Chemical Biology of Natural Products: Target ID and Activity Control - Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Our mission

The goals of this research project are as follows: 1) to develop a
versatile methodology for identifying the target(s) of biologically
active natural products (or naturally occurring ligands,“NOLs”; 2) to establish a rational molecular approach to designing a simplified NOL (such as “Halaven”) based on the structure of the ligand/target complex; and 3) to generate new concepts relating to the control of bioactivity that depend on the “master key” characteristics of natural NOLs, for instance, the idea that a living organism selects the precise “master key” bioactivity appropriate for each situation in vivo.

 

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