Therapy”, Pacifichem 2015 Natural Product-based Drug Discovery, Hawaii (USA), December 18, 2015. (Invited)
    3. Uesugi, M., “Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells”, NEA & ASIAHORCs Joint Symposium – Chemical Biology – in Okinawa, OIST (Okinawa), November 9, 2015. (Invited)
    4. Uesugi, M., “Synthetic Molecules for Cell Biology and Cell Therapy”, XVII NOST-Organic Chemistry Conference, Jaipur (India), October 28, 2015. (Invited)
    5. Uesugi, M., “Small Molecule Tools for Cell Biology and Cell Therapy”, 2015 Fall Annual Convention of Pharmaceutical Society of Korea, Daegu (Korea), October 22, 2015. (Keynote speech)
    6. Uesugi, M., “Synthetic Molecules for Cell Biology and Cell Therapy”, AIMECS 2015 (10th AFMC International Medicinal Chemistry Symposium in 2015), Jeju (Korea), October 19, 2015. (Invited)
    7. Uesugi, M., “Synthetic Molecules for Cell Biology and Cell Therapy”, IUPAC2015, Busan (Korea), August 11, 2015. (Invited)
    8. Uesugi, M., “Synthetic Molecules for Cell Biology and Cell Therapy”, The 51th International Conference on Medicinal Chemistry (RICT 2015) – “Drug Discovery and Selection – Understanding Targets and Mechanisms”, Avignon (France), July 2, 2015. (Keynote speech)
    9. Motonari Uesugi, “Introduction of Chemical Biology”, Cell Biology, Developmental Biology, and Systems Biology Course Meeting, Kyoto, Japan (February 13, 2015). (Invited)
    10. Uesugi, M., “Synthetic Molecules for Cell Biology and Cell Therapy”, The 8th Takeda Science Foundation Symposium on PharmaSciences, Center for Learning and Innovation Takeda Pharmaceutical Company, Ltd. (Osaka), January 22, 2015. (Invited)
    【Group Ⅱ】
    Kazuhiro Mio
    Senior Research Scientist, National Institute of Advanced Industrial Science and Technology (AIST)
    1. Muneyo Mio, Depiction of 3D structure of membrane proteins and assignment of functional subunits using a transmission electron microscopy. 2015 International Chemical Congress of Pacific Basin Societies, 2015/12/15, Honoluilu, USA
    2. Junichiro Takaya, Discovery of a potent and selective agonist of TRPA1 and direct observation of its binding to TRPA1 by electron microscopy. 2015 International Chemical Congress of Pacific Basin Societies, 2015/12/16, Honoluilu, USA
    3. MEMTILY Nassirhadjy, Quick Observation of Tissues in Solution by Atmospheric Scanning Electron Microscopy (ASEM), M&M 2015, 2015/8/3, Portland

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